Method to Identify CD40-Sensitive Cells Using Gene Expression

ABSTRACT

Gene expression patterns were analyzed in CD40-sensitive and CD40-resistant diffuse large-cell B-lymphoma (DLCBL) cell lines to identify signaling pathways which are involved in CD40-mediated apoptosis. CD40-resistant lines expressed pre-B cell markers including RAG and VPREB, whereas CD40-sensitive cells resembled mature B-cells and expressed higher levels of transcripts encoding several members of the CD40 signaling pathway including LCK and VAV. In addition, CD40 sensitive DLCBL cell lines also displayed constitutive activation of ERK and failed to undergo apoptosis when ERK phosphorylation was inhibited. In contrast, CD40 resistant lines showed no constitutive activation of ERK and no increase in ERK activity in response to CD40 stimulation. The invention includes methods to differentiate between CD40-sensitive and CD-40 resistant cells based on these differences in gene expression.

RELATED APPLICATION

This application claims the benefit of U.S. Provisional Application No.60/760,648, filed on Jan. 20, 2006. The entire teachings of the aboveapplication are incorporated herein by reference.

BACKGROUND OF THE INVENTION

CD40 promotes survival, proliferation, and differentiation of normalB-cells, but can cause activation-induced cell death in malignantB-lymphocytes. CD40 ligand and anti-CD40 antibodies have been usedsuccessfully to induce apoptosis in lymphoma lines both in vitro and inxenograft tumor models. While this makes CD40 an attractive target foranti-tumor therapies, the response of malignant B-cells to CD40signaling is variable and CD40 stimulation can enhance proliferation andincrease chemoresistance in some cell lines.

CD40 is first expressed prior to the rearrangement of immunoglobulinheavy chain genes in early B-cell development; its expression ismaintained through all subsequent stages of B-cell development and isnot lost during malignant transformation (2). Malignant B-lymphocytesand other CD40-positive tumor cells differ from normal B-cells in thatthey undergo apoptosis following CD40 stimulation (3). CD40 stimulationshows promise as an anti-tumor therapy in murine models of B-celllymphoma and breast cancer (4, 5). CD40 ligand has also been tested inphase I clinical trials (6); however, the use of CD40-directed therapyremains controversial because CD40 signaling can enhance cellproliferation and survival as well as induce resistance tochemotherapeutic agents in some B-cell malignancies (7, 8).Consequently, elucidation of the mechanisms involved in CD40-mediatedapoptosis may help to identify markers for susceptibility toCD40-mediated cell death and reveal proteins that specifically controlthe apoptotic arm of CD40 signaling. It would be useful to have a methodto use to predict whether a specific cell line or tumor will undergoapoptosis when stimulated with CD40, and to identify targets downstreamof CD40 which affect only the apoptotic arm of CD40 signaling.

SUMMARY OF THE INVENTION

In one embodiment, the invention is a method of determining whetherfirst cells respond to CD40 stimulation by undergoing apoptosis, saidmethod comprising testing said first cells for their profile of geneexpression, and comparing said profile with a second profile of geneexpression of second cells known to respond to CD40 stimulation byundergoing apoptosis. If the profile of gene expression of the firstcells shows expression levels of genes characteristic of the secondprofile, said first cells respond to CD40 stimulation by undergoingapoptosis. The method can be performed by analyzing RNA from the firstcells and the second cells on one or more arrays prepared for detectionand/or quantitation of RNA purified or partially purified from cells.

In another embodiment, the invention is a method of determining whetherfirst cells respond to CD40 stimulation by undergoing apoptosis, saidmethod comprising testing said first cells for levels of expression ofone or more genes, and comparing a first set of levels of expression ofsaid one or more genes to a second set of levels of expression of saidone or more genes in second cells known to respond to CD40 stimulationby undergoing apoptosis; wherein, if the first set of levels ofexpression of said one or more genes in said first cells ischaracteristic of said second set of levels of the second cells, saidfirst cells respond to CD40 stimulation by undergoing apoptosis.

Methods for quantitating levels of gene expression and/or providingmeans to compare levels of expression of selected genes are known in theart, and any such method previously described can be used where a stepof a method requires such quantitation and/or comparison. Methods thatrely on nucleic acid hybridization or hybridizable analogs thereof areparticularly useful. They can include, for example, analysis byoligonucleotide (or hybridizable analogs thereof) arrays or microarrays,commercially available or custom-made. Other methods that can be usedfor quantitating and comparing gene expression are RT-PCR, westernblotting or immunostaining methods.

In a further embodiment, the invention is a method for determiningwhether a population of cells is CD40-sensitive, said method comprisingquantitating expression of one or more genes in a sample of cells fromthe population, wherein said one or more genes in diffuse large-cellB-lymphoma (DLCBL) cell lines are differentially regulated betweenCD40-sensitive DLCBL cell lines and CD40-resistant DLCBL cell lines, andcomparing quantities of expression of said one or more genes in saidsample to quantities of expression of said one or more genes inCD40-resistant DLCBL cell lines, wherein if said one or more genes aredifferentially regulated between the cells in the sample and theCD40-resistant DLCBL cell lines, then the population of cells isCD40-sensitive.

The genes to be examined for gene expression can be one or more of anyof a number of genes described herein that were found to be expressedconstitutively at significantly different levels in CD40-resistant cellsas compared to expression of those genes in CD40-sensitive cells. Thegenes can be one or any number of genes selected from B-cell maturationspecific genes and members of the CD40/BCR signaling pathway (see Tables7A, 7B, 10A and 10B). Preferred genes to examine are RAG1, RAG2, IGLL1,CD9, VPREB1, CD22, CD38, Bruton's tyrosine kinase, VAV1, LYN, LCK andMEK1/MAP2K1. In other methods, the gene to be examined can be RAG1 orVAV1 or both.

Methods to quantitate gene expression are known by persons of skill inthe art. One such suitable method is reverse transcription polymerasechain reaction (RT-PCR). Another method that allows quantitating geneexpression and comparing levels of expression among or between genes isanalysis on arrays. A further method to quantitate expression of a geneis immunohistochemistry, which employs antibodies that can be added to asample of cells prepared for immunohistochemical testing. The antibodiesbind specifically to the protein product of the gene.

Yet another embodiment of the invention is a method for determiningwhether a population of cells is CD40-sensitive or CD40-resistant, saidmethod comprising testing a sample of cells from said population for thepresence or absence of phosphorylated ERK, whereby, if phosphorylatedERK is present, the population of cells is CD40-sensitive, and ifphosphorylated ERK is absent, population of cells is CD40-resistant. Themethod can be carried out by testing the sample of cells byimmunohistochemical methods, such as immunoblot of non-denatured lysatesfrom the sample of cells using anti-phospho-ERK antibodies, orimmunostaining with immunofluorescent labeled anti-phospho-ERKantibodies or with anti-phospho-ERK antibodies conjugated to a reactivelabel that can be readily visualized, for example.

Any of the above methods can be carried out on a sample of cells whereinthe sample is a tissue biopsy or a fluid sample from a human or animal.Any of the methods can be carried out on a population of cells or aportion of a population of cells wherein the population of cells is aprimary culture of cells from a human or animal, or the population ofcells is a cell line. The population of cells can comprise B-celllymphoma cells, diffuse large-cell B-lymphoma cells, cancer cells, forexample cancer cells derived from endothelial cells, epithelial cells,fibroblasts, or breast cancer cells, prostate cancer cells, lung cancercells, or colon cancer cells, for instance.

A further method can be used to identify CD40-sensitive cells, performedby treating said cells to activate CD40, and testing said cells for anincrease in the quantity of phosphorylated ERK, whereby if an increasein the quantity of phosphorylated ERK is observed, said cells areCD40-sensitive cells.

Cells in a population of cells, following one or more generations ofcell divisions, may change in phenotype and/or genotype relative to theoriginal population of cells. Cells may have been grown in culture forone or more generations or they may have undergone mutation(s) at theirnormal site in a human or animal. Cancer cells are widely recognized ascells that have undergone genotypic and phenotypic changes so that theydiffer from their cell of origin. Cells that are derived from a specificcell type means that the original population of cells some generationsago were of that cell type.

Arrays or microarrays for detection and quantitation of RNA are notlimited to the use of oligonucleotides as probes. Arrays can include asprobes oligonucleotides, peptide nucleic acids, locked nucleic acids,phosphorothioate analogs of oligonucleotides and other analogs or mimicsof oligonucleotides that can hybridize to RNA. Such probes can also beused in other methods based on hybridization.

BRIEF DESCRIPTION OF THE DRAWINGS

FIGS. 1A-1D are graphs showing that antiproliferative and apoptoticeffects of CD40 signaling differ among DLCBL lines. OCI-Ly1, OCI-Ly7,OCI-Ly8 or Su-DHL4 cells were seeded at 100,000 cells per mL insupplemented RPMI containing 10 μg/mL anti-CD40 antibody and 10 μg/mLcrosslinking secondary antibody (anti-CD40; filled squares), orsecondary antibody alone (control; open circles). For assessment of cellviability, aliquots were removed at 24-hour intervals, stained withpropidium iodide without prior permeabilization, and analyzed by flowcytometry using a fixed-time setting of 30 seconds to quantitate thenumber of viable cells per unit volume. Results of two experiments ofthree replicates each were combined. Error bars represent standarddeviations; where these are not visible they are covered by theoverlying symbol. Growth of OCI-Ly7 and Su-DHL4 cells was inhibited bycrosslinked anti-CD40. For quantitation of apoptosis, cells werestimulated for 48 hours with anti-CD40 or control antibody as describedabove, and then permeabilized with ethanol prior to staining withpropidium iodide. Intracellular DNA content was analyzed by flowcytometry.

FIG. 2 is a bar graph showing the percentage of cells with sub-G1 DNA.Cells containing less DNA than the G1 fraction, representing apoptoticcells, were quantitated. Results from two experiments of threereplicates each are shown. Error bars indicate standard deviations;asterisks indicate statistically significant differences between controland anti-CD40 treated cells. The fraction of cells with sub-G1 DNAcontent increased in OCI-Ly7 and Su-DHL4 cells.

FIGS. 3A-3D are profiles of fluorescence from cells sorted by flowcytometry. CD40 could be detected on all four DLCBL cell lines by flowcytometry. Open profiles indicate fluorescence fromphycoerythrin-conjugated anti-CD40 antibody and shaded profilesrepresent similarly conjugated isotype control antibody. Cells were notpermeabilized prior to staining, thereby restricting staining toantigens exposed on the cell surface.

FIGS. 4A and 4B are gene expression profiles of CD40-sensitive andCD40-resistant DLCBL: B-cell markers and CD40 signaling. mRNA fromunstimulated DLCBL lines was analyzed on Affymetrix HG-U133A v 2.0 GeneChips as described in the Materials and Methods section of the Examples.B-cell differentiation markers and genes in the CD40/BCR signalingpathway were compared in triplicate samples of each of the four celllines. Brackets indicate hierarchical clustering performed with Genesissoftware (23). The vertical bar indicates a group of co-segregatingpre-B cell markers (pre-B). See also Tables 2A, 2B, 3A, 3B, 4A, 4B, 5A,5B, 6A, 6B, 7A, 7B, 8A, 8B, 9A, 9B, 10A and 10B.

FIGS. 5A-5E are bar graphs showing relative expression levels of genesin the CD40 signaling pathway. Expression of several genes which hadshown differential expression by oligonucleotide array analysis wasverified by RT-PCR. PCR products were analyzed by gel electrophoresisand photographed with a Syngene gel documentation system. Relativelevels of expression were quantitated with GeneTools software bycomparison with a standard curve generated by amplification of PCRproduct from serially diluted cDNA. Results from triplicate samples areshown. Error bars indicate standard deviations. Where these are notvisible variations between samples were very small. N.D. indicates notdetectable.

FIG. 6 is a diagram illustrating the sites of action of two kinaseinhibitors. Two genes involved in CD40-mediated ERK signaling aredifferentially expressed among CD40-sensitive and CD40-resistant celllines. Differences in expression levels based on oligonucleotide arrayanalysis are indicated. Fold difference in expression could not becalculated for VAV, as this mRNA was not detectable in CD40-resistantcells.

FIGS. 7A and 7B are images of immunoblots. Activity of LCK and ERK wasanalyzed with phosphorylation-specific antibodies. LCK wasimmunoprecipitated from nondenatured cell lysates and detected byWestern blotting with phospho-src-family antibody (phospho-src). Theblot was stripped and reprobed with an antibody against LCK (LCK). Acommercially available Jurkat cell lysate was used as a positivecontrol. This sample was used without prior immunoprecipitation,allowing distinction of LCK from the slightly lower mobility bandrepresenting the antibody used in immunoprecipitation. ERK was detectedby immunoblotting with an antibody recognizing phosphorylated ERK1/2(phospho) and the blot was reprobed with a pan-specific anti-ERK1/2antibody (total).

FIGS. 8A and 8B are graphs of absorbance of cells, as a measure ofviability, following the addition of PP1 or U0126. Sensitivity of thecell lines to inhibition of LCK and ERK activity was tested by additionof the src family kinase inhibitor PP1 or the MEK1/2 inhibitor U0126.Cells were incubated for 96 hours in inhibitor concentrations rangingfrom 10⁻⁴ to 10⁻⁸ M, and viability was assessed by MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay.Viability is expressed as a percentage of the absorbance at 570 nm ascompared to untreated samples. Results of two experiments withquadruplicate samples each were combined. Error bars indicate standarddeviations.

FIG. 9 consists of images of stained Western blots. Cytoplasmic cellextracts were prepared from cells stimulated with crosslinked anti-CD40antibody for 0 to 180 minutes. Total and phosphorylated ERK was detectedby Western blot. Blots were first probed with the phospho-specificantibody, then the same membrane was re-probed for total protein withthe pan-specific antibody.

FIG. 10 is a bar graph showing the effect of ERK inhibition onCD40-mediated apoptosis. Cells were subjected to CD40 stimulation for 96hours in the presence of the MEK1/2 inhibitors U0126 (10 μM) or PD98059(50 μM), or the p38 inhibitor SB203580 (10 μM). Cell viability wasquantitated by staining nonpermeabilized cells with propidium iodide,and counting the number of unstained (live) cells per unit volume usinga Becton-Dickinson FACScan flow cytometer set to count for 30 seconds.The number of viable cells in anti-CD40-treated samples was expressed asa percentage of the number of viable cells incubated in secondaryantibody only. Results from three experiments of four replicates eachare shown. Error bars represent standard deviations. In the presence ofDMSO (control) or the p38 inhibitor SB203580, the number of viableOCI-Ly7 and Su-DHL4 cells was reduced by CD40 ligation, p<0.01. TheMEK1/2 inhibitors U0126 and PD98059 prevented CD40-mediated reduction inviability. Constitutive ERK phosphorylation is correlated withCD40-mediated cell death.

DETAILED DESCRIPTION OF THE INVENTION

Differences in the effects elicited by CD40 stimulation in B-cell linessuggest that different signal transduction pathways may be expressed inCD40-sensitive and CD40-resistant cells. To assess this, expressionmicroarray studies were performed on CD40-sensitive and CD40-resistantDLCBL cell lines. The data showing that CD40-sensitive and resistantcells display different gene expression profiles suggests that theselines may be derived from two distinct B-cell populations.CD40-sensitive cells overexpressed CD22 and CD38, which are found onmature, activated B-cells (35). CD40-resistant cells expressed highlevels of CD9, the recombination activating genes RAG1 and RAG2, and thepre-B cell receptor genes IGLL1 and VPREB1, which are characteristic ofpre-B cells at the stage of immunoglobulin rearrangement (36-39), andhave also been detected in B-lymphocytes in germinal centers (40). Thissuggests that the CD40-sensitive OCI-Ly7 and Su-DHL4 cell lines may bederived from mature, activated B-cells whereas the CD40-resistantOCI-Ly1 and OCI-Ly8 lines resemble immature B-cells. Expression ofmembers of the CD40 signaling pathway was investigated to determine theunderlying mechanism of CD40-mediated cell death. Failure of OCI-Ly1 andOCI-Ly8 cells to undergo apoptosis upon CD40 stimulation may be theresult of defects in the CD40 signal transduction pathway. These twocell lines showed reduced expression of several genes involved in CD40signaling, including LCK, VAV, and MEK1. Analysis of LCK by RT-PCR andWestern blot revealed that although RNA levels differed amongCD40-sensitive and CD40-resistant lines, all four cell lines expressedsignificant amounts of active LCK. This suggests that differences in LCKmRNA levels may not have any functional consequences. However,differences in VAV, a phosphorylation target of LCK, were striking, withstrong mRNA expression in CD40-sensitive lines and undetectable levelsin CD40-resistant lines. LCK and VAV have been previously shown tomaintain constitutive activation of ERK via stimulation of the RASpathway (31) which is consistent with our observation that ERK wasconstitutively phosphorylated in CD40-sensitive DLCBL cell lines butpermanently inactive in VAV-deficient CD40-resistant lines. Although allfour cell lines expressed active LCK, the SRC family inhibitor PP1 wasmore effective at reducing proliferation of OCI-Ly7 and Su-DHL4 cells.Differential sensitivity to PP1 could result from inhibition of otherSRC family kinases or from the differential function of downstreameffectors such as VAV, RAS, and ERK. Lack of VAV and inactive ERK inOCI-Ly1 and OCI-Ly8 cells is consistent with a dead-end in the SRCsignal transduction pathway. This could render the cells resistant toSRC family kinase inhibitors even if the targeted kinase itself isactive.

ERK activation has often been reported to be anti-apoptotic in bothlymphoid and non-lymphoid malignancies (34, 41); however, the effect ofERK phosphorylation varies, even among different stimuli in the samecell line (12). Two different ERK inhibitors did not affect the growthof DLCBL cell lines containing activated ERK, which suggests that theselines are not dependent on ERK signaling for survival or proliferation.Addition of ERK inhibitors prior to CD40 stimulation blockedactivation-induced cell death, which indicates that overexpression oraberrant activation of a protein in the ERK signaling cascade maysensitize DLCBL cell lines to CD40. The observation reported herein thatERK is constitutively active in these cell lines suggests that theactual death signal must be initiated by a second pathway when CD40signaling occurs. ERK has been implicated in apoptosis in other systemsof activation-induced cell death, both directly and as a predisposingfactor. TCR-mediated activation-induced cell death in a TCR hybridomacell line was shown to be mediated by activation of VAV and ERK (42).Transfection of RAT-1 fibroblasts or MCF-7 human breast cancer cellswith the ERK-regulated transcription factor elk-1 did not induceapoptosis directly, but rendered the cells susceptible to killing by acalcium ionophore (38). ERK may function in a similar way in DLCBL celllines, rendering cells susceptible to a second signal caused by CD40stimulation. However, the signal is unlikely to be calcium-mediated, astreatment of the cells with the calcium ionophore ionomycin induced celldeath in Su-DHL4 but not OCI-Ly7 cells.

The observations herein on two pairs of cell lines are insufficient todetermine whether differential expression of maturation-specific genesoutside of the LCK-ERK pathway plays a role in determiningsusceptibility to CD40-mediated cell death; however, they are consistentwith a previous report that B-cells at different stages of developmentdiffer in the protein phosphorylation patterns elicited by CD40stimulation (43). As CD40 signaling can promote proliferation andresistance to apoptosis in normal B-cells (44), it is possible thatconstitutive activation of this pathway in a tumor may lead to a moreaggressive phenotype. DLCBL has been shown to segregate into twosubtypes with distinct gene expression patterns, one resembling germinalcenter cells (germinal center type) and the other similar to matureB-cells that have been subjected to CD40 and B-cell receptor stimulation(activated B-cell type) (45). The prognosis was shown to differsignificantly, with five-year survival being 76% for germinal center and34% for activated type DLCBL (46). Neither the prevalence ofconstitutive ERK activation in either subtype of DLCBL nor correlationwith CD40 sensitivity has yet been investigated in tumor tissue. Thisarea may be fruitful for future investigation based not only on ourobservations, but also on recent development of inhibitors whichmodulate relevant signal transduction pathways. The SRC-VAV-ERK signaltransduction pathway is activated by both CD40 and B-cell receptorsignaling (12), and been implicated in proliferation of B-cellmalignancies (41). Several proteins in this pathway, including CD40, SRCfamily kinases, RAS, and MEK are being investigated as targets foranti-tumor therapies (47-50).

The studies herein show that increased expression of genes involvedCD40/BCR signal transduction coincided with constitutive ERK activationand susceptibility to CD40-mediated cell death in DLCBL cell lines. Aconstitutively active phenotype has previously been associated withreduced survival in DLCBL (45). This raises the question whether thepoor prognosis of activated type DLCBL may be the result of one or moreoveractive proteins in the CD40 signal transduction pathway. Aninteresting but as yet untested hypothesis is that the mechanismunderlying the aggressive nature of activated DLCBL may also be itsAchilles heel, leaving it vulnerable to therapies targeting the CD40signal transduction pathway.

REFERENCES

-   1. van Kooten C, Banchereau J. CD40-CD40 ligand. J Leukoc Biol 2000;    67:2-17.-   2. Uckun F M, Gajl-Peczalska K, Myers D E, Jaszcz W, Haissig S,    Ledbetter J A. Temporal association of CD40 antigen expression with    discrete stages of human B-cell ontogeny and the efficacy of    anti-CD40 immunotoxins against clonogenic B-lineage acute    lymphoblastic leukemia as well as B-lineage non-Hodgkin's lymphoma    cells. Blood 1990; 76:2449-2456.-   3. Tong A W, Stone M J. Prospects for CD40-directed experimental    therapy of human cancer. Cancer Gene Ther 2003; 10:1-13.-   4. Funakoshi S, Longo D L, Beckwith M, et al. Inhibition of human    B-cell lymphoma growth by CD40 stimulation. Blood 1994;    83:2787-2794.-   5. Hirano A, Longo D L, Taub D D, et al. Inhibition of human breast    carcinoma growth by a soluble recombinant human CD40 ligand. Blood    1999; 93:2999-3007.-   6. Vonderheide R H, Dutcher J P, Anderson J E, et al. Phase I study    of recombinant human CD40 ligand in cancer patients. J Clin Oncol    2001; 19:3280-3287.-   7. Voorzanger-Rousselot N, Favrot M, Blay J Y. Resistance to    cytotoxic chemotherapy induced by CD40 ligand in lymphoma cells.    Blood 1998; 92:3381-3387.-   8. Buske C, Twiling A, Gogowski G, et al. In vitro activation of    low-grade non-Hodgkin's lymphoma by murine fibroblasts, IL-4,    anti-CD40 antibodies and the soluble CD40 ligand. Leukemia 1997;    11:1862-1867.-   9. Gerondakis S, Strasser A. The role of Re1/NF-kappaB transcription    factors in B lymphocyte survival. Semin Immunol 2003; 15:159-166.-   10. Franklin R A, McCubrey J A. Kinases: positive and negative    regulators of apoptosis. Leukemia 2000; 14:2019-2034.-   11. Craxton A, Shu G, Graves J D, Saklatvala J, Krebs E G, Clark    E A. p38 MAPK is required for CD40-induced gene expression and    proliferation in B lymphocytes. J Immunol 1998; 161:3225-3236.-   12. Gauld S B, Blair D, Moss C A, Reid S D, Harnett M M.    Differential roles for extracellularly regulated    kinase-mitogen-activated protein kinase in B cell antigen    receptor-induced apoptosis and CD40-mediated rescue of WEHI-231    immature B cells. J Immunol 2002; 168:3855-3864.-   13. Chang H, Blondal J A, Benchimol S, Minden M D, Messner H A. p53    mutations, c-myc and bcl-2 rearrangements in human non-Hodgkin's    lymphoma cell lines. Leuk Lymphoma 1995; 19:165-171.-   14. Epstein A L, Kaplan H S. Feeder layer and nutritional    requirements for the establishment and cloning of human malignant    lymphoma cell lines. Cancer Res 1979; 39:1748-1759.-   15. Clark E A, Yip T C, Ledbetter J A, et al. CDw40 and    BLCa-specific monoclonal antibodies detect two distinct molecules    which transmit progression signals to human B lymphocytes. Eur J    Immunol 1988; 18:451-457.-   16. Hollmann A C, Gong Q, Owens T. CD40-mediated apoptosis in murine    B-lymphoma lines containing mutated p53. Exp Cell Res 2002;    280:201-211.-   17. Hollmann C A, Kittrell F S, Medina D, Butel J S. Wnt-1 and int-2    mammary oncogene effects on the β-catenin pathway in immortalized    mouse mammary epithelial cell lines are not sufficient for    tumorigenesis. Oncogene 2001; 20:7645-7657.-   18. Kurland J F, Voehringer D W, Meyn R E. The MEK/ERK pathway acts    upstream of NF kappa B1 (p50) homodimer activity and Bcl-2    expression in a murine B-cell lymphoma cell line. MEK inhibition    restores radiation-induced apoptosis. J Biol Chem 2003;    278:32465-32470.-   19. Novak J P, Sladek R, Hudson T J. Characterization of variability    in large-scale gene expression data: implications for study design.    Genomics 2002; 79:104-113.-   20. Bolstad B M, Irizarry R A, Astrand M, Speed T P. A comparison of    normalization methods for high density oligonucleotide array data    based on variance and bias. Bioinformatics 2003; 19:185-193.-   21. Benjamini Y, Drai D, Elmer G, Kafkafi N, Golani I. Controlling    the false discovery rate in behavior genetics research. Behav Brain    Res 2001; 125:279-284.-   22. Donze O, Deng J, Curran J, Sladek R, Picard D, Sonenberg N. The    protein kinase PKR: a molecular clock that sequentially activates    survival and death programs. Embo J 2004; 23:564-571.-   23. Sturn A, Quackenbush J, Trajanoski Z. Genesis: cluster analysis    of microarray data. Bioinformatics 2002; 18:207-208.-   24. Karolchik D, Baertsch R, Diekhans M, et al. The UCSC Genome    Browser Database. Nucleic Acids Res 2003; 31:51-54.-   25. Rozen S, Skaletsky H. Primer 3 on the WWW for general users and    for biologist programmers. Methods Mol Biol 2000; 132:365-386.-   26. Altschul S F, Gish W, Miller W, Myers E W, Lipman D J. Basic    local alignment search tool. J Mol Biol 1990; 215:403-410.-   27. Von Knethen A, Abts H, Kube D, Diehl V, Tesch H. Expression of    p56lck in B-cell neoplasias. Leuk Lymphoma 1997; 26:551-562.-   28. Grammer A C, Swantek J L, McFarland R D, Miura Y, Geppert T,    Lipsky P E. TNF receptor-associated factor-3 signaling mediates    activation of p38 and Jun N-terminal kinase, cytokine secretion, and    Ig production following ligation of CD40 on human B cells. J Immunol    1998; 161:1183-1193.-   29. Salojin K V, Zhang J, Delovitch T L. TCR and CD28 are coupled    via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK    signaling pathway. J Immunol 1999; 163:844-853.-   30. Song J S, Haleem-Smith H, Arudchandran R, et al. Tyrosine    phosphorylation of Vav stimulates IL-6 production in mast cells by a    Rac/c-Jun N-terminal kinase-dependent pathway. J Immunol 1999;    163:802-810.-   31. Lin K, Abraham K M. Targets of p56(lck) activity in immature    thymoblasts: stimulation of the Ras/Raf/MAPK pathway. Int Immunol    1997; 9:291-306.-   32. Liu Y, Bishop A, Witucki L, et al. Structural basis for    selective inhibition of Src family kinases by PP1. Chem Biol 1999;    6:671-678.-   33. Favata M F, Horiuchi K Y, Manos E J, et al. Identification of a    novel inhibitor of mitogen-activated protein kinase kinase. J Biol    Chem 1998; 273:18623-18632.-   34. Davies C C, Mason J, Wakelam M J, Young L S, Eliopoulos A G.    Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated    protein synthesis reveals the pro-apoptotic properties of CD40    ligation in carcinoma cells. J Biol Chem 2004; 279:1010-1019.-   35. Perfetti V, Vignarelli M C, Bellotti V, et al. Membrane CD22    defines circulating myeloma-related cells as mature or later B    cells. Lab Invest 1997; 77:333-344.-   36. Burrows P D, Cooper M D. B cell development and differentiation.    Curr Opin Immunol 1997; 9:239-244.-   37. Williamson J M, Grigor I, Smith M E, et al. Cluster    differentiation antigen expression, proliferative activity and    clinical stage in centroblastic centrocytic lymphomas. J Pathol    1986; 150:51-59.-   38. Shao N, Chai Y, Cui J Q, et al. Induction of apoptosis by Elk-1    and deltaElk-1 proteins. Oncogene 1998; 17:527-532.-   39. Wang Y H, Nomura J, Faye-Petersen O M, Cooper M D. Surrogate    light chain production during B cell differentiation: differential    intracellular versus cell surface expression. J Immunol 1998;    161:1132-1139.-   40. Tarlinton D. Germinal centers: a second childhood for    lymphocytes. Curr Biol 1997; 7:R155-159.-   41. Zheng B, Fiumara P, Li Y V, et al. MEK/ERK pathway is aberrantly    active in Hodgkin disease: a signaling pathway shared by CD30, CD40,    and RANK that regulates cell proliferation and survival. Blood 2003;    102:1019-1027.-   42. Tanimoto Y, Kizaki H. Proteasome inhibitors block Ras/ERK    signaling pathway resulting in the downregulation of Fas ligand    expression during activation-induced cell death in T cells. J    Biochem (Tokyo) 2002; 131:319-326.-   43. Uckun F M, Schieven G L, Dibirdik I, Chandan-Langlie M,    Tuel-Ahlgren L, Ledbetter J A. Stimulation of protein tyrosine    phosphorylation, phosphoinositide turnover, and multiple previously    unidentified serine/threonine-specific protein kinases by the    Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of    human B-cell ontogeny. J Biol Chem 1991; 266:17478-17485.-   44. Gruss H J, Herrmann F, Gattei V, Gloghini A, Pinto A, Carbone A.    CD40/CD40 ligand interactions in normal, reactive and malignant    lympho-hematopoietic tissues. Leuk Lymphoma 1997; 24:393-422.-   45. Alizadeh A A, Eisen M B, Davis R E, et al. Distinct types of    diffuse large B-cell lymphoma identified by gene expression    profiling. Nature 2000; 403:503-511.-   46. Hans C P, Weisenburger D D, Greiner T C, et al. Confirmation of    the molecular classification of diffuse large B-cell lymphoma by    immunohistochemistry using a tissue microarray. Blood 2004;    103:275-282.-   47. Law C L, Gordon K A, Collier J, et al. Preclinical antilymphoma    activity of a humanized anti-CD40 monoclonal antibody, SGN-40.    Cancer Res 2005; 65:8331-8338.-   48. Karp J E, Lancet J E, Kaufmann S H, et al. Clinical and biologic    activity of the farnesyltransferase inhibitor R115777 in adults with    refractory and relapsed acute leukemias: a phase 1    clinical-laboratory correlative trial. Blood 2001; 97:3361-3369.-   49. He H, Hirokawa Y, Levitzki A, Maruta H. An anti-Ras cancer    potential of PP1, an inhibitor specific for Src family kinases: in    vitro and in vivo studies. Cancer J 2000; 6:243-248.-   50. James J A, Smith M A, Court E L, et al. An investigation of the    effects of the MEK inhibitor U0126 on apoptosis in acute leukemia.    Hematol J 2003; 4:427-432.

EXAMPLES Materials & Methods Lymphoma and Hybridoma Cell Lines

Diffuse large-cell lymphoma lines OCI-Ly1, OCI-Ly7, OCI-Ly8, and Su-DHL4(13, 14) were provided by Dr. Neil Berinstein, Ontario Cancer Institute,Toronto, ON, Canada. A hybridoma line producing anti-human CD40 (cloneG28.5) (15) was provided by Dr. Bruce Mazer, McGill University,Montreal, PQ, Canada. The cell lines were maintained in RPMI1640 medium(Sigma, Oakville, ON, Canada) supplemented with 10% bovine growth serum(VWR Canlab, Montreal, PQ, Canada), 0.2 mM glutamine, 0.05 mMβ-mercaptoethanol, 100 U/mL penicillin and 100 μg/mL streptomycin in a5% CO₂ atmosphere at 37° C. Antibodies against human CD40 (clone G28.5)and murine IgG (clone HB58) were purified from hybridoma supernatantswith a Protein G sepharose column as described by the manufacturer(Amersham, Baie d'Urfe, PQ, Canada).

CD40 Stimulation and Assessment of Viability

Cells were resuspended at 1×10⁵ cells/mL in RPMI 1640 mediumsupplemented as described above. Anti-CD40 antibody G28.5 and secondarycrosslinking antibody HB58 were added to a final concentration of 10μg/mL each, and the cells were incubated at 37° C. At 24 hour intervalsaliquots of cells were harvested by centrifugation, washed once inphosphate buffered saline, and resuspended in FACS buffer.Non-permeabilized cells were stained by addition of 1 μg/mL propidiumiodide, and the density of viable cells was determined using a FACScanflow cytometer and CellQuest software (Becton Dickinson, Mississauga,ON, Canada) set to count for a fixed 30-second time interval. Todetermine the fraction of cells that had undergone apoptosis, totalintracellular DNA content was measured by propidium iodide staining ofethanol-permeabilized cells as previously described (16). Expression ofCD40 on the cell surface was confirmed by staining non-permeabilizedcells with a phycoerythrin-linked anti-CD40 antibody (clone 5C3,Becton-Dickinson) as per the manufacturer's directions, followed by flowcytometry.

Growth Inhibition by Kinase Inhibitors

The src family kinase inhibitor PP1 and the MEK inhibitor U0126 werepurchased from Biomol (Plymouth Meeting, Pa., USA), and from CellSignaling Technology (Beverly, Mass., USA) respectively. Kinaseinhibition assays were performed using cells seeded at a density of5×10⁴ per mL in 96-well plates, to which kinase inhibitors were added tofinal concentrations of 10⁻⁴ to 10⁻⁸ M. The treated cells were incubatedat 37° C. for 96 hours and cell viability was quantitated by MTT assayas previously described (17). For inhibition of CD40-mediated apoptosis,the MEK inhibitors U0126 (10 μM) and PD98059 (50 μM) as well as the p38inhibitor SB203580 (10 μM) (Cell Signaling Technologies) were added 30minutes prior to CD40 stimulation. The dose of kinase inhibitors used inthis study have been previously shown to mediate target-specific effectsin lymphocytes (18).

Detection of Intracellular Phosphorylated ERK by Flow Cytometry

Cells were permeabilized in Cytofix/Cytoperm (Becton-Dickinson) for 20minutes, and stained with anti-phospho-ERK antibody (Cell SignalingTechnology #9101) and FITC-conjugated anti-rabbit secondary antibody(Cedarlane Laboratories, Hornby, ON, CA) following the manufacturers'instructions. The stained cells were analyzed by flow cytometry with aFACScan flow cytometer and CellQuest software.

Preparation of Cell Extracts

Nondenatured whole cell lysates were prepared by sonicating cells innondenaturing lysis buffer (20 mM Tris pH 7.5, 150 mM NaCl, 1 mM EDTA, 1mM EGTA, 1% Triton-X 100, 1 mM Na₃VO₄) containing a protease inhibitorcocktail (Roche Diagnostics, Laval, PQ, Canada). Cytoplasmic-enrichedextracts were prepared by lysing cells in hypotonic lysis buffer (10 mMHepes pH 7.9, 1.5 mM MgCl₂, 100 mM KCl, 1 mM DTT, 1% protease inhibitorcocktail (Sigma, P8340)) followed by shearing through a 23 G needle torelease the nuclei. The nuclei were pelleted at 450×g and thesupernatant (cytoplasmic-enriched cell extract) was removed and storedat −80° C. Protein concentration was determined using the BCA proteinassay (Pierce, Rockford, Ill., USA).

Immunoprecipitation and Western Blot:

LCK was immunoprecipitated from nondenatured cell lysate with apolyclonal rabbit antibody (Cell Signaling Technology #2752) asrecommended by the manufacturer. Proteins were separated by SDS-PAGE ona 14% polyacrylamide gel at 180V for 1 h and transferred to anitrocellulose membrane by electrophoretic transfer at 100V for 1 h.Western blots were performed as previously described (16). Primaryantibodies against total and phosphorylated ERK, JNK, and p38 (CellSignaling Technology #9101, #9102, #9151, #9152, #9211 and #9212) wereused at a dilution of 1:100, primary antibodies against LCK andactivated src family kinases (Cell Signaling Technology #2752 and #2101)were diluted 1:500, and peroxidase-conjugated goat anti-mouse or donkeyanti-rabbit secondary antibodies (BioCan Scientific, Mississauga, ON,Canada) were used at a dilution of 1:10000. The compositions of blockingand antibody dilution solutions were as specified by the manufacturer.Blots were immersed in Femto West ECL staining solution (Pierce) for 30seconds and photographed with a Syngene chemiluminescence imaging systemand GeneSnap software. Image size and contrast was adjusted using Canvassoftware.

Expression Microarrays

Total RNA was prepared from cultured cells using Trizol reagentaccording to the manufacturer's instructions (Invitrogen, Carlsbad,Calif.). The integrity of the purified RNA was verified using an Agilent2100 Bioanalyzer (Agilent Technologies, Palo Alto, Calif.). Probes formicroarray analysis were prepared using 10 micrograms of total RNA andhybridized to Affymetrix HG-U113A Gene Chips (Affymetrix, Santa Clara,Calif.) as previously described (19). In order to minimize technicalvariability, RNA processing steps (RNA extraction, probe labeling andchip hybridization) were performed in parallel for each set of four RNAsamples.

The hybridized arrays were scanned and raw data extracted using theMicroarray Analysis Suite 5.0 (MAS5, Affymetrix, Santa Clara, Calif.).The raw data were normalized using RMAExpress (20)(http://stat-www.berkeley.edu/users/bolstad/RMAExpress/RMAExpress.html)and filtered to exclude genes that MAS5 did not identify as “Present” inany expression profile. Differentially expressed genes were identifiedby performing a t-test between each pair of CD40-sensitive andCD40-resistant lines. False positive error correction was performed tomaintain a 10% false discovery rate (FDR) (21). Genes whose expressiondiffered significantly and showed the same direction of change in allfour comparisons were considered to be differentially regulated betweensensitive and resistant lines. Functional assessment of these expressiondifferences was performed using contingency table analysis, based onhand-curated lists of NFκB targets ((22) and references obtained fromhttp://people.bu.edu/gilmore/nf-kb)) genes involved in CD40 and BCRsignal transduction, B-cell maturation markers and the Gene Ontologyclassification of proteins implicated in apoptosis (Affymetrix, SantaClara, Calif.). See Tables 4A, 4B, 5A, 5B, 6A, 6B, 7A, 7B, 8A, 8B, 9A,9B, 10A and 10B. FIGS. 4A and 4B illustrating relevant expressionprofiles were prepared using Genesis(http://genome.tugraz.at/Software/GenesisCenter.html) (23).

Semi-Quantitative RT-PCR

RNA isolation and cDNA synthesis was performed as for the microarrayanalyses. Primers were designed to span introns to ensure specificityfor cDNA as opposed to genomic DNA sequences. Intron/exon junctions wereidentified by use of the UCSC genome browser(http://www.genome.ucsc.edu) (24). Primers were designed using Primer3software (http://frodo.wi.mit.edu/cgi-bin/primer3/primer3_www.cgi) (25)and their specificity was verified by performing a BLAST search(http://www.ncbi.nlm.nih.gov/BLAST/) of the NCBI “nr” nucleotidesequence database (26). The following primer pairs were used:

(SEQ ID NO:1) BTK 5′TGATGAAGGGCCTCTCTACG; (SEQ ID NO:2)3′CGGTGAGAACTCCCAGGTTT; (SEQ ID NO:3) CD9 5′GACTATGGCTCCGATTCGAC; (SEQID NO:4) 3′AGGAAGCCGAAGAACAGTCC; (SEQ ID NO:5) GAPDH5′GAAGGTGAAGGTCGGAGTCA; (SEQ ID NO:6) 3′GACAAGCTTCCCGTTCTCAG; (SEQ IDNO:7) LCK 5′ATGAACTGGTCCGCCATTAC; (SEQ ID NO:8) 3′CCCGTTGTAGTACCCCATCC;(SEQ ID NO:9) RAG1 5′AGAGAGCAGAGAACACACTTTGC; (SEQ ID NO:10)3′GATCTCACCCGGAACAGCTT; (SEQ ID NO:11) VAV1 5′CACCTGCTGTGAGAAGTTCG (SEQID NO:12) 3′GTCGGACAGGCCACTGTAGAT.PCR amplification was performed with 0.01 U/μL Taq DNA polymerase(Sigma) in PCR buffer (Sigma) containing 2 mM MgCl₂, 0.25 μg/μL bovineserum albumin (New England Biolabs), and 0.1 mM each dATP, DCTP, dGTP,and dTTP (Amersham). Amplification was performed with 25 cycles (GAPDH,BTK) or 35 cycles (all other primers) of 30 seconds each at 95° C., 58°C., and 72° C. PCR products were detected by gel electrophoresis andethidium bromide staining. Images were acquired with a Syngene geldocumentation system and GeneSnap software. Gene expression wasquantitated with GeneTools software, using PCR products amplified from acDNA dilution series as a standard curve. Images were transferred toCanvas software for adjustment of contrast and image size.

Example 1 Susceptibility of DLCBL Cell Lines to CD40-Mediated Cell Death

Diffuse large-cell B-lymphoma cell lines were screened forsusceptibility to CD40-mediated cell death. The number of viable OCI-Ly7and Su-DHL4 cells was reduced after 72 hours of exposure to crosslinkedanti-CD40 antibody, whereas the viability of OCI-Ly1 and OCI-Ly8 cellswas unaffected (FIGS. 1A-1D). CD40 stimulation also increased theproportion of cells with sub-G1 DNA content at 48 hours in OCI-Ly7 andSu-DHL4, but not OCI-Ly1 or OCI-Ly8 (FIG. 2). Expression of CD40 on thecell surface was confirmed by flow cytometry for all four cell lines(FIGS. 3A-3D).

Example 2 Gene Expression Profiling of CD40-Sensitive and CD40-ResistantDLCBL Lines

To identify pre-existing gene expression patterns that may predictsusceptibility to CD40-mediated cell death, RNA from unstimulatedOCI-Ly1, OCI-Ly8, OCI-Ly7, and Su-DHL4 cells was analyzed on AffymetrixU133A oligonucleotide arrays. In total, 304 genes were differentiallyexpressed among CD40-sensitive and CD40-resistant cells (FIGS. 4A and4B; Tables 2A, 2B, 3A and 3B. Further analysis was restricted to subsetsof genes likely to be involved in CD40 signaling, including regulatorsof apoptosis, B-cell specific genes, and NFκB-regulated genes.Susceptibility to CD40-mediated apoptosis was not associated withdifferences in expression of pro-apoptotic or anti-apoptotictranscripts, and there was no statistically significant difference inexpression of NFκB-regulated genes (Table 1). Differences in expressionof transcripts encoding B-cell maturation-specific genes and members ofthe CD40 signaling pathway were statistically significant. CD40resistant OCI-Ly1 and OCI-Ly8 cells expressed significantly higherlevels of pre-B cell genes including RAG1, RAG2, IGLL1, CD9, and VPREB1,whereas CD40-sensitive OCI-Ly7 and Su-DHL4 cells expressed higher levelsof CD22 and CD38. CD40-sensitive cells also expressed higher levels ofseveral genes in the CD40 signaling pathway, including Bruton's tyrosinekinase, VAV, LYN, LCK, and MEK1/MAP2K1. Differential expression ofseveral genes was confirmed by RT-PCT (FIGS. 5A-5E). Transcripts for twoof these genes could only be detected in one group of cell lines: RAG1was easily detectable in CD40-resistant OCI-Ly1 and OCI-Ly8 cells butabsent in CD40-sensitive OCI-Ly7 and Su-DHL4 cells, and VAV1 was presentin CD40-sensitive but undetectable in CD40-resistant cells.

TABLE 1 Differences in gene expression among CD40-sensitive andCD40-resistant DLCBL lines number differences Group of genes expectedobserved Chi Square p-value Total unique markers 8003 N.A. 298 N.A. N.A.Pre-B markers* 14 0.5 5.0 38.5 <0.001 Mature, activated B-cell* 18 0.73.0 8.1 <0.005 Pan-B cell* 10 0.4 1 1.1 n.s. CD40/BCR signaling* 35 1.35.0 10.5 <0.005 NFκB regulated * 117 4.4 6.0 0.6 n.s. Apoptosis* 90 3.43 0.0 n.s. Anti-apoptosis* 56 1.1 0 1.1 n.s. N.A. = not applicable, n.s.= not significant. *Genes in these groups are listed in Tables 4A, 4B,5A, 5B, 6A, 6B, 7A, 7B, 8A, 8B, 9A, 9B, 10A and 10B.

TABLE 2A Genes With Increased Expression in CD40-Sensitive Cell LinesLog2 fluorescence intensity D4 Probesets Ly1 (A1) Ly1 (A2) Ly1 (A3) Ly7(B1) Ly7 (B2) Ly7 (B3) Ly8 (C1) Ly8 (C2) Ly8 (C3) D4 (D1) D4 (D2) (D3)200011_s_at 9.37 9.43 9.33 9.70 9.59 9.63 9.31 9.23 9.40 10.31 10.3010.42 200090_at 8.94 8.60 8.88 9.95 9.99 9.90 8.77 8.54 8.83 10.35 10.2210.44 200625_s_at 9.62 9.46 9.54 10.25 10.12 10.13 9.77 9.77 9.66 10.0610.22 10.15 200679_x_at 10.87 11.27 11.16 12.13 12.00 12.04 10.97 11.1511.22 12.13 12.12 12.32 200762_at 6.64 6.56 6.91 9.22 9.03 8.98 6.486.50 7.17 8.51 8.16 8.78 200833_s_at 9.81 9.59 9.83 10.35 10.24 10.479.82 9.74 9.92 10.57 10.57 10.79 200998_s_at 5.24 5.07 5.26 6.84 7.216.83 6.05 5.70 5.77 6.75 6.89 7.11 201029_s_at 7.24 7.18 7.18 9.63 9.669.37 8.31 7.88 8.11 10.81 11.04 10.86 201077_s_at 10.70 10.63 10.5511.13 10.99 10.98 10.66 10.59 10.54 10.96 11.02 10.89 201089_at 8.187.80 7.79 8.87 8.64 8.84 7.96 7.78 7.97 9.21 9.21 9.51 201090_x_at 13.0713.16 13.11 13.60 13.50 13.51 13.19 13.19 13.15 13.59 13.52 13.61201209_at 9.60 9.38 9.66 10.43 10.38 10.40 9.67 9.39 9.63 10.63 10.3710.62 201260_s_at 7.65 7.59 8.15 9.44 9.34 9.55 7.62 7.59 7.99 9.62 9.649.71 201375_s_at 8.03 7.78 8.17 9.52 9.38 9.56 8.15 7.75 8.23 9.53 9.379.73 201405_s_at 9.04 9.20 9.02 9.39 9.43 9.52 9.25 9.14 9.23 9.68 9.779.80 201422_at 9.85 9.47 9.78 10.90 10.97 10.90 9.76 9.64 9.53 11.9112.37 12.03 201453_x_at 9.97 9.88 10.00 10.55 10.55 10.60 9.92 9.73 9.8710.44 10.53 10.49 201503_at 9.80 9.85 9.99 10.66 10.48 10.49 10.05 9.929.80 10.73 10.51 10.72 201561_s_at 7.98 7.71 7.60 8.68 8.46 8.34 7.967.83 7.68 8.67 8.48 8.73 201584_s_at 9.90 10.09 9.89 10.78 10.61 10.549.69 9.83 9.84 10.86 10.78 10.91 201663_s_at 8.95 9.05 8.91 10.27 10.069.98 8.91 8.97 9.13 10.37 10.52 10.36 201664_at 8.90 8.94 9.04 10.089.78 10.05 8.77 8.96 9.14 10.35 10.23 10.50 201764_at 8.92 9.00 8.749.51 9.54 9.37 8.84 8.84 8.92 10.18 10.15 10.12 201954_at 9.41 9.55 9.3810.02 10.12 10.07 9.31 9.46 9.35 10.32 10.70 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10.05 10.17 10.24 208644_at10.85 10.87 10.77 11.26 11.17 11.24 10.85 11.00 10.88 11.25 11.32 11.14208679_s_at 10.44 10.29 10.31 11.05 10.99 10.89 10.50 10.22 10.36 10.8810.98 11.08 208857_s_at 7.38 7.19 7.50 9.18 9.03 9.09 7.22 7.12 7.448.46 8.27 8.69 208875_s_at 7.73 7.71 7.90 8.79 8.83 8.68 7.74 7.63 7.898.92 9.07 9.21 209075_s_at 8.63 8.72 8.87 9.71 9.61 9.65 8.53 8.74 8.799.52 9.42 9.77 209229_s_at 7.66 7.88 7.54 8.59 8.36 8.56 7.70 7.83 7.868.68 8.84 8.91 209251_x_at 13.04 13.11 13.10 13.55 13.52 13.52 13.1613.20 13.17 13.61 13.54 13.51 209316_s_at 7.47 7.35 7.53 8.28 8.26 8.537.51 7.58 7.88 8.62 8.55 8.81 209471_s_at 7.88 7.43 7.71 9.07 9.08 8.947.58 7.28 7.54 9.23 9.23 9.31 209517_s_at 8.71 8.56 8.47 9.66 9.38 9.598.64 8.48 8.85 9.79 9.67 9.85 209569_x_at 5.47 5.77 5.47 7.81 8.14 7.625.66 5.70 5.86 9.56 10.22 9.75 209714_s_at 8.76 8.51 8.31 9.67 9.38 9.498.67 8.49 8.80 9.65 9.40 9.63 209765_at 5.48 5.62 6.00 7.00 7.32 7.235.61 5.86 5.78 6.80 7.14 7.04 209932_s_at 9.62 9.77 9.74 11.06 10.8310.98 9.47 9.58 9.83 10.74 10.57 10.85 210981_s_at 6.38 6.52 6.57 7.537.63 7.35 6.48 6.63 6.60 7.62 7.73 7.57 211043_s_at 8.46 8.58 8.59 9.249.40 9.37 8.63 8.56 8.66 9.36 9.49 9.64 211066_x_at 6.88 6.96 7.12 8.788.96 8.77 6.69 7.25 6.47 8.43 8.77 8.94 211072_x_at 12.84 12.91 12.8013.32 13.22 13.21 12.88 12.87 12.92 13.28 13.20 13.29 211593_s_at 6.726.83 6.49 8.01 7.85 7.79 6.90 6.89 6.79 7.50 7.65 7.43 211686_s_at 7.637.68 7.87 8.52 8.36 8.43 7.76 7.81 7.77 8.34 8.52 8.52 211945_s_at 8.608.38 8.65 9.72 9.71 9.63 8.75 8.59 8.67 9.81 9.76 9.74 212066_s_at 8.658.17 8.35 9.83 9.80 9.86 8.36 8.25 8.54 9.61 9.47 9.73 212085_at 10.379.99 9.82 11.37 11.59 11.21 10.35 9.88 9.84 11.87 12.10 11.95 212094_at4.40 4.54 4.51 8.25 8.01 7.83 4.76 4.50 4.55 7.21 6.53 6.96 212313_at6.83 6.82 6.57 7.68 7.37 7.44 6.70 6.50 6.60 8.05 8.18 8.08 212350_at8.52 8.36 8.23 9.69 9.67 9.42 8.53 8.40 8.36 9.39 9.41 9.56 212372_at5.27 5.50 5.12 7.31 7.35 7.31 5.35 5.53 5.36 8.37 7.97 8.41 212443_at6.25 6.20 6.08 6.97 6.77 6.72 6.33 6.18 6.24 6.76 6.92 7.01 212573_at5.32 5.48 5.39 7.84 8.00 7.64 5.05 5.50 5.35 6.88 7.47 7.26 212587_s_at6.54 6.75 7.23 8.95 9.22 9.32 6.96 6.91 7.23 9.75 9.82 10.39 212588_at6.03 5.99 6.67 8.57 8.83 8.77 5.95 6.22 6.52 9.67 9.40 9.56 212619_at5.28 5.12 5.21 5.77 5.66 5.78 5.25 5.15 5.30 5.99 6.10 5.85 212646_at8.94 9.08 9.33 10.88 10.91 10.80 9.10 9.05 8.89 11.46 11.81 11.52212656_at 8.53 8.54 8.67 9.06 8.87 8.99 8.48 8.65 8.68 9.05 9.13 9.23212735_at 6.78 6.62 6.58 7.35 7.23 7.22 6.48 6.60 6.56 7.48 7.67 7.69212812_at 6.58 6.30 6.41 8.92 9.37 8.74 6.45 6.04 6.64 7.79 8.27 8.32212826_s_at 10.03 9.73 9.68 11.13 11.40 10.98 9.93 9.75 9.70 11.72 11.8411.78 213093_at 6.63 6.66 6.70 8.38 8.08 8.16 6.71 6.40 6.59 8.59 8.368.80 213106_at 5.60 5.35 5.79 7.75 8.01 7.35 5.62 5.29 5.56 6.72 6.797.09 213476_x_at 10.82 10.82 10.43 11.94 11.75 11.80 10.94 10.71 10.5911.56 11.80 11.69 213504_at 7.78 7.95 7.93 8.43 8.45 8.55 7.69 7.83 7.918.75 8.69 8.89 213603_s_at 9.64 9.37 9.35 10.60 10.55 10.47 9.32 9.149.22 10.71 11.00 10.86 213646_x_at 13.20 13.25 13.09 13.72 13.59 13.6013.16 13.20 13.24 13.64 13.60 13.65 213906_at 4.88 4.60 4.66 8.17 7.487.46 4.53 4.49 4.72 8.37 8.21 8.60 214157_at 5.17 5.02 5.35 7.31 7.347.34 4.99 5.03 4.98 7.49 7.03 7.36 214219_x_at 8.30 7.85 7.89 9.41 9.218.89 8.23 7.62 7.57 9.52 10.01 9.75 214339_s_at 7.79 7.44 7.78 9.09 8.838.74 7.92 7.33 7.21 9.17 9.58 9.55 214553_s_at 5.80 5.76 5.89 6.16 6.306.37 5.62 5.75 5.81 6.62 6.55 6.82 215023_s_at 5.08 5.03 5.18 5.82 5.946.09 5.16 4.90 5.04 5.93 6.27 6.27 215158_s_at 7.59 7.63 7.64 8.25 8.408.16 7.64 7.46 7.50 7.96 8.06 7.98 215836_s_at 6.90 6.50 6.93 7.93 8.447.90 6.64 6.87 6.93 7.90 8.12 7.99 216241_s_at 9.97 9.78 9.91 10.5010.63 10.50 9.75 9.66 9.75 10.99 10.98 10.91 216321_s_at 5.82 5.76 6.167.65 7.57 7.58 5.29 5.44 5.78 6.98 7.38 7.57 217118_s_at 7.74 7.90 8.159.29 9.52 9.44 7.82 8.17 8.30 9.06 9.23 9.43 217898_at 7.72 7.69 7.348.99 9.00 9.10 7.62 7.61 7.81 8.85 8.94 9.32 217933_s_at 9.27 9.25 9.3910.04 9.91 9.92 9.53 9.53 9.64 9.90 9.82 9.92 218039_at 8.92 8.90 8.7710.40 10.04 10.21 8.79 8.92 9.06 10.48 10.12 10.44 218096_at 7.41 7.758.00 9.23 8.99 9.05 7.80 7.73 8.00 9.13 9.00 9.25 218250_s_at 8.74 8.608.70 10.06 9.99 9.98 8.83 8.59 8.73 9.95 10.02 10.14 218287_s_at 6.576.61 6.65 7.11 7.12 7.07 6.64 6.69 6.67 7.23 7.32 7.20 218336_at 8.468.77 8.67 9.43 9.19 9.40 8.61 8.52 8.77 9.79 9.63 9.97 218404_at 5.896.20 5.99 7.67 7.60 7.59 6.14 6.38 6.63 8.23 8.20 8.14 218473_s_at 7.487.41 7.37 7.94 7.90 7.91 7.44 7.45 7.32 8.20 8.13 8.11 218640_s_at 6.546.29 6.79 7.80 8.13 8.02 6.35 6.25 6.68 8.41 8.87 8.40 218654_s_at 9.069.11 9.09 9.85 9.90 9.86 8.87 8.77 8.80 9.97 10.09 10.11 218680_x_at6.26 6.60 6.81 8.56 8.60 8.48 6.50 6.47 6.77 8.28 8.03 8.30 218802_at8.33 8.37 8.38 9.46 9.41 9.41 8.25 8.43 8.44 9.17 9.06 9.03 219220_x_at7.86 7.92 7.75 8.76 8.75 8.76 7.88 7.84 7.90 8.84 8.86 8.95 219304_s_at4.91 5.22 5.29 5.86 6.16 5.78 4.89 5.08 5.13 6.18 6.44 6.26 219428_s_at6.72 6.90 6.74 7.50 7.44 7.41 6.54 6.61 6.76 7.83 7.66 7.71 219551_at7.09 7.43 7.37 8.78 8.53 8.49 7.11 7.16 7.39 8.04 7.92 8.15 219911_s_at6.55 7.05 6.73 8.15 8.04 7.93 6.82 7.12 6.79 8.27 8.45 8.30 220059_at8.32 8.08 8.17 10.14 10.19 10.19 8.09 7.95 7.95 9.89 9.72 9.93221059_s_at 8.14 7.89 8.04 9.25 9.06 9.26 8.04 7.87 8.21 9.84 9.80 9.93221080_s_at 6.78 6.82 6.67 7.70 7.47 7.39 6.97 6.76 6.84 7.83 8.06 7.76221483_s_at 8.93 8.86 8.93 9.94 9.79 9.79 8.81 8.90 8.87 9.71 9.63 9.89221558_s_at 7.50 7.50 7.64 10.19 10.30 10.31 7.12 7.29 7.79 9.60 9.289.71 221692_s_at 7.80 7.95 8.07 9.03 9.02 8.82 7.85 7.89 7.85 8.77 8.738.72 221893_s_at 6.81 6.49 6.76 8.88 8.63 8.40 6.61 6.70 6.54 7.91 7.938.35 222065_s_at 6.15 6.17 6.02 7.43 7.23 7.15 6.28 6.21 6.01 6.90 7.116.91 222199_s_at 6.94 6.94 6.84 7.33 7.30 7.38 7.04 7.04 6.97 7.50 7.667.53 32541_at 4.63 4.49 4.60 5.61 5.46 5.68 4.53 4.34 4.47 5.52 5.825.89 35820_at 8.26 8.13 8.01 8.95 8.83 8.58 8.13 7.89 8.04 9.75 9.739.72 35974_at 7.77 8.03 8.34 9.68 9.75 9.56 7.79 8.25 8.40 9.31 9.729.42 36564_at 8.10 7.92 7.74 9.01 9.14 8.94 8.14 7.91 7.81 9.09 9.169.46 38521_at 8.75 8.60 8.51 9.72 9.86 9.76 8.71 8.54 8.42 9.89 10.1910.05 39835_at 8.36 8.30 8.26 9.32 9.16 9.11 8.20 7.98 8.11 9.33 9.489.40 44120_at 7.28 7.12 7.18 8.52 8.55 8.58 7.01 6.97 7.10 8.32 8.288.41 200911_s_at 7.34 7.20 7.19 9.69 9.63 9.63 7.65 7.42 7.82 9.32 9.419.69 201028_s_at 5.78 5.51 5.49 8.02 8.00 7.83 6.45 6.08 6.35 9.35 9.749.46 201328_at 5.16 4.90 4.97 6.25 6.14 6.22 5.12 4.92 5.04 7.37 7.668.08 201425_at 5.63 5.67 5.49 6.12 6.12 6.04 5.58 5.78 5.60 7.46 7.197.39 201718_s_at 6.50 6.34 6.46 7.41 7.28 7.22 6.72 6.36 6.66 7.52 7.427.68 201909_at 6.61 6.56 6.49 11.15 11.15 11.32 6.52 6.35 6.65 11.3611.53 11.41 202118_s_at 3.87 3.93 4.15 8.64 8.64 8.67 3.95 3.98 4.017.79 7.85 8.25 202119_s_at 4.66 4.50 4.69 10.02 9.91 9.70 4.45 4.51 4.549.37 9.70 9.53 202359_s_at 4.16 4.26 4.21 4.82 4.63 4.70 4.14 4.25 4.104.59 4.62 4.70 202367_at 6.64 6.35 6.60 8.00 7.93 7.87 6.53 6.65 6.258.22 8.31 8.00 202391_at 5.87 5.92 5.16 8.31 8.14 7.81 5.90 5.61 5.699.88 10.45 9.94 202729_s_at 5.92 6.14 6.19 8.39 8.59 8.34 5.92 5.96 6.077.78 7.83 7.97 202848_s_at 6.61 6.74 6.65 7.53 7.43 7.64 6.61 6.61 6.457.74 7.77 7.75 203072_at 5.05 4.89 5.18 5.89 5.76 5.87 5.09 4.90 4.966.15 6.52 6.35 203744_at 5.59 5.75 5.66 8.77 8.47 8.85 5.61 5.82 5.758.08 7.83 8.34 203805_s_at 6.39 6.53 6.44 8.09 7.96 7.88 6.57 6.69 6.596.94 7.02 7.08 203814_s_at 4.87 4.99 4.68 6.87 6.60 6.60 4.88 4.85 4.807.71 7.75 8.19 204081_at 5.47 5.58 5.48 6.19 6.48 6.31 5.37 5.41 5.447.00 7.37 7.21 204141_at 4.16 4.15 4.03 9.09 8.74 8.53 4.13 3.98 4.188.82 8.34 8.83 204197_s_at 5.43 5.37 5.62 8.43 8.38 8.25 5.43 5.64 5.427.73 8.37 8.47 204198_s_at 4.66 4.37 4.58 8.71 8.68 8.47 4.54 4.62 4.578.25 8.59 8.57 204529_s_at 4.00 4.07 3.94 5.26 4.93 5.13 4.04 3.93 3.687.61 7.39 7.85 204890_s_at 6.02 5.83 5.85 8.82 8.88 8.99 6.16 6.07 5.988.20 8.66 8.47 205000_at 4.26 4.34 4.26 8.37 7.29 8.03 3.79 4.09 4.397.90 7.62 7.88 205120_s_at 4.86 4.73 4.63 6.62 6.28 6.69 4.70 4.56 4.836.30 5.97 6.53 205718_at 5.75 5.51 5.13 8.62 8.80 8.15 5.74 5.83 5.677.80 7.83 7.87 205903_s_at 5.44 5.02 5.01 6.93 6.73 6.59 5.56 5.07 5.166.14 6.26 6.42 206219_s_at 6.09 6.19 5.90 8.23 8.18 8.01 6.40 6.15 6.048.44 8.86 9.03 206641_at 4.61 4.74 4.44 7.47 8.13 7.40 4.55 4.51 4.666.82 7.58 7.39 206700_s_at 5.30 5.46 5.33 6.52 6.67 6.56 5.11 5.19 5.226.24 6.42 6.58 207000_s_at 5.19 5.18 5.20 6.73 6.64 6.39 5.31 5.40 5.136.56 6.73 6.81 207238_s_at 6.36 6.31 6.45 8.13 8.55 8.18 6.65 6.58 6.599.05 9.22 9.11 207621_s_at 6.50 6.47 6.29 7.50 7.44 7.26 6.59 6.19 6.457.32 7.06 7.24 208119_s_at 5.40 5.42 5.49 5.86 5.82 5.90 5.33 5.38 5.216.87 6.70 6.77 208190_s_at 4.54 4.43 4.57 6.28 6.57 6.46 4.69 4.43 4.726.37 6.63 6.69 208502_s_at 6.78 7.26 7.31 8.28 8.98 8.45 6.53 7.02 6.348.68 9.52 9.22 209200_at 4.86 4.86 4.89 5.19 5.12 5.21 4.88 4.88 4.837.88 9.00 8.55 209372_x_at 7.72 7.76 7.47 8.44 8.32 8.46 7.86 7.69 7.698.36 8.43 8.50 209447_at 5.74 5.37 5.54 6.44 6.55 6.42 5.44 5.47 5.347.00 7.51 7.42 209570_s_at 5.24 5.00 4.92 6.55 6.83 6.52 5.15 5.09 5.108.40 8.96 8.77 209967_s_at 5.79 5.49 5.41 7.34 7.27 7.06 5.62 5.55 5.458.83 9.13 9.01 209980_s_at 6.44 6.29 6.19 7.31 7.48 7.28 6.38 6.15 6.317.09 7.21 7.17 210258_at 4.01 3.82 4.02 10.27 10.50 10.68 3.84 3.74 3.8610.40 10.22 10.28 211543_s_at 5.48 5.22 5.20 6.66 6.61 6.51 5.44 5.135.27 6.80 7.04 6.79 212254_s_at 4.56 4.53 4.64 6.67 7.48 7.11 4.34 4.904.45 6.04 6.45 6.19 212592_at 4.44 5.43 4.51 10.54 10.70 10.57 4.57 4.694.37 10.66 9.93 10.44 213029_at 4.69 4.83 4.85 5.35 5.54 5.66 4.83 4.764.90 5.48 5.60 5.83 213457_at 4.66 5.02 4.84 7.61 7.66 7.34 4.93 4.964.73 8.91 9.37 9.51 213533_at 5.47 5.69 5.95 6.71 7.00 6.83 5.45 6.055.61 8.15 8.26 8.46 214508_x_at 6.31 6.11 6.64 7.52 7.83 7.63 6.22 6.416.36 9.00 9.46 9.50 214669_x_at 5.77 5.73 5.75 9.90 9.95 9.97 5.78 5.356.15 9.42 9.51 9.16 214836_x_at 7.95 8.27 7.93 10.54 10.90 10.46 7.488.03 7.98 11.55 11.68 11.37 215016_x_at 4.19 4.20 4.33 6.45 7.17 6.734.24 4.53 4.41 5.78 6.04 6.28 215903_s_at 6.38 6.17 6.05 7.93 7.52 7.736.34 6.46 6.46 7.29 7.05 7.29 215967_s_at 5.79 5.65 5.83 6.41 6.24 6.215.61 5.60 5.76 6.93 6.85 6.76 217422_s_at 6.48 6.12 6.21 8.47 8.56 8.336.65 5.98 5.96 8.61 9.38 8.76 218017_s_at 6.07 6.19 6.24 7.08 7.26 7.076.04 6.15 5.96 6.99 7.08 7.10 218412_s_at 5.37 5.65 5.48 7.49 7.55 7.215.63 5.93 5.49 6.98 6.91 6.76 218573_at 4.60 4.62 4.48 5.09 5.25 5.354.59 4.70 4.61 5.47 5.40 5.68 218723_s_at 4.98 4.98 4.60 8.42 9.04 8.414.67 4.74 4.82 7.79 8.08 7.44 218858_at 4.92 4.96 4.97 9.15 9.68 9.244.92 5.00 5.04 9.10 9.07 9.16 219165_at 4.97 4.68 4.69 6.34 6.30 6.315.17 5.10 4.82 7.28 7.80 7.92 219299_at 4.97 5.26 5.26 6.16 6.17 6.445.11 5.21 5.12 5.71 5.95 5.98 219855_at 6.44 6.55 6.21 9.17 9.23 8.976.18 6.29 6.33 7.48 7.59 7.68 220432_s_at 3.89 3.83 3.73 4.63 4.90 4.643.74 3.86 3.89 4.32 4.55 4.54 221003_s_at 5.52 5.57 5.72 6.36 6.38 6.205.76 5.64 5.68 6.95 7.33 6.97 221651_x_at 7.68 7.66 7.69 12.88 12.9512.92 7.92 7.45 8.17 12.63 12.62 12.64 221671_x_at 7.73 7.73 7.73 12.9212.99 12.96 7.67 7.11 8.16 12.59 12.71 12.61 222307_at 5.48 5.49 5.366.19 5.99 6.19 5.46 5.31 5.34 6.11 6.10 6.09 203722_at 5.88 5.76 5.766.15 6.06 6.18 5.71 5.70 5.71 6.67 6.67 6.78 219998_at 4.86 4.87 4.815.10 5.20 5.20 4.81 4.85 4.84 5.06 5.14 5.14 221487_s_at 6.06 6.07 6.216.62 6.80 6.76 6.17 5.90 6.12 6.67 6.53 6.67

TABLE 2B Genes With Increased Expression in CD40-Sensitive Cell Linest-test(two-tailed) Gene Probesets pAB pAD pBC pCD Measured SymbolUniGene ID Gene Title FDR Cutoff 1.0E−02 8.2E−03 1.2E−02 9.4E−03200011_s_at 4.2E−03 8.2E−05 7.4E−03 1.1E−04 Yes ARF3 Hs.119177ADP-ribosyiation factor 3 200090_at 6.4E−03 7.4E−04 3.0E−03 2.0E−04 YesFNTA Hs.356463 farnesyltransferase CAAX box, alpha 200625_s_at 5.8E−047.3E−04 1.5E−03 2.4E−03 Yes CAP1 Hs.104125 CAP, adenylatecyclase-associated protein 1 (yeast) 200679_x_at 9.6E−03 3.7E−03 1.5E−034.5E−04 Yes HMGB1 Hs.434102 high-mobility group box 1 200762_at 1.3E−042.4E−03 5.4E−03 4.4E−03 Yes DPYSL2 Hs.173381 dihydropyrimidinase-like 2200833_s_at 3.8E−03 1.0E−03 3.8E−03 1.3E−03 Yes RAP1B Hs.374418 RAP1B,member of RAS oncogene family 200998_s_at 1.2E−03 4.9E−04 2.6E−032.0E−03 Yes CKAP4 Hs.74368 cytoskeleton-associated protein 4 201029_s_at9.4E−04 1.3E−04 1.1E−03 2.2E−04 Yes CD99 Hs.283477 CD99 antigen201077_s_at 3.8E−03 4.8E−03 2.9E−03 2.2E−03 Yes NHP2L1 Hs.182255 NHP2non-histone chromosome protein 2-like 1(S. cerevisiae) 201089_at 9.0E−031.4E−03 7.8E−04 6.4E−04 Yes ATP6V1B2 Hs.295917 ATPase, H+ transporting,lysosomal 56/58 kDa, V1 subunit B, isoform 2 201090_x_at 4.8E−04 2.4E−042.2E−03 1.0E−03 Yes K-ALPHA-1 Hs.446608 tubulin, alpha, ubiquitous201209_at 8.5E−03 1.2E−03 9.2E−03 1.3E−03 Yes HDAC1 Hs.88556 histonedeacetylase 1 201260_s_at 6.8E−03 7.9E−03 1.7E−03 3.2E−03 Yes SYPLHs.80919 synaptophysin-like protein 201375_s_at 1.6E−03 5.6E−04 5.6E−032.0E−03 Yes PPP2CB Hs.80350 protein phosphatase 2 (formerly 2A),catalytic subunit, beta isoform 201405_s_at 9.2E−03 1.3E−03 8.7E−034.2E−04 Yes COPS6 Hs.15591 COP9 constitutive photomorphogenic homologsubunit 6 (Arabidopsis) 201422_at 7.0E−03 2.0E−04 1.0E−03 5.5E−04 YesIFI30 Hs.14623 interferon, gamma-inducible protein 30 201453_x_at8.4E−04 4.8E−04 3.7E−03 2.8E−03 Yes RHEB Hs.279903 Ras homolog enrichedin brain 201503_at 1.3E−03 1.4E−03 2.8E−03 2.0E−03 Yes G3BP Hs.48549Ras-GTPase-activating protein SH3-domain-binding protein 201561_s_at8.8E−03 5.0E−03 6.8E−03 1.9E−03 Yes CLSTN1 Hs.29665 calsyntenin 1201584_s_at 2.3E−03 9.9E−04 1.1E−03 1.2E−04 Yes DDX39 Hs.311609 DEAD(Asp-Glu-Ala-Asp) box polypeptide 39 201663_s_at 1.9E−03 3.9E−05 7.7E−041.1E−04 Yes SMC4L1 Hs.50758 SMC4 structural maintenance of chromosomes4-like 1 (yeast) 201664_at 3.1E−03 5.2E−04 2.2E−03 6.9E−04 Yes SMC4L1Hs.50758 SMC4 structural maintenance of chromosomes 4-like 1 (yeast)201764_at 4.2E−03 2.2E−03 2.1E−03 9.8E−06 Yes MGC5576 Hs.103834hypothetical protein MGC5576 201954_at 1.4E−03 4.1E−03 5.1E−04 4.2E−03Yes ARPC1B Hs.433506 actin related protein 2/3 complex, subunit 16, 41kDa 202016_at 1.4E−05 1.1E−03 1.3E−05 1.4E−03 Yes MEST Hs.440459mesoderm specific transcript homolog (mouse) 202078_at 2.1E−05 4.7E−046.4E−04 2.1E−04 Yes COPS3 Hs.6076 COP9 constitutive photomorphogenichomolog subunit 3 (Arabidopsis) 202154_x_at 3.4E−03 7.3E−03 3.6E−036.7E−03 Yes TUBB4 Hs.511743 tubulin, beta, 4 202174_s_at 4.6E−03 4.7E−034.6E−03 4.7E−03 Yes PCM1 Hs.348501 pericentriolar material 1 202263_at4.0E−03 4.0E−03 2.6E−03 8.4E−03 Yes CYB5R1 Hs.334832 cytochrome b5reductase 1 (B5R.1) 202313_at 1.4E−03 3.1E−03 8.5E−04 1.3E−03 YesPPP2R2A Hs.512628 protein phosphatase 2 (formerly 2A), regulatorysubunit B (PR 52), alpha isoform 202355_s_at 3.2E−03 8.1E−03 4.1E−035.2E−03 Yes GTF2F1 Hs.68257 general transcription factor IIF,polypeptide 1, 74 kDa 202356_s_at 2.9E−03 1.8E−03 1.0E−03 4.2E−03 YesGTF2F1 Hs.68257 general transcription factor IIF, polypeptide 1, 74 kDa202415_s_at 3.6E−03 2.7E−03 5.3E−03 4.6E−03 Yes HSPBP1 Hs.53066hsp70-interacting protein 202467_s_at 1.7E−03 4.2E−03 8.9E−04 2.9E−03Yes TRIP15 Hs.30212 thyroid receptor interacting protein 15 202475_at6.1E−04 4.3E−04 3.2E−06 1.1E−03 Yes NIFIE14 Hs.9234 seven transmembranedomain protein 202484_s_at 3.7E−03 3.4E−04 7.8E−03 5.3E−04 Yes MBD2Hs.25674 methyl-CpG binding domain protein 2 202675_at 7.9E−04 6.6E−042.9E−03 2.0E−03 Yes SDHB Hs.64 succinate dehydrogenase complex, subunitB, iron sulfur (Ip) 202691_at 5.3E−03 7.0E−03 3.3E−03 3.8E−03 Yes SNRPD1Hs.86948 small nuclear ribonucleoprotein D1 polypeptide 16 kDa202736_s_at 8.4E−03 3.5E−03 12E−02 1.1E−03 Yes LSM4 Hs.76719 LSM4homolog, U6 small nuclear RNA associated (S. cerevisiae) 2028_s_at5.3E−04 2.4E−03 2.5E−04 1.6E−03 Yes E2F1 Hs.96055 E2F transcriptionfactor 1 202816_s_at 1.9E−04 6.9E−03 7.0E−04 5.9E−03 Yes SS18 Hs.404263synovial sarcoma translocation, chromosome 18 203046_s_at 1.8E−031.4E−03 5.3E−03 4.4E−03 Yes TIMELESS Hs.118631 timeless homolog(Drosophila) 203314_at 7.2E−04 9.7E−04 1.1E−03 9.4E−04 Yes PGPLHs.522840 pseudoautosomal GTP-binding protein-like 203534_at 2.4E−042.6E−03 2.2E−03 1.0E−03 Yes LSM1 Hs.425311 LSM1 homolog, U6 smallnuclear RNA associated (S. cerevisiae) 203537_at 1.7E−03 1.5E−03 1.5E−038.9E−04 Yes PRPSAP2 Hs.13339 phosphoribosyl pyrophosphate synthetase-associated protein 2 203605_at 3.3E−04 2.6E−03 1.2E−03 5.7E−03 Yes SRP54Hs.49346 signal recognition particle 54 kDa 203729_at 2.9E−05 2.1E−049.4E−05 4.5E−04 Yes EMP3 Hs.9999 epithelial membrane protein 3 203905_at4.8E−04 1.1E−03 9.2E−05 3.7E−03 Yes PARN Hs.43445 poly(A)-specificribonuclease (deadenylation nuclease) 203941_at 2.1E−03 1.8E−03 8.7E−035.8E−03 Yes FLJ10871 Hs.15562 hypothetical protein FLJ10871 203972_s_at9.2E−05 4.9E−03 3.0E−03 3.2E−03 Yes PEX3 Hs.7277 peroxisomal biogenesisfactor 3 204057_at 3.8E−04 1.9E−04 9.3E−05 1.2E−04 Yes ICSBP1 Hs.14453interferon consensus sequence binding protein 1 204581_at 3.8E−031.4E−03 8.7E−03 3.9E−03 Yes CD22 Hs.262150 CD22 antigen 204604_at2.4E−04 2.4E−05 1.1E−04 2.4E−05 Yes PFTK1 Hs.57856 PFTAIRE proteinkinase 1 204674_at 7.7E−04 1.0E−03 5.5E−03 4.1E−03 Yes LRMP Hs.124922lymphoid-restricted membrane protein 204867_at 5.7E−03 4.1E−03 3.3E−032.2E−03 Yes GCHFR Hs.245644 GTP cyclohydrolase I feedback regulatoryprotein 204891_s_at 1.6E−03 3.6E−04 1.5E−03 3.3E−04 Yes LCK Hs.1765lymphocyte-specific protein tyrosine kinase 205022_s_at 3.7E−03 3.1E−031.0E−02 6.7E−03 Yes CHES1 Hs.211773 checkpoint suppressor 1 205245_at6.6E−04 2.2E−04 1.3E−03 7.8E−03 Yes PARD6A Hs.112933 par-6 partitioningdefective 6 homolog alpha (C.elegans) 205356_at 6.9E−04 3.2E−03 2.5E−037.0E−03 Yes USP13 Hs.85482 ubiquitin specific protease 13 (isopeptidaseT-3) 205367_at 2.9E−04 7.2E−05 8.6E−05 2.1E−03 Yes APS Hs.371366 adaptorprotein with pleckstrin homology and src homology 2 domains 205412_at2.4E−04 4.7E−05 7.0E−03 9.2E−04 Yes ACAT1 Hs.37 acetyl-Coenzyme Aacetyltransferase 1 (acetoacetyl Coenzyme A thiolase) 205457_at 1.9E−036.4E−03 9.9E−04 4.8E−03 Yes MGC4614 Hs.300691 hypothetical proteinMGC4614 205504_at 1.2E−04 7.0E−05 9.4E−05 2.2E−04 Yes BTK Hs.159494Bruton agammaglobulinemia tyrosine kinase 205685_at 7.1E−03 4.1E−042.8E−03 2.2E−03 Yes CD86 Hs.27954 CD86 antigen (CD28 antigen ligand 2,B7-2 antigen) 205692_s_at 5.2E−03 4.2E−03 4.9E−03 3.9E−03 Yes CD38Hs.174944 CD38 antigen (p45) 205748_s_at 8.2E−04 8.3E−04 7.3E−03 1.7E−03Yes RNF126 Hs.69554 ring finger protein 126 205770_at 2.5E−03 1.9E−052.4E−03 3.7E−05 Yes GSR Hs.414334 glutathione reductase 206060_s_at4.2E−03 2.0E−03 1.5E−03 5.7E−04 Yes PTPN22 Hs.87860 protein tyrosinephosphatase, non-receptor type 22 (lymphoid) 206255_at 3.6E−04 5.8E−055.6E−05 4.6E−05 Yes BLK Hs.389900 B lymphoid tyrosine kinase 206296_x_at6.8E−03 2.2E−03 2.5E−03 6.8E−04 Yes MAP4K1 Hs.95424 mitogen-activatedprotein kinase kinase kinase kinase 1 206571_s_at 3.1E−04 1.6E−036.8E−03 1.3E−03 Yes MAP4K4 Hs.3628 mitogen-activated protein kinasekinase kinase kinase 4 206976_s_at 9.8E−03 3.4E−03 1.2E−02 9.1E−03 YesHSPH1 Hs.36927 heat shock 105 kDa/110 kDa protein 1 207121_s_at 2.0E−034.2E−03 1.8E−03 4.6E−03 Yes MAPK6 Hs.271980 mitogen-activated proteinkinase 6 207419_s_at 6.1E−03 1.3E−03 2.4E−03 6.7E−04 Yes RAC2 Hs.301175ras-related C3 botulinum toxin substrate 2 (rho family, small GTPbinding protein Rac2) 207480_s_at 6.1E−03 5.0E−03 4.6E−03 7.8E−03 YesMEIS2 Hs.362805 Meis1, myeloid ecotropic viral integration site 1homolog 2 (mouse) 207630_s_at 1.1E−03 1.6E−06 4.4E−04 1.4E−04 Yes CREMHs.231975 cAMP responsive element modulator 207760_s_at 7.3E−03 1.7E−034.1E−03 6.5E−04 Yes NCOR2 Hs.287994 nuclear receptor co-repressor 2208459_s_at 7.4E−04 3.2E−05 1.2E−03 4.9E−05 Yes XPO7 Hs.172685 exportin7 208642_s_at 6.2E−04 2.0E−03 7.9E−04 2.8E−03 Yes XRCC5 Hs.257082 X-rayrepair complementing defective repair in Chinese hamster cells 5(double-strand-break rejoining; Ku autoantigen, 80 kDa) 208643_s_at5.6E−03 5.9E−03 9.0E−04 9.7E−04 Yes XRCC5 Hs.257082 X-ray repaircomplementing defective repair in Chinese hamster cells 5(double-strand-break rejoining; Ku autoantigen, 80 kDa) 208644_at5.8E−04 5.5E−03 8.3E−03 9.4E−03 Yes ADPRT Hs.177766ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 208679_s_at7.8E−04 1.3E−03 5.7E−03 4.7E−03 Yes ARPC2 Hs.83583 actin related protein2/3 complex, subunit 2, 34 kDa 208857_s_at 4.6E−04 2.6E−03 5.3E−041.9E−03 Yes PCMT1 Hs.79137 protein-L-isoaspartate (D-aspartate) O-methyltransferase 208875_s_at 3.2E−04 3.8E−04 1.2E−03 3.2E−04 Yes PAK2Hs.284275 p21 (CDKN1A)-activated kinase 2 209075_s_at 2.3E−03 4.4E−032.9E−03 3.3E−03 Yes NIFU Hs.350702 nitrogen fixation cluster-like209229_s_at 3.8E−03 1.3E−03 2.4E−03 5.0E−04 Yes KIAA1115 Hs.411875KIAA1115 protein 209251_x_at 4.8E−04 3.0E−04 2.3E−05 2.6E−03 Yes TUBA6Hs.406578 tubulin alpha 6 209316_s_at 2.1E−03 4.6E−04 9.0E−03 2.8E−03Yes HBS1L Hs.221040 HBS1-like (S. cerevisiae) 209471_s_at 5.0E−035.2E−03 8.2E−04 1.4E−03 Yes FNTA Hs.356463 farnesyltransferase, CAAXbox, alpha 209517_s_at 1.0E−03 2.8E−04 3.7E−03 3.2E−03 Yes ASH2L Hs.6856ash2 (absent, small, or homeotic)-like (Drosophila) 209569_x_at 5.4E−043.0E−04 2.0E−03 1.0E−03 Yes D4S234E Hs.79404 DNA segment on chromosome 4(unique) 234 expressed sequence 209714_s_at 5.2E−03 4.8E−03 2.4E−031.9E−03 Yes CDKN3 Hs.84113 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) 209765_at 2.8E−03 4.0E−033.6E−04 8.3E−04 Yes ADAM19 Hs.289368 a disintegrin and metalloproteinasedomain 19 (meltrin beta) 209932_s_at 2.6E−04 1.5E−03 9.0E−04 1.5E−03 YesDUT Hs.367676 dUTP pyrophosphatase 210981_s_at 1.1E−03 1.1E−04 1.9E−038.0E−05 Yes GPRK6 Hs.235116 G protein-coupled receptor kinase 6211043_s_at 3.5E−04 2.3E−03 8.3E−04 4.5E−03 Yes CLTB Hs.380749 clathrin,light polypeptide (Lcb) 211066_x_at 4.7E−05 2.3E−03 9.1E−03 4.1E−03 YesPCDHGC3 Hs.283794 protocadherin gamma subfamily C, 3 211072_x_at 1.0E−035.9E−04 2.9E−03 7.0E−04 Yes K-ALPHA-1 Hs.446608 tubulin, alpha,ubiquitous 211593_s_at 1.2E−03 3.8E−03 8.0E−04 2.5E−03 Yes MAST205Hs.101474 microtubule associated testis specific serine/threonineprotein kinase 211686_s_at 2.3E−03 1.7E−03 2.5E−03 5.2E−03 Yes LOC84549Hs.77135 RNA binding protein 211945_s_at 2.8E−03 2.8E−03 1.9E−04 2.4E−04Yes ITGB1 Hs.287797 integrin, beta 1 (fibronectin receptor, betapolypeptide, antigen CD29 includes MDF2, MSK12) 212066_s_at 8.6E−034.6E−03 2.4E−03 4.4E−04 Yes USP34 Hs.507665 ubiquitin specific protease34 212085_at 4.0E−03 2.9E−03 3.7E−03 2.8E−03 Yes SLC25A6 Hs.350927solute carrier family 25 (mitochondrial carrier; adenine nucleotidetranslocator), member 6 212094_at 3.9E−04 5.0E−03 6.1E−05 3.0E−03 YesPEG10 Hs.137476 paternally expressed 10 212313_at 3.9E−03 9.8E−042.4E−03 6.7E−05 Yes MGC29816 Hs.5019 hypothetical protein MGC29816212350_at 5.9E−04 9.5E−04 1.1E−03 1.7E−04 Yes TBC1D1 Hs.372659 TBC1(tre-2/USP6, BUB2, cdc16) domain family, member 1 212372_at 2.6E−031.1E−04 5.4E−04 6.8E−04 Yes MYH10 Hs.280311 myosin, heavy polypeptide10, non-muscle 212443_at 4.0E−03 2.1E−03 6.5E−03 3.3E−03 Yes KIAA0540Hs.437043 KIAA0540 protein 212573_at 3.6E−04 6.2E−03 1.6E−04 1.3E−03 YesKIAA0830 Hs.167115 KIAA0830 protein 212587_s_at 1.8E−03 3.9E−04 1.5E−041.1E−03 Yes PTPRC Hs.444324 protein tyrosine phosphatase, receptor type,C 212588_at 3.9E−03 1.9E−03 1.1E−03 4.5E−04 Yes PTPRC Hs.444324 proteintyrosine phosphatase, receptor type, C 212619_at 9.6E−04 1.6E−03 8.7E−042.0E−03 Yes KIAA0286 Hs.14912 KIAA0286 protein 212646_at 2.6E−03 9.7E−051.5E−04 1.6E−04 Yes RAFTLIN Hs.436432 raft-linking protein 212656_at6.0E−03 1.4E−03 1.1E−02 2.8E−03 Yes DKFZP586 Hs.435643hepatocellularcarcinoma-associated antigen D0919 HCA557a 212735_at2.1E−03 4.7E−04 2.1E−04 7.0E−04 Yes KIAA0226 Hs.499355 KIAA0226 geneproduct 212812_at 1.6E−03 3.3E−03 5.1E−04 2.0E−03 Yes — Hs.288232 Homosapiens cDNA: FLJ22642 fis, clone HSI06970 212826_s_at 1.3E−03 1.4E−031.9E−03 1.6E−04 Yes SLC25A6 Hs.350927 solute carrier family 25(mitochondrial carrier; adenine nucleotide translocator), member 6213093_at 2.3E−03 3.7E−03 2.0E−04 3.8E−04 Yes PRKCA Hs.349611 proteinkinase C, alpha 213106_at 1.4E−03 1.8E−03 1.8E−03 8.5E−04 Yes ATP8A1Hs.291385 ATPase, aminophospholipid transporter (APLT), Class I, type8A, member 1 213476_x_at 5.9E−03 6.7E−03 2.1E−03 2.5E−03 Yes TUBB4Hs.511743 tubulin, beta, 4 213504_at 1.3E−03 4.7E−04 2.0E−03 4.0E−04 YesCOPS6 Hs.15591 COP9 constitutive photomorphogenic homolog subunit 6(Arabidopsis) 213603_s_at 3.1E−03 3.8E−04 9.1E−05 2.7E−04 Yes RAC2Hs.301175 ras-related C3 botulinum toxin substrate 2 (rho family, smallGTP binding protein Rac2) 213646_x_at 2.1E−03 6.8E−03 2.6E−03 2.8E−04Yes K-ALPHA-1 Hs.446608 tubulin, alpha, ubiquitous 213906_at 2.8E−032.7E−05 3.2E−03 4.6E−05 Yes MYBL1 Hs.300592 v-myb myeloblastosis viraloncogene homolog (avian)-like 1 214157_at 1.8E−03 4.7E−04 2.6E−083.4E−03 Yes GNAS Hs.157307 GNAS complex locus 214219_x_at 5.2E−031.0E−03 8.4E−03 2.7E−03 Yes MAP4K1 Hs.95424 mitogen-activated proteinkinase kinase kinase kinase 1 214339_s_at 1.5E−03 6.0E−04 1.2E−023.4E−03 Yes MAP4K1 Hs.95424 mitogen-activated protein kinase kinasekinase kinase 1 214553_s_at 5.7E−03 3.3E−03 2.8E−03 1.2E−03 Yes ARPP-19Hs.7351 cyclic AMP phosphoprotein, 19 kD 215023_s_at 2.2E−03 5.9E−031.1E−03 2.2E−03 Yes PEX1 Hs.164682 peroxisome biogenesis factor 1215158_s_at 8.7E−03 1.8E−03 1.3E−03 4.2E−03 Yes DEDD Hs.169681 deatheffector domain containing 215836_s_at 4.8E−03 5.1E−03 7.5E−03 6.9E−04Yes PCDHGC3 Hs.283794 protocadherin gamma subfamily C, 3 216241_s_at1.1E−03 7.6E−04 1.8E−04 7.2E−06 Yes TCEA1 Hs.78869 transcriptionelongation factor A (SII), 1 216321_s_at 4.2E−03 3.9E−03 3.8E−03 1.5E−03Yes NR3C1 Hs.512414 nuclear receptor subfamily 3, group C, member 1(glucocorticoid receptor) 217118_s_at 1.3E−03 1.3E−03 4.2E−03 3.9E−03Yes KIAA0930 Hs.454533 KIAA0930 protein 217898_at 4.0E−03 1.7E−032.4E−04 4.4E−03 Yes LOC56851 Hs.4245 chromosome 15 hypothetical ATG/GTPbinding protein 217933_s_at 3.9E−04 5.5E−04 2.4E−03 2.8E−03 Yes LAP3Hs.182579 leucine aminopeptidase 3 218039_at 1.6E−03 2.1E−03 7.7E−049.4E−04 Yes NUSAP1 Hs.279905 nucleolar and spindle associated protein 1218096_at 7.1E−03 6.4E−03 3.8E−04 3.4E−04 Yes LPAAT-e Hs.281895 acidacyltransferase-epsilon 218250_s_at 4.5E−05 6.4E−05 1.1E−03 1.7E−04 YesCNOT7 Hs.170553 CCR4-NOT transcription complex, subunit 7 218287_s_at1.3E−04 3.9E−04 5.3E−05 1.3E−03 Yes EIF2C1 Hs.309452 eukaryotictranslation initiation factor 2C, 1 218336_at 4.6E−03 9.8E−04 2.5E−039.4E−04 Yes PFDN2 Hs.298229 prefoldin 2 218404_at 1.8E−03 8.5E−041.1E−02 5.0E−03 Yes SNX10 Hs.418132 sorting nexin 10 218473_s_at 2.1E−037.9E−05 4.5E−03 2.7E−04 Yes FLJ22329 Hs.418795 hypothetical proteinFLJ22329 218640_s_at 2.0E−03 6.9E−04 8.9E−04 5.2E−04 Yes PLEKHF2Hs.29724 pleckstrin homology domain containing, family F (with FYVEdomain) member 2 218654_s_at 2.2E−06 8.7E−04 1.0E−04 4.7E−05 Yes MRPS33Hs.83006 mitochondrial ribosomal protein S33 218680_x_at 4.6E−03 2.5E−037.9E−04 2.5E−04 Yes HYPK Hs.511978 Huntingtin interacting protein K218802_at 9.1E−07 1.7E−03 2.1E−03 1.1E−03 Yes FLJ20647 Hs.234149hypothetical protein FLJ20647 219220_x_at 3.2E−03 2.2E−04 3.5E−041.0E−04 Yes MRPS22 Hs.512649 mitochondrial ribosomal protein S22219304_s_at 8.4E−03 2.2E−03 4.8E−03 2.8E−04 Yes SCDGF-B Hs.112885 spinalcord-derived growth factor-B 219428_s_at 2.9E−03 3.0E−04 2.4E−03 2.3E−04Yes PXMP4 Hs.436924 peroxisomal membrane protein 4, 24 kDa 219551_at8.1E−04 6.8E−03 4.0E−04 2.1E−03 Yes EAF2 Hs.383018 ELL associated factor2 219911_s_at 5.7E−03 3.8E−03 1.9E−03 1.1E−03 Yes SLCO4A1 Hs.235782solute carrier organic anion transporter family, member 4A1 220059_at7.0E−04 6.3E−05 1.2E−04 3.9E−05 Yes BRDG1 Hs.121128 BCR downstreamsignaling 1 221059_s_at 2.8E−04 1.6E−04 1.2E−03 9.6E−04 Yes CHST6Hs.157439 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6221080_s_at 5.3E−03 1.8E−03 5.6E−03 1.3E−03 Yes FLJ22757 Hs.236449hypothetical protein FLJ22757 221483_s_at 6.8E−04 5.8E−03 3.3E−044.1E−03 Yes ARPP-19 Hs.7351 cyclic AMP phosphoprotein, 19 kD 221558_s_at2.0E−06 1.8E−03 3.8E−03 1.8E−03 Yes LEF1 Hs.44865 lymphoidenhancer-binding factor 1 221692_s_at 6.4E−04 7.5E−03 2.7E−03 2.0E−06Yes MRPL34 Hs.238808 mitochondrial ribosomal protein L34 221893_s_at5.7E−04 2.2E−03 2.3E−03 5.8E−03 Yes ADCK2 Hs.210397 aarF domaincontaining kinase 2 222065_s_at 8.6E−04 9.6E−04 6.5E−04 1.7E−03 Yes FLIIHs.445182 flightless I homolog (Drosophila) 222199_s_at 6.0E−04 8.4E−046.8E−04 2.8E−03 Yes BIN3 Hs.68090 bridging integrator 3 32541_at 4.8E−044.2E−03 2.2E−04 2.3E−03 Yes PPP3CC Hs.75206 protein phosphatase 3(formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)35820_at 1.0E−02 1.8E−03 6.0E−03 1.5E−03 Yes GM2A Hs.387156 GM2ganglioside activator protein 35974_at 5.6E−03 2.8E−03 9.1E−03 5.5E−03Yes LRMP Hs.124922 lymphoid-restricted membrane protein 36564_at 2.0E−031.1E−03 1.9E−03 1.1E−03 Yes FLJ90005 Hs.511807 hypothetical proteinFLJ90005 38521_at 4.5E−04 3.0E−04 1.3E−03 2.6E−04 Yes CD22 Hs.262150CD22 antigen 39835_at 1.5E−03 1.1E−04 2.6E−04 1.7E−04 Yes SBF1 Hs.112049SET binding factor 1 44120_at 3.2E−04 5.3E−05 9.0E−05 1.9E−05 Yes ADCK2Hs.210397 aarF domain containing kinase 2 200911_s_at 4.6E−05 6.9E−042.6E−03 3.4E−04 Yes TACC1 Hs.279245 transforming, acidic coiled-coilcontaining protein 1 201028_s_at 8.6E−05 1.8E−05 7.4E−04 3.6E−05 YesCD99 Hs.283477 CD99 antigen 201328_at 1.5E−03 2.6E−03 3.3E−04 3.7E−03Yes ETS2 Hs.292477 v-ets erythroblastosis virus E26 oncogene homolog 2(avian) 201425_at 3.9E−03 1.3E−04 1.0E−02 1.1E−04 Yes ALDH2 Hs.331141aldehyde dehydrogenase 2 family (mitochondrial) 201718_s_at 3.2E−045.5E−04 1.1E−02 3.5E−03 Yes EPB41L2 Hs.440387 erythrocyte membraneprotein band 4.1-like 2 201909_at 2.5E−06 7.2E−07 8.1E−06 1.2E−05 YesRPS4Y Hs.180911 ribosomal protein S4, Y-linked 202118_s_at 3.0E−041.0E−04 2.8E−07 1.2E−03 Yes CPNE3 Hs.14158 copine III 202119_s_at8.1E−06 1.2E−05 1.4E−04 1.7E−04 Yes CPNE3 Hs.14158 copine III202359_s_at 3.7E−03 8.2E−04 1.7E−03 1.5E−03 Yes SNX19 Hs.409862 sortingnexin 19 202367_at 1.5E−03 2.3E−04 3.8E−03 5.0E−04 Yes CUTL1 Hs.438974cut-like 1, CCAAT displacement protein (Drosophila) 202391_at 2.4E−032.3E−04 6.0E−04 2.8E−04 Yes BASP1 Hs.511745 brain abundant, membraneattached signal protein 1 202729_s_at 3.2E−05 1.4E−04 5.8E−05 2.1E−05Yes LTBP1 Hs.241257 latent transforming growth factor beta bindingprotein 1 202848_s_at 6.9E−04 6.7E−04 2.7E−04 1.4E−03 Yes GPRK6Hs.235116 G protein-coupled receptor kinase 6 203072_at 3.8E−03 9.2E−044.0E−04 1.6E−03 Yes MYO1E Hs.437459 myosin IE 203744_at 3.3E−04 1.7E−031 6E−04 1.2E−03 Yes HMGB3 Hs.19114 high-mobility group box 3 203805_s_at8.2E−05 7.3E−04 1.8E−04 2.2E−03 Yes FANCA Hs.284153 Fanconi anemia,complementation group A 203814_s_at 1.3E−04 2.9E−04 1.3E−03 2.1E−03 YesNQO2 Hs.441039 NAD(P)H dehydrogenase, quinone 2 204081_at 4.3E−031.9E−03 5.6E−03 2.7E−03 Yes NRGN Hs.232004 neurogranin (protein kinase Csubstrate, RC3) 204141_at 6.7E−04 6.5E−04 3.7E−04 3.5E−04 Yes TUBBHs.512712 tubulin, beta polypeptide 204197_s_at 1.3E−05 4.0E−03 9.9E−064.3E−03 Yes RUNX3 Hs.170019 runt-related transcription factor 3204198_s_at 4.8E−06 1.5E−05 1.2E−04 5.1E−04 Yes RUNX3 Hs.170019runt-related transcription factor 3 204529_s_at 3.5E−03 6.6E−04 1.1E−033.9E−05 Yes TOX Hs.439767 thymus high mobility group box protein TOX204890_s_at 4.0E−06 6.5E−04 2.6E−06 1.0E−03 Yes LCK Hs.1765lymphocyte-specific protein tyrosine kinase 205000_at 7.4E−03 2.6E−041.6E−03 3.3E−04 Yes DDX3Y Hs.99120 DEAD (Asp-Glu-Ala-Asp) boxpolypeptide 3, Y-linked 205120_s_at 1.1E−03 5.0E−03 7.1E−04 3.7E−03 YesSGCB Hs.438953 sarcoglycan, beta (43 kDa dystrophin- associatedglycoprotein) 205718_at 3.3E−04 5.4E−03 3.2E−03 7.5E−05 Yes ITGB7Hs.1741 integrin, beta 7 205903_s_at 1.3E−03 5.2E−03 2.1E−03 8.6E−03 YesKCNN3 Hs.89230 potassium intermediate/small conductancecalcium-activated channel, subfamily N, member 3 206219_s_at 6.2E−059.8E−04 2.9E−04 6.7E−04 Yes VAV1 Hs.116237 vav 1 oncogene 206641_at2.4E−03 3.1E−03 4.3E−03 5.5E−03 Yes TNFRSF17 Hs.2556 tumor necrosisfactor receptor superfamily, member 17 206700_s_at 6.0E−05 2.5E−032.6E−05 3.1E−03 Yes SMCY Hs.80358 Smcy homolog, Y-linked (mouse)207000_s_at 5.2E−03 2.2E−03 7.2E−04 2.0E−04 Yes PPP3CC Hs.75206 proteinphosphatase 3 (formerly 2B), catalytic subunit, gamma isoform(calcineurin A gamma) 207238_s_at 2.7E−03 2.5E−06 5.4E−03 4.6E−05 YesPTPRC Hs.444324 protein tyrosine phosphatase, receptor type, C207621_s_at 5.4E−04 1.6E−03 4.3E−03 7.7E−03 Yes PEMT Hs.15192phosphatidylethanolamine N-methyl- transferase 208119_s_at 4.4E−048.0E−05 2.8E−03 3.2E−05 Yes ZNF505 Hs.515284 zinc finger protein 505208190_s_at 3.4E−04 6.2E−04 1.4E−04 1.4E−04 Yes LISCH7 Hs.312129liver-specific bHLH-Zip transcription factor 208502_s_at 6.6E−03 3.7E−032.7E−03 1.6E−03 Yes PITX1 Hs.84136 paired-like homeodomain transcriptionfactor 1 209200_at 3.1E−03 8.1E−03 1.6E−03 8.0E−03 Yes MEF2C Hs.368950MADS box transcription enhancer factor 2, polypeptide C (myocyteenhancer factor 2C) 209372_x_at 5.6E−03 5.2E−03 1.0E−03 9.2E−04 Yes TUBBHs.512712 tubulin, beta polypeptide 209447_at 6.9E−03 1.4E−03 5.4E−054.6E−03 Yes SYNE1 Hs.282117 spectrin repeat containing, nuclear envelope1 209570_s_at 3.3E−04 2.1E−04 3.2E−03 1.9E−03 Yes D4S234E Hs.79404 DNAsegment on chromosome 4 (unique) 234 expressed sequence 209967_s_at5.1E−04 3.3E−05 2.9E−04 3.9E−05 Yes CREM Hs.231975 cAMP responsiveelement modulator 209980_s_at 4.1E−04 1.9E−03 3.1E−04 1.3E−03 Yes SHMT1Hs.293636 serine hydroxymethyltransferase 1 (soluble) 210258_at 1.0E−054.1E−07 8.6E−05 2.6E−07 Yes RGS13 Hs.17165 regulator of G-proteinsignalling 13 211543_s_at 1.2E−03 2.2E−04 1.0E−03 2.0E−04 Yes GPRK6Hs.235116 G protein-coupled receptor kinase 6 212254_s_at 7.8E−033.3E−03 1.4E−03 2.2E−03 Yes BPAG1 Hs.443518 bullous pemphigoid antigen1, 230/240 kDa 212592_at 2.5E−03 2.9E−04 1.0E−05 2.9E−04 Yes IGJHs.381568 immunoglobulin J polypeptide, linker protein forimmunoglobulin alpha and mu polypeptides 213029_at 5.2E−03 6.0E−037.5E−03 8.3E−03 Yes NFIB Hs.302690 nuclear factor I/B 213457_at 4.9E−051.6E−04 5.5E−05 5.0E−04 Yes MFHAS1 Hs.379414 malignant fibroushistiocytoma amplified sequence 1 213533_at 4.2E−03 2.6E−04 1.2E−021.1E−03 Yes D4S234E Hs.79404 DNA segment on chromosome 4 (unique) 234expressed sequence 214508_x_at 4.2E−03 1.9E−04 5.7E−04 1.1E−03 Yes CREMHs.231975 cAMP responsive element modulator 214669_x_at 6.1E−08 7.4E−042.8E−03 1.1E−03 Yes — Hs.525893 Homo sapiens cDNA FLJ26296 fis, cloneDMC07192, highly similar to Ig kappa chain V-III region HAH precursor214836_x_at 1.7E−04 2.2E−05 3.3E−04 3.5E−04 Yes — Hs.525895 Homo sapienscDNA FLJ39619 fis, clone SMINT2000984, highly similar to IG KAPPA CHAINV-II REGION GM607 PRECURSOR. 215016_x_at 4.8E−03 3.6E−03 3.1E−03 1.8E−03Yes BPAG1 Hs.443518 bullous pemphigoid antigen 1, 230/240 kDa215903_s_at 6.9E−04 1.5E−03 4.5E−03 3.4E−03 Yes MAST205 Hs.101474microtubule associated testis specific serine/threonine protein kinase215967_s_at 2.9E−03 1.3E−04 1.5E−03 7.0E−05 Yes LY9 Hs.403857 lymphocyteantigen 9 217422_s_at 2.4E−04 2.7E−03 6.2E−03 1.2E−03 Yes CD22 Hs.262150CD22 antigen 218017_s_at 3.5E−04 2.7E−04 2.2E−04 3.0E−04 Yes FLJ32731Hs.191320 hypothetical protein FLJ32731 218412_s_at 1.8E−04 2.3E−046.3E−04 3.9E−03 Yes GTF2IRD1 Hs.430854 GTF2I repeat domain containing 1218573_at 4.4E−03 2.5E−03 7.6E−03 4.1E−03 Yes MAGEH1 Hs.279819 APR-1protein 218723_s_at 3.5E−04 4.2E−04 2.0E−03 2.5E−03 Yes RGC32 Hs.76640RGC32 protein 218858_at 1.3E−03 4.4E−07 9.6E−04 1.6E−07 Yes FLJ12428Hs.87729 hypothetical protein FLJ12428 219165_at 3.1E−03 1.2E−03 6.1E−031.2E−03 Yes PDLIM2 Hs.375560 PDZ and LIM domain 2 (mystique) 219299_at1.1E−03 4.9E−03 3.1E−03 6.6E−03 Yes FLJ20772 Hs.9925 hypotheticalprotein FLJ20772 219855_at 4.0E−05 1.3E−03 4.0E−05 9.4E−05 Yes NUDT11Hs.200016 nudix (nucleoside diphosphate linked moiety X)-type motif 11220432_s_at 2.8E−03 3.8E−03 3.0E−03 4.1E−03 Yes CYP39A1 Hs.387367cytochrome P450, family 39, subfamily A, polypeptide 1 221003_s_at1.1E−03 1.8E−03 1.7E−03 4.5E−03 Yes FLJ12577 Hs.87159 hypotheticalprotein FLJ12577 221651_x_at 1.4E−06 1.2E−10 1.6E−03 1.9E−03 Yes — — —221671_x_at 1.7E−05 5.7E−05 3.1E−03 3.3E−03 Yes — Hs.377975 Homo sapiensimmunoglobulin kappa light chain mRNA, partial cds 222307_at 2.1E−033.6E−03 1.3E−03 3.6E−03 Yes — Hs.293219 Homo sapiens cDNA FLJ40384 fis,clone TESTI2035796. 203722_at 3.8E−03 8.4E−05 6.9E−03 1.4E−03 No ALDH4A1Hs.77448 aldehyde dehydrogenase 4 family, member A1 219998_at 3.0E−031.7E−03 4.3E−03 2.2E−03 No HSPC159 Hs.372208 HSPC159 protein 221487_s_at1.1E−03 1.6E−03 4.2E−03 8.1E−03 No ENSA Hs.511916 endosulfine alpha

TABLE 3A Genes With Reduced Expression in CD40-Sensitive Cell Lines Log2fluorescence intensity D4 Probesets Ly1 (A1) Ly1 (A2) Ly1 (A3) Ly7 (B1)Ly7 (B2) Ly7 (B3) Ly8 (C1) Ly8 (C2) Ly8 (C3) D4 (D1) D4 (D2) (D3)200068_s_at 11.55 11.59 11.58 11.36 11.29 11.33 11.54 11.50 11.46 11.1011.03 11.12 200670_at 9.90 9.51 10.05 7.15 7.18 6.83 10.00 9.39 9.517.84 8.10 7.97 200701_at 9.15 8.73 9.02 7.92 8.05 7.83 9.19 8.73 8.797.60 7.84 7.82 200736_s_at 10.16 9.88 9.93 9.46 9.47 9.25 10.48 10.2410.32 9.01 9.19 9.02 200765_x_at 7.24 7.35 7.27 6.39 6.26 6.25 7.89 7.697.88 4.96 5.26 4.97 200814_at 11.23 11.07 11.11 10.08 10.11 9.72 11.3911.31 11.15 9.27 9.52 9.31 200846_s_at 10.32 10.20 10.21 10.01 9.94 9.9910.33 10.27 10.36 9.88 9.98 9.98 200887_s_at 8.85 8.58 8.62 7.98 7.587.65 8.68 8.76 8.89 7.28 7.06 7.32 200905_x_at 10.71 10.51 10.44 8.848.76 8.82 10.60 10.37 10.45 7.96 8.09 8.08 200936_at 13.09 13.10 13.0812.67 12.70 12.72 13.12 13.07 13.17 12.87 12.92 12.89 200941_at 8.938.75 8.68 8.02 7.60 7.79 8.94 8.91 8.98 7.68 7.63 7.98 201011_at 8.788.70 8.80 8.43 8.50 8.39 8.85 8.88 9.00 8.55 8.44 8.52 201160_s_at 10.7810.64 10.85 10.21 10.01 10.16 10.72 10.68 10.91 5.15 5.16 5.18201161_s_at 9.93 9.63 9.57 8.77 8.90 8.58 10.01 9.76 9.50 5.58 5.61 5.17201200_at 9.71 9.46 9.66 8.50 8.91 8.89 9.99 9.89 9.75 8.43 8.18 8.64201204_s_at 8.32 8.44 8.93 7.02 6.75 7.19 8.67 8.70 8.46 7.20 6.92 7.29201206_s_at 8.01 8.19 8.16 6.60 6.77 6.20 8.28 8.39 8.02 6.49 6.91 6.67201226_at 10.47 10.43 10.39 9.23 9.27 9.21 10.48 10.34 10.46 10.07 10.1510.12 201263_at 9.79 9.91 9.59 8.72 8.90 8.55 10.22 9.92 9.87 7.74 8.008.28 201307_at 9.03 9.14 9.22 7.75 7.71 7.77 8.91 8.93 9.13 6.67 6.966.87 201398_s_at 10.71 10.97 10.99 9.80 9.77 9.93 10.77 10.90 10.84 9.349.30 9.55 201399_s_at 10.49 10.25 10.36 9.13 9.20 9.45 10.24 10.05 10.258.37 8.56 8.59 201470_at 10.34 10.47 10.20 5.78 5.46 5.80 10.52 10.5310.57 8.93 8.75 8.96 201487_at 9.57 9.89 9.84 8.74 8.66 8.76 9.45 9.699.68 8.63 8.60 8.76 201499_s_at 10.04 9.96 10.06 9.43 9.25 9.29 10.009.92 10.11 9.35 9.30 9.52 201566_x_at 8.27 8.30 8.07 7.46 7.54 7.66 8.779.00 8.56 6.89 6.73 6.82 201590_x_at 9.41 9.46 9.20 7.12 6.89 6.92 9.499.28 9.26 7.00 6.97 6.73 201601_x_at 10.14 9.56 9.84 7.96 7.90 7.8710.08 9.97 10.05 6.93 6.95 6.88 201649_at 9.26 9.15 9.06 8.16 8.54 8.329.34 9.24 9.18 5.72 5.44 5.23 201746_at 9.96 9.88 10.01 9.17 9.14 9.099.99 9.94 9.86 9.33 9.49 9.47 201874_at 8.65 8.67 8.51 7.63 7.84 7.498.49 8.47 8.33 7.32 7.26 7.28 201937_s_at 8.28 8.24 7.98 7.65 7.54 7.468.22 8.16 8.23 6.94 7.17 6.86 201968_s_at 9.90 9.45 9.75 8.53 8.30 8.3410.01 9.60 9.89 7.28 7.59 7.56 202096_s_at 9.04 8.67 8.55 7.26 7.16 7.169.08 8.86 8.89 6.28 6.06 6.06 202123_s_at 8.35 8.27 8.44 7.06 6.75 7.098.21 8.19 8.37 7.72 7.78 7.90 202261_at 8.45 8.44 8.35 8.03 8.13 8.008.55 8.39 8.47 8.18 8.14 8.06 202279_at 10.46 10.39 10.33 9.96 9.87 9.7810.83 10.78 10.84 9.96 9.96 10.09 202315_s_at 8.91 9.16 9.06 7.33 7.367.13 9.12 9.05 8.71 7.02 6.91 6.89 202382_s_at 7.66 7.40 7.34 6.90 6.626.74 7.77 7.58 7.46 4.95 5.16 4.96 202429_s_at 8.69 8.33 8.33 6.48 6.116.45 8.27 8.42 8.43 6.21 6.23 6.81 202443_x_at 7.54 7.27 7.22 6.68 6.366.41 7.68 7.49 7.39 4.66 4.84 4.93 202447_at 8.94 8.90 8.98 8.55 8.468.40 8.90 8.88 8.92 7.41 7.41 7.73 202457_s_at 8.98 8.52 8.87 7.08 6.827.34 8.70 8.42 8.94 7.48 7.32 7.74 202536_at 6.73 6.78 7.17 5.90 5.696.05 7.11 6.96 7.50 4.24 4.27 4.34 202696_at 8.63 8.47 8.57 8.33 8.218.18 8.64 8.55 8.62 8.10 8.25 8.24 202732_at 9.53 9.63 9.36 7.48 7.887.41 9.14 9.48 9.33 6.59 7.03 6.85 202811_at 7.98 7.82 8.04 6.68 6.706.49 7.80 7.93 7.98 6.91 6.98 7.18 202982_s_at 7.96 7.90 7.81 6.53 6.576.55 7.83 7.69 7.85 5.02 4.88 4.71 203031_s_at 9.17 8.91 8.84 7.06 7.056.71 8.96 8.80 8.66 7.53 7.72 7.73 203113_s_at 11.40 11.29 11.21 10.7510.77 10.75 11.45 11.23 11.34 10.48 10.71 10.76 203142_s_at 9.52 9.439.39 8.05 8.12 7.98 9.56 9.21 9.24 8.18 8.17 8.23 203217_s_at 8.27 7.888.31 6.11 6.53 6.65 8.29 8.06 8.15 6.39 6.59 6.34 203335_at 8.36 8.348.58 4.78 4.62 4.75 8.75 8.33 8.32 4.27 4.32 4.34 203343_at 7.22 7.647.64 6.30 6.60 6.64 7.23 7.44 7.64 5.30 5.93 5.96 203459_s_at 7.77 7.617.54 7.18 7.07 6.91 7.60 7.49 7.63 6.75 6.55 6.41 203659_s_at 7.56 7.547.97 6.43 6.42 6.64 7.45 7.38 7.71 5.96 6.07 6.35 203825_at 8.10 8.257.95 6.94 6.97 6.96 7.96 8.06 7.95 6.94 6.99 6.99 203957_at 7.85 7.837.84 7.14 7.31 7.17 7.78 8.04 7.98 5.89 6.09 6.18 204003_s_at 8.03 8.128.04 7.55 7.34 7.41 7.76 7.89 7.93 7.07 7.02 7.19 204044_at 7.91 7.687.81 6.17 6.54 6.44 8.35 8.23 7.87 6.71 6.97 6.82 204168_at 7.91 7.987.95 6.83 6.90 6.87 8.16 8.21 8.29 7.16 7.21 7.20 204172_at 6.16 6.106.51 4.77 4.76 4.83 6.05 6.05 6.38 3.87 4.57 4.49 204220_at 9.58 9.359.28 8.69 8.23 8.47 9.44 9.14 9.41 7.38 7.13 7.52 204234_s_at 7.75 7.487.28 6.52 6.42 6.36 7.61 7.16 7.42 6.00 6.33 6.29 204256_at 7.12 7.578.02 5.14 5.45 5.33 7.07 7.58 7.74 4.74 4.75 5.30 204279_at 10.03 10.0310.06 8.83 9.06 8.96 10.09 9.94 10.06 5.49 5.88 5.75 204326_x_at 10.6610.55 10.74 7.84 8.05 7.93 10.79 10.65 10.45 9.44 9.28 9.42 204386_s_at10.92 11.04 11.05 10.20 10.07 10.03 11.00 11.07 11.02 10.41 10.21 10.42204418_x_at 7.57 7.57 7.42 6.44 6.66 6.67 7.37 7.35 7.12 6.77 6.50 6.47204565_at 9.31 9.15 9.07 7.55 7.59 7.51 9.18 8.84 9.12 6.36 6.31 6.69204766_s_at 11.23 10.84 11.06 8.35 7.85 7.99 11.02 10.41 10.57 8.52 8.628.73 204769_s_at 7.91 8.05 7.79 6.83 7.05 7.05 7.76 7.84 7.87 6.10 6.196.19 204779_s_at 8.11 8.13 8.06 7.44 7.30 7.27 8.24 8.23 8.58 6.94 6.957.03 204806_x_at 10.73 10.67 10.38 8.83 8.96 8.54 10.45 10.30 10.31 7.677.82 7.49 204937_s_at 8.57 8.55 8.62 7.61 7.47 7.55 8.75 8.61 8.79 5.725.86 6.24 205048_s_at 8.88 8.65 8.92 6.13 6.37 6.19 9.07 9.15 8.77 6.335.82 6.60 205297_s_at 10.93 10.97 10.91 9.82 9.84 9.68 10.91 10.80 10.649.51 9.79 9.71 205659_at 6.94 7.23 7.38 6.06 6.40 6.44 7.24 7.56 7.736.08 6.31 6.27 206928_at 6.49 6.45 6.68 5.92 5.81 6.05 6.67 6.37 6.695.72 5.55 5.88 207181_s_at 6.65 6.64 6.83 6.24 6.01 6.12 6.78 6.80 6.815.49 5.27 5.07 207304_at 4.80 4.81 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7.07 4.14 4.66 4.69 6.296.60 6.66 4.75 4.62 4.51 205691_at 8.97 9.21 9.50 6.40 7.01 7.11 8.748.81 8.64 5.98 6.41 6.24 205790_at 8.04 7.91 7.79 5.72 5.68 5.79 7.887.53 7.92 6.37 6.02 6.05 205932_s_at 6.08 5.86 6.03 5.10 5.28 5.02 6.226.15 5.84 4.87 5.19 4.85 206082_at 7.66 7.32 7.79 5.36 5.84 5.45 7.557.68 7.32 5.38 5.20 5.17 206261_at 6.56 6.92 7.25 4.87 5.19 5.29 6.536.74 6.42 5.52 5.27 5.15 206437_at 8.10 8.40 814 6.54 6.39 6.05 7.927.85 8.00 6.34 6.49 6.07 206554_x_at 5.68 5.61 5.56 4.83 4.83 4.89 5.805.75 5.70 4.64 4.75 4.52 206591_at 7.55 8.15 8.76 4.39 4.15 4.25 8.348.84 8.68 4.23 4.00 4.32 206660_at 10.68 11.35 10.55 5.41 4.82 4.94 9.0710.28 10.32 5.10 4.93 5.30 206698_at 7.52 7.70 8.28 4.28 4.31 4.26 7.407.79 7.74 4.31 4.57 4.31 206866_at 6.71 6.83 6.67 5.57 5.33 5.27 6.606.43 6.25 5.62 5.55 5.33 208146_s_at 7.20 6.74 6.94 5.35 5.55 5.11 6.426.58 6.70 5.31 5.44 5.37 208964_s_at 7.75 7.57 7.71 5.82 6.30 5.96 7.987.88 7.41 6.08 6.48 5.93 209129_at 7.17 7.66 7.38 5.34 4.82 4.98 7.337.36 7.25 5.60 4.88 5.00 209310_s_at 7.06 6.66 7.29 5.21 4.80 4.95 6.616.44 6.84 5.08 4.93 4.97 209398_at 6.73 6.61 6.92 6.11 5.86 6.05 7.016.65 6.99 6.04 6.03 5.90 209590_at 7.34 7.81 7.51 6.30 6.17 6.36 8.108.52 7.92 6.14 6.21 5.94 209728_at 9.38 9.04 9.49 6.91 6.87 7.18 9.389.02 9.20 7.25 6.86 7.07 209790_s_at 6.67 6.85 6.71 5.30 5.23 5.19 6.997.04 7.33 6.29 6.19 6.40 210427_x_at 9.55 9.37 8.94 6.88 6.91 6.73 9.159.03 9.17 6.90 7.23 6.60 210715_s_at 9.21 8.81 9.23 6.01 5.82 5.74 8.888.72 9.19 5.87 6.52 5.70 210830_s_at 5.03 4.96 4.88 4.15 4.30 4.31 5.025.00 5.24 4.40 4.25 4.43 211367_s_at 5.99 6.23 6.16 4.32 4.02 4.13 6.126.25 6.63 4.38 4.41 4.14 211368_s_at 7.23 7.48 7.16 4.88 4.89 4.78 7.077.48 7.78 4.84 4.75 4.56 211812_s_at 5.54 5.76 6.09 4.23 4.26 4.43 5.315.66 5.58 4.46 4.37 4.23 212268_at 8.22 8.12 8.07 5.91 5.97 5.78 8.508.10 8.52 6.92 7.12 7.22 212442_s_at 8.75 8.85 8.52 5.88 5.73 6.27 8.768.72 8.97 6.11 5.74 5.82 212561_at 7.80 7.39 7.20 6.10 6.31 6.50 7.817.39 7.62 6.56 6.20 5.96 213147_at 7.84 8.00 7.80 6.32 6.58 6.51 7.347.65 7.54 6.14 6.27 6.34 213150_at 6.85 7.41 7.76 4.40 4.74 4.66 6.476.59 7.01 4.35 4.60 4.65 213371_at 6.96 6.96 6.89 4.58 4.93 4.61 7.437.11 7.02 4.95 4.78 4.59 213419_at 6.52 6.47 6.71 5.72 5.99 5.81 6.606.44 6.84 5.02 5.46 5.04 213502_x_at 9.93 10.40 9.72 6.52 6.78 6.55 9.609.86 9.68 7.01 7.06 7.30 213503_x_at 9.33 9.29 9.11 6.93 6.99 6.80 9.219.20 9.24 7.11 7.21 6.83 213566_at 7.24 6.91 7.15 4.80 5.20 4.83 7.096.63 7.05 4.95 4.85 4.89 213568_at 4.82 4.76 4.79 4.11 4.16 4.22 4.814.88 4.92 4.10 4.02 4.05 213572_s_at 7.30 6.68 7.22 4.48 4.52 4.44 7.157.00 7.42 5.55 5.32 5.72 213625_at 5.83 5.88 5.85 5.33 5.28 5.42 5.665.59 5.61 5.12 5.13 5.18 213788_s_at 5.89 6.20 6.17 5.22 5.13 5.46 5.936.09 5.97 5.44 5.22 5.49 215071_s_at 9.91 8.89 8.75 5.01 5.37 5.26 10.118.63 9.06 5.62 5.24 5.58 215379_x_at 11.62 11.63 11.58 5.86 5.97 5.9511.58 11.63 11.46 8.05 8.92 8.29 216565_x_at 7.47 7.34 7.50 6.52 6.716.39 7.57 7.50 7.37 6.85 6.88 6.74 217022_s_at 8.41 8.43 8.70 5.16 4.794.95 8.98 9.42 8.50 5.39 5.20 5.07 217360_x_at 7.17 7.42 7.18 5.76 5.815.51 7.39 7.34 6.76 5.93 5.61 5.61 217759_at 9.36 9.34 9.61 4.88 5.285.17 9.17 9.18 9.34 5.68 5.82 6.07 217760_at 8.00 7.80 7.56 4.84 4.754.80 7.87 7.65 7.59 5.26 5.12 5.27 217977_at 8.24 8.28 8.29 7.97 7.987.91 8.26 8.26 8.33 8.08 8.13 8.07 218005_at 10.08 10.07 10.21 5.41 5.615.37 10.28 10.09 9.97 8.54 8.72 8.67 218006_s_at 7.90 8.08 8.61 4.674.71 4.65 8.13 8.23 8.03 5.82 6.15 6.21 218154_at 8.00 7.97 7.94 6.956.85 6.86 7.96 7.88 7.83 6.82 6.67 6.47 218457_s_at 5.49 5.36 5.56 4.854.93 5.03 5.53 5.41 5.53 5.15 5.03 4.92 218503_at 6.52 6.59 6.71 5.285.45 5.60 6.66 6.70 7.21 5.30 5.26 5.09 218618_s_at 6.53 6.15 6.50 5.165.45 5.49 6.83 6.83 6.60 4.91 4.90 5.08 218676_s_at 7.89 7.44 7.50 5.735.52 5.71 7.79 7.35 7.87 5.10 5.28 4.85 218689_at 7.06 7.09 7.50 6.046.39 6.15 7.24 7.00 6.96 5.82 6.33 6.10 218729_at 7.33 7.31 6.98 4.884.70 5.13 7.17 6.85 7.03 5.29 5.49 5.35 219143_s_at 8.66 9.03 8.70 5.425.03 5.30 9.04 8.82 8.48 5.40 5.37 5.06 219362_at 5.71 5.62 5.66 5.225.02 5.19 5.66 5.81 5.94 4.83 4.60 4.92 219684_at 7.69 7.89 7.74 5.585.45 5.32 7.60 7.71 7.91 5.76 5.67 5.10 219734_at 4.89 4.56 4.89 3.824.01 4.00 4.66 4.66 4.87 3.87 3.81 4.01 219953_s_at 6.78 7.01 6.88 5.695.93 5.81 6.66 6.46 6.77 5.68 5.92 5.57 220104_at 5.56 5.64 5.78 4.915.12 4.87 5.74 6.13 5.92 4.84 4.90 4.76 220230_s_at 6.25 6.03 5.90 5.235.32 5.40 5.96 6.20 6.15 5.32 5.28 5.16 220235_s_at 9.03 8.80 9.04 4.084.13 4.15 8.85 8.71 8.92 5.71 5.91 6.56 220784_s_at 6.05 5.80 6.04 4.494.31 4.65 5.86 5.58 5.90 4.74 4.35 4.55 221081_s_at 7.68 7.82 8.21 5.485.55 5.38 7.35 7.55 7.25 6.27 6.33 6.14 221349_at 7.42 7.98 8.39 3.974.10 3.83 7.19 7.15 7.10 4.75 4.85 4.35 221641_s_at 7.16 7.32 7.50 5.606.19 5.85 7.84 7.82 7.88 5.82 5.78 5.71 221666_s_at 8.11 8.25 8.15 5.955.54 5.61 8.25 7.98 8.13 5.49 5.41 5.20 221690_s_at 7.11 7.15 7.54 5.425.46 5.57 7.43 7.35 7.34 5.47 5.52 5.40 36030_at 7.98 8.10 8.39 6.837.22 7.17 8.18 8.13 8.20 7.40 7.19 7.49 51158_at 5.40 5.54 5.45 4.864.90 4.91 5.53 5.70 5.52 5.14 4.94 4.94 207714_s_at 7.38 7.55 7.30 6.276.32 6.51 7.61 7.56 7.33 6.76 6.88 6.67 208816_x_at 7.91 7.98 8.01 6.916.96 6.75 8.01 7.87 7.89 7.15 7.11 7.26 211566_x_at 7.57 7.44 7.39 7.016.99 6.95 7.42 7.33 7.32 7.15 7.11 7.03 212235_at 5.90 5.93 5.80 4.965.24 5.01 6.19 6.33 6.14 4.83 5.00 4.98

TABLE 3B Genes With Reduced Expression in CD40-Sensitive Cell Linest-test (two-tailed) Probesets pAB pAD pBC pCD Measured Gene Symbol FDRCutoff 1.0E−02 8.2E−03 1.2E−02 9.4E−03 200068_s_at 1.7E−03 1.0E−035.6E−03 5.2E−04 Yes CANX 200670_at 3.2E−04 2.5E−03 9.0E−04 6.1E−03 YesXBP1 200701_at 4.7E−03 2.2E−03 1.1E−02 5.6E−03 Yes NPC2 200736_s_at6.2E−03 1.4E−03 7.7E−04 2.1E−04 Yes GPX1 200765_x_at 1.2E−04 7.0E−048.0E−05 6.1E−05 Yes CTNNA1 200814_at 5.5E−03 1.6E−04 2.2E−03 5.9E−05 YesPSME1 200846_s_at 9.4E−03 4.9E−03 6.9E−04 1.2E−03 Yes PPP1CA 200887_s_at4.8E−03 2.4E−04 5.1E−03 1.7E−04 Yes STAT1 200905_x_at 1.1E−03 9.5E−055.7E−04 2.8E−05 Yes HLA-E 200936_at 1.1E−04 1.3E−03 1.2E−03 6.6E−03 YesRPL8 200941_at 4.2E−03 2.5E−03 9.5E−03 7.2E−03 Yes HSBP1 201011_at1.9E−03 4.3E−03 1.6E−03 2.6E−03 Yes RPN1 201160_s_at 1.9E−03 9.0E−052.7E−03 1.4E−04 Yes CSDA 201161_s_at 2.8E−03 3.1E−05 7.3E−03 3.0E−05 YesCSDA 201200_at 9.9E−03 3.5E−03 4.9E−03 2.2E−03 Yes CREG 201204_s_at3.5E−03 5.5E−03 1.1E−03 7.6E−04 Yes RRBP1 201206_s_at 6.1E−03 2.2E−031.9E−03 7.3E−04 Yes RRBP1 201226_at 2.9E−06 5.8E−04 2.8E−04 7.7E−03 YesNDUFB8 201263_at 1.8E−03 1.6E−03 1.0E−03 8.5E−04 Yes TARS 201307_at6.6E−04 7.6E−05 2.0E−03 5.4E−05 Yes FLJ10849 201398_s_at 1.7E−03 2.7E−041.4E−04 6.0E−04 Yes TRAM1 201399_s_at 1.2E−03 4.3E−05 2.3E−03 5.9E−05Yes TRAM1 201470_at 1.3E−05 1.6E−04 4.5E−04 1.0E−03 Yes GSTO1 201487_at5.9E−03 2.7E−03 3.6E−03 1.2E−03 Yes CTSC 201499_s_at 1.1E−03 4.3E−039.0E−04 2.3E−03 Yes USP7 201566_x_at 2.6E−03 2.8E−04 3.9E−03 1.8E−03 YesID2 201590_x_at 2.6E−05 3.3E−05 2.1E−05 3.4E−05 Yes ANXA2 201601_x_at6.5E−03 2.9E−03 2.0E−06 1.1E−06 Yes IFITM1 201649_at 7.0E−03 3.6E−046.7E−03 5.3E−04 Yes UBE2L6 201746_at 2.2E−04 1.6E−03 2.5E−04 1.8E−03 YesTP53 201874_at 3.8E−03 4.6E−04 7.0E−03 6.0E−04 Yes FLJ21047 201937_s_at9.3E−03 8.5E−04 2.8E−03 4.1E−03 Yes DNPEP 201968_s_at 3.3E−03 2.9E−041.4E−03 1.4E−04 Yes PGM1 202096_s_at 6.4E−03 6.2E−04 2.2E−04 1.0E−05 YesBZRP 202123_s_at 2.0E−03 1.5E−03 1.9E−03 4.0E−03 Yes ABL1 202261_at2.6E−03 4.1E−03 2.7E−03 5.2E−03 Yes TCFL1 202279_at 2.0E−03 3.0E−031.4E−03 1.0E−03 Yes C14orf2 202315_s_at 6.9E−05 9.0E−05 9.9E−04 1.8E−03Yes BCR 202382_s_at 5.2E−03 6.7E−05 2.3E−03 3.8E−05 Yes GNPDA1202429_s_at 2.4E−04 2.1E−03 1.0E−03 6.9E−03 Yes PPP3CA 202443_x_at3.5E−03 5.1E−05 1.4E−03 2.2E−05 Yes NOTCH2 202447_at 1.8E−03 3.8E−036.8E−03 5.4E−03 Yes DECR1 202457_s_at 1.1E−03 2.4E−03 1.6E−03 4.2E−03Yes PPP3CA 202536_at 5.4E−03 1.9E−03 4.0E−03 2.3E−03 Yes DKFZP564O123202696_at 9.2E−03 5.8E−03 5.5E−03 4.2E−03 Yes OSR1 202732_at 1.3E−032.2E−04 1.2E−03 1.7E−04 Yes PKIG 202811_at 1.5E−04 1.1E−03 1.6E−041.5E−03 Yes AMSH 202982_s_at 4.2E−04 1.0E−04 1.0E−03 5.1E−05 Yes ZAP128203031_s_at 2.1E−04 8.1E−04 3.3E−04 6.8E−04 Yes UROS 203113_s_at 9.2E−035.6E−03 1.0E−02 4.1E−03 Yes EEF1D 203142_s_at 1.7E−05 1.5E−04 3.5E−038.0E−03 Yes AP3B1 203217_s_at 1.5E−03 1.5E−03 4.0E−03 7.7E−05 Yes SIAT9203335_at 1.2E−05 1.5E−04 4.4E−04 8.9E−04 Yes PHYH 203343_at 6.3E−033.9E−03 4.9E−03 5.3E−03 Yes UGDH 203459_s_at 5.0E−03 1.5E−03 9.0E−034.1E−03 Yes — 203659_s_at 4.7E−03 1.1E−03 1.8E−03 8.9E−04 Yes RFP2203825_at 5.1E−03 4.2E−03 5.7E−04 1.3E−04 Yes BRD3 203957_at 6.1E−032.2E−03 2.4E−03 8.6E−05 Yes E2F6 204003_s_at 3.5E−03 3.9E−04 6.5E−034.7E−04 Yes NUPL2 204044_at 9.2E−04 7.1E−04 9.1E−04 4.0E−03 Yes QPRT204168_at 3.0E−06 1.3E−05 5.0E−05 2.2E−04 Yes MGST2 204172_at 6.1E−033.9E−03 4.9E−03 5.5E−03 Yes CPO 204220_at 6.7E−03 2.1E−04 8.6E−032.4E−04 Yes GMFG 204234_s_at 8.9E−03 2.0E−03 1.1E−02 2.5E−03 Yes ZNF195204256_at 7.4E−03 1.8E−03 3.3E−03 8.0E−04 Yes ELOVL6 204279_at 3.2E−036.5E−04 3.8E−04 1.5E−04 Yes PSMB9 204326_x_at 5.4E−06 7.7E−05 9.0E−051.5E−03 Yes MT1X 204386_s_at 2.1E−04 3.0E−03 7.9E−04 6.0E−03 Yes MRP63204418_x_at 8.7E−04 2.8E−03 3.4E−03 5.4E−03 Yes GSTM2 204565_at 6.4E−042.1E−04 3.6E−03 9.8E−05 Yes THEM2 204766_s_at 1.6E−04 3.2E−04 4.6E−044.4E−03 Yes NUDT1 204769_s_at 8.7E−04 4.7E−04 2.3E−03 3.9E−06 Yes TAP2204779_s_at 2.1E−03 1.6E−05 5.2E−03 4.8E−03 Yes HOXB7 204806_x_at4.4E−04 3.5E−05 2.6E−03 1.5E−04 Yes HLA-F 204937_s_at 2.0E−04 2.9E−031.2E−04 1.2E−03 Yes ZNF274 205048_s_at 2.1E−05 3.7E−03 1.2E−04 1.7E−03Yes — 205297_s_at 7.0E−04 3.1E−03 1.1E−03 6.3E−04 Yes CD79B 205659_at7.2E−03 6.1E−03 3.4E−03 4.6E−03 Yes HDAC9 206928_at 3.2E−03 3.0E−039.9E−03 3.8E−03 Yes ZNF124 207181_s_at 3.2E−03 1.9E−03 9.0E−03 5.8E−03Yes CASP7 207304_at 3.4E−03 4.5E−03 1.4E−03 2.4E−03 Yes ZNF45207585_s_at 4.9E−03 8.0E−04 9.4E−03 1.7E−03 Yes RPL36AL 207777_s_at2.4E−04 5.8E−04 1.1E−04 2.4E−04 Yes SP140 207809_s_at 6.1E−03 7.1E−031.0E−03 4.8E−03 Yes ATP6AP1 208490_x_at 2.7E−03 6.5E−03 2.3E−03 3.2E−03Yes HIST1H2BG 208527_x_at 4.7E−05 4.8E−03 1.9E−03 1.5E−03 Yes HIST1H2BE208579_x_at 3.6E−04 6.3E−04 2.5E−04 3.1E−04 Yes H2BFS 208581_x_at6.9E−04 4.9E−03 7.8E−04 6.3E−03 Yes MT1X 208690_s_at 6.0E−05 8.4E−053.0E−05 1.5E−05 Yes PDLIM1 208729_x_at 1.7E−03 2.2E−05 1.2E−04 1.8E−04Yes HLA-B 208812_x_at 5.3E−04 8.6E−08 7.1E−04 9.3E−08 Yes HLA-C208918_s_at 7.1E−04 1.7E−03 5.5E−03 2.6E−03 Yes FLJ13052 209040_s_at6.1E−04 8.3E−04 5.0E−04 9.3E−04 Yes PSMB8 209112_at 8.7E−05 2.3E−031.6E−04 1.9E−03 Yes CDKN1B 209124_at 8.2E−03 3.5E−03 1.9E−03 5.5E−04 YesMYD88 209138_x_at 1.4E−05 5.8E−03 1.3E−06 4.0E−03 Yes IGL@ 209140_x_at6.0E−04 1.4E−04 3.6E−04 6.9E−05 Yes HLA-B 209175_at 6.3E−03 5.9E−035.5E−03 7.1E−03 Yes SEC23IP 209201_x_at 1.2E−03 7.3E−04 1.1E−02 5.6E−03Yes CXCR4 209472_at 5.4E−05 9.6E−04 1.9E−05 8.5E−04 Yes LOC56267209476_at 3.7E−03 7.7E−03 5.3E−03 8.8E−03 Yes TXNDC 209591_s_at 4.1E−033.9E−04 8.9E−04 2.7E−04 Yes BMP7 209970_x_at 8.9E−04 1.0E−03 1.0E−031.2E−03 Yes CASP1 209995_s_at 6.0E−04 7.8E−06 1.4E−03 2.9E−05 Yes TCL1A210136_at 4.5E−03 2.0E−04 6.9E−04 6.6E−04 Yes MBP 210844_x_at 8.1E−032.8E−04 8.0E−04 3.8E−05 Yes CTNNA1 211061_s_at 2.3E−03 6.0E−03 3.0E−037.5E−03 Yes MGAT2 211089_s_at 1.3E−03 1.8E−03 2.6E−03 3.4E−03 Yes NEK3211366_x_at 8.1E−05 5.4E−04 2.4E−04 3.5E−04 Yes CASP1 211528_x_at1.5E−03 5.1E−04 1.4E−03 1.9E−04 Yes HLA-G 211529_x_at 1.1E−03 2.4E−041.7E−03 1.1E−03 Yes HLA-G 211530_x_at 1.9E−03 1.5E−05 3.2E−03 7.0E−04Yes HLA-G 211799_x_at 3.5E−03 9.9E−04 1.9E−03 3.3E−04 Yes HLA-C211911_x_at 1.3E−05 2.4E−06 9.6E−05 1.3E−05 Yes HLA-B 211919_s_at7.8E−04 4.6E−04 1.1E−02 5.1E−03 Yes CXCR4 211989_at 8.8E−04 3.5E−031.3E−03 2.2E−03 Yes SMARCE1 212057_at 1.9E−04 3.4E−03 2.1E−04 9.0E−04Yes KIAA0182 212071_s_at 3.9E−06 7.0E−04 2.7E−06 7.8E−04 Yes SPTBN1212149_at 5.6E−03 4.8E−04 5.2E−03 5.7E−04 Yes KIAA0143 212382_at 5.7E−033.5E−03 1.4E−03 8.1E−04 Yes TCF4 212385_at 1.5E−03 4.7E−04 5.5E−031.6E−03 Yes TCF4 212386_at 2.1E−04 2.0E−03 3.4E−05 2.9E−03 Yes TCF4212387_at 5.9E−04 2.5E−05 5.0E−06 1.2E−04 Yes TCF4 212408_at 1.2E−035.9E−03 1.1E−03 6.4E−03 Yes LAP1B 212446_s_at 6.4E−05 9.6E−04 2.6E−037.5E−03 Yes LOC253782 212507_at 1.2E−03 4.3E−03 4.7E−03 2.6E−03 Yes RW1212547_at 1.4E−04 4.7E−03 2.5E−04 1.4E−03 Yes — 212739_s_at 1.7E−041.9E−03 1.4E−04 8.7E−04 Yes NME4 212774_at 1.7E−03 3.0E−04 1.3E−032.0E−04 Yes ZNF238 212792_at 6.2E−03 6.5E−03 1.5E−05 7.7E−03 YesKIAA0877 212798_s_at 6.6E−04 8.2E−05 3.8E−04 5.9E−05 Yes DKFZP564O043212946_at 1.4E−03 1.1E−04 4.4E−03 7.1E−04 Yes KIAA0564 213020_at 8.5E−032.9E−03 4.1E−03 2.6E−03 Yes GOSR1 213116_at 6.7E−04 7.9E−04 1.5E−042.1E−04 Yes NEK3 213233_s_at 7.7E−04 7.3E−05 4.9E−04 6.5E−04 YesKIAA1354 213293_s_at 8.1E−03 3.2E−03 3.9E−04 1.5E−04 Yes TRIM22213357_at 8.8E−03 7.4E−04 5.7E−03 5.6E−04 Yes — 213361_at 6.3E−031.5E−04 7.4E−03 2.7E−03 Yes PCTAIRE2BP 213435_at 6.2E−03 1.6E−03 1.0E−031.8E−03 Yes SATB2 213793_s_at 5.3E−03 1.8E−03 1.0E−02 3.2E−03 Yes HOMER1213891_s_at 1.6E−04 6.7E−04 9.5E−05 5.3E−04 Yes TCF4 214022_s_at 3.8E−041.6E−03 1.1E−03 9.0E−05 Yes IFITM1 214032_at 3.5E−04 5.5E−04 1.0E−032.2E−04 Yes ZAP70 214172_x_at 4.0E−04 4.7E−04 2.6E−04 2.9E−04 Yes RYK214369_s_at 2.4E−03 1.0E−03 7.9E−03 4.4E−04 Yes RASGRP2 214394_x_at4.2E−04 4.9E−04 1.2E−03 2.0E−03 Yes EEF1D 214459_x_at 7.3E−03 2.8E−031.7E−03 9.0E−04 Yes HLA-C 214512_s_at 5.3E−06 9.6E−05 2.2E−04 2.3E−04Yes PC4 214677_x_at 3.9E−07 9.9E−04 3.0E−06 1.5E−03 Yes IGLJ3214749_s_at 6.2E−04 1.8E−03 2.5E−04 2.6E−03 Yes FLJ20811 214835_s_at1.1E−03 5.6E−03 1.0E−03 5.3E−03 Yes SUCLG2 214916_x_at 2.6E−03 6.5E−049.5E−03 7.9E−04 Yes — 215121_x_at 7.2E−04 2.7E−03 1.1E−03 3.9E−03 Yes —215516_at 7.3E−03 7.7E−03 3.0E−03 4.0E−03 Yes LAMB4 215772_x_at 4.3E−036.3E−03 5.4E−04 1.6E−03 Yes SUCLG2 215946_x_at 1.6E−03 1.1E−03 4.8E−056.5E−04 Yes — 216526_x_at 1.7E−03 2.1E−07 2.2E−03 2.6E−07 Yes HLA-C216733_s_at 5.9E−05 1.2E−03 6.5E−05 5.6E−05 Yes GATM 216973_s_at 6.3E−043.9E−03 5.5E−03 7.4E−04 Yes HOXB7 216976_s_at 1.2E−05 3.2E−03 1.1E−021.2E−03 Yes RYK 217028_at 2.8E−03 4.0E−05 1.1E−03 8.6E−04 Yes —217436_x_at 1.6E−03 1.0E−04 2.2E−03 5.9E−04 Yes — 217456_x_at 2.5E−046.4E−05 6.9E−05 1.8E−04 Yes HLA-E 217809_at 1.7E−05 2.2E−03 2.1E−053.0E−03 Yes BZW2 217839_at 5.6E−03 2.3E−04 8.8E−04 6.7E−04 Yes TFG217911_s_at 3.2E−03 1.1E−03 8.4E−04 1.7E−03 Yes BAG3 217940_s_at 1.4E−047.1E−03 1.4E−03 2.7E−03 Yes FLJ10769 217950_at 8.2E−04 4.5E−04 3.2E−032.3E−03 Yes NOSIP 217988_at 1.4E−03 2.2E−03 2.4E−04 1.1E−03 Yes C14orf18218026_at 1.1E−03 6.6E−03 1.1E−03 6.3E−04 Yes HSPC009 218093_s_at3.3E−04 6.1E−04 2.0E−03 5.2E−03 Yes ANKRD10 218100_s_at 5.3E−04 3.9E−036.5E−04 7.3E−03 Yes ESRRBL1 218187_s_at 4.2E−03 4.8E−03 3.3E−03 4.0E−03Yes FLJ20989 218224_at 1.5E−03 1.7E−03 1.4E−05 1.8E−05 Yes PNMA1218276_s_at 1.3E−03 1.1E−04 2.3E−04 1.1E−04 Yes SAV1 218285_s_at 1.4E−035.0E−04 2.4E−03 6.3E−04 Yes DHRS6 218316_at 4.2E−03 3.0E−04 9.7E−036.2E−04 Yes TIMM9 218343_s_at 1.0E−03 1.5E−03 4.3E−04 1.7E−03 Yes GTF3C3218358_at 7.9E−04 5.7E−04 3.7E−03 2.6E−03 Yes MGC11256 218377_s_at1.5E−03 6.1E−04 2.7E−03 8.0E−04 Yes C21orf6 218490_s_at 1.0E−02 3.7E−036.2E−03 2.9E−03 Yes ZNF302 218491_s_at 4.4E−03 3.5E−03 3.1E−03 8.4E−03Yes THY28 218543_s_at 1.1E−03 3.4E−04 1.2E−04 4.5E−04 Yes ZC3HDC1218557_at 1.1E−05 3.0E−05 3.0E−03 3.9E−04 Yes NIT2 218633_x_at 2.1E−043.3E−03 4.1E−04 4.0E−03 Yes FLJ11342 218648_at 3.9E−03 5.3E−04 4.0E−035.4E−04 Yes FLJ21868 218735_s_at 5.3E−03 1.6E−03 5.7E−04 6.6E−04 YesAF020591 218738_s_at 2.7E−03 3.8E−03 6.4E−04 9.5E−04 Yes RNF138218773_s_at 2.1E−03 6.4E−03 2.3E−03 9.2E−03 Yes PILB 219008_at 2.0E−035.2E−03 1.4E−03 1.9E−03 Yes FLJ21820 219184_x_at 1.9E−03 2.3E−04 1.0E−027.9E−03 Yes TIMM22 219209_at 4.3E−03 7.4E−04 1.3E−03 4.4E−04 Yes MDA5219215_s_at 2.9E−03 5.0E−05 3.2E−03 6.7E−05 Yes SLC39A4 219248_at1.5E−03 5.1E−03 1.7E−03 1.9E−03 Yes C2orf8 219471_at 4.7E−03 3.7E−033.0E−03 2.9E−03 Yes C13orf18 219489_s_at 2.2E−04 1.5E−03 3.7E−04 2.0E−03Yes RHBDL2 219563_at 3.9E−05 1.8E−05 3.4E−05 3.4E−04 Yes C14orf139219664_s_at 1.9E−03 2.4E−03 7.9E−04 1.0E−03 Yes DECR2 219767_s_at3.9E−03 3.3E−03 1.9E−03 1.0E−03 Yes CRYZL1 219822_at 6.3E−04 7.5E−037.3E−04 7.1E−03 Yes MTRF1 220741_s_at 1.0E−03 4.5E−05 7.8E−05 6.4E−04Yes PPA2 221234_s_at 5.9E−04 4.7E−04 3.2E−03 3.4E−04 Yes BACH2221614_s_at 6.4E−03 3.8E−03 1.9E−03 2.6E−04 Yes RPH3AL 221847_at 2.0E−031.6E−03 1.1E−02 5.0E−03 Yes TAS2R14 221874_at 6.0E−03 1.9E−03 1.4E−032.4E−04 Yes KIAA1324 221875_x_at 3.1E−03 6.3E−04 8.5E−04 8.3E−05 YesHLA-F 222146_s_at 1.1E−03 4.3E−04 3.8E−03 2.4E−03 Yes TCF4 35671_at1.3E−04 6.1E−04 6.0E−04 4.1E−04 Yes GTF3C1 36830_at 3.5E−04 1.5E−039.0E−03 6.4E−03 Yes MIPEP 36936_at 7.6E−03 6.4E−06 1.0E−02 2.0E−04 YesTSTA3 37384_at 3.1E−04 4.9E−03 2.7E−04 3.5E−03 Yes PPM1F 39318_at3.2E−04 3.8E−04 2.7E−04 1.2E−04 Yes TCL1A 40148_at 1.9E−03 1.6E−041.2E−02 5.8E−03 Yes APBB2 200660_at 3.1E−05 1.3E−04 4.7E−04 1.4E−03 YesS100A11 200671_s_at 2.2E−04 1.1E−04 1.8E−03 5.0E−04 Yes SPTBN1200672_x_at 1.2E−03 1.3E−03 9.7E−04 1.5E−03 Yes SPTBN1 200704_at 3.3E−043.3E−04 2.6E−04 2.4E−04 Yes LITAF 200706_s_at 2.2E−05 1.8E−04 1.2E−033.1E−03 Yes LITAF 200782_at 1.5E−04 5.9E−04 5.6E−05 9.4E−05 Yes ANXA5200923_at 1.8E−04 2.7E−04 7.5E−06 7.5E−06 Yes LGALS3BP 201005_at 1.1E−042.7E−04 2.4E−06 1.0E−05 Yes CD9 201426_s_at 3.3E−05 1.0E−03 2.2E−045.5E−04 Yes VIM 201485_s_at 9.7E−04 9.1E−07 1.0E−02 1.1E−03 Yes RCN2201792_at 3.1E−04 6.0E−04 8.2E−04 1.5E−03 Yes AEBP1 202218_s_at 5.1E−032.2E−03 4.1E−03 1.6E−03 Yes FADS2 202283_at 3.1E−03 4.1E−03 2.1E−032.9E−03 Yes SERPINF1 202719_s_at 8.4E−04 2.1E−03 2.4E−03 3.0E−04 Yes TES202855_s_at 4.0E−03 2.1E−03 4.4E−03 7.7E−04 Yes SLC16A3 202856_s_at2.0E−03 1.2E−03 8.7E−04 1.4E−03 Yes SLC16A3 203045_at 1.0E−03 3.8E−043.3E−03 2.7E−03 Yes NINJ1 203063_at 8.0E−04 6.8E−04 1.2E−03 8.9E−04 YesPPM1F 203068_at 2.0E−04 3.6E−04 1.9E−04 4.8E−04 Yes KIAA0469 203211_s_at2.1E−05 6.2E−06 2.8E−04 1.4E−04 Yes MTMR2 203212_s_at 1.9E−03 2.5E−033.7E−03 1.4E−03 Yes MTMR2 203222_s_at 1.5E−03 2.0E−03 2.5E−03 2.4E−03Yes TLE1 203305_at 1.8E−03 2.5E−03 7.7E−04 1.0E−03 Yes F13A1 203408_s_at1.1E−03 1.7E−03 1.6E−03 2.7E−03 Yes SATB1 203557_s_at 6.9E−05 1.1E−034.7E−05 4.2E−04 Yes PCBD 203708_at 8.7E−03 8.0E−03 8.6E−05 1.0E−04 YesPDE4B 203853_s_at 3.3E−05 4.2E−05 3.5E−03 7.4E−03 Yes GAB2 204305_at1.9E−03 3.9E−03 8.3E−05 1.3E−04 Yes MIPEP 204821_at 3.0E−04 1.5E−034.7E−04 4.6E−03 Yes BTN3A3 204994_at 1.4E−03 3.7E−03 8.1E−04 2.5E−03 YesMX2 205173_x_at 2.5E−03 1.2E−03 6.5E−05 1.1E−03 Yes CD58 205181_at4.0E−03 5.5E−03 4.0E−03 4.2E−03 Yes ZNF193 205366_s_at 6.4E−03 7.4E−034.6E−03 8.3E−03 Yes HOXB6 205401_at 4.6E−05 8.5E−04 2.8E−04 6.4E−04 YesAGPS 205668_at 1.0E−03 3.6E−03 1.4E−03 4.6E−04 Yes LY75 205691_at1.5E−03 1.4E−04 1.1E−02 7.7E−04 Yes SYNGR3 205790_at 2.0E−04 4.4E−042.1E−03 6.3E−04 Yes SCAP1 205932_s_at 1.1E−03 2.8E−03 4.1E−03 2.3E−03Yes MSX1 206082_at 5.5E−04 7.8E−04 6.9E−04 1.7E−04 Yes HCP5 206261_at3.2E−03 5.4E−03 1.1E−03 1.1E−03 Yes ZNF239 206437_at 8.6E−04 3.3E−045.0E−03 2.5E−03 Yes EDG6 206554_x_at 2.0E−04 8.7E−04 2.6E−05 1.0E−03 YesSETMAR 206591_at 6.2E−03 4.9E−03 1.5E−04 5.3E−05 Yes RAG1 206660_at8.7E−05 4.3E−04 2.5E−03 4.9E−03 Yes IGLL1 206698_at 4.0E−03 1.8E−031.1E−03 6.1E−05 Yes XK 206866_at 9.8E−04 1.0E−03 1.6E−03 2.4E−03 YesCDH4 208146_s_at 9.3E−04 4.3E−03 2.5E−03 1.2E−03 Yes CPVL 208964_s_at3.0E−03 6.6E−03 1.9E−03 2.8E−03 Yes FADS1 209129_at 3.5E−04 2.1E−033.2E−03 9.3E−03 Yes TRIP6 209310_s_at 1.5E−03 6.0E−03 6.1E−04 2.0E−03Yes CASP4 209398_at 3.6E−03 5.6E−03 5.2E−03 9.2E−03 Yes HIST1H1C209590_at 5.1E−03 2.0E−03 5.1E−03 2.5E−03 Yes BMP7 209728_at 2.7E−042.6E−04 1.0E−04 1.6E−04 Yes HLA-DRB3 209790_s_at 1.1E−04 5.7E−03 1.7E−035.6E−03 Yes CASP6 210427_x_at 2.9E−03 7.4E−04 8.7E−06 4.6E−03 Yes ANXA2210715_s_at 1.7E−04 1.4E−03 1.9E−04 1.7E−03 Yes SPINT2 210830_s_at6.8E−04 1.5E−03 1.5E−03 2.2E−03 Yes PON2 211367_s_at 8.7E−05 1.1E−048.7E−04 1.1E−03 Yes CASP1 211368_s_at 4.8E−04 3.8E−05 5.3E−03 2.2E−03Yes CASP1 211812_s_at 5.5E−03 5.7E−03 1.4E−03 1.5E−03 Yes B3GALT3212268_at 8.5E−06 1.9E−03 9.3E−04 2.5E−03 Yes SERPINB1 212442_s_at4.0E−04 4.9E−05 6.5E−04 6.2E−05 Yes LOC253782 212561_at 8.4E−03 8.1E−031.5E−03 4.4E−03 Yes RAB6IP1 213147_at 2.0E−04 4.4E−05 1.0E−03 6.5E−04Yes HOXA10 213150_at 4.2E−03 4.7E−03 1.0E−03 1.2E−03 Yes HOXA10213371_at 1.8E−03 1.5E−03 1.3E−04 1.4E−04 Yes LDB3 213419_at 2.5E−033.4E−03 7.3E−03 1.7E−03 Yes — 213502_x_at 1.1E−03 1.4E−03 1.1E−052.9E−05 Yes — 213503_x_at 1.7E−05 2.7E−04 3.5E−04 2.4E−03 Yes ANXA2213566_at 2.6E−04 8.3E−04 6.0E−04 4.0E−03 Yes RNASE6 213568_at 2.8E−043.0E−05 1.2E−04 9.1E−05 Yes OSR2 213572_s_at 5.2E−03 5.0E−03 1.6E−036.2E−04 Yes SERPINB1 213625_at 3.8E−03 4.1E−05 1.1E−02 8.7E−05 YesP1P373C6 213788_s_at 4.1E−03 6.0E−03 7.5E−03 6.7E−03 Yes — 215071_s_at5.1E−03 5.4E−03 8.6E−03 9.3E−03 Yes — 215379_x_at 1.1E−06 6.3E−036.8E−07 5.2E−03 Yes IGLJ3 216565_x_at 3.5E−03 7.4E−04 2.2E−03 1.3E−03Yes — 217022_s_at 1.9E−05 1.4E−05 1.6E−03 2.4E−03 Yes MGC27165217360_x_at 2.4E−04 4.5E−04 8.9E−03 7.9E−03 Yes — 217759_at 1.8E−052.5E−05 1.2E−04 1.6E−04 Yes TRIM44 217760_at 1.2E−03 8.1E−04 3.4E−049.5E−05 Yes TRIM44 217977_at 7.5E−04 2.7E−03 5.0E−04 3.7E−03 Yes SEPX1218005_at 4.2E−06 4.1E−05 3.5E−06 4.7E−04 Yes ZNF22 218006_s_at 3.5E−032.6E−03 1.0E−04 7.6E−04 Yes ZNF22 218154_at 9.8E−05 4.8E−03 4.1E−052.8E−03 Yes FLJ12150 218457_s_at 2.6E−03 7.5E−03 1.3E−03 6.5E−03 YesDNMT3A 218503_at 1.2E−03 8.9E−05 5.6E−03 6.2E−03 Yes KIAA1797218618_s_at 3.5E−03 2.4E−03 6.4E−04 8.0E−05 Yes FAD104 218676_s_at1.5E−03 1.9E−04 2.5E−03 3.1E−04 Yes PCTP 218689_at 5.6E−03 5.3E−033.1E−03 8.7E−03 Yes FANCF 218729_at 1.7E−04 6.6E−04 2.7E−04 3.4E−04 YesLXN 219143_s_at 2.8E−05 2.6E−05 1.2E−04 1.5E−04 Yes Rpp25 219362_at6.1E−03 7.8E−03 3.5E−03 1.3E−03 Yes — 219684_at 2.7E−05 4.9E−03 5.1E−053.1E−03 Yes IFRG28 219734_at 6.1E−03 5.6E−03 1.3E−03 1.0E−03 YesFLJ20174 219953_s_at 3.7E−04 1.5E−03 2.6E−03 3.0E−03 Yes C11orf17220104_at 2.6E−03 9.0E−04 3.7E−03 5.7E−03 Yes ZC3HAV1 220230_s_at8.5E−03 7.4E−03 1.5E−03 1.3E−03 Yes CYB5R2 220235_s_at 1.3E−04 4.4E−035.0E−05 6.0E−03 Yes RIF1 220784_s_at 4.0E−04 8.6E−04 7.9E−04 1.3E−03 YesUTS2 221081_s_at 2.2E−03 4.4E−03 2.7E−04 9.1E−04 Yes FLJ22457 221349_at3.1E−03 1.7E−03 1.5E−04 3.0E−03 Yes VPREB1 221641_s_at 4.1E−03 2.1E−036.9E−03 7.6E−06 Yes ACATE2 221666_s_at 9.7E−04 1.0E−04 2.5E−04 2.1E−05Yes ASC 221690_s_at 3.2E−03 3.9E−03 1.9E−05 2.8E−06 Yes NALP2 36030_at3.3E−03 8.1E−03 1.0E−02 8.4E−03 Yes HOM-TES-103 51158_at 2.0E−03 7.1E−035.0E−03 2.8E−03 Yes — 207714_s_at 5.4E−04 2.8E−03 6.2E−04 3.2E−03 NoSERPINH1 208816_x_at 7.8E−04 2.9E−04 3.8E−04 2.7E−04 No — 211566_x_at6.9E−03 6.7E−03 1.6E−03 5.5E−03 No — 212235_at 4.1E−03 2.2E−04 7.0E−047.9E−05 No PLXND1 Probesets UniGene ID Gene Title FDR Cutoff 200068_s_atHs.155560 calnexin 200670_at Hs.437638 X-box binding protein 1 200701_atHs.433222 Niemann-Pick disease, type C2 200736_s_at Hs.76686 glutathioneperoxidase 1 200765_x_at Hs.254321 catenin (cadherin-associatedprotein), alpha 1, 102 kDa 200814_at Hs.75348 proteasome (prosome,macropain) activator subunit 1 (PA28 alpha) 200846_s_at Hs.183994protein phosphatase 1, catalytic subunit, alpha isoform 200887_s_atHs.21486 signal transducer and activator of transcription 1, 91 kDa200905_x_at Hs.381008 major histocompatibility complex, class I, E200936_at Hs.178551 ribosomal protein L8 200941_at Hs.250899 heat shockfactor binding protein 1 201011_at Hs.2280 ribophorin I 201160_s_atHs.221889 cold shock domain protein A 201161_s_at Hs.221889 cold shockdomain protein A 201200_at Hs.5710 cellular repressor of E1A-stimulatedgenes 201204_s_at Hs.98614 ribosome binding protein 1 homolog 180 kDa(dog) 201206_s_at Hs.98614 ribosome binding protein 1 homolog 180 kDa(dog) 201226_at Hs.198273 NADH dehydrogenase (ubiquinone) 1 betasubcomplex, 8, 19 kDa 201263_at Hs.84131 threonyl-tRNA synthetase201307_at Hs.386784 hypothetical protein FLJ10849 201398_s_at Hs.4147translocation associated membrane protein 1 201399_s_at Hs.4147translocation associated membrane protein 1 201470_at Hs.11465glutathione S-transferase omega 1 201487_at Hs.128065 cathepsin C201499_s_at Hs.386939 ubiquitin specific protease 7 (herpes virus-associated) 201566_x_at Hs.180919 inhibitor of DNA binding 2, dominantnegative helix-loop-helix protein 201590_x_at Hs.462864 annexin A2201601_x_at Hs.458414 interferon induced transmembrane protein 1 (9-27)201649_at Hs.425777 ubiquitin-conjugating enzyme E2L 6 201746_atHs.408312 tumor protein p53 (Li-Fraumeni syndrome) 201874_at Hs.512729hypothetical protein FLJ21047 201937_s_at Hs.258551 aspartylaminopeptidase 201968_s_at Hs.1869 phosphoglucomutase 1 202096_s_atHs.202 benzodiazapine receptor (peripheral) 202123_s_at Hs.446504 v-ablAbelson murine leukemia viral oncogene homolog 1 202261_at Hs.2430transcription factor-like 1 202279_at Hs.109052 chromosome 14 openreading frame 2 202315_s_at Hs.446394 breakpoint cluster region202382_s_at Hs.278500 glucosamine-6-phosphate deaminase 1 202429_s_atHs.272458 protein phosphatase 3 (formerly 2B), catalytic subunit, alphaisoform (calcineurin A alpha) 202443_x_at Hs.8121 Notch homolog 2(Drosophila) 202447_at Hs.414754 2,4-dienoyl CoA reductase 1,mitochondrial 202457_s_at Hs.272458 protein phosphatase 3 (formerly 2B),catalytic subunit, alpha isoform (calcineurin A alpha) 202536_atHs.11449 DKFZP564O123 protein 202696_at Hs.95220 oxidative-stressresponsive 1 202732_at Hs.3407 protein kinase (cAMP-dependent,catalytic) inhibitor gamma 202811_at Hs.12479 associated molecule withthe SH3 domain of STAM 202982_s_at Hs.446685 peroxisomal long-chainacyl-coA thioesterase 203031_s_at Hs.75593 uroporphyrinogen III synthase(congenital erythropoietic porphyria) 203113_s_at Hs.334798 eukaryotictranslation elongation factor 1 delta (guanine nucleotide exchangeprotein) 203142_s_at Hs.446648 adaptor-related protein complex 3, beta 1subunit 203217_s_at Hs.415117 sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3- sialyltransferase; GM3 synthase)203335_at Hs.172887 phytanoyl-CoA hydroxylase (Refsum disease) 203343_atHs.28309 UDP-glucose dehydrogenase 203459_s_at Hs.188838 vacuolarprotein sorting protein 16 203659_s_at Hs.436922 ret finger protein 2203825_at Hs.86896 bromodomain containing 3 203957_at Hs.135465 E2Ftranscription factor 6 204003_s_at Hs.408241 nucleoporin like 2204044_at Hs.335116 quinolinate phosphoribosyltransferase(nicotinate-nucleotide pyrophosphorylase (carboxylating)) 204168_atHs.81874 microsomal glutathione S-transferase 2 204172_at Hs.89866coproporphyrinogen oxidase (coproporphyria, harderoporphyria) 204220_atHs.5210 glia maturation factor, gamma 204234_s_at Hs.104382 zinc fingerprotein 195 204256_at Hs.211556 ELOVL family member 6, elongation oflong chain fatty acids (FEN1/Elo2, SUR4/Elo3- like, yeast) 204279_atHs.381081 proteasome (prosome, macropain) subunit, beta type, 9 (largemultifunctional protease 2) 204326_x_at Hs.374950 metallothionein 1X204386_s_at Hs.458367 mitochondrial ribosomal protein 63 204418_x_atHs.279837 glutathione S-transferase M2 (muscle) 204565_at Hs.9676thioesterase superfamily member 2 204766_s_at Hs.413078 nudix(nucleoside diphosphate linked moiety X)-type motif 1 204769_s_at Hs.502transporter 2, ATP-binding cassette, sub- family B (MDR/TAP) 204779_s_atHs.436181 homeo box B7 204806_x_at Hs.411958 major histocompatibilitycomplex, class I, F 204937_s_at Hs.83761 zinc finger protein 274205048_s_at — — 205297_s_at Hs.89575 CD79Bantigen(immunoglobulin-associated beta) 205659_at Hs.487662 histonedeacetylase 9 206928_at Hs.458362 zinc finger protein 124 (HZF-16)207181_s_at Hs.9216 caspase 7, apoptosis-related cysteine protease207304_at Hs.381285 zinc finger protein 45 (a Kruppel-associated box(KRAB) domain polypeptide) 207585_s_at Hs.444749 ribosomal proteinL36a-like 207777_s_at Hs.399826 SP140 nuclear body protein 207809_s_atHs.6551 ATPase, H+ transporting, lysosomal accessory protein 1208490_x_at Hs.182137 histone 1, H2bg 208527_x_at Hs.182138 histone 1,H2be 208579_x_at Hs.473961 H2B histone family, member S 208581_x_atHs.374950 metallothionein 1X 208690_s_at Hs.75807 PDZ and LIM domain 1(elfin) 208729_x_at Hs.77961 major histocompatibility complex, class I,B 208812_x_at Hs.274485 major histocompatibility complex, class I, C208918_s_at Hs.220324 NAD kinase 209040_s_at Hs.180062 proteasome(prosome, macropain) subunit, beta type, 8 (large multifunctionalprotease 7) 209112_at Hs.238990 cyclin-dependent kinase inhibitor 1B(p27, Kip1) 209124_at Hs.82116 myeloid differentiation primary responsegene (88) 209138_x_at Hs.458262 immunoglobulin lambda locus 209140_x_atHs.77961 major histocompatibility complex, class I, B 209175_atHs.300208 SEC23 interacting protein 209201_x_at Hs.421986 chemokine(C—X—C motif) receptor 4 209472_at Hs.134460 hypothetical protein 669209476_at Hs.125221 thioredoxin domain containing 209591_s_at Hs.170195bone morphogenetic protein 7 (osteogenic protein 1) 209970_x_at Hs.2490caspase 1, apoptosis-related cysteine protease (interleukin 1, beta,convertase) 209995_s_at Hs.2484 T-cell leukemia/lymphoma 1A 210136_atHs.408543 myelin basic protein 210844_x_at Hs.254321 catenin(cadherin-associated protein), alpha 1, 102 kDa 211061_s_at Hs.93338mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 211089_s_at Hs.2236 NIMA (never inmitosis gene a)-related kinase 3 211366_x_at Hs.2490 caspase 1,apoptosis-related cysteine protease (interleukin 1, beta, convertase)211528_x_at Hs.512152 HLA-G histocompatibility antigen, class I, G211529_x_at Hs.512152 HLA-G histocompatibility antigen, class I, G211530_x_at Hs.512152 HLA-G histocompatibility antigen, class I, G211799_x_at Hs.274485 major histocompatibility complex, class I, C211911_x_at Hs.77961 major histocompatibility complex, class I, B211919_s_at Hs.421986 chemokine (C—X—C motif) receptor 4 211989_atHs.437546 SWI/SNF related, matrix associated, actin dependent regulatorof chromatin, subfamily e, member 1 212057_at Hs.222171 KIAA0182 protein212071_s_at Hs.205401 spectrin, beta, non-erythrocytic 1 212149_atHs.84087 KIAA0143 protein 212382_at Hs.359289 transcription factor 4212385_at Hs.359289 transcription factor 4 212386_at Hs.359289transcription factor 4 212387_at Hs.359289 transcription factor 4212408_at Hs.234265 lamina-associated polypeptide 1B 212446_s_atHs.503941 hypothetical protein LOC253782 212507_at Hs.318783 RW1 protein212547_at Hs.6580 Homo sapiens clone 23718 mRNA sequence 212739_s_atHs.9235 non-metastatic cells 4, protein expressed in 212774_at Hs.446677zinc finger protein 238 212792_at Hs.408623 KIAA0877 protein 212798_s_atHs.112605 hypothetical protein DKFZp564O043 212946_at Hs.405457 KIAA0564protein 213020_at Hs.124436 golgi SNAP receptor complex member 1213116_at Hs.2236 NIMA (never in mitosis gene a)-related kinase 3213233_s_at Hs.147717 KIAA1354 protein 213293_s_at Hs.318501 tripartitemotif-containing 22 213357_at Hs.356224 Homo sapiens cDNA clone IMAGE:4446165, partial cds 213361_at Hs.416543 tudor repeat associator withPCTAIRE 2 213435_at Hs.412327 SATB family member 2 213793_s_at Hs.129051homer homolog 1 (Drosophila) 213891_s_at Hs.359289 transcription factor4 214022_s_at Hs.458414 interferon induced transmembrane protein 1(9-27) 214032_at Hs.234569 zeta-chain (TCR) associated protein kinase 70kDa 214172_x_at Hs.285346 RYK receptor-like tyrosine kinase 214369_s_atHs.99491 RAS guanyl releasing protein 2 (calcium and DAG-regulated)214394_x_at Hs.334798 eukaryotic translation elongation factor 1 delta(guanine nucleotide exchange protein) 214459_x_at Hs.274485 majorhistocompatibility complex, class I, C 214512_s_at Hs.229641 activatedRNA polymerase II transcription cofactor 4 214677_x_at Hs.449601immunoglobulin lambda joining 3 214749_s_at Hs.83530 hypotheticalprotein FLJ20811 214835_s_at Hs.446476 succinate-CoA ligase,GDP-forming, beta subunit 214916_x_at Hs.448957 Homo sapiens partialmRNA for IgM immunoglobulin heavy chain variable region (IGHV gene),clone LIBPM376 215121_x_at Hs.356861 Homo sapiens cDNA FLJ26905 fis,clone RCT01427, highly similar to Ig lambda chain C regions 215516_atHs.62022 laminin, beta 4 215772_x_at Hs.446476 succinate-CoA ligase,GDP-forming, beta subunit 215946_x_at Hs.272302 Homo sapiens, cloneIMAGE: 5728597, mRNA 216526_x_at Hs.274485 major histocompatibilitycomplex, class I, C 216733_s_at Hs.75335 glycine amidinotransferase (L-arginine:glycine amidinotransferase) 216973_s_at Hs.436181 homeo box B7216976_s_at Hs.285346 RYK receptor-like tyrosine kinase 217028_at — —217436_x_at — — 217456_x_at Hs.381008 major histocompatibility complex,class I, E 217809_at Hs.5216 basic leucine zipper and W2 domains 2217839_at Hs.446568 TRK-fused gene 217911_s_at Hs.15259 BCL2-associatedathanogene 3 217940_s_at Hs.8083 hypothetical protein FLJ10769 217950_atHs.7236 nitric oxide synthase interacting protein 217988_at Hs.107003chromosome 14 open reading frame 18 218026_at Hs.16059 HSPC009 protein218093_s_at Hs.164969 ankyrin repeat domain 10 218100_s_at Hs.170318estrogen-related receptor beta like 1 218187_s_at Hs.169615 hypotheticalprotein FLJ20989 218224_at Hs.194709 paraneoplastic antigen MA1218276_s_at Hs.257341 salvador homolog 1 (Drosophila) 218285_s_atHs.124696 dehydrogenase/reductase (SDR family) member 6 218316_atHs.440525 translocase of inner mitochondrial membrane 9 homolog (yeast)218343_s_at Hs.512838 general transcription factor IIIC, polypeptide 3,102 kDa 218358_at Hs.28029 hypothetical protein MGC11256 218377_s_atHs.34136 chromosome 21 open reading frame 6 218490_s_at Hs.436350 zincfinger protein 302 218491_s_at Hs.13645 likely ortholog of the mousethymocyte protein Thy28 218543_s_at Hs.12646 zinc finger CCCH typedomain containing 1 218557_at Hs.439152 Nit protein 2 218633_x_atHs.266514 hypothetical protein FLJ11342 218648_at Hs.434956 hypotheticalprotein FLJ21868 218735_s_at Hs.438994 zinc finger protein 218738_s_atHs.180403 ring finger protein 138 218773_s_at Hs.461420 pilin-liketranscription factor 219008_at Hs.63300 hypothetical protein FLJ21820219184_x_at Hs.87595 translocase of inner mitochondrial membrane 22homolog (yeast) 219209_at Hs.389539 melanoma differentiation associatedprotein-5 219215_s_at Hs.411274 solute carrier family 39 (zinctransporter), member 4 219248_at Hs.368545 chromosome 2 open readingframe 8 219471_at Hs.413071 chromosome 13 open reading frame 18219489_s_at Hs.133999 rhomboid, veinlet-like 2 (Drosophila) 219563_atHs.41502 chromosome 14 open reading frame 139 219664_s_at Hs.158982,4-dienoyl CoA reductase 2, peroxisomal 219767_s_at Hs.352671crystallin, zeta (quinone reductase)-like 1 219822_at Hs.348472mitochondrial translational release factor 1 220741_s_at Hs.421825inorganic pyrophosphatase 2 221234_s_at Hs.88414 BTB and GNC homology 1,basic leucine zipper transcription factor 2 221614_s_at Hs.437436rabphilin 3A-like (without C2 domains) 221847_at Hs.278469 tastereceptor, type 2, member 14 221874_at Hs.104696 maba1 221875_x_atHs.411958 major histocompatibility complex, class I, F 222146_s_atHs.359289 transcription factor 4 35671_at Hs.331 general transcriptionfactor IIIC, polypeptide 1, alpha 220 kDa 36830_at Hs.68583mitochondrial intermediate peptidase 36936_at Hs.404119 tissue specifictransplantation antigen P35B 37384_at Hs.278441 protein phosphatase 1F(PP2C domain containing) 39318_at Hs.2484 T-cell leukemia/lymphoma 1A40148_at Hs.324125 amyloid beta (A4) precursor protein-binding, familyB, member 2 (Fe65-like) 200660_at Hs.417004 S100 calcium binding proteinA11 (calgizzarin) 200671_s_at Hs.205401 spectrin, beta, non-erythrocytic1 200672_x_at Hs.205401 spectrin, beta, non-erythrocytic 1 200704_atHs.76507 lipopolysaccharide-induced TNF factor 200706_s_at Hs.76507lipopolysaccharide-induced TNF factor 200782_at Hs.145741 annexin A5200923_at Hs.79339 lectin, galactoside-binding, soluble, 3 bindingprotein 201005_at Hs.387579 CD9 antigen (p24) 201426_s_at Hs.435800vimentin 201485_s_at Hs.79088 reticulocalbin 2, EF-hand calcium bindingdomain 201792_at Hs.439463 AE binding protein 1 202218_s_at Hs.388164fatty acid desaturase 2 202283_at Hs.173594 serine (or cysteine)proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epitheliumderived factor), member 1 202719_s_at Hs.129129 testis derivedtranscript (3 LIM domains) 202855_s_at Hs.386678 solute carrier family16 (monocarboxylic acid transporters), member 3 202856_s_at Hs.386678solute carrier family 16 (monocarboxylic acid transporters), member 3203045_at Hs.11342 ninjurin 1 203063_at Hs.278441 protein phosphatase 1F(PP2C domain containing) 203068_at Hs.7764 KIAA0469 gene product203211_s_at Hs.181326 myotubularin related protein 2 203212_s_atHs.181326 myotubularin related protein 2 203222_s_at Hs.406491transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)203305_at Hs.80424 coagulation factor XIII, A1 polypeptide 203408_s_atHs.416026 special AT-rich sequence binding protein 1 (binds to nuclearmatrix/scaffold-associating DNA's) 203557_s_at Hs.31926-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocytenuclear factor 1 alpha (TCF1) 203708_at Hs.188 phosphodiesterase 4B,cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)203853_s_at Hs.30687 GRB2-associated binding protein 2 204305_atHs.68583 mitochondrial intermediate peptidase 204821_at Hs.167741butyrophilin, subfamily 3, member A3 204994_at Hs.926 myxovirus(influenza virus) resistance 2 (mouse) 205173_x_at Hs.75626 CD58antigen, (lymphocyte function- associated antigen 3) 205181_at Hs.100921zinc finger protein 193 205366_s_at Hs.98428 homeo box B6 205401_atHs.407933 alkylglycerone phosphate synthase 205668_at Hs.153563lymphocyte antigen 75 205691_at Hs.435277 synaptogyrin 3 205790_atHs.411942 src family associated phosphoprotein 1 205932_s_at Hs.424414msh homeo box homolog 1 (Drosophila) 206082_at Hs.511759 HLA complex P5206261_at Hs.25040 zinc finger protein 239 206437_at Hs.159543endothelial differentiation, G-protein-coupled receptor 6 206554_x_atHs.265855 SET domain and mariner transposase fusion gene 206591_atHs.73958 recombination activating gene 1 206660_at Hs.348935immunoglobulin lambda-like polypeptide 1 206698_at Hs.78919 Kell bloodgroup precursor (McLeod phenotype) 206866_at Hs.376792 cadherin 4, type1, R-cadherin (retinal) 208146_s_at Hs.95594 carboxypeptidase,vitellogenic-like 208964_s_at Hs.503546 fatty acid desaturase 1209129_at Hs.380230 thyroid hormone receptor interactor 6 209310_s_atHs.74122 caspase 4, apoptosis-related cysteine protease 209398_atHs.7644 histone 1, H1c 209590_at Hs.170195 bone morphogenetic protein 7(osteogenic protein 1) 209728_at Hs.308026 major histocompatibilitycomplex, class II, DR beta 3 209790_s_at Hs.3280 caspase 6,apoptosis-related cysteine protease 210427_x_at Hs.462864 annexin A2210715_s_at Hs.31439 serine protease inhibitor, Kunitz type, 2210830_s_at Hs.165598 paraoxonase 2 211367_s_at Hs.2490 caspase 1,apoptosis-related cysteine protease (interleukin 1, beta, convertase)211368_s_at Hs.2490 caspase 1, apoptosis-related cysteine protease(interleukin 1, beta, convertase) 211812_s_at Hs.418062UDP-Gal:betaGlcNAc beta 1,3- galactosyltransferase, polypeptide 3212268_at Hs.381167 serine (or cysteine) proteinase inhibitor clade B(ovalbumin), member 1 212442_s_at Hs.503941 hypothetical proteinLOC253782 212561_at Hs.26797 RAB6 interacting protein 1 213147_atHs.110637 homeo box A10 213150_at Hs.110637 homeo box A10 213371_atHs.49998 LIM domain binding 3 213419_at — — 213502_x_at Hs.272302 Homosapiens, clone IMAGE: 5728597, mRNA 213503_x_at Hs.462864 annexin A2213566_at Hs.23262 ribonuclease, RNase A family, k6 213568_at Hs.152823odd-skipped-related 2A protein 213572_s_at Hs.381167 serine (orcysteine) proteinase inhibitor, clade B (ovalbumin), member 1 213625_atHs.44720 hypothetical protein P1 p373c6 213788_s_at Hs.6580 Homo sapiensclone 23718 mRNA sequence 215071_s_at — — 215379_x_at Hs.449601immunoglobulin lambda joining 3 216565_x_at — — 217022_s_at Hs.366hypothetical protein MGC27165 217360_x_at — — 217759_at Hs.14512tripartite motif-containing 44 217760_at Hs.14512 tripartitemotif-containing 44 217977_at Hs.279623 selenoprotein X, 1 218005_atHs.108642 zinc finger protein 22 (KOX 15) 218006_s_at Hs.108642 zincfinger protein 22 (KOX 15) 218154_at Hs.118983 hypothetical proteinFLJ12150 218457_s_at Hs.241565 DNA (cytosine-5-)-methyltransferase 3alpha 218503_at Hs.257696 KIAA1797 218618_s_at Hs.299883 FAD104218676_s_at Hs.285218 phosphatidylcholine transfer protein 218689_atHs.65328 Fanconi anemia, complementation group F 218729_at Hs.124491latexin protein 219143_s_at Hs.8562 RNase P protein subunit p25219362_at Hs.325923 Homo sapiens transcribed sequence with strongsimilarity to protein ref: NP_078911.1 (H. sapiens) hypothetical proteinFLJ22643 [Homo sapiens] 219684_at Hs.43388 28 kD interferon responsiveprotein 219734_at Hs.272416 hypothetical protein FLJ20174 219953_s_atHs.131180 chromosome 11 open reading frame 17 220104_at Hs.35254 zincfinger CCCH type, antiviral 1 220230_s_at Hs.414362 cytochrome b5reductase b5R.2 220235_s_at Hs.25245 receptor-interacting factor 1220784_s_at Hs.162200 urotensin 2 221081_s_at Hs.447624 hypotheticalprotein FLJ22457 221349_at Hs.247979 pre-B lymphocyte gene 1 221641_s_atHs.298885 likely ortholog of mouse acyl-Coenzyme A thioesterase 2,mitochondrial 221666_s_at Hs.197875 apoptosis-associated speck-likeprotein containing a CARD 221690_s_at Hs.369279 NACHT, leucine richrepeat and PYD containing 2 36030_at Hs.46659 HOM-TES-103 tumorantigen-like 51158_at Hs.27373 Homo sapiens, clone IMAGE: 4816940, mRNA207714_s_at Hs.241579 serine (or cysteine) proteinase inhibitor, clade H(heat shock protein 47), member 1, (collagen binding protein 1)208816_x_at Hs.437110 Human lipocortin (LIP) 2 pseudogene mRNA, completecds-like region. 211566_x_at — — 212235_at Hs.301685 plexin D1

TABLE 4A NFκB-Regulated Genes (See tables reference 1) Log2 fluorescenceintensity D4 Probesets Ly1 (A1) Ly1 (A2) Ly1 (A3) Ly7 (B1) Ly7 (B2) Ly7(B3) Ly8 (C1) Ly8 (C2) Ly8 (C3) D4 (D1) D4 (D2) (D3) 205481_at 5.59 6.355.96 5.42 5.21 5.36 5.63 6.59 6.09 5.66 5.40 5.42 216220_s_at 5.39 5.615.43 5.33 5.38 5.22 5.31 5.82 5.51 5.34 5.33 5.21 202834_at 5.58 5.845.84 5.79 6.06 5.92 5.79 5.94 5.74 6.04 6.02 6.03 204151_x_at 6.84 6.887.03 6.63 6.91 6.98 6.88 6.99 6.92 6.90 7.04 6.74 216594_x_at 6.35 6.326.33 6.17 6.32 6.45 6.28 6.42 6.16 6.49 6.65 6.24 204445_s_at 7.06 6.706.75 6.37 6.41 6.19 7.05 6.65 6.46 6.54 6.72 6.55 204446_s_at 8.83 8.549.09 7.84 7.92 8.09 8.89 8.88 9.00 8.17 8.15 8.85 214366_s_at 6.87 6.476.50 6.14 5.92 6.06 7.27 6.33 6.41 6.17 6.31 6.39 214953_s_at 4.78 5.065.02 4.53 5.03 5.06 4.63 5.05 4.79 4.81 5.35 5.10 211621_at 4.47 4.644.79 4.51 4.65 4.62 4.52 4.55 4.53 4.58 4.61 4.57 203174_s_at 7.70 7.867.69 7.88 7.93 7.79 7.74 7.78 7.77 8.15 7.84 7.80 215984_s_at 6.01 6.486.24 6.53 6.66 6.51 6.32 6.29 6.45 6.43 6.20 6.25 201891_s_at 12.0012.00 12.13 12.01 12.13 11.98 11.99 12.32 12.04 12.14 11.85 11.88216231_s_at 12.17 12.10 12.09 12.06 12.15 12.20 12.12 12.16 12.13 12.0812.00 11.92 203685_at 4.75 4.61 4.79 4.33 4.46 4.42 4.62 4.65 4.68 4.484.58 4.41 207005_s_at 6.62 6.60 6.62 6.35 6.12 5.92 7.06 6.73 6.62 6.536.85 6.23 205681_at 4.31 4.32 4.29 4.59 4.61 4.49 4.45 4.48 4.30 6.848.14 7.47 202076_at 8.63 8.09 8.59 8.79 8.32 8.73 8.67 8.13 8.76 7.567.54 8.28 210538_s_at 4.64 4.75 4.80 6.89 6.65 6.57 4.49 4.35 4.62 4.955.43 5.21 205114_s_at 4.61 4.61 4.69 4.63 5.15 4.59 4.61 4.81 4.46 4.996.04 4.94 204103_at 6.95 6.97 6.93 6.16 6.49 6.36 6.80 7.08 6.54 6.617.13 6.62 201700_at 9.37 9.74 9.72 10.56 10.72 10.78 9.35 9.64 9.48 8.398.57 8.77 204118_at 9.63 8.78 9.07 9.76 10.02 9.44 9.69 8.64 8.84 9.9410.36 9.91 209795_at 4.56 4.42 4.80 4.00 4.14 4.03 4.36 4.48 4.27 4.074.06 4.06 209619_at 12.37 11.96 12.10 12.07 12.17 11.94 12.11 11.6311.56 12.67 12.83 12.63 207176_s_at 6.11 6.33 6.32 6.31 6.25 6.39 6.136.37 6.25 6.58 6.49 6.50 204440_at 7.44 7.55 7.48 7.19 7.41 7.33 7.537.60 7.15 8.55 9.42 8.62 202246_s_at 10.32 10.61 10.25 10.63 10.70 10.4510.37 10.53 10.35 10.50 10.55 10.32 203198_at 7.63 7.79 7.90 8.06 7.917.96 7.68 7.75 7.82 7.36 7.11 7.11 202284_s_at 8.10 7.23 7.18 6.96 8.456.88 8.74 7.87 7.04 6.85 6.54 6.42 208485_x_at 5.64 5.22 5.33 5.39 5.515.40 5.30 5.36 5.30 5.31 5.25 4.96 209508_x_at 6.13 6.12 6.08 6.12 6.315.96 6.16 6.13 6.03 5.98 5.95 5.74 209939_x_at 6.86 6.88 7.01 7.80 7.757.78 6.85 7.01 7.04 6.40 6.16 6.11 210563_x_at 6.61 6.84 6.71 7.62 7.367.39 6.74 6.73 6.85 6.59 6.34 6.51 211316_x_at 6.52 6.42 6.35 6.52 6.686.33 6.48 6.64 6.28 6.06 5.97 5.95 211317_s_at 4.50 4.60 4.70 4.66 4.654.71 4.51 4.60 4.59 4.42 4.51 4.47 211862_x_at 5.34 5.18 5.07 5.44 5.235.21 5.02 5.04 5.05 4.80 4.82 4.56 214618_at 4.41 4.69 4.77 4.70 4.554.85 4.68 4.69 4.73 4.81 4.98 4.74 209716_at 5.79 5.84 5.75 5.61 5.865.82 5.93 5.85 5.72 5.85 5.93 5.85 200838_at 5.36 5.36 5.27 5.18 5.005.04 5.41 5.50 5.37 5.35 5.15 5.18 200839_s_at 6.35 6.15 6.04 5.43 5.335.59 6.11 6.30 6.56 5.87 5.66 5.63 213274_s_at 4.90 4.91 5.00 4.66 5.025.02 4.86 5.12 4.95 4.84 5.01 4.83 204470_at 4.01 4.12 4.00 3.99 4.184.03 3.96 4.06 3.97 3.89 4.12 4.00 210163_at 3.84 3.75 3.75 3.79 3.863.78 3.73 3.78 3.81 3.76 3.81 3.82 214974_x_at 3.82 3.75 3.86 3.75 3.953.84 3.70 3.79 3.78 3.81 3.89 3.81 203700_s_at 5.40 5.39 5.32 5.45 5.265.44 5.30 5.50 5.37 5.55 5.57 5.35 201041_s_at 6.21 6.25 6.14 5.90 5.815.72 6.52 6.52 6.34 5.50 5.12 5.20 203692_s_at 7.19 6.93 6.66 7.29 7.066.97 7.05 6.91 7.07 7.15 7.02 7.17 203693_s_at 7.74 7.57 8.21 8.08 7.608.05 7.49 7.68 7.86 7.78 7.11 8.18 211551_at 5.94 5.90 5.89 5.71 6.155.96 5.76 5.82 5.80 5.98 6.04 5.78 201694_s_at 5.28 5.32 5.40 5.19 5.375.44 5.27 5.32 5.47 6.19 5.34 5.75 214766_s_at 5.28 5.51 5.55 6.06 5.575.87 5.38 5.38 5.59 4.76 4.60 5.05 201313_at 4.81 4.57 4.51 7.05 7.146.55 4.66 4.84 4.55 4.88 4.81 4.70 205767_at 3.77 3.79 3.77 3.77 3.753.74 3.85 3.79 3.78 3.78 3.77 3.76 202081_at 9.51 9.31 9.03 10.39 10.2310.27 9.52 9.16 9.15 10.35 10.75 10.50 205756_s_at 5.46 5.28 5.32 5.065.29 5.22 5.25 5.25 5.34 5.13 5.30 5.27 214701_s_at 5.44 5.40 5.21 5.485.39 5.28 5.63 5.48 5.31 5.52 5.64 5.43 202275_at 7.07 7.09 6.80 7.027.11 6.67 7.11 7.11 6.89 7.27 7.49 7.32 207574_s_at 7.55 6.78 6.81 6.376.11 6.33 7.73 6.90 7.36 7.45 7.12 7.56 209304_x_at 7.93 7.32 6.99 6.936.71 6.64 7.80 7.38 7.66 7.92 7.70 7.83 209305_s_at 7.57 6.94 6.82 6.596.37 6.71 7.51 6.69 7.25 7.40 7.40 7.39 202269_x_at 4.45 5.13 5.03 3.963.99 3.97 4.66 5.02 5.11 3.98 3.95 3.87 202270_at 4.47 4.42 4.92 3.793.76 3.92 4.53 4.62 5.11 3.91 3.81 3.92 200651_at 12.85 12.93 13.0212.61 12.79 12.73 13.12 13.03 13.01 12.85 12.91 12.85 222034_at 5.065.16 5.28 5.45 5.31 5.31 5.25 5.11 5.25 5.38 5.07 5.46 200824_at 10.6810.43 10.32 11.31 11.31 11.17 10.62 10.37 10.54 10.94 11.08 10.94208729_x_at 12.62 12.49 12.18 9.61 9.63 9.55 12.28 12.26 12.09 8.01 8.438.04 209140_x_at 13.05 12.93 13.01 10.68 10.95 10.64 13.05 12.96 12.898.24 8.59 8.46 211911_x_at 12.27 12.11 12.01 9.49 9.50 9.28 12.20 11.9711.83 7.81 7.96 7.69 200943_at 11.40 11.49 11.48 11.74 11.63 11.66 11.2611.62 11.44 11.65 11.60 11.63 200944_s_at 11.32 11.47 11.55 11.63 11.6111.69 11.40 11.68 11.50 11.72 11.63 11.69 202638_s_at 8.64 7.77 7.467.18 7.29 6.90 7.99 7.52 7.28 7.32 7.87 7.25 215485_s_at 6.87 6.62 6.396.69 6.41 6.63 6.82 6.57 6.43 6.77 6.99 6.49 210354_at 4.51 4.61 4.524.46 4.57 4.57 4.43 4.67 4.43 4.67 4.73 4.57 202718_at 9.02 6.64 7.875.46 5.55 5.74 8.21 6.43 7.16 5.80 5.58 5.57 207901_at 4.00 4.00 3.993.97 4.10 3.96 3.90 3.97 3.92 4.01 3.94 3.99 208200_at 4.85 4.98 4.974.80 4.84 4.94 4.86 4.98 4.91 5.02 4.93 4.96 205207_at 4.73 4.82 4.864.76 4.90 4.82 4.92 4.79 4.74 4.91 4.84 4.75 202531_at 7.23 7.83 7.696.08 6.64 6.37 7.36 7.91 7.11 5.89 6.37 6.03 203275_at 6.41 6.61 6.816.03 6.11 6.08 6.61 6.52 6.60 4.37 5.36 4.62 204562_at 8.22 8.60 8.598.69 9.38 8.42 8.35 8.44 7.86 6.36 6.28 6.01 216986_s_at 6.51 6.37 6.356.45 6.80 6.42 6.55 6.43 6.23 6.43 6.42 6.01 208436_s_at 6.62 5.66 5.625.28 5.20 5.19 6.65 5.82 6.12 5.31 4.93 5.00 213281_at 4.36 4.50 4.484.33 4.39 4.32 4.41 4.47 4.41 4.40 4.43 4.37 201473_at 7.65 7.49 7.497.56 7.32 7.43 7.46 7.25 7.43 8.06 8.38 8.13 207029_at 4.03 4.08 4.033.88 4.14 4.00 4.05 4.06 3.93 4.00 4.06 4.02 216264_s_at 4.59 4.66 4.424.60 4.61 4.69 4.59 4.44 4.47 4.80 4.68 4.48 207339_s_at 6.04 5.63 5.886.78 6.47 6.58 5.99 5.80 5.68 6.82 7.57 6.95 213975_s_at 4.87 5.48 5.694.30 4.17 4.18 5.57 6.22 6.92 4.27 4.39 4.33 208037_s_at 6.64 6.46 6.496.40 6.49 6.61 6.54 6.47 6.43 6.72 6.66 6.55 206296_x_at 8.63 8.05 8.159.80 9.53 9.24 8.32 7.87 7.85 9.99 10.33 10.05 214219_x_at 8.30 7.857.89 9.41 9.21 8.89 8.23 7.62 7.57 9.52 10.01 9.75 214339_s_at 7.79 7.447.78 9.09 8.83 8.74 7.92 7.33 7.21 9.17 9.58 9.55 201126_s_at 7.87 7.817.67 7.65 7.70 7.28 7.65 7.90 7.56 7.26 7.14 7.03 203936_s_at 5.85 6.146.00 6.13 5.94 6.04 6.08 6.12 6.07 6.23 6.22 6.12 202086_at 5.28 5.175.31 5.47 5.32 5.27 5.42 5.37 5.29 5.49 5.29 5.26 204798_at 7.85 9.539.60 7.15 7.27 7.39 7.90 9.44 8.38 6.59 7.23 7.08 215152_at 3.85 4.083.91 3.91 3.91 3.86 3.98 3.94 3.90 3.90 3.90 3.86 202431_s_at 10.4710.56 10.92 9.94 10.06 9.69 10.34 10.50 9.93 9.96 10.46 9.66 209239_at8.35 8.59 8.52 7.22 7.63 7.16 8.37 8.51 8.19 8.15 8.49 8.00 207535_s_at5.46 5.26 5.22 6.18 6.01 5.92 5.38 5.08 5.09 5.51 5.90 5.73 201502_s_at9.28 8.98 8.75 9.09 9.14 8.67 9.01 8.78 8.68 9.09 9.69 9.61 201468_s_at6.10 6.24 6.14 6.15 5.99 6.05 6.00 6.26 6.21 6.83 6.57 6.61 210519_s_at6.22 6.59 6.26 5.79 6.08 6.04 6.32 6.44 6.44 7.55 7.37 7.57 201866_s_at5.88 5.84 6.06 6.95 7.02 6.82 5.72 5.83 5.92 6.19 6.47 6.30 211671_s_at6.23 6.16 6.46 8.03 7.78 7.72 5.79 5.73 6.03 6.48 7.23 7.14 216321_s_at5.82 5.76 6.16 7.65 7.57 7.58 5.29 5.44 5.78 6.98 7.38 7.57 204622_x_at4.46 4.53 4.61 4.36 4.43 4.49 4.41 4.52 4.57 4.49 4.50 4.41 216248_s_at4.30 4.22 4.23 4.10 4.05 4.08 4.24 4.18 4.46 4.13 4.12 4.05 210004_at3.87 3.93 3.88 3.78 3.95 3.94 3.82 3.94 3.82 3.83 3.93 3.76 121_at 8.578.75 8.62 8.48 8.89 8.82 8.53 8.56 8.50 8.77 8.93 8.62 203557_s_at 7.387.33 7.19 5.60 5.83 5.66 7.56 7.50 7.37 6.52 6.71 6.57 201202_at 10.9610.86 10.78 11.44 11.45 11.49 10.87 10.89 10.98 11.17 10.60 11.06213791_at 4.72 4.99 5.02 4.62 4.99 4.95 4.73 4.75 4.76 4.78 4.90 4.84200737_at 10.76 10.08 10.46 9.46 9.45 9.54 10.75 10.13 10.39 9.36 9.739.60 200738_s_at 11.89 11.48 11.89 11.19 11.21 11.05 12.00 11.68 11.7311.33 11.18 11.25 217356_s_at 11.83 11.28 11.78 11.05 10.93 10.95 12.0011.41 11.61 11.07 11.00 10.95 217383_at 6.41 5.80 6.53 5.53 5.55 5.935.83 5.82 6.32 5.80 5.66 6.07 209193_at 5.75 5.66 5.64 5.51 5.69 5.755.83 5.87 5.50 5.61 5.71 5.54 210145_at 3.86 3.92 4.04 3.79 3.88 3.743.75 3.69 3.74 3.77 3.75 3.80 201979_s_at 7.80 7.88 7.65 7.74 7.81 7.807.68 7.62 7.77 7.39 7.65 7.53 214617_at 5.12 5.12 5.17 5.23 5.27 5.325.13 5.16 5.16 5.29 5.20 5.15 202545_at 6.69 6.49 6.36 7.95 7.92 7.617.05 6.64 6.57 7.05 7.33 7.17 204279_at 10.03 10.03 10.06 8.83 9.06 8.9610.09 9.94 10.06 5.49 5.88 5.75 211661_x_at 6.44 6.59 6.42 7.18 7.617.33 6.35 6.57 6.31 6.98 7.31 6.74 211892_s_at 4.87 4.75 4.78 4.69 4.774.82 4.84 4.82 4.83 5.04 4.84 4.82 206035_at 5.01 5.39 5.49 5.27 5.565.75 5.13 5.13 5.30 5.63 5.68 5.88 206036_s_at 5.83 5.45 5.71 6.54 6.476.01 5.88 5.48 5.39 6.28 7.65 6.67 205205_at 7.31 7.02 6.65 7.70 7.997.46 7.25 6.85 6.45 7.51 7.92 7.51 209544_at 4.32 4.30 4.29 4.30 4.154.33 4.31 4.25 4.23 4.29 4.38 4.41 209545_s_at 8.73 8.32 8.08 7.95 7.827.89 8.39 8.18 8.47 8.14 8.21 8.11 200872_at 8.54 7.54 8.17 6.39 5.936.11 7.98 7.03 7.20 6.46 6.21 6.15 203186_s_at 6.45 5.90 6.24 5.14 4.784.89 6.78 6.50 6.93 7.20 7.54 7.49 215223_s_at 7.53 7.57 7.64 7.26 7.097.61 7.81 7.41 7.80 6.54 6.54 6.98 216841_s_at 4.99 5.12 5.61 5.35 5.185.93 5.13 5.04 5.38 4.58 4.22 4.67 221477_s_at 7.26 7.05 7.29 7.09 6.857.05 7.35 7.04 7.31 6.36 6.20 6.49 201471_s_at 9.09 8.46 8.37 9.21 9.048.89 9.25 8.54 8.75 8.95 9.47 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205125_at8.59 8.57 8.41 8.54 8.45 8.40 8.59 8.54 8.56 8.67 8.56 8.40 205720_at5.19 5.32 5.11 5.28 5.42 5.14 5.49 5.40 5.21 5.39 5.44 5.24 215705_at6.03 6.32 6.21 6.13 6.33 6.22 6.03 6.36 6.06 6.43 6.28 6.19 206278_at4.81 4.73 4.29 4.72 5.37 4.52 4.62 4.56 4.17 4.65 4.99 4.48 211663_x_at5.54 5.56 5.53 5.54 5.73 5.70 5.56 5.89 5.55 5.91 5.78 5.65 211748_x_at6.87 6.90 6.74 7.00 7.08 6.91 6.87 7.10 6.73 7.11 7.05 6.83 212187_x_at6.73 6.84 6.58 6.93 6.87 6.83 6.82 6.92 6.74 7.29 6.94 6.79 207388_s_at6.54 6.71 6.28 6.78 6.58 6.52 6.49 6.64 6.50 6.96 6.83 6.64 210367_s_at5.71 6.07 6.06 5.92 6.16 6.09 5.82 6.15 5.92 6.06 5.96 5.91 208131_s_at4.77 4.78 4.63 4.76 4.74 4.90 4.74 4.71 4.66 5.06 4.86 4.74 210702_s_at5.51 5.51 5.28 5.35 5.42 5.39 5.41 5.43 5.34 5.51 5.47 5.38 204748_at4.08 4.17 4.11 4.11 4.06 4.15 4.19 4.12 4.16 4.39 4.21 4.25 204201_s_at3.87 3.85 3.86 3.84 3.91 3.83 3.83 3.86 3.83 3.84 3.88 3.85 206157_at3.60 3.72 3.77 3.73 3.72 3.71 3.63 3.75 3.72 3.69 3.85 3.67 216994_s_at4.48 4.47 4.32 4.40 4.42 4.38 4.35 4.47 4.39 4.55 4.66 4.42 221282_x_at5.65 5.74 5.76 5.52 5.81 5.66 5.47 6.01 5.49 5.69 5.72 5.72 221283_at5.67 5.58 5.19 5.61 5.45 5.38 5.40 5.38 5.32 5.79 5.61 5.57 217728_at4.72 4.63 4.63 4.79 4.51 4.70 4.68 4.58 4.66 5.02 4.79 4.76 208607_s_at4.82 4.91 4.51 4.86 4.64 4.49 4.85 4.86 4.56 4.68 4.55 4.50 214456_x_at5.88 5.99 5.56 5.66 5.93 5.66 5.65 5.83 5.69 5.82 5.83 5.54 202071_at5.07 5.18 5.31 4.92 5.15 5.25 5.18 5.37 5.15 5.27 5.36 5.19 206211_at3.82 3.91 3.90 3.92 3.94 3.91 3.87 3.93 3.87 3.93 3.95 3.92 206049_at6.64 6.62 6.57 6.45 6.70 6.87 6.42 6.86 6.40 6.54 6.72 6.57 202627_s_at5.08 5.08 4.92 4.93 5.06 5.06 5.04 5.03 4.76 5.05 4.79 4.91 202628_s_at4.66 4.68 4.46 4.68 4.68 4.69 4.55 4.84 4.52 4.69 4.65 4.61 210073_at3.86 3.83 3.75 3.91 3.88 3.92 3.81 3.88 3.85 3.84 3.79 3.80 215078_at3.99 4.00 4.03 4.04 3.96 4.01 3.98 3.94 4.04 4.04 3.93 3.99 202935_s_at4.10 4.16 4.12 4.14 4.15 4.14 4.04 4.15 4.19 4.19 4.28 4.20 202936_s_at4.54 4.61 4.58 4.42 4.56 4.53 4.50 4.52 4.53 4.58 4.51 4.47 213112_s_at6.08 6.09 5.81 5.99 6.00 5.98 5.87 6.13 5.80 6.02 6.14 6.17 203010_at7.15 7.44 7.25 6.53 6.70 6.58 7.25 7.18 7.12 6.68 6.71 6.62 208049_s_at4.69 4.55 4.68 4.84 4.83 4.77 4.80 4.73 4.76 4.75 4.81 4.76 210637_at5.27 5.61 5.24 5.65 5.32 5.51 5.48 5.34 5.45 5.58 5.59 5.55 210294_at4.60 4.68 4.72 4.52 4.50 4.58 4.65 4.83 4.63 4.69 4.67 4.56 209277_at3.75 3.57 3.55 3.61 3.71 3.64 3.66 3.65 3.56 3.60 3.81 3.62 209278_s_at4.45 4.52 4.45 4.37 4.49 4.55 4.41 4.41 4.42 4.42 4.52 4.37 211003_x_at5.33 5.35 5.13 5.36 5.34 5.44 5.34 5.25 5.42 5.46 5.42 5.44 211573_x_at5.59 5.49 5.24 5.55 5.37 5.70 5.57 5.57 5.63 5.90 5.78 5.61 216183_at6.00 6.12 5.99 5.89 6.07 5.95 5.99 6.05 5.76 6.08 6.14 5.90 201107_s_at5.12 5.07 4.95 5.13 4.90 5.11 5.07 5.15 5.04 5.40 5.25 5.30 201108_s_at5.46 5.59 5.52 5.44 5.70 5.65 5.68 5.75 5.62 5.74 5.62 5.73 201109_s_at4.14 4.34 4.16 4.02 4.39 4.11 4.21 4.25 4.06 4.09 4.24 4.10 201110_s_at3.73 3.78 3.73 3.76 3.80 3.82 3.73 3.72 3.77 3.77 3.81 3.75 203083_at5.33 5.47 5.32 5.19 5.23 5.23 5.23 5.52 5.28 5.26 5.44 5.19 201645_at3.99 4.19 3.98 3.94 4.06 4.05 3.96 4.08 3.99 3.95 4.14 4.08 207113_s_at5.42 5.40 5.17 5.28 5.49 5.28 5.34 5.43 5.25 6.06 6.22 5.75 202509_s_at5.42 5.58 5.37 5.52 5.57 5.54 5.57 5.44 5.49 5.74 5.79 5.55 202510_s_at6.40 6.66 6.51 6.58 6.58 6.60 6.55 6.55 6.44 6.59 6.72 6.41 203508_at4.42 4.41 4.30 4.34 4.34 4.36 4.45 4.58 4.40 4.48 4.29 4.35 205153_s_at5.94 5.42 5.24 6.04 6.24 6.03 5.75 5.47 5.33 6.25 6.50 6.10 222292_at4.59 4.65 4.73 4.57 4.65 4.52 4.51 4.47 4.60 4.66 4.67 4.85 211786_at4.61 4.53 4.49 4.64 4.53 4.64 4.52 4.65 4.62 4.71 4.76 4.67 207892_at5.42 5.61 5.56 5.39 5.63 5.56 5.52 5.57 5.49 5.79 5.62 5.57 210865_at5.13 5.25 4.92 5.08 5.06 4.81 5.02 4.99 4.64 5.23 5.19 4.97 211333_s_at4.60 4.61 4.38 4.69 4.65 4.65 4.48 4.51 4.53 4.61 4.71 4.46 204413_at5.65 5.94 5.50 5.78 5.93 5.58 5.49 5.84 5.49 5.46 5.73 5.28 206067_s_at4.36 4.31 4.27 4.31 4.23 4.33 4.32 4.25 4.32 4.34 4.41 4.31 216953_s_at5.67 5.64 5.65 5.78 5.66 5.96 5.86 5.89 5.85 5.89 5.96 5.97

TABLE 4B NFκB-Regulated Genes (See tables reference 1) t-test(two-tailed) Gene Probesets pAB pAD pBC pCD Measured Changed Symbol FDRCutoff 1.0E−02 8.2E−03 1.2E−02 9.4E−03 AG v. BD AC v. BD 205481_at9.0E−02 1.5E−01 1.0E−01 1.5E−01 Yes No ADORA1 216220_s_at 1.2E−019.4E−02 2.4E−01 2.2E−01 Yes No ADORA1 202834_at 2.1E−01 8.4E−02 3.6E−017.2E−02 Yes No AGT 204151_x_at 5.8E−01 8.6E−01 5.1E−01 7.5E−01 Yes NoAKR1C1 216594_x_at 8.4E−01 4.0E−01 8.3E−01 3.0E−01 Yes No AKR1C1204445_s_at 2.5E−02 1.7E−01 1.4E−01 5.8E−01 Yes No ALOX5 204446_s_at1.9E−02 2.1E−01 1.1E−03 1.4E−01 Yes No ALOX5 214366_s_at 2.9E−02 1.1E−011.7E−01 3.3E−01 Yes No ALOX5 214953_s_at 7.0E−01 5.2E−01 8.2E−01 2.6E−01Yes No APP 211621_at 7.1E−01 6.4E−01 2.7E−01 2.3E−02 Yes No AR203174_s_at 1.6E−01 2.5E−01 1.1E−01 2.7E−01 Yes No ARFRP1 215984_s_at1.2E−01 7.5E−01 3.7E−02 5.3E−01 Yes No ARFRP1 201891_s_at 9.5E−014.6E−01 5.4E−01 3.1E−01 Yes No B2M 216231_s_at 7.4E−01 9.9E−02 9.7E−018.1E−02 Yes No B2M 203685_at 1.2E−02 3.8E−02 1.3E−02 7.5E−02 Yes No BCL2207005_s_at 6.0E−02 7.0E−01 2.1E−02 3.0E−01 Yes No BCL2 205681_at1.7E−02 1.4E−02 8.8E−02 1.3E−02 Yes No BCL2A1 202076_at 4.8E−01 1.1E−017.3E−01 8.4E−02 Yes No BIRC2 210538_s_at 4.3E−04 6.6E−02 7.0E−05 1.9E−02Yes No BIRC3 205114_s_at 4.9E−01 2.0E−01 4.9E−01 1.9E−01 Yes No CCL3204103_at 2.2E−02 4.3E−01 7.5E−02 9.2E−01 Yes No CCL4 201700_at 3.5E−033.1E−03 4.3E−04 3.2E−03 Yes No CCND3 204118_at 1.4E−01 4.8E−02 1.6E−017.0E−02 Yes No CD48 209795_at 2.8E−02 4.2E−02 1.9E−02 4.0E−02 Yes NoCD69 209619_at 5.7E−01 2.4E−02 2.3E−01 2.2E−02 Yes No CD74 207176_s_at5.0E−01 4.9E−02 4.5E−01 3.8E−02 Yes No CD80 204440_at 8.3E−02 3.7E−025.2E−01 2.0E−02 Yes No CD83 202246_s_at 2.2E−01 6.6E−01 1.4E−01 6.7E−01Yes No CDK4 203198_at 1.0E−01 7.3E−03 1.9E−02 1.0E−02 Yes No CDK9202284_s_at 9.1E−01 7.7E−02 5.6E−01 1.1E−01 Yes No CDKN1A 208485_x_at8.3E−01 2.4E−01 9.3E−02 3.0E−01 Yes No CFLAR 209508_x_at 8.8E−01 9.9E−028.5E−01 9.1E−02 Yes No CFLAR 209939_x_at 1.6E−03 5.6E−03 3.6E−03 3.5E−03Yes No CFLAR 210563_x_at 2.5E−03 7.5E−02 5.7E−03 3.8E−02 Yes No CFLAR211316_x_at 5.4E−01 3.3E−03 7.8E−01 3.4E−02 Yes No CFLAR 211317_s_at3.5E−01 1.3E−01 4.3E−02 5.5E−02 Yes No CFLAR 211862_x_at 4.3E−01 1.5E−027.0E−02 6.5E−02 Yes No CFLAR 214618_at 6.0E−01 1.8E−01 9.9E−01 1.8E−01Yes No CFLAR 209716_at 7.4E−01 8.3E−02 5.1E−01 5.7E−01 Yes No CSF1200838_at 2.4E−02 2.3E−01 8.1E−03 6.1E−02 Yes No CTSB 200839_s_at3.7E−03 1.7E−02 8.6E−03 2.5E−02 Yes No CTSB 213274_s_at 7.8E−01 5.5E−016.2E−01 4.3E−01 Yes No CTSB 204470_at 7.6E−01 5.9E−01 3.6E−01 9.7E−01Yes No CXCL1 210163_at 4.9E−01 7.2E−01 3.1E−01 4.9E−01 Yes No CXCL11214974_x_at 5.9E−01 5.7E−01 2.4E−01 1.2E−01 Yes No CXCL5 203700_s_at8.7E−01 2.2E−01 9.4E−01 3.2E−01 Yes No DIO2 201041_s_at 4.7E−03 1.0E−021.3E−03 2.7E−03 Yes No DUSP1 203692_s_at 3.9E−01 3.5E−01 4.3E−01 2.1E−01Yes No E2F3 203693_s_at 7.7E−01 7.1E−01 2.9E−01 9.8E−01 Yes No E2F3211551_at 8.5E−01 8.2E−01 3.7E−01 2.1E−01 Yes No EGFR 201694_s_at9.8E−01 2.3E−01 8.7E−01 2.4E−01 Yes No EGR1 214766_s_at 9.4E−02 1.9E−029.6E−02 2.1E−02 Yes No ELYS 201313_at 1.7E−03 2.1E−01 2.2E−03 3.4E−01Yes No ENO2 205767_at 8.1E−02 3.8E−01 1.5E−01 2.7E−01 Yes No EREG202081_at 1.1E−02 2.6E−03 7.1E−03 1.8E−03 Yes No ETR101 205756_s_at1.3E−01 1.8E−01 3.1E−01 5.0E−01 Yes No F8 214701_s_at 7.2E−01 1.3E−014.7E−01 6.4E−01 Yes No FN1 202275_at 7.7E−01 3.5E−02 5.3E−01 3.1E−02 YesNo G6PD 207574_s_at 8.1E−02 3.3E−01 3.6E−02 8.8E−01 Yes No GADD45B209304_x_at 1.3E−01 2.8E−01 6.8E−03 2.4E−01 Yes No GADD45B 209305_s_at1.2E−01 3.4E−01 1.2E−01 4.1E−01 Yes No GADD45B 202269_x_at 5.2E−024.5E−02 2.0E−02 1.5E−02 Yes No GBP1 202270_at 2.9E−02 3.8E−02 2.9E−023.6E−02 Yes No GBP1 200651_at 3.7E−02 3.3E−01 8.8E−03 1.5E−02 Yes NoGNB2L1 222034_at 8.6E−02 4.0E−01 8.0E−02 5.0E−01 Yes No GNB2L1 200824_at9.0E−03 2.6E−02 2.2E−03 8.8E−03 Yes No GSTP1 208729_x_at 1.7E−03 2.2E−051.2E−04 1.8E−04 Yes Yes HLA-B 209140_x_at 6.0E−04 1.4E−04 3.6E−046.9E−05 Yes Yes HLA-B 211911_x_at 1.3E−05 2.4E−06 9.6E−05 1.3E−05 YesYes HLA-B 200943_at 7.3E−03 1.2E−02 1.5E−01 2.2E−01 Yes No HMGN1200944_s_at 8.2E−02 5.5E−02 2.8E−01 1.9E−01 Yes No HMGN1 202638_s_at1.3E−01 3.2E−01 1.4E−01 7.1E−01 Yes No ICAM1 215485_s_at 7.9E−01 5.7E−018.4E−01 4.9E−01 Yes No ICAM1 210354_at 7.4E−01 1.4E−01 8.1E−01 2.0E−01Yes No IFNG 202718_at 7.9E−02 8.4E−02 7.9E−02 8.5E−02 Yes No IGFBP2207901_at 7.8E−01 5.2E−01 2.3E−01 2.1E−01 Yes No IL12B 208200_at 2.9E−014.9E−01 3.4E−01 3.0E−01 Yes No IL1A 205207_at 7.1E−01 6.5E−01 8.8E−018.0E−01 Yes No IL6 202531_at 7.7E−03 3.6E−03 2.3E−02 1.2E−02 Yes No IRF1203275_at 3.7E−02 1.6E−02 2.7E−04 2.6E−02 Yes No IRF2 204562_at 3.4E−012.1E−04 1.6E−01 1.7E−03 Yes No IRF4 216986_s_at 3.5E−01 4.9E−01 3.8E−015.5E−01 Yes No IRF4 208436_s_at 1.5E−01 1.0E−01 5.4E−02 2.7E−02 Yes NoIRF7 213281_at 1.3E−01 4.0E−01 4.0E−02 2.7E−01 Yes No JUN 201473_at3.2E−01 8.9E−03 5.6E−01 3.7E−03 Yes No JUNB 207029_at 6.7E−01 4.8E−019.6E−01 7.9E−01 Yes No KITLG 216264_s_at 4.1E−01 4.6E−01 9.0E−02 2.4E−01Yes No LAMB2 207339_s_at 8.9E−03 1.7E−02 3.5E−03 2.0E−02 Yes No LTB213975_s_at 4.1E−02 5.2E−02 3.4E−02 3.8E−02 Yes No LYZ 208037_s_at7.3E−01 2.1E−01 8.1E−01 6.9E−02 Yes No MADCAM1 206296_x_at 6.8E−032.2E−03 2.5E−03 6.8E−04 Yes Yes MAP4K1 214219_x_at 5.2E−03 1.0E−038.4E−03 2.7E−03 Yes Yes MAP4K1 214339_s_at 1.5E−03 6.0E−04 1.2E−023.4E−03 Yes Yes MAP4K1 201126_s_at 2.0E−01 1.9E−03 3.9E−01 1.4E−02 YesNo MGAT1 203936_s_at 6.7E−01 1.3E−01 4.5E−01 8.5E−02 Yes No MMP9202086_at 2.5E−01 3.4E−01 9.3E−01 8.7E−01 Yes No MX1 204798_at 9.2E−025.9E−02 1.0E−01 5.5E−02 Yes No MYB 215152_at 5.3E−01 4.8E−01 1.9E−011.4E−01 Yes No MYB 202431_s_at 1.4E−02 1.0E−01 1.6E−01 4.7E−01 Yes NoMYC 209239_at 6.6E−03 1.9E−01 6.8E−03 4.6E−01 Yes No NFKB1 207535_s_at2.4E−03 4.8E−02 3.2E−03 2.4E−02 Yes No NFKB2 201502_s_at 8.8E−01 1.3E−014.7E−01 5.5E−02 Yes No NFKBIA 201468_s_at 2.1E−01 1.1E−02 3.7E−011.0E−02 Yes No NQO1 210519_s_at 6.2E−02 3.2E−03 2.7E−02 2.7E−04 Yes NoNQO1 201866_s_at 4.5E−04 2.3E−02 1.6E−04 1.0E−02 Yes No NR3C1211671_s_at 2.8E−04 9.0E−02 1.1E−04 3.0E−02 Yes No NR3C1 216321_s_at4.2E−03 3.9E−03 3.8E−03 1.5E−03 Yes Yes NR3C1 204622_x_at 1.6E−012.8E−01 3.3E−01 5.8E−01 Yes No NR4A2 216248_s_at 8.8E−03 1.3E−02 1.2E−011.4E−01 Yes No NR4A2 210004_at 9.3E−01 4.0E−01 6.9E−01 7.7E−01 Yes NoOLR1 121_at 5.9E−01 2.9E−01 2.6E−01 1.1E−01 Yes No PAX8 203557_s_at6.9E−05 1.1E−03 4.7E−05 4.2E−04 Yes Yes PCBD 201202_at 4.6E−03 7.1E−019.5E−04 8.9E−01 Yes No PCNA 213791_at 7.4E−01 5.4E−01 4.5E−01 9.5E−02Yes No PENK 200737_at 3.8E−02 2.8E−02 3.3E−02 2.3E−02 Yes No PGK1200738_s_at 3.6E−02 5.7E−02 9.5E−03 1.7E−02 Yes No PGK1 217356_s_at5.8E−02 6.6E−02 4.9E−02 5.6E−02 Yes No PGK1 217383_at 1.1E−01 2.1E−012.1E−01 5.1E−01 Yes No PGK1 209193_at 7.0E−01 3.5E−01 5.7E−01 4.4E−01Yes No PIM1 210145_at 1.2E−01 8.8E−02 2.0E−01 9.3E−02 Yes No PLA2G4A201979_s_at 9.6E−01 6.8E−02 1.3E−01 1.6E−01 Yes No PPP5C 214617_at1.9E−02 1.9E−01 3.7E−02 2.7E−01 Yes No PRF1 202545_at 9.1E−04 6.3E−035.7E−03 8.3E−02 Yes No PRKCD 204279_at 3.2E−03 6.5E−04 3.8E−04 1.5E−04Yes Yes PSMB9 211661_x_at 1.2E−02 7.6E−02 5.5E−03 4.9E−02 Yes No PTAFR211892_s_at 4.9E−01 2.8E−01 1.9E−01 4.1E−01 Yes No PTGIS 206035_at3.2E−01 7.7E−02 1.2E−01 6.2E−03 Yes No REL 206036_s_at 3.4E−02 8.9E−022.8E−02 7.4E−02 Yes No REL 205205_at 4.6E−02 5.6E−02 4.3E−02 5.3E−02 YesNo RELB 209544_at 5.3E−01 2.6E−01 9.8E−01 9.8E−02 Yes No RIPK2209545_s_at 1.2E−01 3.6E−01 2.0E−02 1.4E−01 Yes No RIPK2 200872_at1.1E−02 1.8E−02 3.3E−02 4.9E−02 Yes No S100A10 203186_s_at 4.6E−035.1E−03 4.5E−04 1.6E−02 Yes No S100A4 215223_s_at 2.2E−01 2.2E−021.6E−01 8.0E−03 Yes No SOD2 216841_s_at 4.5E−01 3.6E−02 3.2E−01 1.8E−02Yes No SOD2 221477_s_at 1.3E−01 1.9E−03 1.3E−01 2.6E−03 Yes No SOD2201471_s_at 2.1E−01 9.6E−02 4.6E−01 1.9E−01 Yes No SQSTM1 208048_at9.2E−01 2.0E−01 9.5E−01 2.8E−01 Yes No TACR1 202307_s_at 1.4E−02 6.4E−041.2E−02 5.9E−04 Yes No TAP1 208829_at 2.9E−01 1.8E−01 7.3E−01 5.2E−01Yes No TAPBP 207199_at 1.8E−02 3.9E−02 2.4E−03 1.4E−01 Yes No TERT215775_at 4.0E−01 6.1E−01 2.9E−01 8.4E−02 Yes No THBS1 216005_at 2.6E−015.2E−02 2.7E−01 6.4E−02 Yes No TNC 202643_s_at 1.7E−05 3.5E−02 6.8E−033.9E−02 Yes No TNFAIP3 202644_s_at 7.0E−04 5.2E−02 5.8E−04 1.4E−02 YesNo TNFAIP3 215346_at 1.6E−01 6.1E−02 1.5E−01 7.0E−02 Yes No TNFRSF535150_at 2.5E−01 1.3E−01 8.9E−02 6.3E−02 Yes No TNFRSF5 207536_s_at9.7E−01 9.3E−01 6.4E−01 5.0E−01 Yes No TNFRSF9 202687_s_at 2.2E−023.8E−02 1.4E−03 6.6E−04 Yes No TNFSF10 202688_at 1.7E−04 3.6E−04 2.5E−021.8E−02 Yes No TNFSF10 214329_x_at 6.8E−02 1.1E−01 3.2E−02 7.6E−02 YesNo TNFSF10 201746_at 2.2E−04 1.6E−03 2.5E−04 1.8E−03 Yes Yes TP53211300_s_at 1.6E−02 2.3E−02 8.0E−03 1.2E−02 Yes No TP53 205599_at1.5E−01 1.6E−01 8.5E−02 7.2E−02 Yes No TRAF1 213191_at 8.6E−02 8.7E−023.6E−02 2.7E−02 Yes No TRIF 203109_at 9.2E−02 1.3E−01 4.9E−02 1.1E−01Yes No UBE2M 208997_s_at 1.7E−02 3.2E−01 4.6E−02 7.4E−01 Yes No UCP2208998_at 2.1E−02 7.5E−03 1.3E−02 4.1E−01 Yes No UCP2 204881_s_at6.4E−02 5.4E−02 8.9E−02 8.3E−02 Yes No UGCG 221765_at 9.0E−01 2.1E−015.2E−01 1.3E−01 Yes No UGCG 203868_s_at 2.7E−01 9.7E−01 4.5E−01 9.9E−01Yes No VCAM1 209946_at 3.5E−02 7.8E−02 7.0E−01 9.1E−01 Yes No VEGFC201426_s_at 3.3E−05 1.0E−03 2.2E−04 5.5E−04 Yes Yes VIM 210301_at6.4E−01 9.7E−02 5.3E−01 7.0E−02 Yes No XDH 208544_at 3.4E−01 2.2E−011.7E−01 1.1E−01 No No ADRA2B 210081_at 6.1E−02 3.0E−02 5.1E−01 1.3E−01No No AGER 217046_s_at 5.6E−01 5.6E−01 1.7E−01 2.2E−01 No No AGER207206_s_at 7.0E−01 3.3E−01 7.9E−01 2.6E−01 No No ALOX12 213952_s_at8.6E−01 1.8E−01 7.9E−01 1.9E−01 No No ALOX5 206516_at 6.1E−01 1.4E−018.8E−01 1.9E−01 No No AMH 205820_s_at 5.3E−01 2.8E−02 5.0E−01 2.1E−01 NoNo APOC3 200602_at 4.8E−01 2.1E−02 4.5E−01 2.2E−02 No No APP 211277_x_at1.1E−01 8.3E−01 3.1E−01 2.7E−01 No No APP 211110_s_at 3.2E−01 2.9E−013.8E−01 3.6E−01 No No AR 207367_at 8.2E−01 4.4E−01 9.5E−01 5.1E−01 No NoATP12A 217904_s_at 3.3E−01 6.1E−01 5.1E−01 9.4E−01 No No BACE203684_s_at 1.2E−01 8.2E−01 4.8E−02 6.0E−01 No No BCL2 207004_at 1.9E−012.6E−01 3.3E−01 5.3E−01 No No BCL2 207510_at 9.6E−01 4.3E−01 5.3E−019.2E−02 No No BDKRB1 202357_s_at 8.6E−02 4.7E−02 5.8E−01 5.9E−01 No NoBF 211920_at 9.6E−01 9.2E−01 7.0E−01 6.7E−01 No No BF 201261_x_at6.7E−01 9.1E−01 6.5E−01 1.0E+00 No No BGN 201262_s_at 7.9E−01 5.1E−015.5E−01 3.8E−01 No No BGN 205289_at 8.1E−01 8.0E−01 6.0E−01 9.5E−01 NoNo BMP2 205290_s_at 1.9E−01 1.0E−01 8.3E−01 1.7E−01 No No BMP2 204439_at9.1E−02 3.7E−02 6.7E−02 1.0E−01 No No C1orf29 217767_at 2.1E−01 1.6E−016.9E−01 7.0E−01 No No C3 220066_at 1.3E−02 6.4E−02 5.2E−01 1.1E−01 No NoCARD15 203065_s_at 5.4E−01 2.7E−01 6.8E−01 6.9E−01 No No CAV1 212097_at5.8E−01 7.8E−01 6.5E−01 3.7E−01 No No CAV1 210133_at 7.6E−01 5.6E−027.1E−01 7.7E−02 No No CCL11 216598_s_at 2.6E−01 1.7E−01 4.1E−02 3.3E−02No No CCL2 205476_at 9.2E−01 8.2E−01 3.8E−01 3.3E−01 No No CCL20207861_at 1.4E−01 7.1E−01 7.8E−01 2.9E−01 No No CCL22 1405_i_at 3.4E−013.1E−02 8.1E−01 1.0E−01 No No CCL5 204655_at 6.4E−01 5.7E−01 6.1E−018.2E−01 No No CCL5 208711_s_at 6.7E−02 2.4E−01 7.6E−01 9.9E−01 No NoCCND1 208712_at 7.6E−01 2.5E−01 4.5E−01 4.5E−01 No No CCND1 214019_at9.4E−02 1.2E−01 1.7E−01 2.6E−02 No No CCND1 206991_s_at 3.2E−01 1.6E−011.9E−01 1.1E−01 No No CCR5 206337_at 9.8E−01 4.6E−01 3.0E−01 5.5E−01 NoNo CCR7 207277_at 3.9E−01 2.6E−02 4.3E−01 3.5E−02 No No CD209207278_s_at 8.8E−01 1.9E−01 3.0E−01 2.6E−01 No No CD209 206804_at6.5E−01 2.0E−01 9.7E−01 1.3E−01 No No CD3G 210564_x_at 7.5E−02 5.9E−011.2E−01 7.3E−02 No No CFLAR 214486_x_at 7.2E−01 8.1E−02 1.4E−01 2.5E−01No No CFLAR 202403_s_at 1.9E−01 1.7E−01 2.1E−01 1.5E−01 No No COL1A2202404_s_at 1.9E−01 9.8E−01 2.1E−01 4.6E−01 No No COL1A2 205753_at8.9E−01 3.6E−01 3.5E−01 8.0E−01 No No CRP 37020_at 6.5E−01 1.9E−016.5E−01 2.4E−01 No No CRP 207082_at 4.0E−01 3.5E−01 9.6E−01 9.1E−01 NoNo CSF1 210557_x_at 9.4E−01 1.7E−01 8.6E−01 4.3E−01 No No CSF1211839_s_at 5.4E−01 2.7E−01 5.9E−01 3.0E−01 No No CSF1 210228_at 4.9E−014.9E−01 6.8E−01 9.2E−01 No No CSF2 210229_s_at 6.2E−01 1.7E−01 4.7E−011.1E−01 No No CSF2 207442_at 6.0E−01 5.5E−01 3.9E−01 4.7E−02 No No CSF3213275_x_at 1.2E−02 9.2E−04 9.8E−03 4.3E−02 No No CTSB 202087_s_at8.9E−01 5.5E−01 6.5E−01 7.0E−01 No No CTSL 204533_at 2.5E−01 2.3E−019.3E−01 8.6E−01 No No CXCL10 211122_s_at 8.5E−01 7.3E−01 3.6E−01 1.5E−01No No CXCL11 209774_x_at 3.2E−02 4.4E−01 7.8E−01 9.1E−01 No No CXCL2207852_at 6.8E−01 8.4E−02 7.1E−01 1.7E−01 No No CXCL5 215101_s_at9.4E−01 4.6E−01 5.5E−01 8.0E−01 No No CXCL5 203699_s_at 2.9E−01 2.3E−015.4E−01 9.7E−01 No No DIO2 210819_x_at 7.6E−01 8.3E−01 8.3E−01 4.6E−01No No DIO2 211215_x_at 4.8E−01 3.1E−01 2.6E−01 1.5E−01 No No DIO2201044_x_at 8.2E−01 7.9E−01 8.8E−01 8.5E−01 No No DUSP1 201983_s_at5.3E−01 1.1E−01 3.4E−01 7.5E−02 No No EGFR 201984_s_at 8.1E−01 3.0E−015.0E−01 7.6E−01 No No EGFR 210984_x_at 2.0E−01 2.1E−01 1.3E−01 1.7E−01No No EGFR 211550_at 9.8E−01 3.4E−01 8.3E−01 3.0E−01 No No EGFR211607_x_at 7.9E−01 2.4E−01 6.9E−01 1.8E−01 No No EGFR 201693_s_at3.1E−01 2.2E−01 5.4E−01 6.3E−01 No No EGR1 201808_s_at 5.5E−01 7.6E−013.8E−01 4.8E−01 No No ENG 201809_s_at 7.4E−03 1.3E−02 2.1E−03 3.5E−03 NoNo ENG 207257_at 3.8E−01 3.4E−01 5.4E−01 5.4E−01 No No EPO 204363_at4.4E−01 9.9E−01 9.9E−01 4.1E−01 No No F3 206759_at 5.8E−02 1.6E−012.7E−02 8.7E−02 No No FCER2 206760_s_at 3.8E−02 9.5E−02 2.0E−02 7.0E−02No No FCER2 210495_x_at 7.8E−01 3.9E−01 3.8E−01 6.2E−01 No No FN1211719_x_at 4.7E−01 2.6E−01 8.8E−01 8.0E−01 No No FN1 212464_s_at3.9E−01 3.4E−01 5.1E−01 5.1E−01 No No FN1 214702_at 6.2E−02 1.4E−019.8E−01 7.3E−01 No No FN1 216442_x_at 7.5E−01 8.2E−02 5.6E−01 4.2E−01 NoNo FN1 205278_at 8.7E−02 3.8E−03 9.0E−01 2.6E−01 No No GAD1 206669_at8.4E−01 9.4E−01 9.3E−01 7.7E−01 No No GAD1 206670_s_at 1.8E−01 4.1E−011.6E−01 5.8E−02 No No GAD1 213560_at 4.5E−01 3.1E−01 9.9E−01 9.7E−01 NoNo GADD45B 220821_at 5.8E−01 3.1E−01 6.3E−01 6.2E−01 No No GALR1205914_s_at 4.4E−01 2.3E−01 6.8E−01 3.3E−01 No No GRIN1 205915_x_at6.0E−01 2.2E−01 3.5E−01 1.5E−01 No No GRIN1 210781_x_at 5.7E−01 3.9E−016.2E−01 4.6E−01 No No GRIN1 210782_x_at 8.5E−01 9.3E−01 7.6E−01 8.6E−01No No GRIN1 211125_x_at 4.6E−01 7.3E−01 7.9E−01 4.3E−01 No No GRIN1206534_at 6.1E−01 1.9E−01 4.8E−01 1.5E−01 No No GRIN2A 221942_s_at7.7E−01 1.0E−01 5.7E−01 5.1E−02 No No GUCY1A3 207316_at 1.7E−01 1.4E−013.4E−01 2.9E−01 No No HAS1 205919_at 2.6E−01 9.6E−02 8.1E−01 2.3E−01 NoNo HBE1 217683_at 5.8E−01 6.0E−01 1.9E−01 3.4E−01 No No HBE1 203665_at2.3E−01 7.0E−01 2.8E−02 1.5E−01 No No HMOX1 210439_at 4.6E−02 3.1E−013.7E−01 4.2E−01 No No ICOS 201631_s_at 7.6E−03 1.2E−01 3.3E−02 2.4E−01No No IER3 205302_at 4.8E−01 7.3E−02 6.6E−01 9.5E−01 No No IGFBP1207433_at 9.3E−01 3.1E−01 5.1E−01 9.9E−01 No No IL10 206924_at 1.5E−019.5E−01 5.8E−01 3.8E−01 No No IL11 206926_s_at 4.1E−01 4.6E−01 2.0E−012.7E−01 No No IL11 207844_at 3.9E−01 4.7E−01 2.1E−01 5.9E−01 No No IL13205992_s_at 4.3E−01 4.5E−01 3.0E−01 3.5E−01 No No IL15 210118_s_at2.8E−01 3.9E−01 9.6E−01 1.6E−01 No No IL1A 205067_at 2.2E−01 9.0E−024.3E−01 1.6E−01 No No IL1B 39402_at 7.7E−01 4.6E−01 1.0E−01 7.7E−02 NoNo IL1B 212657_s_at 3.9E−01 8.7E−01 9.4E−01 4.6E−01 No No IL1RN212659_s_at 7.3E−01 2.6E−01 7.2E−01 2.8E−01 No No IL1RN 216243_s_at2.0E−01 3.6E−01 1.2E−01 2.5E−01 No No IL1RN 216244_at 1.0E−01 9.4E−026.2E−01 6.1E−01 No No IL1RN 216245_at 9.3E−01 2.6E−01 7.9E−01 3.0E−01 NoNo IL1RN 207849_at 7.5E−01 4.9E−01 6.1E−01 6.8E−01 No No IL2 206341_at6.7E−02 5.4E−01 2.5E−01 6.7E−01 No No IL2RA 211269_s_at 7.6E−01 1.7E−017.4E−01 8.7E−02 No No IL2RA 202859_x_at 1.1E−01 6.5E−01 9.1E−01 2.6E−01No No IL8 208193_at 7.9E−01 9.8E−01 2.9E−01 3.3E−01 No No IL9 216987_at5.6E−01 7.4E−01 9.1E−01 6.0E−01 No No IRF4 201464_x_at 3.4E−01 9.4E−018.4E−02 5.0E−01 No No JUN 201465_s_at 6.0E−01 7.9E−02 2.6E−01 6.3E−01 NoNo JUN 201466_s_at 2.8E−01 2.9E−01 3.5E−01 8.9E−01 No No JUN 211124_s_at2.3E−01 9.1E−01 1.6E−01 8.7E−01 No No KITLG 204582_s_at 7.6E−01 1.5E−016.3E−02 4.2E−01 No No KLK3 204583_x_at 4.7E−01 3.6E−01 8.9E−01 6.9E−01No No KLK3 204734_at 2.8E−01 4.5E−01 6.8E−01 6.7E−01 No No KRT15208188_at 9.6E−02 3.4E−02 3.0E−02 3.0E−02 No No KRT9 211652_s_at 7.9E−011.8E−01 2.0E−01 1.1E−01 No No LBP 214461_at 8.8E−01 3.5E−01 6.7E−011.7E−01 No No LBP 212531_at 8.7E−01 4.4E−01 5.6E−01 1.7E−01 No No LCN2208949_s_at 9.1E−01 4.9E−02 2.2E−01 1.4E−01 No No LGALS3 206975_at3.5E−01 2.9E−01 2.8E−01 4.6E−01 No No LTA 204475_at 2.5E−01 2.9E−011.9E−01 4.7E−01 No No MMP1 205828_at 8.0E−01 2.9E−01 7.5E−01 2.8E−01 NoNo MMP3 205970_at 6.9E−01 9.5E−01 3.4E−01 6.4E−01 No No MT3 204673_at2.4E−01 1.8E−01 9.3E−01 5.5E−01 No No MUC2 209636_at 8.2E−02 2.1E−021.2E−01 5.8E−02 No No NFKB2 211524_at 7.8E−01 4.7E−01 5.5E−01 5.0E−01 NoNo NFKB2 203828_s_at 7.1E−01 4.1E−01 5.0E−01 3.0E−01 No No NK4205440_s_at 5.0E−01 3.3E−01 5.3E−01 2.5E−01 No No NPY1R 201467_s_at2.9E−01 5.9E−02 3.4E−01 5.0E−02 No No NQO1 204621_s_at 2.7E−01 8.3E−012.4E−02 1.3E−01 No No NR4A2 205040_at 3.2E−01 1.3E−01 7.4E−01 7.6E−01 NoNo ORM1 205041_s_at 4.5E−01 1.0E−01 6.2E−01 8.0E−01 No No ORM1 214465_at9.5E−01 6.6E−02 7.4E−01 1.5E−01 No No ORM1 207921_x_at 8.1E−01 4.4E−015.5E−01 3.2E−01 No No PAX8 207923_x_at 3.6E−01 5.6E−02 1.2E−01 3.0E−02No No PAX8 207924_x_at 4.5E−03 1.9E−04 4.9E−01 4.4E−01 No No PAX8209552_at 2.6E−01 1.5E−01 1.4E−01 1.2E−01 No No PAX8 214528_s_at 9.7E−012.0E−01 9.6E−01 1.9E−01 No No PAX8 221990_at 3.0E−01 2.5E−01 5.4E−013.3E−01 No No PAX8 204200_s_at 1.0E+00 8.1E−01 4.3E−01 6.0E−01 No NoPDGFB 216055_at 3.1E−01 1.8E−01 8.6E−01 3.6E−01 No No PDGFB 216061_x_at2.9E−02 8.9E−02 5.5E−02 1.1E−01 No No PDGFB 206803_at 9.3E−01 3.1E−029.8E−01 1.9E−01 No No PDYN 204213_at 6.0E−01 2.7E−01 4.0E−01 1.8E−01 NoNo PIGR 203649_s_at 1.1E−01 1.1E−01 6.2E−01 5.3E−01 No No PLA2G2A205479_s_at 2.8E−01 2.7E−01 5.1E−01 5.3E−01 No No PLAU 211668_s_at4.3E−01 2.8E−01 2.9E−01 7.3E−01 No No PLAU 205125_at 4.7E−01 8.4E−011.2E−01 8.2E−01 No No PLCD1 205720_at 5.2E−01 1.6E−01 4.9E−01 9.2E−01 NoNo POMC 215705_at 7.6E−01 3.9E−01 5.9E−01 3.2E−01 No No PPP5C 206278_at4.5E−01 6.8E−01 2.5E−01 2.8E−01 No No PTAFR 211663_x_at 2.1E−01 8.9E−029.4E−01 4.6E−01 No No PTGDS 211748_x_at 8.3E−02 2.0E−01 4.7E−01 5.2E−01No No PTGDS 212187_x_at 1.5E−01 1.8E−01 4.5E−01 3.6E−01 No No PTGDS207388_s_at 4.8E−01 1.3E−01 4.1E−01 8.3E−02 No No PTGES 210367_s_at4.9E−01 8.4E−01 5.1E−01 9.3E−01 No No PTGES 208131_s_at 3.5E−01 2.2E−011.8E−01 1.8E−01 No No PTGIS 210702_s_at 6.0E−01 8.2E−01 8.2E−01 2.7E−01No No PTGIS 204748_at 7.7E−01 8.1E−02 2.2E−01 1.5E−01 No No PTGS2204201_s_at 9.7E−01 7.3E−01 5.4E−01 4.7E−01 No No PTPN13 206157_at7.1E−01 6.6E−01 5.9E−01 6.3E−01 No No PTX3 216994_s_at 7.3E−01 2.4E−019.9E−01 1.6E−01 No No RUNX2 221282_x_at 6.1E−01 9.1E−01 9.7E−01 7.8E−01No No RUNX2 221283_at 9.9E−01 3.6E−01 2.4E−01 3.9E−02 No No RUNX2217728_at 9.2E−01 1.3E−01 7.9E−01 1.1E−01 No No S100A6 208607_s_at6.3E−01 2.9E−01 5.5E−01 2.0E−01 No No SAA2 214456_x_at 7.2E−01 6.4E−018.1E−01 9.6E−01 No No SAA2 202071_at 5.4E−01 3.8E−01 3.6E−01 6.7E−01 NoNo SDC4 206211_at 2.1E−01 1.6E−01 2.2E−01 1.5E−01 No No SELE 206049_at6.5E−01 9.9E−01 5.9E−01 7.8E−01 No No SELP 202627_s_at 9.2E−01 3.1E−015.2E−01 8.4E−01 No No SERPINE1 202628_s_at 3.5E−01 5.6E−01 6.8E−019.0E−01 No No SERPINE1 210073_at 1.1E−01 9.6E−01 8.8E−02 2.5E−01 No NoSIAT8A 215078_at 7.8E−01 5.6E−01 7.0E−01 9.6E−01 No No SOD2 202935_s_at5.1E−01 5.8E−02 7.7E−01 1.5E−01 No No SOX9 202936_s_at 2.1E−01 2.3E−017.6E−01 9.2E−01 No No SOX9 213112_s_at 9.7E−01 3.4E−01 6.6E−01 2.2E−01No No SQSTM1 203010_at 4.9E−03 1.2E−02 1.0E−03 6.7E−04 No No STAT5A208049_s_at 5.2E−02 9.1E−02 1.6E−01 7.6E−01 No No TACR1 210637_at4.8E−01 2.2E−01 5.8E−01 6.0E−02 No No TACR1 210294_at 4.1E−02 6.3E−011.1E−01 4.5E−01 No No TAPBP 209277_at 6.9E−01 5.9E−01 5.5E−01 5.4E−01 NoNo TFPI2 209278_s_at 9.7E−01 5.1E−01 3.9E−01 6.7E−01 No No TFPI2211003_x_at 2.5E−01 1.3E−01 5.1E−01 1.6E−01 No No TGM2 211573_x_at5.1E−01 7.7E−02 6.7E−01 1.6E−01 No No TGM2 216183_at 3.7E−01 9.8E−017.2E−01 3.9E−01 No No TGM2 201107_s_at 9.8E−01 1.6E−02 6.2E−01 1.8E−02No No THBS1 201108_s_at 4.8E−01 3.5E−02 4.1E−01 8.2E−01 No No THBS1201109_s_at 7.6E−01 4.5E−01 9.8E−01 7.3E−01 No No THBS1 201110_s_at1.5E−01 3.6E−01 9.9E−02 2.5E−01 No No THBS1 203083_at 7.6E−02 4.5E−013.0E−01 7.1E−01 No No THBS2 201645_at 6.8E−01 9.6E−01 9.0E−01 5.2E−01 NoNo TNC 207113_s_at 8.6E−01 2.0E−02 9.0E−01 2.7E−02 No No TNF 202509_s_at3.2E−01 7.4E−02 3.7E−01 1.0E−01 No No TNFAIP2 202510_s_at 4.8E−016.8E−01 1.7E−01 5.7E−01 No No TNFAIP2 203508_at 5.2E−01 9.9E−01 1.4E−012.7E−01 No No TNFRSF1B 205153_s_at 1.0E−01 4.9E−02 2.3E−02 1.1E−02 No NoTNFRSF5 222292_at 2.1E−01 4.4E−01 4.1E−01 6.6E−02 No No TNFRSF5211786_at 2.9E−01 2.0E−02 9.3E−01 8.0E−02 No No TNFRSF9 207892_at9.8E−01 2.2E−01 9.7E−01 1.8E−01 No No TNFSF5 210865_at 4.0E−01 8.3E−015.6E−01 1.8E−01 No No TNFSF6 211333_s_at 2.2E−01 5.8E−01 1.7E−03 3.2E−01No No TNFSF6 204413_at 7.0E−01 3.3E−01 3.7E−01 5.3E−01 No No TRAF2206067_s_at 4.8E−01 4.1E−01 8.3E−01 2.1E−01 No No WT1 216953_s_at2.4E−01 5.2E−03 5.0E−01 9.6E−02 No No WT1 Probesets UniGene ID GeneTitle FDR Cutoff 205481_at Hs.77867 adenosine A1 receptor 216220_s_atHs.77867 adenosine A1 receptor 202834_at Hs.19383 angiotensinogen204151_x_at Hs.295131 aldo-keto reductase family 1, member C1216594_x_at Hs.295131 aldo-keto reductase family 1, member C1204445_s_at Hs.89499 arachidonate 5-lipoxygenase 204446_s_at Hs.89499arachidonate 5-lipoxygenase 214366_s_at Hs.89499 arachidonate5-lipoxygenase 214953_s_at Hs.177486 amyloid beta (A4) precursor protein211621_at Hs.99915 androgen receptor 203174_s_at Hs.389277ADP-ribosylation factor related protein 1 215984_s_at Hs.389277ADP-ribosylation factor related protein 1 201891_s_at Hs.48516beta-2-microglobulin 216231_s_at Hs.48516 beta-2-microglobulin 203685_atHs.79241 B-cell CLL/lymphoma 2 207005_s_at Hs.79241 B-cell CLL/lymphoma2 205681_at Hs.227817 BCL2-related protein A1 202076_at Hs.289107baculoviral IAP repeat-containing 2 210538_s_at Hs.127799 baculoviralIAP repeat-containing 3 205114_s_at Hs.73817 chemokine (C-C motif)ligand 3 204103_at Hs.75703 chemokine (C-C motif) ligand 4 201700_atHs.83173 cyclin D3 204118_at Hs.901 CD48 antigen 209795_at Hs.82401 CD69antigen 209619_at Hs.446471 CD74 antigen 207176_s_at Hs.838 CD80 antigen204440_at Hs.79197 CD83 antigen 202246_s_at Hs.95577 cyclin-dependentkinase 4 203198_at Hs.150423 cyclin-dependent kinase 9 202284_s_atHs.370771 cyclin-dependent kinase inhibitor 1A (p21, Cip1) 208485_x_atHs.355724 CASP8 and FADD-like apoptosis regulator 209508_x_at Hs.355724CASP8 and FADD-like apoptosis regulator 209939_x_at Hs.355724 CASP8 andFADD-like apoptosis regulator 210563_x_at Hs.355724 CASP8 and FADD-likeapoptosis regulator 211316_x_at Hs.355724 CASP8 and FADD-like apoptosisregulator 211317_s_at Hs.355724 CASP8 and FADD-like apoptosis regulator211862_x_at Hs.355724 CASP8 and FADD-like apoptosis regulator 214618_atHs.355724 CASP8 and FADD-like apoptosis regulator 209716_at Hs.173894colony stimulating factor 1 (macrophage) 200838_at Hs.135226 cathepsin B200839_s_at Hs.135226 cathepsin B 213274_s_at Hs.135226 cathepsin B204470_at Hs.789 chemokine (C—X—C motif) ligand 1 210163_at Hs.103982chemokine (C—X—C motif) ligand 11 214974_x_at Hs.89714 chemokine (C—X—Cmotif) ligand 5 203700_s_at Hs.436020 deiodinase, iodothyronine, type II201041_s_at Hs.171695 dual specificity phosphatase 1 203692_s_at Hs.1189E2F transcription factor 3 203693_s_at Hs.1189 E2F transcription factor3 211551_at Hs.77432 epidermal growth factor receptor 201694_s_atHs.326035 early growth response 1 214766_s_at Hs.33363 ELYStranscription factor-like protein TMBS62 201313_at Hs.511915 enolase 2,(gamma, neuronal) 205767_at Hs.115263 epiregulin 202081_at Hs.737immediate early protein 205756_s_at Hs.413083 coagulation factor VIII214701_s_at Hs.418138 fibronectin 1 202275_at Hs.80206glucose-6-phosphate dehydrogenase 207574_s_at Hs.110571 growth arrestand DNA-damage-inducible, beta 209304_x_at Hs.110571 growth arrest andDNA-damage-inducible, beta 209305_s_at Hs110571 growth arrest andDNA-damage-inducible, beta 202269_x_at Hs.62661 guanylate bindingprotein 1, interferon- inducible, 67 kDa 202270_at Hs.62661 guanylatebinding protein 1, interferon- inducible, 67 kDa 200651_at Hs.5662 Gprotein, beta polypeptide 2-like 1 222034_at Hs.5662 G protein, betapolypeptide 2-like 1 200824_at Hs.411509 glutathione S-transferase pi208729_x_at Hs.77961 major histocompatibility complex, class I, B209140_x_at Hs.77961 major histocompatibility complex, class I, B211911_x_at Hs.77961 major histocompatibility complex, class I, B200943_at Hs.356285 high-mobility group nucleosome binding domain 1200944_s_at Hs.356285 high-mobility group nucleosome binding domain 1202638_s_at Hs.386467 intercellular adhesion molecule 1 (CD54)215485_s_at Hs.386467 intercellular adhesion molecule 1 (CD54) 210354_atHs.856 interferon, gamma 202718_at Hs.433326 insulin-like growth factorbinding protein 2, 36 kDa 207901_at Hs.674 interleukin 12B 208200_atHs.1722 interleukin 1, alpha 205207_at Hs.512234 interleukin 6(interferon, beta 2) 202531_at Hs.80645 interferon regulatory factor 1203275_at Hs.83795 interferon regulatory factor 2 204562_at Hs.127686interferon regulatory factor 4 216986_s_at Hs.127686 interferonregulatory factor 4 208436_s_at Hs.166120 interferon regulatory factor 7213281_at Hs.78465 v-jun sarcoma virus 17 oncogene homolog (avian)201473_at Hs.400124 jun B proto-oncogene 207029_at Hs.1048 KIT ligand216264_s_at Hs.439726 laminin, beta 2 (laminin S) 207339_s_at Hs.376208lymphotoxin beta 213975_s_at Hs.234734 lysozyme 208037_s_at Hs.102598mucosal vascular addressin cell adhesion molecule 1 206296_x_at Hs.95424mitogen-activated protein kinase kinase kinase kinase 1 214219_x_atHs.95424 mitogen-activated protein kinase kinase kinase kinase 1214339_s_at Hs.95424 mitogen-activated protein kinase kinase kinasekinase 1 201126_s_at Hs.120870 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 203936_s_at Hs.151738 matrixmetalloproteinase 9 202086_at Hs.436836 myxovirus (influenza virus)resistance 1 204798_at Hs.407830 v-myb myeloblastosis viral oncogenehomolog (avian) 215152_at Hs.407830 v-myb myeloblastosis viral oncogenehomolog (avian) 202431_s_at Hs.202453 v-myc myelocytomatosis viraloncogene homolog (avian) 209239_at Hs.160557 nuclear factor of kappalight polypeptide gene enhancer in B-cells 1 (p105) 207535_s_at Hs.73090nuclear factor of kappa light polypeptide gene enhancer in B-cells 2(p49/p100) 201502_s_at Hs.81328 nuclear factor of kappa lightpolypeptide gene enhancer in B-cells inhibitor, alpha 201468_s_atHs.406515 NAD(P)H dehydrogenase, quinone 1 210519_s_at Hs.406515 NAD(P)Hdehydrogenase, quinone 1 201866_s_at Hs.512414 nuclear receptorsubfamily 3, group C, member 1 (glucocorticoid receptor) 211671_s_atHs.512414 nuclear receptor subfamily 3, group C, member 1(glucocorticoid receptor) 216321_s_at Hs.512414 nuclear receptorsubfamily 3, group C, member 1 (glucocorticoid receptor) 204622_x_atHs.82120 nuclear receptor subfamily 4, group A, member 2 216248_s_atHs.82120 nuclear receptor subfamily 4, group A, member 2 210004_atHs.445299 oxidised low density lipoprotein (lectin-like) receptor 1121_at Hs.308061 paired box gene 8 203557_s_at Hs.3192 dimerizationcofactor of hepatocyte nuclear factor 1 alpha (TCF1) 201202_at Hs.78996proliferating cell nuclear antigen 213791_at Hs.339831 proenkephalin200737_at Hs.78771 phosphoglycerate kinase 1 200738_s_at Hs.78771phosphoglycerate kinase 1 217356_s_at Hs.78771 phosphoglycerate kinase 1217383_at Hs.78771 phosphoglycerate kinase 1 209193_at Hs.81170 pim-1oncogene 210145_at Hs.211587 phospholipase A2, group IVA (cytosolic,calcium-dependent) 201979_s_at Hs.431861 protein phosphatase 5,catalytic subunit 214617_at Hs.2200 perforin 1 (pore forming protein)202545_at Hs.155342 protein kinase C, delta 204279_at Hs.381081proteasome (prosome, macropain) subunit, beta type, 9 211661_x_at Hs.46platelet-activating factor receptor 211892_s_at Hs.302085 prostaglandinI2 (prostacyclin) synthase 206035_at Hs.44313 v-relreticuloendotheliosis viral oncogene homolog (avian) 206036_s_atHs.44313 v-rel reticuloendotheliosis viral oncogene homolog (avian)205205_at Hs.307905 v-rel reticuloendotheliosis viral oncogene homolog B209544_at Hs.103755 receptor-interacting serine-threonine kinase 2209545_s_at Hs.103755 receptor-interacting serine-threonine kinase 2200872_at Hs.143873 S100 calcium binding protein A10 203186_s_atHs.81256 S100 calcium binding protein A4 215223_s_at Hs.384944superoxide dismutase 2, mitochondrial 216841_s_at Hs.384944 superoxidedismutase 2, mitochondrial 221477_s_at Hs.384944 superoxide dismutase 2,mitochondrial 201471_s_at Hs.182248 sequestosome 1 208048_at Hs.469066tachykinin receptor 1 202307_s_at Hs.352018 transporter 1, ATP-bindingcassette, sub- family B (MDR/TAP) 208829_at Hs.370937 TAP bindingprotein (tapasin) 207199_at Hs.439911 telomerase reverse transcriptase215775_at Hs.164226 thrombospondin 1 216005_at Hs.98998 tenascin C(hexabrachion) 202643_s_at Hs.211600 tumor necrosis factor,alpha-induced protein 3 202644_s_at Hs.211600 tumor necrosis factor,alpha-induced protein 3 215346_at Hs.504816 tumor necrosis factorreceptor superfamily, member 5 35150_at Hs.504816 tumor necrosis factorreceptor superfamily, member 5 207536_s_at Hs.193418 tumor necrosisfactor receptor superfamily, member 9 202687_s_at Hs.387871 tumornecrosis factor (ligand) superfamily, member 10 202688_at Hs.387871tumor necrosis factor (ligand) superfamily, member 10 214329_x_atHs.387871 tumor necrosis factor (ligand) superfamily, member 10201746_at Hs.408312 tumor protein p53 (Li-Fraumeni syndrome) 211300_s_atHs.408312 tumor protein p53 (Li-Fraumeni syndrome) 205599_at Hs.438253TNF receptor-associated factor 1 213191_at Hs.29344 TIR domaincontaining adaptor inducing interferon-beta 203109_at Hs.406068ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) 208997_s_atHs.80658 uncoupling protein 2 (mitochondrial, proton carrier) 208998_atHs.80658 uncoupling protein 2 (mitochondrial, proton carrier)204881_s_at Hs.432605 UDP-glucose ceramide glucosyltransferase 221765_atHs.432605 UDP-glucose ceramide glucosyltransferase 203868_s_at Hs.109225vascular cell adhesion molecule 1 209946_at Hs.79141 vascularendothelial growth factor C 201426_s_at Hs.435800 vimentin 210301_atHs.250 xanthine dehydrogenase 208544_at Hs.247686 adrenergic, alpha-2B-,receptor 210081_at Hs.184 advanced glycosylation end product- specificreceptor 217046_s_at Hs.184 advanced glycosylation end product- specificreceptor 207206_s_at Hs.1200 arachidonate 12-lipoxygenase 213952_s_atHs.89499 arachidonate 5-lipoxygenase 206516_at Hs.112432 anti-Mullerianhormone 205820_s_at Hs.73849 apolipoprotein C-III 200602_at Hs.177486amyloid beta (A4) precursor protein 211277_x_at Hs.177486 amyloid beta(A4) precursor protein 211110_s_at Hs.99915 androgen receptor 207367_atHs.147111 ATPase, H+/K+ transporting, nongastric, alpha polypeptide217904_s_at Hs.49349 beta-site APP-cleaving enzyme 203684_s_at Hs.79241B-cell CLL/lymphoma 2 207004_at Hs.79241 B-cell CLL/lymphoma 2 207510_atHs.46348 bradykinin receptor B1 202357_s_at Hs.69771 B-factor, properdin211920_at Hs.69771 B-factor, properdin 201261_x_at Hs.821 biglycan201262_s_at Hs.821 biglycan 205289_at Hs.73853 bone morphogeneticprotein 2 205290_s_at Hs.73853 bone morphogenetic protein 2 204439_atHs.389724 chromosome 1 open reading frame 29 217767_at Hs.284394complement component 3 220066_at Hs.135201 caspase recruitment domainfamily, member 15 203065_s_at Hs.74034 caveolin 1, caveolae protein, 22kDa 212097_at Hs.74034 caveolin 1, caveolae protein, 22 kDa 210133_atHs.54460 chemokine (C-C motif) ligand 11 216598_s_at Hs.303649 chemokine(C-C motif) ligand 2 205476_at Hs.75498 chemokine (C-C motif) ligand 20207861_at Hs.97203 chemokine (C-C motif) ligand 22 1405_i_at Hs.489044chemokine (C-C motif) ligand 5 204655_at Hs.489044 chemokine (C-C motif)ligand 5 208711_s_at Hs.371468 cyclin D1 208712_at Hs.371468 cyclin D1214019_at Hs.371468 cyclin D1 206991_s_at Hs.511796 chemokine (C-Cmotif) receptor 5 206337_at Hs.1652 chemokine (C-C motif) receptor 7207277_at Hs.278694 CD209 antigen 207278_s_at Hs.278694 CD209 antigen206804_at Hs.2259 CD3G antigen, gamma polypeptide (TiT3 complex)210564_x_at Hs.355724 CASP8 and FADD-like apoptosis regulator214486_x_at Hs.355724 CASP8 and FADD-like apoptosis regulator202403_s_at Hs.232115 collagen, type I, alpha 2 202404_s_at Hs.232115collagen, type I, alpha 2 205753_at Hs.76452 C-reactive protein,pentraxin-related 37020_at Hs.76452 C-reactive protein,pentraxin-related 207082_at Hs.173894 colony stimulating factor 1(macrophage) 210557_x_at Hs.173894 colony stimulating factor 1(macrophage) 211839_s_at Hs.173894 colony stimulating factor 1(macrophage) 210228_at Hs.1349 colony stimulating factor 2 (granulocyte-macrophage) 210229_s_at Hs.1349 colony stimulating factor 2(granulocyte- macrophage) 207442_at Hs.2233 colony stimulating factor 3(granulocyte) 213275_x_at Hs.135226 cathepsin B 202087_s_at Hs.418123cathepsin L 204533_at Hs.413924 chemokine (C—X—C motif) ligand 10211122_s_at Hs.103982 chemokine (C—X—C motif) ligand 11 209774_x_atHs.75765 chemokine (C—X—C motif) ligand 2 207852_at Hs.89714 chemokine(C—X—C motif) ligand 5 215101_s_at Hs.89714 chemokine (C—X—C motif)ligand 5 203699_s_at Hs.436020 deiodinase, iodothyronine, type II210819_x_at Hs.436020 deiodinase, iodothyronine, type II 211215_x_atHs.436020 deiodinase, iodothyronine, type II 201044_x_at Hs.171695 dualspecificity phosphatase 1 201983_s_at Hs.77432 epidermal growth factorreceptor 201984_s_at Hs.77432 epidermal growth factor receptor210984_x_at Hs.77432 epidermal growth factor receptor 211550_at Hs.77432epidermal growth factor receptor 211607_x_at Hs.77432 epidermal growthfactor receptor 201693_s_at Hs.326035 early growth response 1201808_s_at Hs.76753 endoglin (Osler-Rendu-Weber syndrome 1) 201809_s_atHs.76753 endoglin (Osler-Rendu-Weber syndrome 1) 207257_at Hs.2303erythropoietin 204363_at Hs.62192 coagulation factor III(thromboplastin, tissue factor) 206759_at Hs.1416 Fc fragment of IgE,low affinity II, receptor for (CD23A) 206760_s_at Hs.1416 Fc fragment ofIgE, low affinity II, receptor for (CD23A) 210495_x_at Hs.418138fibronectin 1 211719_x_at Hs.418138 fibronectin 1 212464_s_at Hs.418138fibronectin 1 214702_at Hs.418138 fibronectin 1 216442_x_at Hs.418138fibronectin 1 205278_at Hs.420036 glutamate decarboxylase 1 (brain, 67kDa) 206669_at Hs.420036 glutamate decarboxylase 1 (brain, 67 kDa)206670_s_at Hs.420036 glutamate decarboxylase 1 (brain, 67 kDa)213560_at Hs.110571 growth arrest and DNA-damage-inducible, beta220821_at Hs.272191 galanin receptor 1 205914_s_at Hs.105 glutamatereceptor, ionotropic, N-methyl D- aspartate 1 205915_x_at Hs.105glutamate receptor, ionotropic, N-methyl D- aspartate 1 210781_x_atHs.105 glutamate receptor, ionotropic, N-methyl D- aspartate 1210782_x_at Hs.105 glutamate receptor, ionotropic, N-methyl D- aspartate1 211125_x_at Hs.105 glutamate receptor, ionotropic, N-methyl D-aspartate 1 206534_at Hs.125338 glutamate receptor, ionotropic, N-methylD- aspartate 2A 221942_s_at Hs.433488 guanylate cyclase 1, soluble,alpha 3 207316_at Hs.57697 hyaluronan synthase 1 205919_at Hs.117848hemoglobin, epsilon 1 217683_at Hs.117848 hemoglobin, epsilon 1203665_at Hs.202833 heme oxygenase (decycling) 1 210439_at Hs.56247inducible T-cell co-stimulator 201631_s_at Hs.76095 immediate earlyresponse 3 205302_at Hs.401316 insulin-like growth factor bindingprotein 1 207433_at Hs.193717 interleukin 10 206924_at Hs.1721interleukin 11 206926_s_at Hs.1721 interleukin 11 207844_at Hs.845interleukin 13 205992_s_at Hs.168132 interleukin 15 210118_s_at Hs.1722interleukin 1, alpha 205067_at Hs.126256 interleukin 1, beta 39402_atHs.126256 interleukin 1, beta 212657_s_at Hs.81134 interleukin 1receptor antagonist 212659_s_at Hs.81134 interleukin 1 receptorantagonist 216243_s_at Hs.81134 interleukin 1 receptor antagonist216244_at Hs.81134 interleukin 1 receptor antagonist 216245_at Hs.81134interleukin 1 receptor antagonist 207849_at Hs.89679 interleukin 2206341_at Hs.130058 interleukin 2 receptor, alpha 211269_s_at Hs.130058interleukin 2 receptor, alpha 202859_x_at Hs.624 interleukin 8 208193_atHs.960 interleukin 9 216987_at Hs.127686 interferon regulatory factor 4201464_x_at Hs.78465 v-jun sarcoma virus 17 oncogene homolog (avian)201465_s_at Hs.78465 v-jun sarcoma virus 17 oncogene homolog (avian)201466_s_at Hs.78465 v-jun sarcoma virus 17 oncogene homolog (avian)211124_s_at Hs.1048 KIT ligand 204582_s_at Hs.171995 kallikrein 3,(prostate specific antigen) 204583_x_at Hs.171995 kallikrein 3,(prostate specific antigen) 204734_at Hs.80342 keratin 15 208188_atHs.2783 keratin 9 (epidermolytic palmoplantar keratoderma) 211652_s_atHs.154078 lipopolysaccharide binding protein 214461_at Hs.154078lipopolysaccharide binding protein 212531_at Hs.204238 lipocalin 2(oncogene 24p3) 208949_s_at Hs.411701 lectin, galactoside-binding,soluble, 3 (galectin 3) 206975_at Hs.36 lymphotoxin alpha (TNFsuperfamily, member 1) 204475_at Hs.83169 matrix metalloproteinase 1(interstitial collagenase) 205828_at Hs.375129 matrix metalloproteinase3 (stromelysin 1, progelatinase) 205970_at Hs.73133 metallothionein 3(growth inhibitory factor (neurotrophic)) 204673_at Hs.315 mucin 2,intestinal/tracheal 209636_at Hs.73090 nuclear factor of kappa lightpolypeptide gene enhancer in B-cells 2 (p49/p100) 211524_at Hs.73090nuclear factor of kappa light polypeptide gene enhancer in B-cells 2(p49/p100) 203828_s_at Hs.943 natural killer cell transcript 4205440_s_at Hs.169266 neuropeptide Y receptor Y1 201467_s_at Hs.406515NAD(P)H dehydrogenase, quinone 1 204621_s_at Hs.82120 nuclear receptorsubfamily 4, group A, member 2 205040_at Hs.278388 orosomucoid 1205041_s_at Hs.278388 orosomucoid 1 214465_at Hs.278388 orosomucoid 1207921_x_at Hs.308061 paired box gene 8 207923_x_at Hs.308061 paired boxgene 8 207924_x_at Hs.308061 paired box gene 8 209552_at Hs.308061paired box gene 8 214528_s_at Hs.308061 paired box gene 8 221990_atHs.308061 paired box gene 8 204200_s_at Hs.1976 platelet-derived growthfactor beta polypeptide 216055_at Hs.1976 platelet-derived growth factorbeta polypeptide 216061_x_at Hs.1976 platelet-derived growth factor betapolypeptide 206803_at Hs.22584 prodynorphin 204213_at Hs.205126polymeric immunoglobulin receptor 203649_s_at Hs.76422 phospholipase A2,group IIA 205479_s_at Hs.77274 plasminogen activator, urokinase211668_s_at Hs.77274 plasminogen activator, urokinase 205125_at Hs.80776phospholipase C, delta 1 205720_at Hs.1897 proopiomelanocortin(beta-endorphin) 215705_at Hs.431861 protein phosphatase 5, catalyticsubunit 206278_at Hs.46 platelet-activating factor receptor 211663_x_atHs.446429 prostaglandin D2 synthase 21 kDa (brain) 211748_x_at Hs.446429prostaglandin D2 synthase 21 kDa (brain) 212187_x_at Hs.446429prostaglandin D2 synthase 21 kDa (brain) 207388_s_at Hs.146688prostaglandin E synthase 210367_s_at Hs.146688 prostaglandin E synthase208131_s_at Hs.302085 prostaglandin I2 (prostacyclin) synthase210702_s_at Hs.302085 prostaglandin I2 (prostacyclin) synthase 204748_atHs.196384 prostaglandin-endoperoxide synthase 2 204201_s_at Hs.387553APO-1/CD95 (Fas)-associated phosphatase 206157_at Hs.2050pentaxin-related gene, rapidly induced by IL-1 beta 216994_s_atHs.122116 runt-related transcription factor 2 221282_x_at Hs.122116runt-related transcription factor 2 221283_at Hs.122116 runt-relatedtranscription factor 2 217728_at Hs.275243 S100 calcium binding proteinA6 (calcyclin) 208607_s_at Hs.1955 serum amyloid A2 214456_x_at Hs.1955serum amyloid A2 202071_at Hs.252189 syndecan 4 206211_at Hs.89546selectin E 206049_at Hs.73800 selectin P 202627_s_at Hs.414795 serine(or cysteine) proteinase inhibitor, clade E, member 1 202628_s_atHs.414795 serine (or cysteine) proteinase inhibitor, clade E, member 1210073_at Hs.408614 sialyltransferase 8A 215078_at Hs.384944 superoxidedismutase 2, mitochondrial 202935_s_at Hs.2316 SRY (sex determiningregion Y)-box 9 202936_s_at Hs.2316 SRY (sex determining region Y)-box 9213112_s_at Hs.182248 sequestosome 1 203010_at Hs.437058 signaltransducer and activator of transcription 5A 208049_s_at Hs.469066tachykinin receptor 1 210637_at Hs.469066 tachykinin receptor 1210294_at Hs.370937 TAP binding protein (tapasin) 209277_at Hs.438231tissue factor pathway inhibitor 2 209278_s_at Hs.438231 tissue factorpathway inhibitor 2 211003_x_at Hs.512708 transglutaminase 2 211573_x_atHs.512708 transglutaminase 2 216183_at Hs.512708 transglutaminase 2201107_s_at Hs.164226 thrombospondin 1 201108_s_at Hs.164226thrombospondin 1 201109_s_at Hs.164226 thrombospondin 1 201110_s_atHs.164226 thrombospondin 1 203083_at Hs.458354 thrombospondin 2201645_at Hs.98998 tenascin C (hexabrachion) 207113_s_at Hs.241570 tumornecrosis factor (TNF superfamily, member 2) 202509_s_at Hs.101382 tumornecrosis factor, alpha-induced protein 2 202510_s_at Hs.101382 tumornecrosis factor, alpha-induced protein 2 203508_at Hs.256278 tumornecrosis factor receptor superfamily, member 1B 205153_s_at Hs.504816tumor necrosis factor receptor superfamily, member 5 222292_at Hs.504816tumor necrosis factor receptor superfamily, member 5 211786_at Hs.193418tumor necrosis factor receptor superfamily, member 9 207892_at Hs.652tumor necrosis factor (ligand) superfamily, member 5 210865_at Hs.2007tumor necrosis factor (ligand) superfamily, member 6 211333_s_at Hs.2007tumor necrosis factor (ligand) superfamily, member 6 204413_at Hs.437575TNF receptor-associated factor 2 206067_s_at Hs.1145 Wilms tumor 1216953_s_at Hs.1145 Wilms tumor 1

TABLE 5A Apoptosis Genes (See tables reference 2) Log2 fluorescenceintensity D4 Probesets Ly1 (A1) Ly1 (A2) Ly1 (A3) Ly7 (B1) Ly7 (B2) Ly7(B3) Ly8 (C1) Ly8 (C2) Ly8 (C3) D4 (D1) D4 (D2) (D3) FDR Cutoff201715_s_at 7.49 7.34 7.38 7.81 7.43 7.20 7.58 7.31 7.42 7.52 7.26 7.31205013_s_at 6.80 6.61 7.16 8.05 8.54 7.91 6.83 6.96 6.09 8.08 8.97 8.50204833_at 7.13 6.79 6.97 6.46 6.26 6.45 7.08 6.86 7.26 6.87 6.70 7.01213026_at 7.90 7.23 7.61 7.16 6.45 6.79 7.93 7.41 7.72 7.15 6.91 7.43213930_at 4.96 4.73 4.68 4.51 4.47 4.51 4.97 4.54 4.72 4.64 4.52 4.68221666_s_at 8.11 8.25 8.15 5.95 5.54 5.61 8.25 7.98 8.13 5.49 5.41 5.201861_at 5.38 5.57 5.56 5.28 5.68 5.61 5.46 5.50 5.71 5.31 5.75 5.86209406_at 7.02 7.41 7.77 7.40 7.25 7.40 6.73 7.35 7.41 7.52 7.54 7.65217911_s_at 7.04 7.17 7.41 5.54 4.84 5.01 8.02 7.90 7.53 4.87 4.90 4.80202984_s_at 5.59 5.40 6.34 5.66 5.60 5.70 6.03 6.16 6.77 5.35 5.41 5.70202985_s_at 9.47 9.41 9.60 9.16 8.96 9.19 9.85 9.78 9.77 8.03 8.59 8.47203728_at 7.34 7.40 7.41 7.30 7.36 7.43 7.31 7.43 7.33 7.11 7.04 7.36208478_s_at 6.11 5.37 5.76 5.84 6.27 6.23 5.76 5.61 5.71 4.88 5.72 6.59211833_s_at 6.77 6.22 6.94 6.58 6.69 6.92 6.43 6.32 6.74 5.76 6.11 7.50205263_at 7.40 7.11 7.48 7.15 7.15 7.30 7.21 7.26 7.75 6.52 6.52 7.01208536_s_at 4.89 4.82 4.66 5.00 4.35 4.82 4.94 4.81 5.00 4.97 5.22 4.93222343_at 5.34 5.63 5.16 5.01 4.99 4.84 5.36 5.50 5.35 5.19 5.88 5.32205780_at 9.40 9.19 9.01 10.02 9.47 9.65 9.34 9.02 9.14 8.50 8.84 9.07220451_s_at 5.05 4.97 4.89 5.15 5.11 5.03 4.92 5.26 4.92 5.41 5.18 5.20221478_at 7.13 5.29 6.73 6.19 6.58 6.54 7.14 5.77 6.78 6.13 6.07 6.41221479_s_at 7.97 6.69 7.53 7.13 7.46 7.51 8.20 7.14 7.63 7.07 7.32 7.38204950_at 6.57 6.49 6.83 6.05 6.19 6.28 6.23 6.37 6.49 6.03 6.01 5.88220162_s_at 5.13 4.96 4.95 4.88 4.87 4.92 5.03 4.91 4.91 4.92 4.92 4.88209970_x_at 7.75 8.08 7.53 5.51 5.56 5.28 7.44 7.98 7.85 5.44 5.42 5.20211366_x_at 8.01 8.27 8.09 5.91 6.04 5.89 8.06 8.05 8.33 5.83 6.13 5.67211367_s_at 5.99 6.23 6.16 4.32 4.02 4.13 6.12 6.25 6.63 4.38 4.41 4.14211368_s_at 7.23 7.48 7.16 4.88 4.89 4.78 7.07 7.48 7.78 4.84 4.75 4.56202763_at 6.85 6.55 6.50 7.21 6.89 6.88 6.97 6.71 6.80 6.87 6.51 7.04209310_s_at 7.06 6.66 7.29 5.21 4.80 4.95 6.61 6.44 6.84 5.08 4.93 4.97213596_at 4.50 4.30 4.47 4.34 4.21 4.33 4.34 4.33 4.38 4.38 4.40 4.25209790_s_at 6.67 6.85 6.71 5.30 5.23 5.19 6.99 7.04 7.33 6.29 6.19 6.40211464_x_at 4.88 4.96 5.17 4.33 4.56 4.44 4.97 5.27 5.39 4.68 4.76 4.83222201_s_at 6.69 6.56 6.88 6.72 6.61 6.88 6.70 6.56 7.01 6.56 6.20 6.69221188_s_at 7.36 7.50 7.39 6.91 7.14 6.76 7.30 7.63 7.28 7.12 7.15 7.09209833_at 6.99 7.04 6.86 6.48 6.52 6.73 6.98 6.78 6.98 7.25 7.26 7.29201111_at 8.18 8.84 9.16 9.71 9.66 9.89 8.35 8.76 8.92 8.57 8.54 9.09201112_s_at 10.07 10.29 10.14 10.54 10.37 10.61 10.04 10.31 10.40 10.129.88 10.12 210766_s_at 9.10 9.59 9.33 9.77 9.60 9.70 9.21 9.53 9.58 9.068.99 9.27 202468_s_at 7.92 8.28 8.13 7.32 7.29 7.53 8.25 8.48 8.64 8.027.87 8.47 208905_at 12.04 12.19 12.14 11.95 11.77 11.92 12.05 12.1712.17 12.30 12.14 12.28 201095_at 8.80 8.75 8.51 8.92 8.84 8.66 8.578.36 8.37 8.29 8.50 8.47 208822_s_at 9.68 9.55 9.62 9.78 9.66 9.79 9.789.47 9.69 9.53 9.43 9.57 203890_s_at 6.39 6.33 6.45 6.65 6.41 6.62 6.696.37 6.70 6.24 6.65 6.41 203891_s_at 5.49 5.10 5.25 5.76 5.23 5.39 5.545.41 5.39 5.72 5.14 5.37 217840_at 9.40 8.97 8.91 9.08 9.05 8.71 9.408.91 8.84 8.80 8.83 8.81 202480_s_at 5.82 5.86 5.76 6.44 6.46 6.39 5.825.91 5.73 5.99 6.05 5.96 211255_x_at 5.35 5.38 5.42 5.76 6.23 6.15 5.245.22 5.06 5.60 5.69 5.68 215158_s_at 7.59 7.63 7.64 8.25 8.40 8.16 7.647.46 7.50 7.96 8.06 7.98 203277_at 8.42 8.50 8.15 8.90 8.84 8.48 8.548.51 8.30 8.43 8.64 8.18 219350_s_at 9.44 9.31 9.26 9.37 9.40 9.41 9.419.26 9.36 9.07 9.11 9.18 205554_s_at 5.34 5.35 5.26 5.52 5.25 5.43 5.655.39 5.60 5.54 5.44 5.47 209831_x_at 8.53 8.39 7.95 8.03 8.51 8.17 8.448.25 8.04 7.80 7.84 7.76 214992_s_at 6.95 6.24 5.85 6.30 6.84 6.29 6.626.12 6.25 5.51 5.56 5.30 208289_s_at 7.21 7.13 7.21 7.42 7.20 7.49 7.157.23 7.31 7.26 6.89 7.31 216396_s_at 8.60 8.55 8.70 8.69 9.03 9.03 8.618.70 8.54 8.55 8.96 8.80 202535_at 8.37 8.43 8.45 8.53 8.37 8.38 8.398.22 8.28 7.87 8.20 8.09 218080_x_at 8.63 8.78 8.39 9.31 9.52 9.52 8.658.56 8.87 9.13 9.17 9.24 202723_s_at 7.81 8.03 7.97 6.62 6.75 6.77 7.668.26 7.59 6.91 7.66 7.16 202724_s_at 8.53 8.70 9.02 7.33 7.44 7.24 8.638.85 8.29 8.29 8.70 8.15 204132_s_at 6.11 5.80 5.85 5.93 5.30 5.76 6.515.84 6.21 6.06 6.05 6.16 201635_s_at 9.05 8.88 9.03 8.94 8.89 9.14 9.128.85 9.26 8.91 9.10 9.34 201636_at 6.26 6.13 6.67 6.25 5.94 6.10 6.026.39 6.54 6.18 5.96 6.71 201637_s_at 9.55 9.26 9.58 9.54 9.45 9.72 9.689.40 9.71 9.50 9.55 9.96 203725_at 9.09 8.62 9.19 8.20 8.11 8.37 9.598.95 9.20 7.99 7.32 8.24 207574_s_at 7.55 6.78 6.81 6.37 6.11 6.33 7.736.90 7.36 7.45 7.12 7.56 209304_x_at 7.93 7.32 6.99 6.93 6.71 6.64 7.807.38 7.66 7.92 7.70 7.83 209305_s_at 7.57 6.94 6.82 6.59 6.37 6.71 7.516.69 7.25 7.40 7.40 7.39 214467_at 6.83 6.46 6.61 6.38 6.17 6.15 6.216.42 6.51 6.44 6.53 6.57 220864_s_at 10.48 10.34 10.40 10.40 10.41 10.1610.51 10.15 10.37 10.90 11.11 11.03 206864_s_at 5.75 5.74 6.60 4.93 4.994.90 6.34 5.97 5.98 4.47 4.58 4.49 206865_at 6.88 6.92 7.33 6.02 6.276.14 7.20 7.19 6.48 6.10 6.03 6.02 207180_s_at 7.89 7.83 7.60 6.13 5.546.22 7.98 7.64 8.01 7.50 7.50 7.57 209448_at 7.29 7.26 7.43 4.67 4.944.74 7.46 7.46 7.85 7.41 6.82 7.46 210253_at 5.84 6.14 5.94 5.06 5.075.11 5.89 5.97 6.30 5.83 5.64 5.88 209929_s_at 6.93 6.93 7.00 6.99 7.006.90 6.88 6.85 6.74 6.85 6.83 6.92 36004_at 8.59 8.64 8.38 8.44 8.668.44 8.53 8.56 8.33 8.60 8.66 8.42 203836_s_at 4.75 5.26 5.39 5.40 6.055.84 5.05 5.34 5.09 4.84 5.10 5.07 203837_at 4.91 4.95 5.12 5.20 5.515.26 4.69 5.02 4.77 4.82 4.89 4.86 202086_at 5.28 5.17 5.31 5.47 5.325.27 5.42 5.37 5.29 5.49 5.29 5.26 207738_s_at 4.51 4.58 4.63 4.20 4.444.20 4.71 4.74 4.58 4.59 5.48 5.16 217465_at 4.24 4.29 4.34 4.27 4.244.39 4.20 4.35 4.39 4.30 4.45 4.37 201502_s_at 9.28 8.98 8.75 9.09 9.148.67 9.01 8.78 8.68 9.09 9.69 9.61 204862_s_at 7.59 7.26 7.36 6.59 6.486.59 7.69 7.40 7.43 6.66 6.18 6.54 205851_at 5.87 6.41 6.30 5.74 5.715.79 5.99 6.13 5.95 5.60 5.61 5.54 204004_at 8.69 9.02 8.97 8.19 7.927.96 8.50 9.06 8.58 8.97 9.12 8.98 204005_s_at 5.37 5.63 5.98 5.03 4.805.12 5.24 5.26 5.64 5.80 5.60 5.89 204025_s_at 6.56 6.31 6.59 6.70 6.586.63 6.57 6.38 6.54 6.54 6.48 6.79 213581_at 8.25 8.61 8.56 7.88 7.797.68 8.32 8.65 8.59 8.05 7.83 8.06 202730_s_at 7.12 6.85 7.10 6.78 6.846.93 7.01 6.86 6.91 6.47 6.94 6.99 202731_at 7.40 7.15 7.83 7.14 7.067.28 7.44 7.18 7.55 6.96 7.20 7.38 212593_s_at 9.63 9.46 9.83 9.42 9.429.50 9.57 9.59 9.50 9.29 9.44 9.53 212594_at 5.65 5.16 5.88 5.13 4.934.84 5.59 5.38 5.46 5.55 5.32 6.08 219275_at 7.57 7.74 7.77 7.70 7.707.83 7.55 7.63 8.08 7.38 7.50 7.95 203415_at 8.96 8.79 8.98 9.00 8.858.99 8.70 8.53 8.72 8.84 8.85 9.02 217746_s_at 9.70 9.61 9.88 9.75 9.679.79 10.13 9.74 10.03 9.48 9.25 9.64 205512_s_at 8.95 9.24 9.21 8.818.81 8.87 9.20 9.17 9.46 8.95 9.31 9.37 207002_s_at 3.75 3.82 3.74 3.653.73 3.66 3.68 3.71 3.69 3.63 3.70 3.70 209318_x_at 3.93 3.92 3.94 3.833.92 3.96 3.82 3.98 3.97 3.89 3.90 3.93 216347_s_at 6.07 5.66 5.70 5.955.57 5.69 6.09 5.79 5.94 6.20 5.64 5.91 203089_s_at 7.78 7.72 7.44 8.218.02 8.08 7.79 7.50 7.61 7.97 8.07 8.11 211152_s_at 6.93 6.92 6.73 7.157.15 7.07 6.78 6.82 6.67 7.14 7.11 7.09 209941_at 6.82 6.04 6.28 6.486.24 6.40 6.70 6.41 6.52 7.03 7.10 7.13 209544_at 4.32 4.30 4.29 4.304.15 4.33 4.31 4.25 4.23 4.29 4.38 4.41 209545_s_at 8.73 8.32 8.08 7.957.82 7.89 8.39 8.18 8.47 8.14 8.21 8.11 218286_s_at 8.23 7.95 8.38 8.067.78 8.02 8.22 8.01 8.10 8.14 8.20 8.43 203489_at 9.28 9.15 9.05 8.688.61 8.57 9.58 9.52 9.74 8.63 8.95 8.81 210792_x_at 9.72 9.83 9.46 9.229.18 9.13 9.98 10.02 10.05 9.08 9.58 9.37 222030_at 5.94 6.06 6.03 5.986.15 5.96 6.01 6.15 6.02 5.80 5.95 5.86 202693_s_at 8.34 7.38 7.69 7.266.34 6.83 8.48 7.77 7.87 9.78 9.51 9.42 202695_s_at 5.70 5.56 5.72 5.705.51 5.74 5.86 5.58 5.71 7.20 7.48 7.39 205214_at 5.14 5.18 5.77 6.196.35 6.38 5.29 5.51 5.50 6.35 6.94 6.59 200976_s_at 8.89 8.51 8.65 8.228.05 8.18 9.08 8.77 9.01 8.45 8.63 8.76 200977_s_at 9.06 8.77 8.90 8.368.20 8.44 9.10 8.82 9.47 8.87 8.55 9.19 213786_at 4.27 4.16 4.42 4.144.26 4.21 4.23 4.32 4.39 4.20 4.28 4.62 201446_s_at 7.75 7.62 7.84 7.687.50 7.74 7.78 7.49 7.89 7.45 7.25 7.42 201447_at 6.71 6.33 6.53 6.126.28 6.38 6.35 6.12 6.28 6.09 5.86 6.34 201448_at 6.94 6.75 7.43 6.776.48 6.80 6.59 6.52 6.99 6.57 6.15 6.92 201449_at 5.61 5.51 5.90 5.665.52 5.60 5.26 5.56 5.75 5.05 4.98 5.41 201450_s_at 5.42 5.40 5.83 5.435.42 5.41 5.42 5.43 5.54 5.29 4.93 5.38 217052_x_at 5.83 5.69 5.88 5.925.92 5.81 5.79 5.80 5.75 5.98 5.86 5.87 217164_at 4.44 4.24 4.17 4.174.08 4.09 4.37 4.13 4.21 4.18 4.08 4.18 202406_s_at 9.80 9.75 9.65 9.819.67 9.80 9.81 9.73 9.92 9.25 9.26 9.67 217500_at 5.26 5.19 4.95 5.345.06 5.24 5.18 5.04 5.19 5.21 5.17 5.24 207643_s_at 6.10 5.91 5.76 6.196.29 5.86 5.93 5.93 5.72 5.09 5.22 5.32 215346_at 6.64 6.15 6.16 6.826.86 6.41 6.44 6.49 5.92 6.97 6.90 6.83 35150_at 8.56 8.35 8.22 8.428.72 8.53 8.28 8.41 8.06 8.67 8.99 8.50 204780_s_at 4.90 4.78 4.86 4.904.93 5.00 4.59 4.62 4.82 4.71 4.65 4.78 215719_x_at 4.38 4.20 4.35 4.434.35 4.40 4.00 4.26 4.28 4.07 4.27 4.15 216252_x_at 4.83 4.65 4.67 4.914.91 4.79 4.55 4.61 4.66 4.53 4.65 4.47 206150_at 9.36 8.87 9.24 7.957.97 7.90 9.42 9.00 8.86 9.66 9.62 9.70 207536_s_at 5.11 5.46 5.06 5.165.17 5.31 5.18 5.22 5.17 5.17 5.31 5.20 202687_s_at 4.47 4.44 4.24 3.954.07 4.00 4.33 4.39 4.41 4.06 4.09 4.01 202688_at 4.95 4.86 4.95 4.284.36 4.31 5.09 4.80 5.22 4.24 4.25 4.37 214329_x_at 3.74 3.82 3.96 3.583.66 3.63 3.75 3.91 3.88 3.58 3.77 3.63 206508_at 5.59 5.65 5.60 7.858.89 7.93 5.59 5.81 5.45 5.69 5.96 5.81 207216_at 6.14 6.11 6.05 6.686.95 6.86 6.21 6.28 5.95 6.27 6.32 6.03 206907_at 5.15 5.09 5.10 5.766.73 6.15 5.08 5.15 4.94 5.49 6.14 5.81 203120_at 6.09 6.27 6.23 5.605.57 5.66 5.93 6.21 6.14 5.28 5.32 5.09 209863_s_at 4.89 4.89 5.04 5.145.61 5.49 4.74 5.00 4.92 4.93 5.06 4.99 211193_at 4.37 4.60 4.38 4.354.52 4.50 4.33 4.43 4.42 4.50 4.45 4.47 1729_at 6.37 6.32 6.39 6.26 6.256.33 6.32 6.39 6.33 6.28 6.36 6.30 205599_at 5.00 5.55 5.30 5.47 6.035.60 5.07 5.44 5.16 5.51 5.90 5.51 208315_x_at 5.55 5.65 5.56 5.33 5.314.93 5.74 5.57 5.51 5.75 5.81 5.80 221571_at 7.09 6.94 7.35 5.83 5.465.85 6.77 6.73 6.93 7.26 7.41 7.60 202871_at 7.06 6.86 6.80 7.40 7.427.28 7.23 7.06 6.68 7.14 7.65 7.39 211899_s_at 7.63 7.52 7.46 7.86 8.188.14 7.56 7.39 7.10 7.55 8.36 7.84 204352_at 5.72 5.67 6.02 6.04 6.165.88 5.54 5.54 5.40 5.16 5.87 5.35 207953_at 4.94 5.25 5.11 5.09 5.124.98 5.05 5.30 4.88 5.01 4.92 5.02 208014_x_at 5.09 5.22 5.26 4.84 5.725.46 5.20 5.35 5.09 5.60 5.38 5.21 209364_at 6.32 6.16 6.06 6.06 6.056.11 6.35 6.16 6.40 6.32 6.61 6.60 221454_at 5.31 5.26 5.13 5.34 5.235.15 5.32 5.31 5.29 5.56 5.38 5.19 210025_s_at 6.03 6.03 5.71 6.03 5.835.87 5.88 5.90 5.94 6.24 5.90 5.90 210026_s_at 5.08 5.17 5.07 4.97 5.235.10 5.01 5.07 5.03 5.02 5.03 5.02 214207_s_at 4.85 4.79 4.74 4.86 4.834.79 4.96 4.90 4.71 4.94 4.99 4.89 220598_at 5.89 5.75 5.50 5.84 5.795.73 5.83 5.68 5.71 6.01 5.79 5.70 220599_s_at 5.41 5.36 5.47 5.54 5.445.40 5.30 5.52 5.40 5.37 5.57 5.58 220066_at 4.51 4.50 4.51 4.55 4.574.59 4.54 4.61 4.47 4.73 4.60 4.62 221073_s_at 7.60 7.63 7.40 7.24 7.417.30 7.53 7.47 7.47 7.45 7.24 7.07 206011_at 5.71 5.71 5.64 4.95 4.895.07 5.44 5.83 5.76 5.12 5.10 5.17 207500_at 4.76 4.79 4.81 4.72 4.794.63 4.81 4.81 4.79 4.78 4.97 4.73 208791_at 4.89 4.94 4.95 4.93 5.075.05 4.79 4.85 4.88 5.14 4.94 4.90 208792_s_at 5.08 4.98 4.94 5.13 4.875.05 5.00 5.05 5.05 5.26 5.05 5.00 222043_at 4.35 4.37 4.38 4.29 4.504.37 4.26 4.33 4.23 4.41 4.43 4.34 210765_at 5.49 5.46 5.50 5.64 5.555.80 5.40 5.56 5.40 5.55 5.51 5.54 213712_at 4.21 4.07 3.99 4.09 4.153.99 4.09 3.95 4.10 4.23 4.06 4.15 203139_at 4.74 5.00 5.17 4.68 4.994.93 4.77 4.96 4.67 4.95 4.98 4.85 218325_s_at 6.13 6.75 6.70 6.35 6.756.66 6.06 6.79 6.49 5.79 6.45 5.83 206939_at 4.39 4.49 4.67 4.48 4.654.55 4.47 4.74 4.47 4.67 4.74 4.60 210165_at 5.44 5.45 5.33 5.44 5.625.35 5.39 5.41 5.05 5.58 5.73 5.43 210655_s_at 6.86 6.41 6.06 6.12 5.926.05 6.66 6.41 6.48 6.36 6.57 6.39 213560_at 5.74 5.81 5.58 5.53 5.795.52 5.60 5.68 5.57 5.63 5.63 5.58 204121_at 4.46 4.63 4.42 4.67 4.614.67 4.67 4.68 4.64 4.79 4.89 4.70 205848_at 3.88 4.02 3.90 3.86 3.883.90 3.84 3.93 3.89 3.82 4.02 3.88 208000_at 5.69 5.89 5.89 5.78 5.726.05 5.71 5.78 5.92 6.06 6.05 5.88 205488_at 4.57 4.45 4.44 4.51 4.404.49 4.51 4.49 4.46 4.70 4.57 4.53 210164_at 4.43 4.47 4.35 4.39 4.334.37 4.40 4.27 4.27 4.49 4.41 4.37 210321_at 4.93 5.23 4.77 5.03 5.034.95 5.12 5.04 5.00 5.13 5.21 5.07 206863_x_at 4.78 4.58 4.46 4.74 4.764.46 4.61 4.60 4.50 4.66 4.68 4.50 207062_at 4.27 4.35 4.43 4.28 4.494.53 4.10 4.41 4.27 4.32 4.38 4.36 206975_at 5.18 5.31 5.23 5.18 5.255.13 5.49 5.45 5.12 5.38 6.09 5.30 203005_at 5.39 5.35 5.25 5.47 5.275.12 5.62 5.42 5.10 5.66 5.38 5.30 205858_at 4.54 4.55 4.46 4.63 4.434.61 4.57 4.64 4.36 4.62 4.50 4.53 220402_at 4.06 4.01 4.15 4.01 4.214.05 3.98 4.09 4.08 4.06 4.09 4.08 220403_s_at 4.71 4.63 4.63 4.73 4.704.64 4.86 4.69 4.68 4.86 4.74 4.71 214090_at 3.92 4.10 4.18 4.02 4.134.08 3.95 3.96 4.02 4.02 4.25 4.17 214237_x_at 5.58 5.52 5.46 5.71 5.415.50 5.50 5.64 5.57 5.83 5.75 5.59 207634_at 5.73 5.79 5.41 5.66 5.805.69 5.59 6.06 5.52 5.86 5.68 5.60 213585_s_at 6.04 6.08 6.08 6.01 6.086.14 5.89 6.12 5.93 6.03 6.17 5.97 222152_at 5.25 5.20 5.19 5.17 5.295.21 5.15 5.21 5.13 5.52 5.16 5.30 207943_x_at 3.89 4.05 3.99 3.87 4.004.01 3.92 3.96 4.01 3.93 3.94 3.95 218849_s_at 5.97 5.82 5.83 5.89 5.976.07 5.74 5.93 5.91 5.91 6.02 5.97 207468_s_at 4.50 4.48 4.34 4.62 4.504.52 4.57 4.52 4.40 4.57 4.55 4.48 202694_at 4.38 4.55 4.63 4.23 4.524.41 4.41 4.47 4.43 4.45 4.60 4.63 206222_at 4.61 4.55 4.45 4.59 4.424.54 4.51 4.54 4.62 4.78 4.55 4.54 211163_s_at 4.67 4.57 4.53 4.71 4.474.65 4.65 4.54 4.66 4.85 4.68 4.68 210654_at 5.17 4.86 4.83 4.94 4.894.96 5.28 4.89 4.93 5.01 5.03 5.07 210847_x_at 4.91 5.00 4.85 5.02 5.044.82 5.03 5.11 4.92 5.23 5.23 4.89 211282_x_at 5.86 6.00 5.84 5.97 5.965.93 5.90 6.08 5.88 6.36 6.28 5.89 211841_s_at 5.74 5.87 5.59 5.80 5.825.81 5.88 5.81 5.80 6.08 5.85 5.76 216042_at 6.20 6.41 6.49 6.45 6.506.47 6.43 6.48 6.39 6.54 6.51 6.40 219422_at 4.87 4.97 4.78 5.02 5.074.91 5.02 5.00 4.89 5.22 4.93 4.85 219423_x_at 5.37 5.36 5.32 5.35 5.205.38 5.27 5.35 5.26 5.45 5.37 5.30 205153_s_at 5.94 5.42 5.24 6.04 6.246.03 5.75 5.47 5.33 6.25 6.50 6.10 222292_at 4.59 4.65 4.73 4.57 4.654.52 4.51 4.47 4.60 4.66 4.67 4.85 204781_s_at 5.53 5.72 5.57 5.90 5.745.89 5.33 5.36 5.67 5.53 5.76 5.52 211786_at 4.61 4.53 4.49 4.64 4.534.64 4.52 4.65 4.62 4.71 4.76 4.67 207907_at 4.98 4.62 4.72 5.11 4.724.74 5.00 4.87 4.78 5.11 5.00 4.92 207892_at 5.42 5.61 5.56 5.39 5.635.56 5.52 5.57 5.49 5.79 5.62 5.57 210865_at 5.13 5.25 4.92 5.08 5.064.81 5.02 4.99 4.64 5.23 5.19 4.97 211333_s_at 4.60 4.61 4.38 4.69 4.654.65 4.48 4.51 4.53 4.61 4.71 4.46 220804_s_at 4.87 4.91 4.80 5.16 4.875.00 4.99 4.91 5.03 5.34 5.06 5.12 207382_at 5.47 5.47 5.56 5.45 5.395.49 5.01 5.50 5.43 5.52 5.44 5.54 211194_s_at 4.44 4.51 4.48 4.46 4.654.65 4.41 4.42 4.35 4.42 4.67 4.49 211195_s_at 5.10 5.42 5.38 4.98 5.355.36 5.08 5.46 5.19 5.27 5.34 5.40 211834_s_at 4.82 4.91 4.73 4.96 4.844.82 4.95 4.97 4.79 5.01 4.88 4.63 205641_s_at 6.94 6.99 6.88 6.96 6.836.62 7.00 7.03 6.98 7.00 7.02 6.90 213443_at 5.19 5.29 5.31 5.18 5.285.19 5.33 5.23 5.26 5.43 5.33 5.21

TABLE 5B Apoptosis Genes (See tables reference 2) t-test (two-tailed)Probesets pAB pAD pBC pCD Measured Changed Gene Symbol FDR Cutoff1.0E−02 8.2E−03 1.2E−02 9.4E−03 AC v. BD AC v. BD 201715_s_at 7.2E−016.7E−01 8.4E−01 5.4E−01 Yes No ACINUS 205013_s_at 6.6E−03 9.0E−031.2E−02 7.2E−03 Yes No ADORA2A 204833_at 1.1E−02 5.0E−01 1.3E−02 2.4E−01Yes No APG12L 213026_at 5.1E−02 1.7E−01 2.9E−02 6.9E−02 Yes No APG12L213930_at 7.4E−02 1.7E−01 1.8E−01 4.1E−01 Yes No APG12L 221666_s_at9.7E−04 1.0E−04 2.5E−04 2.1E−05 Yes Yes ASC 1861_at 9.1E−01 5.2E−018.4E−01 6.8E−01 Yes No BAD 209406_at 8.6E−01 5.1E−01 4.8E−01 2.0E−01 YesNo BAG2 217911_s_at 3.2E−03 1.1E−03 8.4E−04 1.7E−03 Yes Yes BAG3202984_s_at 7.3E−01 4.3E−01 9.9E−02 4.9E−02 Yes No BAG5 202985_s_at1.5E−02 1.5E−02 5.9E−03 1.2E−02 Yes No BAG5 203728_at 6.6E−01 1.5E−018.7E−01 1.9E−01 Yes No BAK1 208478_s_at 2.4E−01 9.8E−01 8.1E−02 9.5E−01Yes No BAX 211833_s_at 7.5E−01 7.7E−01 2.2E−01 9.5E−01 Yes No BAX205263_at 3.9E−01 3.7E−02 3.6E−01 3.9E−02 Yes No BCL10 208536_s_at7.7E−01 9.9E−02 4.2E−01 3.4E−01 Yes No BCL2L11 222343_at 7.3E−02 7.5E−013.1E−03 8.1E−01 Yes No BCL2L11 205780_at 6.5E−02 1.3E−01 5.4E−02 1.5E−01Yes No BIK 220451_s_at 9.6E−02 3.6E−02 6.6E−01 1.8E−01 Yes No BIRC7221478_at 9.4E−01 7.8E−01 7.8E−01 4.7E−01 Yes No BNIP3L 221479_s_at9.4E−01 7.4E−01 4.5E−01 3.2E−01 Yes No BNIP3L 204950_at 2.7E−02 1.3E−021.4E−01 1.8E−02 Yes No CARD8 220162_s_at 1.7E−01 2.2E−01 2.8E−01 3.9E−01Yes No CARD9 209970_x_at 8.9E−04 1.0E−03 1.0E−03 1.2E−03 Yes Yes CASP1211366_x_at 8.1E−05 5.4E−04 2.4E−04 3.5E−04 Yes Yes CASP1 211367_s_at8.7E−05 1.1E−04 8.7E−04 1.1E−03 Yes Yes CASP1 211368_s_at 4.8E−043.8E−05 5.3E−03 2.2E−03 Yes Yes CASP1 202763_at 8.2E−02 4.2E−01 2.9E−019.1E−01 Yes No CASP3 209310_s_at 1.5E−03 6.0E−03 6.1E−04 2.0E−03 Yes YesCASP4 213596_at 1.7E−01 3.7E−01 3.1E−01 9.1E−01 Yes No CASP4 209790_s_at1.1E−04 5.7E−03 1.7E−03 5.6E−03 Yes Yes CASP6 211464_x_at 7.9E−038.8E−02 1.2E−02 5.8E−02 Yes No CASP6 222201_s_at 8.5E−01 2.8E−01 8.9E−012.4E−01 Yes No CASP8AP2 221188_s_at 3.6E−02 9.0E−03 4.3E−02 1.3E−01 YesNo CIDEB 209833_at 2.0E−02 2.6E−02 3.2E−02 2.9E−02 Yes No CRADD201111_at 6.3E−02 9.8E−01 1.4E−02 8.2E−01 Yes No CSE1L 201112_s_at2.5E−02 2.8E−01 1.3E−01 2.0E−01 Yes No CSE1L 210766_s_at 1.2E−01 2.5E−011.5E−01 8.4E−02 Yes No CSE1L 202468_s_at 6.5E−03 9.5E−01 2.4E−03 2.1E−01Yes No CTNNAL1 208905_at 3.2E−02 1.6E−01 2.7E−02 1.6E−01 Yes No CYCS201095_at 3.7E−01 8.5E−02 2.3E−02 8.9E−01 Yes No DAP 208822_s_at 9.5E−021.4E−01 4.2E−01 2.8E−01 Yes No DAP3 203890_s_at 1.5E−01 7.6E−01 8.4E−013.9E−01 Yes No DAPK3 203891_s_at 4.3E−01 5.7E−01 9.5E−01 8.6E−01 Yes NoDAPK3 217840_at 5.0E−01 2.2E−01 6.6E−01 3.1E−01 Yes No DDX41 202480_s_at1.0E−04 8.0E−03 2.7E−03 5.3E−02 Yes No DEDD 211255_x_at 4.3E−02 2.5E−031.7E−02 4.4E−03 Yes No DEDD 215158_s_at 8.7E−03 1.8E−03 1.3E−03 4.2E−03Yes Yes DEDD 203277_at 8.8E−02 7.4E−01 1.4E−01 8.5E−01 Yes No DFFA219350_s_at 4.2E−01 3.8E−02 3.8E−01 1.9E−02 Yes No DIABLO 205554_s_at4.0E−01 1.5E−02 2.7E−01 5.2E−01 Yes No DNASE1L3 209831_x_at 8.3E−011.1E−01 9.7E−01 5.6E−02 Yes No DNASE2 214992_s_at 7.4E−01 1.0E−015.6E−01 1.3E−02 Yes No DNASE2 208289_s_at 1.6E−01 8.6E−01 2.5E−016.5E−01 Yes No EI24 216396_s_at 1.0E−01 3.3E−01 1.0E−01 3.3E−01 Yes NoEI24 202535_at 8.6E−01 5.8E−02 1.4E−01 1.1E−01 Yes No FADD 218080_x_at5.5E−03 2.7E−02 3.3E−03 2.2E−02 Yes No FAF1 202723_s_at 1.8E−04 7.7E−022.8E−02 1.2E−01 Yes No FOXO1A 202724_s_at 4.8E−03 1.7E−01 1.0E−024.2E−01 Yes No FOXO1A 204132_s_at 3.2E−01 2.0E−01 1.3E−01 6.7E−01 Yes NoFOXO3A 201635_s_at 9.6E−01 4.2E−01 5.9E−01 8.3E−01 Yes No FXR1 201636_at2.6E−01 8.2E−01 3.1E−01 9.1E−01 Yes No FXR1 201637_s_at 4.4E−01 3.0E−018.6E−01 6.9E−01 Yes No FXR1 203725_at 3.6E−02 3.5E−02 2.0E−02 1.8E−02Yes No GADD45A 207574_s_at 8.1E−02 3.3E−01 3.6E−02 8.8E−01 Yes NoGADD45B 209304_x_at 1.3E−01 2.8E−01 6.8E−03 2.4E−01 Yes No GADD45B209305_s_at 1.2E−01 3.4E−01 1.2E−01 4.1E−01 Yes No GADD45B 214467_at4.4E−02 3.9E−01 2.8E−01 2.8E−01 Yes No GPR65 220864_s_at 4.4E−01 1.8E−039.0E−01 1.0E−02 Yes No GRIM19 206864_s_at 6.1E−02 3.2E−02 8.5E−033.5E−03 Yes No HRK 206865_at 1.1E−02 1.8E−02 6.5E−02 6.1E−02 Yes No HRK207180_s_at 6.7E−03 9.8E−02 3.9E−03 9.0E−02 Yes No HTATIP2 209448_at5.1E−05 6.9E−01 1.9E−04 2.3E−01 Yes No HTATIP2 210253_at 7.9E−03 1.7E−011.5E−02 1.6E−01 Yes No HTATIP2 209929_s_at 7.6E−01 7.5E−02 5.9E−024.6E−01 Yes No IKBKG 36004_at 8.4E−01 8.5E−01 7.1E−01 4.5E−01 Yes NoIKBKG 203836_s_at 8.2E−02 5.9E−01 6.9E−02 2.7E−01 Yes No MAP3K5203837_at 5.5E−02 1.6E−01 2.3E−02 8.1E−01 Yes No MAP3K5 202086_at2.5E−01 3.4E−01 9.3E−01 8.7E−01 Yes No MX1 207738_s_at 5.3E−02 1.9E−012.1E−02 2.7E−01 Yes No NCKAP1 217465_at 9.1E−01 2.0E−01 8.5E−01 4.4E−01Yes No NCKAP1 201502_s_at 8.8E−01 1.3E−01 4.7E−01 5.5E−02 Yes No NFKBIA204862_s_at 7.1E−03 8.4E−03 4.2E−03 6.2E−03 Yes No NME3 205851_at1.1E−01 6.4E−02 2.4E−02 8.1E−03 Yes No NME6 204004_at 3.4E−03 3.4E−014.2E−02 2.1E−01 Yes No PAWR 204005_s_at 4.2E−02 6.1E−01 7.6E−02 8.0E−02Yes No PAWR 204025_s_at 2.3E−01 4.3E−01 1.2E−01 4.1E−01 Yes No PDCD2213581_at 1.1E−02 2.7E−02 6.1E−03 1.5E−02 Yes No PDCD2 202730_s_at1.8E−01 3.2E−01 3.0E−01 5.3E−01 Yes No PDCD4 202731_at 2.7E−01 3.1E−011.6E−01 2.7E−01 Yes No PDCD4 212593_s_at 2.1E−01 1.7E−01 5.5E−02 2.0E−01Yes No PDCD4 212594_at 9.0E−02 8.0E−01 1.0E−02 5.3E−01 Yes No PDCD4219275_at 5.6E−01 6.9E−01 9.5E−01 5.8E−01 Yes No PDCD5 203415_at 6.7E−019.4E−01 2.2E−02 4.3E−02 Yes No PDCD6 217746_s_at 9.2E−01 1.3E−01 1.8E−013.4E−02 Yes No PDCD6IP 205512_s_at 7.9E−02 6.7E−01 3.7E−02 7.0E−01 YesNo PDCD8 207002_s_at 6.9E−02 5.4E−02 6.4E−01 5.8E−01 Yes No PLAGL1209318_x_at 5.6E−01 1.8E−01 7.6E−01 7.9E−01 Yes No PLAGL1 216347_s_at6.8E−01 6.5E−01 2.3E−01 8.9E−01 Yes No PPP1R13B 203089_s_at 3.0E−024.5E−02 1.3E−02 2.1E−02 Yes No PRSS25 211152_s_at 4.0E−02 5.4E−025.6E−03 1.2E−02 Yes No PRSS25 209941_at 9.7E−01 9.0E−02 2.0E−01 1.6E−02Yes No RIPK1 209544_at 5.3E−01 2.6E−01 9.8E−01 9.8E−02 Yes No RIPK2209545_s_at 1.2E−01 3.6E−01 2.0E−02 1.4E−01 Yes No RIPK2 218286_s_at2.1E−01 6.7E−01 2.2E−01 2.4E−01 Yes No RNF7 203489_at 5.8E−03 4.1E−029.7E−04 3.2E−03 Yes No SIVA 210792_x_at 3.7E−02 1.5E−01 2.4E−05 4.0E−02Yes No SIVA 222030_at 8.1E−01 6.7E−02 7.1E−01 3.7E−02 Yes No SIVA202693_s_at 6.2E−02 1.5E−02 2.5E−02 9.4E−03 Yes No STK17A 202695_s_at9.0E−01 2.1E−04 5.6E−01 1.5E−04 Yes No STK17A 205214_at 3.5E−02 9.7E−039.1E−04 1.1E−02 Yes No STK17B 200976_s_at 2.7E−02 6.4E−01 4.8E−035.9E−02 Yes No TAX1BP1 200977_s_at 6.7E−03 8.6E−01 3.8E−02 3.8E−01 YesNo TAX1BP1 213786_at 4.0E−01 6.1E−01 1.3E−01 7.4E−01 Yes No TAX1BP1201446_s_at 3.7E−01 1.5E−02 6.1E−01 8.0E−02 Yes No TIA1 201447_at1.2E−01 7.7E−02 9.2E−01 4.0E−01 Yes No TIA1 201448_at 2.2E−01 1.8E−019.4E−01 6.0E−01 Yes No TIA1 201449_at 5.9E−01 4.3E−02 6.7E−01 1.3E−01Yes No TIA1 201450_s_at 4.5E−01 1.5E−01 3.5E−01 1.8E−01 Yes No TIA1217052_x_at 3.0E−01 2.1E−01 9.7E−02 7.7E−02 Yes No TIA1 217164_at1.6E−01 2.3E−01 2.1E−01 3.3E−01 Yes No TIA1 202406_s_at 6.7E−01 1.2E−014.8E−01 7.8E−02 Yes No TIAL1 217500_at 5.6E−01 5.1E−01 4.9E−01 3.0E−01Yes No TIAL1 207643_s_at 3.2E−01 5.6E−03 1.8E−01 2.6E−03 Yes No TNFRSF1A215346_at 1.6E−01 6.1E−02 1.5E−01 7.0E−02 Yes No TNFRSF5 35150_at2.5E−01 1.3E−01 8.9E−02 6.3E−02 Yes No TNFRSF5 204780_s_at 1.0E−015.7E−02 5.1E−02 6.6E−01 Yes No TNFRSF6 215719_x_at 2.9E−01 1.4E−011.3E−01 8.9E−01 Yes No TNFRSF6 216252_x_at 1.1E−01 1.0E−01 8.6E−034.0E−01 Yes No TNFRSF6 206150_at 1.3E−02 7.4E−02 1.9E−02 7.5E−02 Yes NoTNFRSF7 207536_s_at 9.7E−01 9.3E−01 6.4E−01 5.0E−01 Yes No TNFRSF9202687_s_at 2.2E−02 3.8E−02 1.4E−03 6.6E−04 Yes No TNFSF10 202688_at1.7E−04 3.6E−04 2.5E−02 1.8E−02 Yes No TNFSF10 214329_x_at 6.8E−021.1E−01 3.2E−02 7.6E−02 Yes No TNFSF10 206508_at 1.6E−02 1.2E−01 1.0E−022.1E−01 Yes No TNFSF7 207216_at 7.1E−03 3.6E−01 6.7E−03 6.7E−01 Yes NoTNFSF8 206907_at 5.9E−02 6.2E−02 4.9E−02 4.4E−02 Yes No TNFSF9 203120_at2.8E−03 6.3E−04 2.1E−02 1.5E−03 Yes No TP53BP2 209863_s_at 6.4E−024.2E−01 4.3E−02 2.9E−01 Yes No TP73L 211193_at 9.3E−01 7.6E−01 3.8E−011.0E−01 Yes No TP73L 1729_at 8.2E−02 2.1E−01 1.3E−01 3.6E−01 Yes NoTRADD 205599_at 1.5E−01 1.6E−01 8.5E−02 7.2E−02 Yes No TRAF1 208315_x_at8.4E−02 1.4E−02 6.4E−02 1.2E−01 Yes No TRAF3 221571_at 1.3E−03 1.3E−015.2E−03 9.5E−03 Yes No TRAF3 202871_at 1.2E−02 6.0E−02 1.3E−01 1.4E−01Yes No TRAF4 211899_s_at 2.0E−02 2.5E−01 1.6E−02 1.2E−01 Yes No TRAF4204352_at 1.8E−01 2.5E−01 9.0E−03 8.9E−01 Yes No TRAF5 207953_at 7.8E−013.4E−01 9.5E−01 5.4E−01 No No AD7C-NTP 208014_x_at 6.3E−01 2.0E−016.8E−01 2.6E−01 No No AD7C-NTP 209364_at 2.9E−01 5.6E−02 8.0E−02 1.6E−01No No BAD 221454_at 9.5E−01 3.2E−01 3.3E−01 5.7E−01 No No BOK210025_s_at 9.1E−01 5.9E−01 9.9E−01 4.5E−01 No No CARD10 210026_s_at9.4E−01 1.1E−01 5.0E−01 4.1E−01 No No CARD10 214207_s_at 4.1E−01 2.5E−027.8E−01 3.8E−01 No No CARD10 220598_at 6.1E−01 4.6E−01 4.7E−01 4.2E−01No No CARD14 220599_s_at 4.5E−01 3.3E−01 5.4E−01 3.6E−01 No No CARD14220066_at 1.3E−02 6.4E−02 5.2E−01 1.1E−01 No No CARD15 221073_s_at7.3E−02 1.1E−01 6.1E−02 1.7E−01 No No CARD4 206011_at 2.0E−03 5.4E−051.4E−02 4.0E−02 No No CASP1 207500_at 2.6E−01 6.3E−01 1.9E−01 7.7E−01 NoNo CASP5 208791_at 1.7E−01 4.6E−01 3.9E−02 1.7E−01 No No CLU 208792_s_at8.5E−01 3.4E−01 8.5E−01 4.9E−01 No No CLU 222043_at 7.9E−01 4.7E−011.9E−01 4.2E−02 No No CLU 210765_at 1.4E−01 3.4E−02 9.5E−02 2.8E−01 NoNo CSE1L 213712_at 8.7E−01 5.2E−01 6.5E−01 2.0E−01 No No CTNNAL1203139_at 5.5E−01 7.5E−01 6.3E−01 2.9E−01 No No DAPK1 218325_s_at8.0E−01 1.6E−01 6.0E−01 2.3E−01 No No DATF1 206939_at 6.7E−01 1.8E−019.9E−01 3.4E−01 No No DCC 210165_at 5.3E−01 1.7E−01 2.7E−01 1.2E−01 NoNo DNASE1 210655_s_at 2.1E−01 9.8E−01 7.2E−03 4.5E−01 No No FOXO3A213560_at 4.5E−01 3.1E−01 9.9E−01 9.7E−01 No No GADD45B 204121_at1.4E−01 2.8E−02 5.7E−01 1.4E−01 No No GADD45G 205848_at 3.4E−01 7.6E−018.0E−01 7.6E−01 No No GAS2 208000_at 8.4E−01 1.3E−01 6.9E−01 8.2E−02 NoNo GML 205488_at 7.6E−01 1.6E−01 6.1E−01 1.5E−01 No No GZMA 210164_at2.8E−01 8.9E−01 3.5E−01 1.1E−01 No No GZMB 210321_at 8.6E−01 3.6E−013.2E−01 2.2E−01 No No GZMH 206863_x_at 7.6E−01 9.5E−01 4.9E−01 5.4E−01No No HRK 207062_at 4.2E−01 9.6E−01 2.2E−01 4.0E−01 No No IAPP 206975_at3.5E−01 2.9E−01 2.8E−01 4.6E−01 No No LTA 203005_at 7.3E−01 4.0E−016.4E−01 7.5E−01 No No LTBR 205858_at 6.3E−01 5.5E−01 7.7E−01 7.9E−01 NoNo NGFR 220402_at 8.4E−01 9.2E−01 6.3E−01 5.4E−01 No No P53AIP1220403_s_at 4.4E−01 1.3E−01 4.7E−01 7.7E−01 No No P53AIP1 214090_at9.1E−01 4.7E−01 7.2E−02 1.0E−01 No No PAWR 214237_x_at 8.2E−01 7.7E−027.8E−01 1.5E−01 No No PAWR 207634_at 6.2E−01 6.6E−01 9.7E−01 9.6E−01 NoNo PDCD1 213585_s_at 8.5E−01 8.7E−01 3.0E−01 4.3E−01 No No PDCD2222152_at 8.3E−01 4.0E−01 2.2E−01 2.5E−01 No No PDCD6 207943_x_at7.6E−01 5.0E−01 9.0E−01 4.5E−01 No No PLAGL1 218849_s_at 2.3E−01 1.9E−012.1E−01 1.9E−01 No No RAI 207468_s_at 1.6E−01 1.9E−01 4.8E−01 5.7E−01 NoNo SFRP5 202694_at 2.9E−01 6.7E−01 6.1E−01 1.5E−01 No No STK17A206222_at 7.5E−01 4.2E−01 5.5E−01 5.0E−01 No No TNFRSF10C 211163_s_at8.2E−01 1.1E−01 9.2E−01 1.7E−01 No No TNFRSF10C 210654_at 8.5E−015.2E−01 4.9E−01 9.8E−01 No No TNFRSF10D 210847_x_at 6.5E−01 2.2E−015.3E−01 5.1E−01 No No TNFRSF25 211282_x_at 4.2E−01 1.9E−01 9.9E−012.6E−01 No No TNFRSF25 211841_s_at 4.3E−01 2.5E−01 4.7E−01 5.6E−01 No NoTNFRSF25 216042_at 3.3E−01 3.1E−01 2.5E−01 3.5E−01 No No TNFRSF25219422_at 1.5E−01 3.7E−01 6.1E−01 8.0E−01 No No TNFRSF25 219423_x_at5.8E−01 6.7E−01 7.7E−01 2.0E−01 No No TNFRSF25 205153_s_at 1.0E−014.9E−02 2.3E−02 1.1E−02 No No TNFRSF5 222292_at 2.1E−01 4.4E−01 4.1E−016.6E−02 No No TNFRSF5 204781_s_at 4.1E−02 9.5E−01 5.2E−02 3.3E−01 No NoTNFRSF6 211786_at 2.9E−01 2.0E−02 9.3E−01 8.0E−02 No No TNFRSF9207907_at 6.4E−01 1.4E−01 8.7E−01 2.1E−01 No No TNFSF14 207892_at9.8E−01 2.2E−01 9.7E−01 1.8E−01 No No TNFSF5 210865_at 4.0E−01 8.3E−015.6E−01 1.8E−01 No No TNFSF6 211333_s_at 2.2E−01 5.8E−01 1.7E−03 3.2E−01No No TNFSF6 220804_s_at 2.1E−01 5.2E−02 7.5E−01 1.4E−01 No No TP73207382_at 2.6E−01 9.7E−01 4.9E−01 3.5E−01 No No TP73L 211194_s_at2.1E−01 62E−01 7.4E−02 2.2E−01 No No TP73L 211195_s_at 6.7E−01 7.9E−019.3E−01 5.3E−01 No No TP73L 211834_s_at 4.7E−01 8.6E−01 6.9E−01 6.5E−01No No TP73L 205641_s_at 3.3E−01 4.4E−01 1.8E−01 5.2E−01 No No TRADD213443_at 4.0E−01 4.3E−01 2.5E−01 4.9E−01 No No TRADD Probesets UniGeneID Gene Title FDR Cutoff 201715_s_at Hs.227133 apoptotic chromatincondensation inducer in the nucleus 205013_s_at Hs.197029 adenosine A2areceptor 204833_at Hs.264482 APG12 autophagy 12-like (S. cerevisiae)213026_at Hs.264482 APG12 autophagy 12-like (S. cerevisiae) 213930_atHs.264482 APG12 autophagy 12-like (S. cerevisiae) 221666_s_at Hs.197875apoptosis-associated speck-like protein containing a CARD 1861_atHs.76366 BCL2-antagonist of cell death 209406_at Hs.55220BCL2-associated athanogene 2 217911_s_at Hs.15259 BCL2-associatedathanogene 3 202984_s_at Hs.5443 BCL2-associated athanogene 5202985_s_at Hs.5443 BCL2-associated athanogene 5 203728_at Hs.93213BCL2-antagonist/killer 1 208478_s_at Hs.159428 BCL2-associated X protein211833_s_at Hs.159428 BCL2-associated X protein 205263_at Hs.193516B-cell CLL/lymphoma 10 208536_s_at Hs.84063 BCL2-like 11 (apoptosisfacilitator) 222343_at Hs.84063 BCL2-like 11 (apoptosis facilitator)205780_at Hs.155419 BCL2-interacting killer (apoptosis-inducing)220451_s_at Hs.256126 baculoviral IAP repeat-containing 7 (livin)221478_at Hs.132955 BCL2/adenovirus E1B 19 kDa interacting protein3-like 221479_s_at Hs.132955 BCL2/adenovirus E1B 19 kDa interactingprotein 3-like 204950_at Hs.446146 caspase recruitment domain family,member 8 220162_s_at Hs.271815 caspase recruitment domain family, member9 209970_x_at Hs.2490 caspase 1 211366_x_at Hs.2490 caspase 1211367_s_at Hs.2490 caspase 1 211368_s_at Hs.2490 caspase 1 202763_atHs.141125 caspase 3 209310_s_at Hs.74122 caspase 4 213596_at Hs.74122caspase 4 209790_s_at Hs.3280 caspase 6 211464_x_at Hs.3280 caspase 6222201_s_at Hs.122843 CASP8 associated protein 2 221188_s_at Hs.448590cell death-inducing DFFA-like effector b 209833_at Hs.155566 CASP2 andRIPK1 domain containing adaptor with death domain 201111_at Hs.90073CSE1 chromosome segregation 1-like (yeast) 201112_s_at Hs.90073 CSE1chromosome segregation 1-like (yeast) 210766_s_at Hs.90073 CSE1chromosome segregation 1-like (yeast) 202468_s_at Hs.58488 catenin(cadherin-associated protein), alpha-like 1 208905_at Hs.437060cytochrome c, somatic 201095_at Hs.75189 death-associated protein208822_s_at Hs.270920 death associated protein 3 203890_s_at Hs.153908death-associated protein kinase 3 203891_s_at Hs.153908 death-associatedprotein kinase 3 217840_at Hs.274317 DEAD (Asp-Glu-Ala-Asp) boxpolypeptide 41 202480_s_at Hs.169681 death effector domain containing211255_x_at Hs.169681 death effector domain containing 215158_s_atHs.169681 death effector domain containing 203277_at Hs.484782 DNAfragmentation factor, 45 kDa, alpha polypeptide 219350_s_at Hs.169611diablo homolog (Drosophila) 205554_s_at Hs.88646 deoxyribonucleaseI-like 3 209831_x_at Hs.118243 deoxyribonuclease II, lysosomal214992_s_at Hs.118243 deoxyribonuclease II, lysosomal 208289_s_atHs.343911 etoposide induced 2.4 mRNA 216396_s_at Hs.343911 etoposideinduced 2.4 mRNA 202535_at Hs.86131 Fas (TNFRSF6)-associated via deathdomain 218080_x_at Hs.12899 Fas (TNFRSF6) associated factor 1202723_s_at Hs.170133 forkhead box O1A (rhabdomyosarcoma) 202724_s_atHs.170133 forkhead box O1A (rhabdomyosarcoma) 204132_s_at Hs.14845forkhead box O3A 201635_s_at Hs.408096 fragile X mental retardation,autosomal homolog 1 201636_at Hs.408096 fragile X mental retardation,autosomal homolog 1 201637_s_at Hs.408096 fragile X mental retardation,autosomal homolog 1 203725_at Hs.80409 growth arrest andDNA-damage-inducible, alpha 207574_s_at Hs.110571 growth arrest andDNA-damage-inducible, beta 209304_x_at Hs.110571 growth arrest andDNA-damage-inducible, beta 209305_s_at Hs.110571 growth arrest andDNA-damage-inducible, beta 214467_at Hs.131924 G protein-coupledreceptor 65 220864_s_at Hs.279574 cell death-regulatory protein GRIM19206864_s_at Hs.87247 harakiri, BCL2 interacting protein (contains onlyBH3 domain) 206865_at Hs.87247 harakiri, BCL2 interacting protein(contains only BH3 domain) 207180_s_at Hs.90753 HIV-1 Tat interactiveprotein 2, 30 kDa 209448_at Hs.90753 HIV-1 Tat interactive protein 2, 30kDa 210253_at Hs.90753 HIV-1 Tat interactive protein 2, 30 kDa209929_s_at Hs.43505 inhibitor of kappa light polypeptide gene enhancerin B-cells, kinase gamma 36004_at Hs.43505 inhibitor of kappa lightpolypeptide gene enhancer in B-cells, kinase gamma 203836_s_at Hs.151988mitogen-activated protein kinase kinase kinase 5 203837_at Hs.151988mitogen-activated protein kinase kinase kinase 5 202086_at Hs.436836myxovirus (influenza virus) resistance 1 207738_s_at Hs.278411NCK-associated protein 1 217465_at Hs.278411 NCK-associated protein 1201502_s_at Hs.81328 nuclear factor of kappa light polypeptide geneenhancer in B-cells inhibitor, alpha 204862_s_at Hs.81687 non-metastaticcells 3, protein expressed in 205851_at Hs.465558 non-metastatic cells6, protein expressed in (nucleoside-diphosphate kinase) 204004_atHs.406074 PRKC, apoptosis, WT1, regulator 204005_s_at Hs.406074 PRKC,apoptosis, WT1, regulator 204025_s_at Hs.367900 programmed cell death 2213581_at Hs.367900 programmed cell death 2 202730_s_at Hs.257697programmed cell death 4 (neoplastic transformation inhibitor) 202731_atHs.257697 programmed cell death 4 (neoplastic transformation inhibitor)212593_s_at Hs.257697 programmed cell death 4 (neoplastic transformationinhibitor) 212594_at Hs.257697 programmed cell death 4 (neoplastictransformation inhibitor) 219275_at Hs.443831 programmed cell death 5203415_at Hs.24087 programmed cell death 6 217746_s_at Hs.9663programmed cell death 6 interacting protein 205512_s_at Hs.18720programmed cell death 8 (apoptosis- inducing factor) 207002_s_atHs.132911 pleiomorphic adenoma gene-like 1 209318_x_at Hs.132911pleiomorphic adenoma gene-like 1 216347_s_at Hs.371546 proteinphosphatase 1, regulatory (inhibitor) subunit 13B 203089_s_at Hs.115721protease, serine, 25 211152_s_at Hs.115721 protease, serine, 25209941_at Hs.390758 receptor (TNFRSF)-interacting serine- threoninekinase 1 209544_at Hs.103755 receptor-interacting serine-threoninekinase 2 209545_s_at Hs.103755 receptor-interacting serine-threoninekinase 2 218286_s_at Hs.512849 ring finger protein 7 203489_at Hs.112058CD27-binding (Siva) protein 210792_x_at Hs.112058 CD27-binding (Siva)protein 222030_at Hs.112058 CD27-binding (Siva) protein 202693_s_atHs.9075 serine/threonine kinase 17a (apoptosis- inducing) 202695_s_atHs.9075 serine/threonine kinase 17a (apoptosis- inducing) 205214_atHs.88297 serine/threonine kinase 17b (apoptosis- inducing) 200976_s_atHs.5437 Tax1 (human T-cell leukemia virus type I) binding protein 1200977_s_at Hs.5437 Tax1 (human T-cell leukemia virus type I) bindingprotein 1 213786_at Hs.5437 Tax1 (human T-cell leukemia virus type I)binding protein 1 201446_s_at Hs.391858 TIA1 cytotoxicgranule-associated RNA binding protein 201447_at Hs.391858 TIA1cytotoxic granule-associated RNA binding protein 201448_at Hs.391858TIA1 cytotoxic granule-associated RNA binding protein 201449_atHs.391858 TIA1 cytotoxic granule-associated RNA binding protein201450_s_at Hs.391858 TIA1 cytotoxic granule-associated RNA bindingprotein 217052_x_at Hs.391858 TIA1 cytotoxic granule-associated RNAbinding protein 217164_at Hs.391858 TIA1 cytotoxic granule-associatedRNA binding protein 202406_s_at Hs.335786 TIA1 cytotoxicgranule-associated RNA binding protein-like 1 217500_at Hs.335786 TIA1cytotoxic granule-associated RNA binding protein-like 1 207643_s_atHs.159 tumor necrosis factor receptor superfamily, member 1A 215346_atHs.504816 tumor necrosis factor receptor superfamily, member 5 35150_atHs.504816 tumor necrosis factor receptor superfamily, member 5204780_s_at Hs.82359 tumor necrosis factor receptor superfamily, member6 215719_x_at Hs.82359 tumor necrosis factor receptor superfamily,member 6 216252_x_at Hs.82359 tumor necrosis factor receptorsuperfamily, member 6 206150_at Hs.355307 tumor necrosis factor receptorsuperfamily, member 7 207536_s_at Hs.193418 tumor necrosis factorreceptor superfamily, member 9 202687_s_at Hs.387871 tumor necrosisfactor (ligand) superfamily, member 10 202688_at Hs.387871 tumornecrosis factor (ligand) superfamily, member 10 214329_x_at Hs.387871tumor necrosis factor (ligand) superfamily, member 10 206508_at Hs.99899tumor necrosis factor (ligand) superfamily, member 7 207216_at Hs.177136tumor necrosis factor (ligand) superfamily, member 8 206907_at Hs.1524tumor necrosis factor (ligand) superfamily, member 9 203120_at Hs.44585tumor protein p53 binding protein, 2 209863_s_at Hs.137569 tumor proteinp73-like 211193_at Hs.137569 tumor protein p73-like 1729_at Hs.89862TNFRSF1A-associated via death domain 205599_at Hs.438253 TNFreceptor-associated factor 1 208315_x_at Hs.297660 TNFreceptor-associated factor 3 221571_at Hs.297660 TNF receptor-associatedfactor 3 202871_at Hs.8375 TNF receptor-associated factor 4 211899_s_atHs.8375 TNF receptor-associated factor 4 204352_at Hs.385685 TNFreceptor-associated factor 5 207953_at Hs.129735 neuronal thread protein208014_x_at Hs.129735 neuronal thread protein 209364_at Hs.76366BCL2-antagonist of cell death 221454_at Hs.293753 /// BCL2-relatedovarian killer /// BCL2-related Hs.293753 ovarian killer 210025_s_atHs.57973 caspase recruitment domain family, member 10 210026_s_atHs.57973 caspase recruitment domain family, member 10 214207_s_atHs.57973 caspase recruitment domain family, member 10 220598_atHs.306227 caspase recruitment domain family, member 14 220599_s_atHs.306227 caspase recruitment domain family, member 14 220066_atHs.135201 caspase recruitment domain family, member 15 221073_s_atHs.19405 caspase recruitment domain family, member 4 206011_at Hs.2490caspase 1 207500_at Hs.213327 caspase 5, apoptosis-related cysteineprotease 208791_at Hs.436657 clusterin 208792_s_at Hs.436657 clusterin222043_at Hs.436657 clusterin 210765_at Hs.90073 CSE1 chromosomesegregation 1-like (yeast) 213712_at Hs.58488 catenin(cadherin-associated protein), alpha-like 1 203139_at Hs.244318death-associated protein kinase 1 218325_s_at Hs.438300 death associatedtranscription factor 1 206939_at Hs.172562 deleted in colorectalcarcinoma 210165_at Hs.436928 deoxyribonuclease I 210655_s_at Hs.14845forkhead box O3A 213560_at Hs.110571 growth arrest andDNA-damage-inducible, beta 204121_at Hs.9701 growth arrest andDNA-damage-inducible, gamma 205848_at Hs.135665 growth arrest-specific 2208000_at Hs.86161 GPI anchored molecule like protein 205488_at Hs.90708granzyme A 210164_at Hs.1051 granzyme B 210321_at Hs.348264 granzyme H206863_x_at Hs.87247 harakiri 207062_at Hs.142255 islet amyloidpolypeptide 206975_at Hs.36 lymphotoxin alpha (TNF superfamily,member 1) 203005_at Hs.1116 lymphotoxin beta receptor (TNFR superfamily,member 3) 205858_at Hs.415768 nerve growth factor receptor (TNFRsuperfamily, member 16) 220402_at Hs.160953 p53-regulatedapoptosis-inducing protein 1 220403_s_at Hs.160953 p53-regulatedapoptosis-inducing protein 1 214090_at Hs.406074 PRKC, apoptosis, WT1,regulator 214237_x_at Hs.406074 PRKC, apoptosis, WT1, regulator207634_at Hs.158297 programmed cell death 1 213585_s_at Hs.367900programmed cell death 2 222152_at Hs.24087 programmed cell death 6207943_x_at Hs.132911 pleiomorphic adenoma gene-like 1 218849_s_atHs.324051 ReIA-associated inhibitor 207468_s_at Hs.279565 secretedfrizzled-related protein 5 202694_at Hs.9075 serine/threonine kinase 17a(apoptosis- inducing) 206222_at Hs.119684 tumor necrosis factor receptorsuperfamily, member 10c, decoy without an intracellular domain211163_s_at Hs.119684 tumor necrosis factor receptor superfamily, member10c, decoy without an intracellular domain 210654_at Hs.129844 tumornecrosis factor receptor superfamily, member 10d, decoy with truncateddeath domain 210847_x_at Hs.299558 tumor necrosis factor receptorsuperfamily, member 25 211282_x_at Hs.299558 tumor necrosis factorreceptor superfamily, member 25 211841_s_at Hs.299558 tumor necrosisfactor receptor superfamily, member 25 216042_at Hs.299558 tumornecrosis factor receptor superfamily, member 25 219422_at Hs.299558tumor necrosis factor receptor superfamily, member 25 219423_x_atHs.299558 tumor necrosis factor receptor superfamily, member 25205153_s_at Hs.504816 tumor necrosis factor receptor superfamily, member5 222292_at Hs.504816 tumor necrosis factor receptor superfamily, member5 204781_s_at Hs.82359 tumor necrosis factor receptor superfamily,member 6 211786_at Hs.193418 /// tumor necrosis factor receptorsuperfamily, Hs.193418 member 9 207907_at Hs.129708 tumor necrosisfactor (ligand) superfamily, member 14 207892_at Hs.652 tumor necrosisfactor (ligand) superfamily, member 5 (hyper-IgM syndrome) 210865_atHs.2007 tumor necrosis factor (ligand) superfamily, member 6 211333_s_atHs.2007 tumor necrosis factor (ligand) superfamily, member 6 220804_s_atHs.192132 tumor protein p73 207382_at Hs.137569 tumor protein p73-like211194_s_at Hs.137569 tumor protein p73-like 211195_s_at Hs.137569 tumorprotein p73-like 211834_s_at Hs.137569 tumor protein p73-like205641_s_at Hs.89862 TNFRSF1A-associated via death domain 213443_atHs.89862 TNFRSF1A-associated via death domain

TABLE 6A Anti-apoptosis Genes (See tables reference 2) Log2 fluorescenceintensity Ly1 Ly1 Ly7 Probesets (A1) Ly1 (A2) (A3) Ly7 (B1) (B2) Ly7(B3) Ly8 (C1) Ly8 (C2) Ly8 (C3) D4 (D1) D4 (D2) D4 (D3) 209165_at 8.628.82 8.67 9.02 9.04 9.05 8.63 8.75 8.87 8.79 8.83 8.88 207163_s_at 8.378.44 8.22 8.02 7.99 7.73 8.91 8.88 9.02 7.82 8.07 8.05 219366_at 6.897.05 7.18 7.20 7.26 7.11 6.72 6.91 7.16 7.39 7.24 7.57 202387_at 8.528.61 8.78 8.20 8.16 8.25 8.52 8.55 8.67 8.88 9.19 9.28 211475_s_at 8.879.19 9.17 8.66 8.62 8.74 8.86 9.00 9.14 9.48 9.71 9.88 219624_at 4.354.34 4.42 4.54 4.47 4.64 4.35 4.41 4.63 4.53 4.44 4.65 203685_at 4.754.61 4.79 4.33 4.46 4.42 4.62 4.65 4.68 4.48 4.58 4.41 207005_s_at 6.626.60 6.62 6.35 6.12 5.92 7.06 6.73 6.62 6.53 6.85 6.23 205681_at 4.314.32 4.29 4.59 4.61 4.49 4.45 4.48 4.30 6.84 8.14 7.47 206665_s_at 4.494.59 4.55 4.82 4.99 4.84 4.70 4.49 4.54 4.63 4.57 4.51 212312_at 5.946.29 6.48 6.61 6.93 6.42 6.13 6.05 6.30 6.07 6.30 6.33 215037_s_at 6.266.14 6.06 6.32 6.32 6.15 6.21 6.00 5.84 5.72 6.04 5.80 209311_at 5.345.42 5.37 5.36 5.30 5.48 5.26 5.52 5.31 5.13 5.13 5.11 208945_s_at 7.707.53 7.75 7.37 7.22 7.31 7.78 7.50 7.93 7.41 7.17 7.54 208946_s_at 8.107.84 8.04 7.39 7.20 7.16 8.03 8.06 8.09 7.74 7.43 7.93 202076_at 8.638.09 8.59 8.79 8.32 8.73 8.67 8.13 8.76 7.56 7.54 8.28 210538_s_at 4.644.75 4.80 6.89 6.65 6.57 4.49 4.35 4.62 4.95 5.43 5.21 206536_s_at 4.284.41 4.82 4.26 4.40 4.42 4.42 4.48 4.62 4.25 4.44 4.33 202094_at 8.058.01 7.73 8.69 8.38 8.37 7.94 8.10 8.08 8.54 8.31 8.45 202095_s_at 9.089.07 8.69 8.95 8.59 8.79 8.92 8.79 9.01 9.52 9.38 9.59 210334_x_at 8.248.19 7.87 8.34 8.21 8.27 8.13 7.97 8.29 8.75 8.54 8.49 220451_s_at 5.054.97 4.89 5.15 5.11 5.03 4.92 5.26 4.92 5.41 5.18 5.20 204930_s_at 6.456.22 6.30 6.33 6.24 6.40 6.46 6.44 6.50 6.61 6.40 6.44 207829_s_at 6.536.20 6.04 6.06 5.97 5.91 6.29 5.82 6.14 6.09 6.25 6.11 37226_at 6.075.86 5.75 5.62 5.75 5.71 5.90 5.81 5.90 5.82 5.76 5.83 209308_s_at 7.787.94 8.01 8.21 8.48 8.42 7.82 7.98 8.09 7.73 7.51 7.99 201848_s_at 8.636.93 7.89 7.57 7.62 7.52 9.02 7.71 8.66 6.81 6.87 7.16 201849_at 9.017.37 8.80 8.63 8.71 8.80 9.58 8.66 9.43 7.94 7.51 8.25 206044_s_at 5.455.87 5.68 5.76 5.94 5.90 5.59 5.79 5.66 5.82 5.86 5.71 208485_x_at 5.645.22 5.33 5.39 5.51 5.40 5.30 5.36 5.30 5.31 5.25 4.96 209508_x_at 6.136.12 6.08 6.12 6.31 5.96 6.16 6.13 6.03 5.98 5.95 5.74 209939_x_at 6.866.88 7.01 7.80 7.75 7.78 6.85 7.01 7.04 6.40 6.16 6.11 210563_x_at 6.616.84 6.71 7.62 7.36 7.39 6.74 6.73 6.85 6.59 6.34 6.51 211316_x_at 6.526.42 6.35 6.52 6.68 6.33 6.48 6.64 6.28 6.06 5.97 5.95 211317_s_at 4.504.60 4.70 4.66 4.65 4.71 4.51 4.60 4.59 4.42 4.51 4.47 211862_x_at 5.345.18 5.07 5.44 5.23 5.21 5.02 5.04 5.05 4.80 4.82 4.56 214618_at 4.414.69 4.77 4.70 4.55 4.85 4.68 4.69 4.73 4.81 4.98 4.74 200046_at 9.679.39 9.48 9.81 9.69 9.87 9.64 9.29 9.63 10.02 10.12 10.22 208309_s_at6.42 6.54 6.55 6.69 6.71 6.79 6.49 6.49 6.56 7.10 7.29 7.23 210017_at4.77 4.61 4.96 5.15 5.09 5.35 4.57 4.64 4.90 5.35 5.34 5.91 210018_x_at6.59 6.48 6.63 6.63 6.76 6.77 6.25 6.20 6.68 6.95 7.11 7.28 209239_at8.35 8.59 8.52 7.22 7.63 7.16 8.37 8.51 8.19 8.15 8.49 8.00 201739_at5.51 5.60 5.45 7.04 6.57 6.94 5.46 5.43 5.43 6.23 6.92 6.69 218878_s_at7.86 7.41 7.82 8.01 7.75 8.14 7.74 7.38 7.89 7.59 7.24 7.67 207827_x_at4.96 5.09 5.07 5.42 5.36 5.17 4.94 5.48 5.04 5.37 5.08 5.18 211546_x_at4.85 5.05 4.98 5.20 5.08 4.95 5.09 5.24 4.98 5.35 5.11 5.12 201085_s_at7.33 7.39 8.10 7.28 7.32 7.53 7.50 7.44 7.87 6.48 7.17 7.28 201086_x_at9.82 9.89 9.88 9.81 9.67 9.54 9.87 9.88 9.69 9.29 9.29 9.40 213538_at7.15 7.26 7.53 7.58 7.73 7.69 7.04 7.29 7.30 6.94 7.14 7.32 214988_s_at9.49 9.56 9.84 9.65 9.46 9.44 9.60 9.67 9.60 9.02 9.09 9.32 200803_s_at9.79 9.57 9.21 9.70 9.80 9.80 9.59 9.50 9.51 10.10 10.30 10.17 200804_at9.84 9.29 9.26 9.40 9.38 9.24 9.62 9.39 9.29 9.75 10.02 10.00202643_s_at 5.55 5.58 5.49 6.45 6.41 6.37 5.45 5.43 5.12 5.70 5.71 5.85202644_s_at 5.97 6.21 6.10 7.05 7.32 7.10 5.88 6.03 5.70 6.31 6.63 6.37206092_x_at 6.40 6.62 6.47 6.78 6.77 6.53 6.47 6.53 6.28 6.44 6.53 6.29206467_x_at 5.20 5.29 5.20 5.60 5.61 5.43 4.97 5.54 5.21 5.31 5.45 5.40213829_x_at 6.99 7.06 7.06 6.75 7.16 6.99 7.16 7.21 6.91 7.00 7.19 6.73203684_s_at 5.83 5.85 5.80 5.67 5.80 5.73 5.90 5.99 5.83 5.84 6.00 5.70207004_at 5.45 5.49 5.32 5.60 5.63 5.42 5.40 5.56 5.41 5.52 5.47 5.50221320_at 5.08 5.13 4.93 5.10 5.14 5.07 5.07 5.34 5.00 5.29 5.13 5.09204861_s_at 4.72 4.63 4.66 4.41 4.56 4.38 4.38 4.34 4.36 4.44 4.32 4.27206537_at 4.52 4.59 4.74 4.53 4.72 4.61 4.63 4.56 4.61 4.70 4.65 4.59210564_x_at 5.67 5.47 5.43 5.94 5.68 5.73 5.60 5.55 5.62 5.40 5.54 5.48214486_x_at 6.39 6.54 6.38 6.43 6.58 6.39 6.30 6.43 6.28 6.22 6.34 6.06201631_s_at 5.33 5.28 5.26 5.58 5.57 5.71 5.37 5.46 5.24 5.68 5.40 5.44221566_s_at 5.07 4.97 4.76 5.18 4.75 5.03 5.16 5.01 5.19 5.37 5.10 5.06221567_at 5.33 5.41 5.25 5.18 5.11 5.18 5.46 5.47 5.35 5.41 5.46 5.28206248_at 5.94 5.88 5.69 5.78 5.87 5.91 5.80 5.83 5.83 6.09 5.93 5.70204466_s_at 5.34 5.61 5.50 5.34 5.68 5.51 5.33 5.50 5.37 5.46 5.68 5.39204467_s_at 5.23 5.24 5.43 5.27 5.16 5.36 5.23 5.12 5.35 5.42 5.27 5.29221371_at 5.35 5.52 5.46 5.20 5.25 5.47 5.23 5.45 5.34 5.36 5.58 5.53221601_s_at 6.63 6.71 6.50 5.84 5.82 6.09 6.48 6.45 6.36 6.18 6.28 5.85221602_s_at 7.02 6.91 6.92 6.78 6.73 6.61 7.12 7.15 6.83 7.25 6.88 6.78

TABLE 6B Anti-apoptosis Genes (See tables reference 2) t-test(two-tailed) Meas- Gene Probesets pAB pAD pBC pCD ured Changed SymbolUniGene ID Gene Title 209165_at 2.6E−02 1.4E−01 5.0E−02 3.4E−01 Yes NoAATF Hs.311079 apoptosis antagonizing transcription factor 207163_s_at2.3E−02 2.5E−02 2.6E−03 1.5E−03 Yes No AKT1 Hs.368861 v-akt murinethymoma viral oncogene homolog 1 219366_at 2.2E−01 4.9E−02 1.7E−014.7E−02 Yes No AVEN Hs.63168 apoptosis, caspase activation inhibitor202387_at 2.2E−02 3.8E−02 4.9E−03 3.6E−02 Yes No BAG1 Hs.377484BCL2-associated athanogene 211475_s_at 4.7E−02 1.7E−02 3.9E−02 1.1E−02Yes No BAG1 Hs.377484 BCL2-associated athanogene 219624_at 4.6E−029.1E−02 4.4E−01 5.0E−01 Yes No BAG4 Hs.194726 BCL2-associated athanogene4 203685_at 1.2E−02 3.8E−02 1.3E−02 7.5E−02 Yes No BCL2 Hs.79241 B-cellCLL/lymphoma 2 207005_s_at 6.0E−02 7.0E−01 2.1E−02 3.0E−01 Yes No BCL2Hs.79241 B-cell CLL/lymphoma 2 205681_at 1.7E−02 1.4E−02 8.8E−02 1.3E−02Yes No BCL2A1 Hs.227817 BCL2-related protein A1 206665_s_at 1.2E−025.8E−01 2.2E−02 9.5E−01 Yes No BCL2L1 Hs.305890 BCL2-like 1 212312_at1.3E−01 9.8E−01 6.1E−02 5.7E−01 Yes No BCL2L1 Hs.305890 BCL2-like 1215037_s_at 2.4E−01 6.7E−02 1.3E−01 3.3E−01 Yes No BCL2L1 Hs.305890BCL2-like 1 209311_at 9.4E−01 4.8E−03 8.8E−01 9.5E−02 Yes No BCL2L2Hs.410026 BCL2-like 2 208945_s_at 1.5E−02 1.1E−01 6.2E−02 9.8E−02 Yes NoBECN1 Hs.12272 beclin 1 (coiled-coil, myosin- like BCL2 interactingprotein) 208946_s_at 2.4E−03 1.7E−01 5.6E−03 1.3E−01 Yes No BECN1Hs.12272 beclin 1 (coiled-coil, myosin- like BCL2 interacting protein)202076_at 4.8E−01 1.1E−01 7.3E−01 8.4E−02 Yes No BIRC2 Hs.289107baculoviral IAP repeat- containing 2 210538_s_at 4.3E−04 6.6E−02 7.0E−051.9E−02 Yes No BIRC3 Hs.127799 /// baculoviral IAP repeat- Hs.127799containing 3 206536_s_at 5.0E−01 4.3E−01 1.5E−01 1.1E−01 Yes No BIRC4Hs.356076 baculoviral IAP repeat- containing 4 202094_at 1.9E−02 1.9E−023.6E−02 1.1E−02 Yes No BIRC5 Hs.1578 baculoviral IAP repeat- containing5 (survivin) 202095_s_at 3.6E−01 3.2E−02 3.6E−01 2.7E−03 Yes No BIRC5Hs.1578 baculoviral IAP repeat- containing 5 (survivin) 210334_x_at2.6E−01 3.0E−02 2.5E−01 2.1E−02 Yes No BIRC5 Hs.1578 baculoviral IAPrepeat- containing 5 (survivin) 220451_s_at 9.6E−02 3.6E−02 6.6E−011.8E−01 Yes No BIRC7 Hs.256126 baculoviral IAP repeat- containing 7(livin) 204930_s_at 9.6E−01 1.6E−01 7.1E−02 8.6E−01 Yes No BNIP1Hs.145726 BCL2/adenovirus E1B 19 kDa interacting protein 1 207829_s_at1.9E−01 5.5E−01 5.3E−01 6.9E−01 Yes No BNIP1 Hs.145726 BCL2/adenovirusE1B 19 kDa interacting protein 1 37226_at 1.6E−01 4.4E−01 2.5E−021.6E−01 Yes No BNIP1 Hs.145726 BCL2/adenovirus E1B 19 kDa interactingprotein 1 209308_s_at 1.3E−02 3.7E−01 2.3E−02 2.6E−01 Yes No BNIP2Hs.204539 BCL2/adenovirus E1B 19 kDa interacting protein 2 201848_s_at6.7E−01 2.2E−01 1.5E−01 5.1E−02 Yes No BNIP3 Hs.79428 BCL2/adenovirusE1B 19 kDa interacting protein 3 201849_at 6.0E−01 4.5E−01 2.1E−012.4E−02 Yes No BNIP3 Hs.79428 BCL2/adenovirus E1B 19 kDa interactingprotein 3 206044_s_at 2.2E−01 3.9E−01 7.9E−02 2.0E−01 Yes No BRAFHs.162967 v-raf murine sarcoma viral oncogene homolog B1 208485_x_at8.3E−01 2.4E−01 9.3E−02 3.0E−01 Yes No CFLAR Hs.355724 CASP8 andFADD-like apoptosis regulator 209508_x_at 8.8E−01 9.9E−02 8.5E−019.1E−02 Yes No CFLAR Hs.355724 CASP8 and FADD-like apoptosis regulator209939_x_at 1.6E−03 5.6E−03 3.6E−03 3.5E−03 Yes No CFLAR Hs.355724 CASP8and FADD-like apoptosis regulator 210563_x_at 2.5E−03 7.5E−02 5.7E−033.8E−02 Yes No CFLAR Hs.355724 CASP8 and FADD-like apoptosis regulator211316_x_at 5.4E−01 3.3E−03 7.8E−01 3.4E−02 Yes No CFLAR Hs.355724 CASP8and FADD-like apoptosis regulator 211317_s_at 3.5E−01 1.3E−01 4.3E−025.5E−02 Yes No CFLAR Hs.355724 CASP8 and FADD-like apoptosis regulator211862_x_at 4.3E−01 1.5E−02 7.0E−02 6.5E−02 Yes No CFLAR Hs.355724 CASP8and FADD-like apoptosis regulator 214618_at 6.0E−01 1.8E−01 9.9E−011.8E−01 Yes No CFLAR Hs.355724 CASP8 and FADD-like apoptosis regulator200046_at 5.5E−02 5.4E−03 1.3E−01 2.0E−02 Yes No DAD1 Hs.82890 defenderagainst cell death 1 208309_s_at 1.5E−02 7.2E−04 5.9E−03 2.4E−03 Yes NoMALT1 Hs.180566 mucosa associated lymphoid tissue lymphoma translocationgene 1 210017_at 3.6E−02 3.7E−02 2.0E−02 2.9E−02 Yes No MALT1 Hs.180566mucosa associated lymphoid tissue lymphoma translocation gene 1210018_x_at 7.4E−02 1.6E−02 1.4E−01 2.0E−02 Yes No MALT1 Hs.180566mucosa associated lymphoid tissue lymphoma translocation gene 1209239_at 6.6E−03 1.9E−01 6.8E−03 4.6E−01 Yes No NFKB1 Hs.160557 nuclearfactor of kappa light polypeptide gene enhancer in B- cells 1 (p105)201739_at 7.2E−03 2.8E−02 9.8E−03 2.9E−02 Yes No SGK Hs.296323serum/glucocorticoid regulated kinase 218878_s_at 2.1E−01 3.7E−012.0E−01 4.4E−01 Yes No SIRT1 Hs.31176 sirtuin (silent mating typeinformation regulation 2 homolog) 1 (S. cerevisiae) 207827_x_at 4.4E−021.8E−01 4.4E−01 7.9E−01 Yes No SNCA Hs.76930 synuclein, alpha (non A4component of amyloid precursor) 211546_x_at 2.7E−01 8.2E−02 8.1E−014.5E−01 Yes No SNCA Hs.76930 synuclein, alpha (non A4 component ofamyloid precursor) 201085_s_at 4.6E−01 1.5E−01 2.3E−01 1.1E−01 Yes NoSON Hs.430541 SON DNA binding protein 201086_x_at 1.3E−01 5.3E−042.3E−01 5.1E−03 Yes No SON Hs.430541 SON DNA binding protein 213538_at7.5E−02 3.1E−01 1.7E−02 6.0E−01 Yes No SON Hs.430541 SON DNA bindingprotein 214988_s_at 4.3E−01 2.6E−02 2.6E−01 2.6E−02 Yes No SON Hs.430541SON DNA binding protein 200803_s_at 2.8E−01 4.6E−02 6.2E−03 2.3E−03 YesNo TEGT Hs.35052 testis enhanced gene transcript (BAX inhibitor 1)200804_at 5.9E−01 1.2E−01 4.6E−01 2.0E−02 Yes No TEGT Hs.35052 testisenhanced gene transcript (BAX inhibitor 1) 202643_s_at 1.7E−05 3.5E−026.8E−03 3.9E−02 Yes No TNFAIP3 Hs.211600 tumor necrosis factor,alpha-induced protein 3 202644_s_at 7.0E−04 5.2E−02 5.8E−04 1.4E−02 YesNo TNFAIP3 Hs.211600 tumor necrosis factor, alpha-induced protein 3206092_x_at 1.3E−01 4.6E−01 7.0E−02 9.4E−01 Yes No TNFRSF6B Hs.348183tumor necrosis factor receptor superfamily, member 6b, decoy 206467_x_at1.6E−02 3.7E−02 2.0E−01 4.6E−01 Yes No TNFRSF6B Hs.348183 tumor necrosisfactor receptor superfamily, member 6b, decoy 213829_x_at 6.2E−016.9E−01 4.5E−01 5.1E−01 Yes No TNFRSF6B Hs.348183 tumor necrosis factorreceptor superfamily, member 6b, decoy 203684_s_at 1.2E−01 8.2E−014.8E−02 6.0E−01 No No BCL2 Hs.79241 B-cell CLL/lymphoma 2 207004_at1.9E−01 2.6E−01 3.3E−01 5.3E−01 No No BCL2 Hs.79241 B-cell CLL/lymphoma2 221320_at 4.3E−01 2.2E−01 7.9E−01 7.9E−01 No No BCL2L10 Hs.283672BCL2-like 10 (apoptosis facilitator) 204861_s_at 4.6E−02 9.8E−03 2.7E−017.8E−01 No No BIRC1 Hs.79019 baculoviral IAP repeat- containing 1206537_at 9.6E−01 6.9E−01 7.6E−01 3.0E−01 No No BIRC4 Hs.356076baculoviral IAP repeat- containing 4 210564_x_at 7.5E−02 5.9E−01 1.2E−017.3E−02 No No CFLAR Hs.355724 CASP8 and FADD-like apoptosis regulator214486_x_at 7.2E−01 8.1E−02 1.4E−01 2.5E−01 No No CFLAR Hs.355724 CASP8and FADD-like apoptosis regulator 201631_s_at 7.6E−03 1.2E−01 3.3E−022.4E−01 No No IER3 Hs.76095 immediate early response 3 221566_s_at7.3E−01 1.4E−01 4.1E−01 6.4E−01 No No NOL3 Hs.462911 nucleolar protein 3(apoptosis repressor with CARD domain) 221567_at 4.1E−02 5.0E−01 7.0E−035.5E−01 No No NOL3 Hs.462911 nucleolar protein 3 (apoptosis repressorwith CARD domain) 206248_at 8.9E−01 6.5E−01 4.7E−01 5.1E−01 No No PRKCEHs.155281 protein kinase C, epsilon 204466_s_at 8.3E−01 8.2E−01 4.0E−013.6E−01 No No SNCA Hs.76930 synuclein, alpha (non A4 component ofamyloid precursor) 204467_s_at 6.9E−01 7.3E−01 7.6E−01 3.2E−01 No NoSNCA Hs.76930 synuclein, alpha (non A4 component of amyloid precursor)221371_at 2.7E−01 5.9E−01 7.6E−01 1.9E−01 No No TNFSF18 Hs.248197 tumornecrosis factor (ligand) superfamily, member 18 221601_s_at 4.0E−034.2E−02 1.7E−02 1.2E−01 No No TOSO Hs.58831 regulator of Fas-inducedapoptosis 221602_s_at 2.1E−02 9.1E−01 6.5E−02 7.2E−01 No No TOSOHs.58831 regulator of Fas-induced apoptosis

TABLE 7A B-Cell Maturation Specific Genes Log2 fluorescence intensityLy1 Ly1 Ly7 Probesets (A1) Ly1 (A2) (A3) Ly7 (B1) (B2) Ly7 (B3) Ly8 (C1)Ly8 (C2) Ly8 (C3) D4 (D1) D4 (D2) D4 (D3) 202094_at 8.05 8.01 7.73 8.698.38 8.37 7.94 8.10 8.08 8.54 8.31 8.45 202095_s_at 9.08 9.07 8.69 8.958.59 8.79 8.92 8.79 9.01 9.52 9.38 9.59 210334_x_at 8.24 8.19 7.87 8.348.21 8.27 8.13 7.97 8.29 8.75 8.54 8.49 204581_at 7.31 6.65 6.97 9.299.12 9.07 7.64 6.88 7.08 9.45 9.76 9.57 217422_s_at 6.48 6.12 6.21 8.478.56 8.33 6.65 5.98 5.96 8.61 9.38 8.76 38521_at 8.75 8.60 8.51 9.729.86 9.76 8.71 8.54 8.42 9.89 10.19 10.05 206545_at 4.02 3.98 4.01 6.136.64 5.89 3.90 3.92 3.96 4.05 3.99 3.95 211856_x_at 5.39 5.68 5.60 5.936.48 6.52 5.47 5.51 5.52 5.61 5.69 5.51 211861_x_at 4.01 4.10 3.93 4.354.88 4.82 3.89 3.97 4.11 4.17 4.14 4.07 204192_at 10.20 8.83 9.62 9.589.67 9.21 9.74 8.62 8.54 9.85 9.94 9.72 205692_s_at 6.94 7.34 7.45 9.329.34 9.36 6.89 7.41 7.26 9.01 9.14 8.98 209835_x_at 4.51 4.41 4.43 4.504.51 4.58 4.52 4.56 4.51 4.57 4.59 4.57 209795_at 4.56 4.42 4.80 4.004.14 4.03 4.36 4.48 4.27 4.07 4.06 4.06 200675_at 11.42 11.58 11.3010.93 10.69 10.90 11.18 11.33 11.20 11.17 11.01 11.17 202910_s_at 6.466.62 6.38 6.06 6.19 5.99 6.51 6.78 6.67 6.22 6.45 6.40 207691_x_at 5.605.66 5.54 5.00 5.03 4.97 5.40 5.14 5.33 4.95 4.99 4.73 209473_at 6.696.41 6.61 5.49 6.05 6.08 6.38 6.44 6.45 5.77 5.45 5.61 209474_s_at 4.914.79 4.92 4.40 4.63 4.46 4.79 4.71 4.87 4.27 4.51 4.34 219731_at 6.647.01 6.91 6.84 6.91 6.64 6.59 6.86 6.69 6.28 6.68 6.18 211430_s_at 10.7010.74 10.73 5.10 5.78 5.96 11.52 11.37 10.89 10.06 10.59 9.59211641_x_at 5.33 5.52 5.28 5.10 4.90 4.92 5.28 5.34 5.36 4.95 5.09 4.95214973_x_at 6.67 6.76 6.76 6.37 6.65 6.31 6.67 7.06 6.47 6.48 6.50 6.49217281_x_at 5.93 5.68 5.35 5.19 4.81 5.11 5.87 5.69 5.41 5.41 5.27 5.05203233_at 6.56 6.42 6.48 7.84 7.90 7.58 6.86 6.55 6.39 7.02 7.41 6.91204864_s_at 4.96 4.97 4.82 4.84 4.96 5.03 5.02 5.02 4.99 5.10 4.94 4.98212195_at 4.36 4.05 4.17 4.19 4.22 4.08 5.14 4.49 4.80 3.83 3.92 3.88204562_at 8.22 8.60 8.59 8.69 9.38 8.42 8.35 8.44 7.86 6.36 6.28 6.01216986_s_at 6.51 6.37 6.35 6.45 6.80 6.42 6.55 6.43 6.23 6.43 6.42 6.01201286_at 4.49 4.58 4.38 4.48 4.61 4.54 4.48 4.46 4.55 4.70 4.60 4.43206641_at 4.61 4.74 4.44 7.47 8.13 7.40 4.55 4.51 4.66 6.82 7.58 7.39206729_at 5.68 5.98 5.69 5.51 5.49 5.75 5.68 5.76 5.65 5.70 5.76 5.59206508_at 5.59 5.65 5.60 7.85 8.89 7.93 5.59 5.81 5.45 5.69 5.96 5.81220674_at 4.69 4.54 4.34 4.92 4.75 4.68 4.72 4.52 4.54 4.81 4.87 4.68204489_s_at 5.37 5.38 5.30 5.34 5.37 5.26 5.34 5.40 5.22 5.33 5.32 5.20204490_s_at 4.32 4.47 4.55 4.72 4.51 4.47 4.44 4.35 4.38 4.72 4.51 4.44210916_s_at 4.67 4.58 4.52 4.58 4.54 4.57 4.65 4.59 4.61 4.93 4.81 4.67212014_x_at 4.45 4.45 4.32 4.42 4.48 4.45 4.44 4.44 4.43 4.57 4.51 4.48212063_at 3.94 4.15 4.11 4.02 4.17 4.06 3.95 4.08 3.97 4.04 4.06 4.14216056_at 4.69 4.92 5.00 4.77 5.03 5.04 4.71 4.79 4.79 4.86 4.86 4.78216062_at 5.78 5.65 5.73 5.81 5.57 5.76 5.77 5.72 5.76 6.13 5.76 5.89217523_at 3.76 3.80 3.80 3.79 3.78 3.86 3.79 3.76 3.82 3.84 3.81 3.77205544_s_at 4.95 4.95 4.88 4.82 4.97 4.88 4.88 4.83 5.04 4.90 4.95 4.83203716_s_at 4.97 5.02 5.03 5.20 4.75 5.08 5.16 4.95 5.07 5.69 5.14 5.22203717_at 4.07 3.92 4.05 4.07 4.07 4.05 3.97 4.06 4.03 4.16 4.12 4.07211478_s_at 3.98 3.98 3.95 3.98 4.09 4.02 4.10 4.03 3.85 4.03 4.09 4.02206759_at 4.75 4.58 4.59 5.06 4.88 4.78 4.63 4.51 4.49 5.09 4.88 4.68206760_s_at 5.79 5.92 5.84 6.05 5.96 5.97 5.89 5.79 5.82 6.00 6.09 5.90211636_at 4.17 4.18 3.93 4.13 4.09 4.16 4.32 4.18 4.14 4.20 4.24 4.09211642_at 4.35 4.44 4.33 4.41 4.10 4.36 4.57 4.24 4.37 4.55 4.23 4.29211878_at 4.06 3.90 3.82 4.00 3.92 4.01 3.99 3.94 3.89 3.96 3.99 3.98215721_at 5.21 5.04 5.02 4.84 4.64 4.81 5.15 5.06 5.00 4.87 4.86 4.69217260_x_at 5.40 5.36 5.29 4.82 5.15 5.13 4.98 5.47 5.21 5.15 5.21 4.82206341_at 4.41 4.38 4.35 4.32 4.23 4.32 4.47 4.27 4.43 4.50 4.52 4.29211269_s_at 5.99 5.92 6.07 5.93 6.13 5.99 6.01 6.15 5.98 5.84 5.90 5.96205945_at 4.07 4.13 4.08 4.02 4.16 4.17 3.99 4.08 4.05 4.06 4.25 4.06217489_s_at 4.53 4.54 4.44 4.51 4.47 4.54 4.59 4.44 4.51 4.56 4.89 4.61204863_s_at 4.10 4.16 4.08 4.11 4.19 4.16 4.12 4.10 4.18 4.19 4.12 4.14211000_s_at 5.05 5.01 4.88 4.98 4.95 5.02 5.03 5.17 5.05 5.14 5.09 4.90212196_at 4.13 4.06 4.04 4.04 4.07 4.13 4.26 4.25 4.22 4.02 4.15 4.09216987_at 3.88 3.74 3.80 3.79 3.74 3.79 3.78 3.72 3.82 3.80 3.77 3.80201287_s_at 6.37 6.41 6.38 6.27 6.36 6.24 6.32 6.44 6.29 6.43 6.24 6.28

TABLE 7B B-Cell Maturation Specific Genes t-test (two-tailed) GeneProbesets pAB pAD pBC pCD Measured Changed Symbol UniGene ID Gene TitleRef. FDR Cutoff 1.0E−02 8.2E−03 1.2E−02 9.4E−03 AC v. BD AC v. BD202094_at 1.9E−02 1.9E−02 3.6E−02 1.1E−02 Yes No BIRC5 Hs.1578baculoviral IAP repeat- 3 containing 5 (survivin) 202095_s_at 3.6E−013.2E−02 3.6E−01 2.7E−03 Yes No BIRC5 Hs.1578 baculoviral IAP repeat- 3containing 5 (survivin) 210334_x_at 2.6E−01 3.0E−02 2.5E−01 2.1E−02 YesNo BIRC5 Hs.1578 baculoviral IAP repeat- 3 containing 5 (survivin)204581_at 3.8E−03 1.4E−03 8.7E−03 3.9E−03 Yes Yes CD22 Hs.262150 CD22antigen 4 217422_s_at 2.4E−04 2.7E−03 6.2E−03 1.2E−03 Yes Yes CD22Hs.262150 CD22 antigen 4 38521_at 4.5E−04 3.0E−04 1.3E−03 2.6E−04 YesYes CD22 Hs.262150 CD22 antigen 4 206545_at 9.6E−03 8.7E−01 8.8E−031.3E−01 Yes No CD28 Hs.1987 CD28 antigen (Tp44) 4 211856_x_at 4.2E−026.6E−01 5.0E−02 1.7E−01 Yes No CD28 Hs.1987 CD28 antigen (Tp44) 4211861_x_at 4.7E−02 1.2E−01 3.9E−02 1.6E−01 Yes No CD28 Hs.1987 CD28antigen (Tp44) 4 204192_at 8.9E−01 5.5E−01 3.1E−01 1.5E−01 Yes No CD37Hs.153053 CD37 antigen 4 205692_s_at 5.2E−03 4.2E−03 4.9E−03 3.9E−03 YesYes CD38 Hs.174944 CD38 antigen (p45) 4 209835_x_at 1.1E−01 4.6E−029.6E−01 8.9E−02 Yes No CD44 Hs.306278 CD44 antigen 5 209795_at 2.8E−024.2E−02 1.9E−02 4.0E−02 Yes No CD69 Hs.82401 CD69 antigen (p60, early 4T-cell activation antigen) 200675_at 5.9E−03 3.7E−02 1.7E−02 1.7E−01 YesNo CD81 Hs.54457 CD81 antigen (target of 4 antiproliferative antibody 1)202910_s_at 1.2E−02 2.5E−01 5.7E−03 4.9E−02 Yes No CD97 Hs.3107 CD97antigen 4 207691_x_at 1.0E−03 5.2E−03 6.0E−02 2.3E−02 Yes No ENTPD1Hs.444105 CD39 antigen 4 209473_at 5.1E−02 1.6E−03 1.0E−01 9.3E−03 YesNo ENTPD1 Hs.444105 CD39 antigen 4 209474_s_at 1.5E−02 6.4E−03 3.0E−021.1E−02 Yes No ENTPD1 Hs.444105 CD39 antigen 4 219731_at 7.1E−01 7.4E−025.0E−01 1.5E−01 Yes No ENTPD1 Hs.444105 CD39 antigen 4 211430_s_at2.6E−03 1.6E−01 1.2E−04 3.4E−02 Yes No IGHG3 Hs.413826 immunoglobulinheavy 4 constant gamma 3 (G3m marker) 211641_x_at 1.5E−02 1.7E−021.9E−02 8.8E−03 Yes No IGHG3 Hs.413826 immunoglobulin heavy 4 constantgamma 3 (G3m marker) 214973_x_at 1.0E−01 1.2E−02 2.3E−01 2.9E−01 Yes NoIGHG3 Hs.413826 immunoglobulin heavy 4 constant gamma 3 (G3m marker)217281_x_at 4.6E−02 1.2E−01 2.7E−02 7.7E−02 Yes No IGHG3 Hs.413826immunoglobulin heavy 4 constant gamma 3 (G3m marker) 203233_at 2.2E−034.6E−02 3.2E−03 6.6E−02 Yes No IL4R Hs.75545 CD124 antigen 4 204864_s_at7.5E−01 2.4E−01 3.4E−01 9.8E−01 Yes No IL6ST Hs.71968 gp130 4 212195_at8.0E−01 6.6E−02 6.8E−02 3.6E−02 Yes No IL6ST Hs.71968 gp130 4 204562_at3.4E−01 2.1E−04 1.6E−01 1.7E−03 Yes No IRF4 Hs.127686 interferonregulatory 6 factor 4 216986_s_at 3.5E−01 4.9E−01 3.8E−01 5.5E−01 Yes NoIRF4 Hs.127686 interferon regulatory 6 factor 4 201286_at 4.8E−014.0E−01 4.0E−01 4.2E−01 Yes No SDC1 Hs.82109 CD138 antigen 4 206641_at2.4E−03 3.1E−03 4.3E−03 5.5E−03 Yes Yes TNFRSF17 Hs.2556 B-cellmaturation factor 7 206729_at 2.0E−01 4.4E−01 3.2E−01 8.6E−01 Yes NoTNFRSF8 Hs.1314 CD30 antigen 4 206508_at 1.6E−02 1.2E−01 1.0E−02 2.1E−01Yes No TNFSF7 Hs.99899 CD70 antigen 4 220674_at 1.1E−01 1.1E−01 1.1E−018.5E−02 No No CD22 Hs.262150 CD22 antigen 4 204489_s_at 5.3E−01 2.4E−019.7E−01 6.0E−01 No No CD44 Hs.306278 CD44 antigen 5 204490_s_at 3.1E−013.6E−01 1.5E−01 1.8E−01 No No CD44 Hs.306278 CD44 antigen 5 210916_s_at6.4E−01 8.4E−02 8.2E−02 1.2E−01 No No CD44 Hs.306278 CD44 antigen 5212014_x_at 4.2E−01 1.1E−01 4.5E−01 9.0E−02 No No CD44 Hs.306278 CD44antigen 5 212063_at 8.0E−01 8.1E−0.1 2.2E−01 1.8E−01 No No CD44Hs.306278 CD44 antigen 5 216056_at 5.8E−01 7.4E−01 1.6E−01 1.3E−01 No NoCD44 Hs.306278 CD44 antigen 5 216062_at 9.5E−01 1.9E−01 6.7E−01 2.4E−01No No CD44 Hs.306278 CD44 antigen 5 217523_at 4.2E−01 4.0E−01 4.5E−014.5E−01 No No CD44 Hs.306278 CD44 antigen 5 205544_s_at 5.5E−01 5.1E−018.1E−01 8.3E−01 No No CR2 Hs.73792 CD21 antigen 4 203716_s_at 9.9E−011.8E−01 7.5E−01 2.2E−01 No No DPP4 Hs.44926 CD26 antigen 4 203717_at3.7E−01 1.4E−01 2.4E−01 6.3E−02 No No DPP4 Hs.44926 CD26 antigen 4211478_s_at 2.0E−01 4.2E−02 7.3E−01 5.7E−01 No No DPP4 Hs.44926 CD26antigen 4 206759_at 5.8E−02 1.6E−01 2.7E−02 8.7E−02 No No FCER2 Hs.1416CD23 antigen 4 206760_s_at 3.8E−02 9.5E−02 2.0E−02 7.0E−02 No No FCER2Hs.1416 CD23 antigen 4 211636_at 7.2E−01 4.3E−01 2.3E−01 6.1E−01 No NoIGHG3 Hs.413826 immunoglobulin heavy 4 constant gamma 3 (G3m marker)211642_at 5.0E−01 9.0E−01 4.8E−01 7.9E−01 No No IGHG3 Hs.413826immunoglobulin heavy 4 constant gamma 3 (G3m marker) 211878_at 5.5E−015.7E−01 3.8E−01 3.3E−01 No No IGHG3 Hs.413826 immunoglobulin heavy 4constant gamma 3 (G3m marker) 215721_at 1.9E−02 2.7E−02 2.0E−02 2.5E−02No No IGHG3 Hs.413826 immunoglobulin heavy 4 constant gamma 3 (G3mmarker) 217260_x_at 8.6E−02 1.3E−01 3.6E−01 4.4E−01 No No IGHG3Hs.413826 immunoglobulin heavy 4 constant gamma 3 (G3m marker) 206341_at6.7E−02 5.4E−01 2.5E−01 6.7E−01 No No IL2RA Hs.130058 CD25 antigen 4211269_s_at 7.6E−01 1.7E−01 7.4E−01 8.7E−02 No No IL2RA Hs.130058 CD25antigen 4 205945_at 7.1E−01 7.1E−01 2.5E−01 3.1E−01 No No IL6R Hs.193400CD126 antigen 4 217489_s_at 8.6E−01 2.1E−01 9.6E−01 2.3E−01 No No IL6RHs.193400 CD126 antigen 4 204863_s_at 2.5E−01 2.9E−01 5.7E−01 6.4E−01 NoNo IL6ST Hs.71968 CD126 antigen 4 211000_s_at 9.8E−01 5.4E−01 1.2E−016.4E−01 No No IL6ST Hs.71968 CD126 antigen 4 212196_at 9.6E−01 8.8E−011.3E−02 4.1E−02 No No IL6ST Hs.71968 CD126 antigen 4 216987_at 5.6E−017.4E−01 9.1E−01 6.0E−01 No No IRF4 Hs.127686 interferon regulatory 6factor 4 201287_s_at 1.1E−01 3.6E−01 3.6E−01 6.6E−01 No No SDC1 Hs.82109CD138 antigen 4

TABLE 8A Pan-B-Cell Genes Log2 fluorescence intensity Ly1 Ly1 Ly7Probesets (A1) Ly1 (A2) (A3) Ly7 (B1) (B2) Ly7 (B3) Ly8 (C1) Ly8 (C2)Ly8 (C3) D4 (D1) D4 (D2) D4 (D3) 206398_s_at 10.29 10.05 10.02 9.37 9.439.01 10.05 9.89 9.62 8.35 8.93 8.50 215925_s_at 7.46 6.84 7.74 6.66 7.116.71 7.15 6.81 6.93 7.20 7.36 7.17 209619_at 12.37 11.96 12.10 12.0712.17 11.94 12.11 11.63 11.56 12.67 12.83 12.63 205049_s_at 10.15 9.849.81 10.50 10.49 10.12 9.82 9.54 9.51 10.19 10.41 10.05 205297_s_at10.93 10.97 10.91 9.82 9.84 9.68 10.91 10.80 10.64 9.51 9.79 9.71207176_s_at 6.11 6.33 6.32 6.31 6.25 6.39 6.13 6.37 6.25 6.58 6.49 6.50210356_x_at 10.06 9.78 10.31 10.94 11.02 10.94 9.54 9.82 9.63 11.0211.32 10.99 217418_x_at 10.10 97.6 10.14 10.89 10.94 10.87 9.45 9.759.59 10.96 11.22 10.85 221969_at 8.41 8.70 8.84 7.69 7.68 7.55 8.46 8.758.41 8.01 8.06 7.96 215346_at 6.64 6.15 6.16 6.82 6.86 6.41 6.44 6.495.92 6.97 6.90 6.83 35150_at 8.56 8.35 8.22 8.42 8.72 8.53 8.28 8.418.06 8.67 8.99 8.50 220068_at 10.38 10.38 10.30 10.12 10.15 10.03 9.9510.02 10.07 9.85 10.05 10.03 206802_at 6.05 6.11 5.94 6.12 6.03 5.876.18 6.05 5.78 6.25 6.05 5.91 205153_s_at 5.94 5.42 5.24 6.04 6.24 6.035.75 5.47 5.33 6.25 6.50 6.10 222292_at 4.59 4.65 4.73 4.57 4.65 4.524.51 4.47 4.60 4.66 4.67 4.85

TABLE 8B Pan-B-Cell Genes t-test (two-tailed) Gene Probesets pAB pAD pBCpCD Measured Changed Symbol UniGene ID Gene Title Ref. 206398_s_at8.4E−03 4.9E−03 3.3E−02 5.8E−03 Yes No CD19 Hs.96023 CD19 antigen 4215925_s_at 1.8E−01 7.4E−01 4.8E−01 8.8E−02 Yes No CD72 Hs.116481 CD72antigen 4 209619_at 5.7E−01 2.4E−02 2.3E−01 2.2E−02 Yes No CD74Hs.446471 CD74 antigen 4 205049_s_at 5.9E−02 1.4E−01 1.0E−02 1.5E−02 YesNo CD79A Hs.79630 CD79A antigen 4 (immunoglobulin- associated alpha)205297_s_at 7.0E−04 3.1E−03 1.1E−03 6.3E−04 Yes Yes CD79B Hs.89575 CD79Bantigen 4 (immunoglobulin- associated beta) 207176_s_at 5.0E−01 4.9E−024.5E−01 3.8E−02 Yes No CD80 Hs.838 CD80 antigen (CD28 4 antigen ligand1, B7-1 antigen) 210356_x_at 2.4E−02 6.6E−03 1.9E−03 5.9E−04 Yes NoMS4A1 Hs.438040 CD20 antigen 4 217418_x_at 1.5E−02 3.5E−03 3.0E−037.2E−04 Yes No MS4A1 Hs.438040 CD20 antigen 4 221969_at 8.5E−03 3.2E−026.1E−03 3.1E−02 Yes No PAX5 Hs.22030 paired box gene 5 (B-cell 7 lineagespecific activator protein) 215346_at 1.6E−01 6.1E−02 1.5E−01 7.0E−02Yes No TNFRSF5 Hs.504816 CD40 antigen 4 35150_at 2.5E−01 1.3E−01 8.9E−026.3E−02 Yes No TNFRSF5 Hs.504816 CD40 antigen 4 220068_at 6.7E−031.5E−02 1.7E−01 6.4E−01 Yes No VPREB3 Hs.136713 pre-B lymphocyte gene 38 206802_at 8.0E−01 7.5E−01 9.8E−01 6.8E−01 No No PAX5 Hs.22030 pairedbox gene 5 (B-cell 7 lineage specific activator protein) 205153_s_at1.0E−01 4.9E−02 2.3E−02 1.1E−02 No No TNFRSF5 Hs.504816 CD40 antigen 4222292_at 2.1E−01 4.4E−01 4.1E−01 6.6E−02 No No TNFRSF5 Hs.504816 CD40antigen 4

TABLE 9A Pre-B/GC Marker Genes Log2 fluorescence intensity Ly1 Ly1 Ly7Probesets (A1) Ly1 (A2) (A3) Ly7 (B1) (B2) Ly7 (B3) Ly8 (C1) Ly8 (C2)Ly8 (C3) D4 (D1) D4 (D2) D4 (D3) 219488_at 5.20 5.39 5.13 5.80 5.94 5.605.40 5.34 5.33 5.84 5.77 5.52 204639_at 8.75 8.80 8.72 9.11 9.15 8.838.78 8.89 8.83 5.93 6.35 5.98 203140_at 8.23 7.80 9.55 9.61 9.72 9.338.39 8.31 7.70 9.82 10.45 9.94 215990_s_at 7.37 6.79 7.81 8.18 8.00 7.787.47 7.01 6.83 8.45 8.89 8.25 208650_s_at 8.87 8.94 9.42 8.48 8.33 8.519.08 9.14 9.02 3.88 3.93 4.12 208651_x_at 9.18 9.18 9.57 8.92 8.82 8.879.26 9.36 9.01 6.22 6.34 6.23 209771_x_at 11.06 11.00 11.43 10.63 10.4510.50 11.13 11.13 10.86 6.02 6.69 6.70 209772_s_at 9.04 8.92 9.10 8.218.10 8.25 9.20 8.71 8.61 7.01 6.93 6.84 266_s_at 8.55 8.65 9.22 8.308.13 8.35 8.60 8.66 8.61 5.50 4.92 5.35 201005_at 10.54 10.55 10.64 4.884.53 4.83 10.91 10.82 10.60 5.25 4.95 4.80 203066_at 8.28 9.29 9.15 5.616.06 5.98 8.64 9.25 8.62 6.19 6.26 6.02 209374_s_at 12.45 12.38 12.4712.36 12.36 12.26 12.49 12.46 12.41 6.35 5.73 5.78 212827_at 12.25 12.1312.18 11.99 12.17 11.86 12.24 12.01 11.91 6.42 6.55 6.25 213674_x_at9.33 7.92 9.07 7.08 7.36 7.05 9.34 8.15 8.32 6.30 6.00 5.70 222285_at6.09 5.74 6.62 5.59 5.99 5.48 5.90 5.86 5.69 5.61 5.54 5.43 206660_at10.68 11.35 10.55 5.41 4.82 4.94 9.07 10.28 10.32 5.10 4.93 5.30203434_s_at 7.60 7.86 8.01 7.56 7.39 7.64 8.20 8.29 8.55 8.97 8.79 9.05203435_s_at 8.64 8.83 8.81 8.37 7.97 8.43 8.75 8.99 9.11 8.96 8.86 8.97206591_at 7.55 8.15 8.76 4.39 4.15 4.25 8.34 8.84 8.68 4.23 4.00 4.32215117_at 4.08 4.38 4.81 3.72 3.60 3.69 4.16 4.87 4.38 3.78 3.78 3.72213435_at 6.68 6.84 7.27 5.62 5.52 5.94 7.01 7.31 7.28 5.24 4.63 5.11215591_at 3.86 3.90 3.70 3.83 3.66 3.76 3.85 3.77 3.84 3.85 3.75 3.77209995_s_at 11.95 12.19 12.19 10.79 11.03 10.72 12.13 12.27 12.15 8.598.80 8.85 39318_at 12.14 12.32 12.26 11.06 11.18 10.93 12.27 12.49 12.258.75 8.94 8.48 221349_at 7.42 7.98 8.39 3.97 4.10 3.83 7.19 7.15 7.104.75 4.85 4.35 210487_at 4.94 4.60 4.78 5.05 4.70 4.78 4.91 4.79 4.895.12 5.05 4.87 203939_at 4.68 4.72 4.66 4.71 4.61 4.67 4.68 4.62 4.784.66 4.73 4.73

TABLE 9B Pre-B/GC Marker Genes t-test (two-tailed) Gene Probesets pABpAD pBC pCD Measured Changed Symbol UniGene ID Gene Title Ref. 219488_at1.4E−02 2.2E−02 4.3E−02 6.3E−02 Yes No A4GALT Hs.105956 alpha 1,4- 9galactosyltransferase 204639_at 1.0E−01 1.8E−03 1.8E−01 1.4E−03 Yes NoADA Hs.407135 adenosine deaminase 10 203140_at 1.9E−01 8.5E−02 9.9E−032.8E−03 Yes No BCL6 Hs.155024 B-cell CLL/lymphoma 6 6 (zinc fingerprotein 51) 215990_s_at 1.4E−01 3.4E−02 2.5E−02 6.1E−03 Yes No BCL6Hs.155024 B-cell CLL/lymphoma 6 6 (zinc finger protein 51) 208650_s_at5.4E−02 2.1E−04 1.3E−03 1.2E−05 Yes No CD24 Hs.375108 CD24 antigen 4208651_x_at 7.0E−02 8.9E−04 7.2E−02 3.9E−04 Yes No CD24 Hs.375108 CD24antigen 4 209771_x_at 2.8E−02 2.2E−04 1.2E−02 7.2E−04 Yes No CD24Hs.375108 CD24 antigen 4 209772_s_at 3.4E−04 9.5E−06 6.2E−02 6.0E−03 YesNo CD24 Hs.375108 CD24 antigen 4 266_s_at 1.1E−01 2.5E−04 2.5E−022.4E−03 Yes No CD24 Hs.375108 CD24 antigen 4 201005_at 1.1E−04 2.7E−042.4E−06 1.0E−05 Yes Yes CD9 Hs.387579 CD9 antigen (p24) 4 203066_at4.3E−03 9.8E−03 5.9E−04 2.7E−03 Yes No GALNAC4S- Hs.523379 B cell RAGassociated 4 protein 6ST 209374_s_at 8.0E−02 7.5E−04 5.0E−02 7.6E−04 YesNo IGHM Hs.439852 immunoglobulin heavy 4 constant mu 212827_at 1.7E−013.8E−05 7.4E−01 2.0E−06 Yes No IGHM Hs.439852 immunoglobulin heavy 4constant mu 213674_x_at 5.9E−02 1.4E−02 5.3E−02 9.4E−03 Yes No IGHMHs.439852 immunoglobulin heavy 4 constant mu 222285_at 2.1E−01 1.3E−015.1E−01 3.0E−02 Yes No IGHM Hs.439852 immunoglobulin heavy 4 constant mu206660_at 8.7E−05 4.3E−04 2.5E−03 4.9E−03 Yes Yes IGLL1 Hs.348935immunoglobulin 11 lambda-like polypeptide 1 203434_s_at 1.2E−01 2.8E−034.7E−03 1.4E−02 Yes No MME Hs.307734 CALLA (CD10) 4 203435_s_at 5.9E−028.0E−02 2.2E−02 8.8E−01 Yes No MME Hs.307734 CALLA (CD10) 4 206591_at6.2E−03 4.9E−03 1.5E−04 5.3E−05 Yes Yes RAG1 Hs.73958 recombination 4activating gene 1 215117_at 6.6E−02 8.5E−02 5.8E−02 7.4E−02 Yes No RAG2Hs.159376 recombination 4 activating gene 2 213435_at 6.2E−03 1.6E−031.0E−03 1.8E−03 Yes Yes SATB2 Hs.412327 SATB family member 12 2215591_at 4.0E−01 6.7E−01 2.9E−01 5.1E−01 Yes No SATB2 Hs.412327 SATBfamily member 12 2 209995_s_at 6.0E−04 7.8E−06 1.4E−03 2.9E−05 Yes YesTCL1A Hs.2484 T-cell leukemia/ 13 lymphoma 1A 39318_at 3.2E−04 3.8E−042.7E−04 1.2E−04 Yes Yes TCL1A Hs.2484 T-cell leukemia/ 13 lymphoma 1A221349_at 3.1E−03 1.7E−03 1.5E−04 3.0E−03 Yes Yes VPREB1 Hs.247979 pre-Blymphocyte 4 gene 1 210487_at 6.5E−01 1.3E−01 8.6E−01 1.7E−01 No No DNTTHs.397294 deoxynucleotidyl- 4 transferase, terminal 203939_at 5.7E−015.2E−01 6.4E−01 8.1E−01 No No NT5E Hs.153952 5′-nucleotidase, ecto 4(CD73)

TABLE 10A CD40/BCR Signaling Genes Log2 fluorescence intensity Ly1 Ly1Ly7 Probesets (A1) Ly1 (A2) (A3) Ly7 (B1) (B2) Ly7 (B3) Ly8 (C1) Ly8(C2) Ly8 (C3) D4 (D1) D4 (D2) D4 (D3) 207163_s_at 8.37 8.44 8.22 8.027.99 7.73 8.91 8.88 9.02 7.82 8.07 8.05 205367_at 7.63 7.61 7.50 10.5910.54 10.27 7.14 7.60 7.42 10.20 10.20 10.16 205263_at 7.40 7.11 7.487.15 7.15 7.30 7.21 7.26 7.75 6.52 6.52 7.01 207655_s_at 8.48 8.44 9.009.52 9.42 9.15 8.32 8.53 8.60 7.89 7.90 8.20 220059_at 8.32 8.08 8.1710.14 10.19 10.19 8.09 7.95 7.95 9.89 9.72 9.93 205504_at 5.84 5.90 6.118.32 8.16 7.96 6.01 5.67 5.89 8.53 8.41 8.56 202987_at 3.92 4.01 3.983.91 3.98 3.98 3.98 3.98 3.91 4.05 4.00 3.99 215411_s_at 8.69 8.39 8.387.63 7.89 7.72 8.67 8.42 8.46 7.63 8.29 7.97 202514_at 5.84 5.68 6.026.28 5.89 6.29 5.72 5.37 5.83 7.48 7.16 7.52 202515_at 7.80 7.90 8.228.34 8.38 8.41 7.32 7.66 7.95 9.27 9.16 9.57 202516_s_at 4.11 4.09 4.214.25 4.27 4.29 4.08 4.01 4.00 4.35 4.38 4.65 210105_s_at 7.34 6.89 7.319.23 9.39 9.09 8.35 7.31 7.86 6.33 6.57 6.74 212486_s_at 4.25 4.27 4.294.44 4.47 4.50 4.50 4.35 4.41 4.34 4.45 4.27 216033_s_at 5.83 5.47 5.457.46 7.51 7.15 6.70 5.65 5.99 5.34 5.24 5.18 215075_s_at 8.22 8.28 8.299.36 8.96 9.22 8.40 8.16 8.52 8.88 8.84 8.95 209341_s_at 6.54 6.37 6.606.94 6.59 6.67 6.40 6.25 6.63 6.68 6.61 7.33 209342_s_at 5.13 5.16 5.245.28 5.44 5.22 5.11 4.98 5.01 5.21 5.56 5.47 204890_s_at 6.02 5.83 5.858.82 8.88 8.99 6.16 6.07 5.98 8.20 8.66 8.47 204891_s_at 6.82 6.23 6.6810.30 10.26 10.18 6.71 6.30 6.10 9.51 9.88 9.69 202625_at 7.52 7.05 6.968.05 8.27 7.82 7.75 7.24 7.63 8.01 8.07 8.29 202626_s_at 8.72 8.09 8.049.19 9.51 8.74 9.08 8.55 8.65 9.02 9.22 9.30 210754_s_at 8.53 7.97 8.029.13 9.22 8.82 8.96 8.19 8.62 9.01 9.00 9.13 202670_at 8.89 8.59 8.739.68 9.64 9.73 8.99 8.45 8.93 9.89 9.95 10.12 202424_at 9.87 9.65 9.699.89 9.91 9.76 9.95 9.69 9.59 10.40 10.75 10.68 213490_s_at 7.94 7.587.44 7.80 7.95 7.56 7.97 7.51 7.38 8.42 8.90 8.51 205192_at 5.77 5.645.85 6.24 6.35 6.41 5.69 6.02 5.69 5.95 5.90 5.78 204725_s_at 7.15 6.757.14 7.83 7.71 7.78 7.05 6.66 6.99 7.45 7.60 7.70 211063_s_at 6.89 6.737.12 7.76 7.33 7.66 6.79 6.67 6.99 7.56 7.21 7.74 209239_at 8.35 8.598.52 7.22 7.63 7.16 8.37 8.51 8.19 8.15 8.49 8.00 207535_sat 5.46 5.265.22 6.18 6.01 5.92 5.38 5.08 5.09 5.51 5.90 5.73 201502_s_at 9.28 8.988.75 9.09 9.14 8.67 9.01 8.78 8.68 9.09 9.69 9.61 203879_at 8.35 8.588.42 7.09 6.98 6.98 7.93 8.47 8.19 7.56 7.75 7.61 211230_s_at 6.07 5.965.42 5.58 5.82 5.30 5.95 5.81 5.37 5.58 5.98 5.40 204613_at 9.30 9.439.38 9.25 9.63 9.25 9.37 9.37 9.34 9.19 9.44 9.34 207957_s_at 5.70 5.095.70 5.41 5.87 5.58 8.16 7.82 7.67 4.39 4.59 4.42 209685_s_at 7.37 6.446.92 7.33 7.47 7.24 9.65 9.18 8.97 5.98 5.98 5.71 201244_s_at 8.29 8.308.19 8.62 8.29 8.43 8.63 8.44 8.49 8.06 8.28 8.38 201783_s_at 8.92 8.758.73 9.02 8.78 8.74 8.90 8.78 8.67 8.52 8.39 8.45 209878_s_at 8.04 7.747.64 7.97 8.00 7.87 8.09 7.67 7.73 7.33 7.82 7.42 205205_at 7.31 7.026.65 7.70 7.99 7.46 7.25 6.85 6.45 7.51 7.92 7.51 212777_at 5.76 5.735.67 5.92 6.09 6.00 5.78 5.68 5.72 6.03 5.78 5.82 212780_at 6.36 5.945.97 6.28 5.81 6.13 6.25 5.69 6.41 5.82 5.79 6.27 208991_at 8.05 7.957.88 7.14 7.51 7.43 8.24 8.17 7.94 6.72 6.86 7.39 207540_s_at 9.18 9.269.23 8.25 8.11 8.30 9.16 9.14 9.44 8.20 8.38 8.56 209269_s_at 6.75 6.817.10 6.33 6.52 6.35 6.94 6.74 7.14 6.22 6.22 6.25 207616_s_at 8.31 7.687.48 8.12 8.06 8.05 8.29 7.58 8.20 8.65 8.61 8.53 209451_at 5.19 4.515.20 5.32 5.25 5.66 5.18 4.88 5.39 5.59 5.65 5.70 210458_s_at 3.97 3.833.98 3.91 3.91 3.99 3.93 3.84 3.98 4.14 4.12 4.11 205599_at 5.00 5.555.30 5.47 6.03 5.60 5.07 5.44 5.16 5.51 5.90 5.51 208315_x_at 5.55 5.655.56 5.33 5.31 4.93 5.74 5.57 5.51 5.75 5.81 5.80 221571_at 7.09 6.947.35 5.83 5.46 5.85 6.77 6.73 6.93 7.26 7.41 7.60 204352_at 5.72 5.676.02 6.04 6.16 5.88 5.54 5.54 5.40 5.16 5.87 5.35 206219_s_at 6.09 6.195.90 8.23 8.18 8.01 6.40 6.15 6.04 8.44 8.86 9.03 215988_s_at 4.45 4.324.29 4.34 4.32 4.23 4.34 4.39 4.26 4.33 4.15 4.36 211027_s_at 4.96 4.644.82 4.93 4.98 4.92 4.82 4.63 4.92 4.93 4.95 4.99 207187_at 7.17 7.417.19 7.19 7.37 7.31 7.41 7.34 7.08 7.13 7.30 6.98 211108_s_at 4.89 4.864.80 4.87 4.90 4.75 5.10 4.77 4.81 4.91 4.75 4.65 211109_at 4.61 4.704.63 4.77 4.65 4.64 4.70 4.67 4.62 4.61 4.74 4.63 213487_at 6.08 6.095.75 6.04 5.97 6.03 5.79 5.95 6.00 6.17 6.23 5.99 209636_at 5.26 5.154.96 6.02 5.62 5.38 5.43 5.18 5.00 5.55 5.84 5.51 211524_at 4.38 4.484.55 4.30 4.55 4.48 4.31 4.47 4.37 4.40 4.44 4.43 216995_x_at 5.36 5.545.37 5.45 5.58 5.39 5.35 5.51 5.41 5.41 5.42 5.27 208992_s_at 7.88 7.907.71 7.45 7.52 7.51 7.95 7.75 7.98 7.61 7.33 7.52 204413_at 5.65 5.945.50 5.78 5.93 5.58 5.49 5.84 5.49 5.46 5.73 5.28 205558_at 6.49 6.366.72 6.31 6.41 6.41 6.30 6.50 6.44 6.00 6.45 6.20

TABLE 10B CD40/BCR Signaling Genes t-test (two-tailed) Gene ProbesetspAB pAD pBC pCD Measured Changed Symbol UniGene ID Gene Title Ref.207163_s_at 2.3E−02 2.5E−02 2.6E−03 1.5E−03 Yes No AKT1 Hs.368861 v-aktmurine thymoma viral 14 oncogene homolog 1 205367_at 2.9E−04 7.2E−058.6E−05 2.1E−03 Yes Yes APS Hs.371366 adaptor protein with 15 pleckstrinhomology and src homology 2 domains 205263_at 3.9E−01 3.7E−02 3.6E−013.9E−02 Yes No BCL10 Hs.193516 B-cell CLL/lymphoma 10 16 207655_s_at3.6E−02 5.0E−02 3.8E−03 2.2E−02 Yes No BLNK Hs.167746 B-cell linker 17220059_at 7.0E−04 6.3E−05 1.2E−04 3.9E−05 Yes Yes BRDG1 Hs.121128 BCRdownstream signaling 18 1 205504_at 1.2E−04 7.0E−05 9.4E−05 2.2E−04 YesYes BTK Hs.159494 Bruton 19 agammaglobulinemia tyrosine kinase 202987_at7.1E−01 2.8E−01 9.9E−01 1.3E−01 Yes No ACT1 Hs.437508 Nuclear factorkappa B 20 activator 1 215411_s_at 5.2E−03 9.2E−02 2.2E−03 8.5E−02 YesNo ACT1 Hs.437508 Nuclear factor kappa B 20 activator 1 202514_at1.4E−01 5.5E−04 5.5E−02 7.3E−04 Yes No DLG1 Hs.389893 discs, largehomolog 1 21 (Drosophila) 202515_at 8.1E−02 1.5E−03 5.6E−02 2.7E−03 YesNo DLG1 Hs.389893 discs, large homolog 1 21 (Drosophila) 202516_s_at5.6E−02 6.4E−02 2.6E−03 4.0E−02 Yes No DLG1 Hs389893 discs, largehomolog 1 22 (Drosophila) 210105_s_at 8.1E−04 3.1E−02 3.5E−02 3.6E−02Yes No FYN Hs.390567 FYN oncogene related to 22 SRC, FGR, YES212486_s_at 1.0E−03 2.6E−01 3.8E−01 3.7E−01 Yes No FYN Hs.390567 FYNoncogene related to 22 SRC, FGR, YES 216033_s_at 4.4E−04 9.9E−02 4.3E−021.0E−01 Yes No FYN Hs.390567 FYN oncogene related to 22 SRC, FGR, YES215075_s_at 1.4E−02 1.9E−04 6.8E−03 2.9E−02 Yes No GRB2 Hs.411366 growthfactor receptor- 23 bound protein 2 209341_s_at 1.6E−01 2.5E−01 1.2E−011.8E−01 Yes No IKBKB Hs.413513 inhibitor of kappa light 24 polypeptidegene enhancer in B-cells, kinase beta 209342_s_at 1.5E−01 1.4E−012.8E−02 5.5E−02 Yes No IKBKB Hs.413513 inhibitor of kappa light 24polypeptide gene enhancer in B-cells, kinase beta 204890_s_at 4.0E−066.5E−04 2.6E−06 1.0E−03 Yes Yes LCK Hs.1765 lymphocyte-specific protein25 tyrosine kinase 204891_s_at 1.6E−03 3.6E−04 1.5E−03 3.3E−04 Yes YesLCK Hs.1765 lymphocyte-specific protein 25 tyrosine kinase 202625_at1.9E−02 1.8E−02 6.7E−02 4.2E−02 Yes No LYN Hs.80887 v-yes-1 Yamaguchi 26sarcoma viral related oncogene homolog 202626_s_at 5.1E−02 4.1E−022.4E−01 1.1E−01 Yes No LYN Hs.80887 v-yes-1 Yamaguchi 26 sarcoma viralrelated oncogene homolog 210754_s_at 2.0E−02 3.4E−02 1.6E−01 1.7E−01 YesNo LYN Hs.80887 v-yes-1 Yamaguchi 26 sarcoma viral related oncogenehomolog 202670_at 4.6E−03 4.5E−04 3.2E−02 1.1E−02 Yes No MAP2K1Hs.132311 mitogen-activated protein 27 kinase kinase 1 202424_at 2.4E−014.2E−03 4.2E−01 4.6E−03 Yes No MAP2K2 Hs.366546 mitogen-activatedprotein 27 kinase kinase 2 213490_s_at 5.6E−01 1.0E−02 5.1E−01 1.4E−02Yes No MAP2K2 Hs.366546 mitogen-activated protein 27 kinase kinase 2205192_at 2.2E−03 1.9E−01 2.5E−02 5.8E−01 Yes No MAP3K14 Hs.440315 NIK28 204725_s_at 2.2E−02 2.9E−02 1.3E−02 1.4E−02 Yes No NCK1 Hs.54589 NOKadaptor protein 1 29 211063_s_at 1.8E−02 4.3E−02 1.1E−02 2.8E−02 Yes NoNCK1 Hs.54589 NCK adaptor protein 1 29 209239_at 6.6E−03 1.9E−01 6.8E−034.6E−01 Yes No NFKB1 Hs.160557 nuclear factor of kappa 30 lightpolypeptide gene enhancer in B-cells 1 (p105) 207535_s_at 2.4E−034.8E−02 3.2E−03 2.4E−02 Yes No NFKB2 Hs.73090 nuclear factor of kappa 31light polypeptide gene enhancer in B-cells 2 (p49/p100) 201502_s_at8.8E−01 1.3E−01 4.7E−01 5.5E−02 Yes No NFKBIA Hs.81328 nuclear factor ofkappa 30 light polypeptide gene enhancer in B-cells inhibitor, alpha203879_at 2.5E−04 8.6E−04 1.3E−02 5.7E−02 Yes No PIK3CD Hs.426967phosphoinositide-3-kinase, 26 catalytic, delta polypeptide 211230_s_at3.8E−01 5.7E−01 5.7E−01 8.2E−01 Yes No PIK3CD Hs.426967phosphoinositide-3-kinase, 26 catalytic, delta polypeptide 204613_at9.7E−01 5.9E−01 9.1E−01 6.5E−01 Yes No PLCG2 Hs.512298 phospholipase C,gamma 2 26 (phosphatidylinositol- Specific) 207957_s_at 6.4E−01 2.8E−023.5E−04 4.2E−04 Yes No PRKCB1 Hs.349845 protein kinase C, beta 1 32209685_s_at 2.4E−01 5.2E−02 6.1E−03 9.2E−04 Yes No PRKCB1 Hs.349845protein kinase C, beta 1 32 201244_s_at 1.8E−01 8.7E−01 5.7E−01 8.4E−02Yes No RAF1 Hs.257266 v-raf-1 murine leukemia 26 viral oncogene homolog1 201783_s_at 7.2E−01 1.4E−02 6.1E−01 1.9E−02 Yes No RELA Hs.132594v-rel reticuloendotheliosis 30 viral oncogene homolog A 209878_s_at3.8E−01 2.2E−01 4.8E−01 2.0E−01 Yes No RELA Hs.132594 v-relreticuloendotheliosis 30 viral oncogene homolog A 205205_at 4.6E−025.6E−02 4.3E−02 5.3E−02 Yes No RELB Hs.307905 v-relreticuloendotheliosis 31 viral oncogene homolog B 212777_at 1.4E−021.7E−01 1.4E−02 1.9E−01 Yes No SOS1 Hs.326392 son of sevenless homolog 123 (Drosophila) 212780_at 9.4E−01 5.6E−01 8.8E−01 6.0E−01 Yes No SOS1Hs.326392 son of sevenless homolog 1 23 (Drosophila) 208991_at 1.9E−023.5E−02 6.8E−03 1.9E−02 Yes No STAT3 Hs.421342 signal transducer and 26activator of transcription 3 207540_s_at 7.9E−04 1.1E−02 2.0E−03 3.7E−03Yes No SYK Hs.192182 spleen tyrosine kinase 26 209269_s_at 2.7E−022.6E−02 2.6E−02 2.6E−02 Yes No SYK Hs.192182 spleen tyrosine kinase 26207616_s_at 4.2E−01 8.7E−02 8.2E−01 1.2E−01 Yes No TANK Hs.146847 TRAFfamily member- 33 associated NFKB activator 209451_at 1.9E−01 9.5E−022.6E−01 7.4E−02 Yes No TANK Hs.146847 TRAF family member- 33 associatedNFKB activator 210458_s_at 9.1E−01 4.8E−02 7.3E−01 3.3E−02 Yes No TANKHs.146847 TRAF family member- 33 associated NFKB activator 205599_at1.5E−01 1.6E−01 8.5E−02 7.2E−02 Yes No TRAF1 Hs.438253 TNFreceptor-associated 26 factor 1 208315_x_at 8.4E−02 1.4E−02 6.4E−021.2E−01 Yes No TRAF3 Hs.297660 TNF receptor-associated 26 factor 3221571_at 1.3E−03 1.3E−01 5.2E−03 9.5E−03 Yes No TRAF3 Hs.297660 TNFreceptor-associated 26 factor 3 204352_at 1.8E−01 2.5E−01 9.0E−038.9E−01 Yes No TRAF5 Hs.385685 TNF receptor-associated 26 factor 5206219_s_at 6.2E−05 9.8E−04 2.9E−04 6.7E−04 Yes Yes VAV1 Hs.116237 vav 1oncogene 23 215988_s_at 4.0E−01 4.3E−01 5.7E−01 5.8E−01 No No DLG1Hs.389893 discs, large homolog 1 21 (Drosophila) 211027_s_at 2.8E−012.4E−01 2.2E−01 1.8E−01 No No IKBKB Hs.413513 inhibitor of kappa light24 polypeptide gene enhancer in B-cells, kinase bete 207187_at 7.5E−013.8E−01 9.1E−01 3.7E−01 No No JAK3 Hs.210387 Janus kinase 3 (a protein26 tyrosine kinase, leukocyte) 211108_s_at 9.1E−01 4.3E−01 6.7E−014.0E−01 No No JAK3 Hs.210387 Janus kinase 3 (a protein 26 tyrosinekinase, leukocyte) 211109_at 4.6E−01 8.1E−01 6.2E−01 9.5E−01 No No JAK3Hs.210387 Janus kinase 3 (a protein 26 tyrosine kinase, leukocyte)213487_at 7.4E−01 3.1E−01 2.4E−01 8.2E−02 No No MAP2K2 Hs.366546mitogen-activated protein 27 kinase kinase 2 209636_at 8.2E−02 2.1E−021.2E−01 5.8E−02 No No NFKB2 Hs.73090 nuclear factor of kappa 14 lightpolypeptide gene enhancer in B-cells 2 (p49/p100) 211524_at 7.8E−014.7E−01 5.5E−01 5.0E−01 No No NFKB2 Hs.73090 nuclear factor of kappa 14light polypeptide gene enhancer in B-cells 2 (p49/p100) 216995_x_at5.8E−01 4.8E−01 5.4E−01 4.4E−01 No No RAF1 Hs.257266 v-raf-1 murineleukemia 26 viral oncogene homolog 1 208992_s_at 2.0E−02 3.1E−02 2.4E−022.1E−02 No No STAT3 Hs.421342 signal transducer and 26 activator oftranscription 3 204413_at 7.0E−01 3.3E−01 3.7E−01 5.3E−01 No No TRAF2Hs.437575 TNF receptor-associated 26 factor 2 205558_at 3.0E−01 1.4E−016.5E−01 2.7E−01 No No TRAF6 Hs.444172 TNF receptor-associated 26 factor6

FDR (false discovery rate) cutoffs are the same for Tables 5B and 6B.FDR cutoffs are the same for Tables 7B, 8B, 9B and 10B.

TABLE REFERENCES

-   1. Donze O, Deng J, Curran J, Sladek R, Picard D, Sonenberg N. The    protein kinase PKR: a molecular clock that sequentially activates    survival and death programs. Embo J. 2004; 23:564-571.-   2. Affymetrix, Santa Ana, Calif., USA. Gene Ontology Classification.    2004.-   3. Granziero L, Ghia P, Circosta P, Gottardi D, Strola G, Geuna M,    Montagna L, Piccoli P, Chilosi M, Caligaris-Cappio F. Survivin is    expressed on CD40 stimulation and interfaces proliferation and    apoptosis in B-cell chronic lymphocytic leukemia. Blood. 2001;    97:2777-2783.-   4. Janeway C A, Travers P, Walport M, Shlomchik M. Immunobiology (ed    5th): Garland Publishing; 2001.-   5. Collado A, de Andres A, Canadas E, Ruiz-Cabello F, Gomez O,    Pedrinaci S, Gamido F. Characterization of CD44 antigen during    lymphoid ontogeny. Immunobiology. 1991; 183:1-11.-   6. Colomo L, Lopez-Guillermo A, Perales M, Rives S, Martinez A,    Bosch F, Colomer D, Falini B, Montserrat E, Campo E. Clinical impact    of the differentiation profile assessed by immunophenotyping in    patients with diffuse large B-cell lymphoma. Blood. 2003; 101:78-84.-   7. Hamada T, Yonetani N, Ueda C, Maesako Y, Akasaka H, Akasaka T,    Ohno H, Kawakami K, Amakawa R, Okuma M. Expression of the PAX5/BSAP    transcription factor in haematological tumour cells and further    molecular characterization of the t(9; 14)(p13; q32) translocation    in B-cell non-Hodgkin's lymphoma. Br J Haematol. 1998; 102:691-700.-   8. Rosnet O, Mattei M G, Delattre O, Schiff C. VPREB3: cDNA    characterization and expression in human and chromosome mapping in    human and mouse. Cytogenet Cell Genet. 1999; 87:205-208.-   9. Taga S, Tetaud C, Mangeney M, Tursz T, Wiels J. Sequential    changes in glycolipid expression during human B cell    differentiation: enzymatic bases. Biochim Biophys Acta. 1995;    1254:56-65.-   10. Pieters R, Huismans D R, Loonen A H, Peters G J, Hahlen K, van    der Does-van den Berg A, van Wering E R, Veerman A J. Adenosine    deaminase and purine nucleoside phosphorylase in childhood    lymphoblastic leukemia: relation with differentiation stage, in    vitro drug resistance and clinical prognosis. Leukemia. 1992;    6:375-380.-   11. Wang Y H, Nomura J, Faye-Petersen O M, Cooper M D. Surrogate    light chain production during B cell differentiation: differential    intracellular versus cell surface expression. J Immunol. 1998;    161:1132-1139.-   12. Dobreva G, Dambacher J, Grosschedl R. SUMO modification of a    novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene    expression. Genes Dev. 2003; 17:3048-3061.-   13. Narducci M G, Pescarmona E, Lazzeri C, Signoretti S, Lavinia A    M, Remotti D, Scala E, Baroni C D, Stoppacciaro A, Croce C M,    Russo G. Regulation of TCL1 expression in B- and T-cell lymphomas    and reactive lymphoid tissues. Cancer Res. 2000; 60:2095-2100.-   14. Andjelic S, Hsia C, Suzuki H, Kadowaki T, Koyasu S, Liou H C.    Phosphatidylinositol 3-kinase and NF-kappa B/Rel are at the    divergence of CD40-mediated proliferation and survival pathways. J    Immunol. 2000; 165:3860-3867.-   15. Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A,    Yoshimura A. Cloning and characterization of APS, an adaptor    molecule containing PH and SH2 domains that is tyrosine    phosphorylated upon B-cell receptor stimulation. Oncogene. 1997;    15:7-15.-   16. Ruland J, Mak T W. Transducing signals from antigen receptors to    nuclear factor kappaB. Immunol Rev. 2003; 193:93-100.-   17. Tsuji S, Okamoto M, Yamada K, Okamoto N, Goitsuka R, Arnold R,    Kiefer F, Kitamura D. B cell adaptor containing src homology 2    domain (BASH) links B cell receptor signaling to the activation of    hematopoietic progenitor kinase 1. J Exp Med. 2001; 194:529-539.-   18. Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita    Y, Yamanaka T, Ikeda U, Shimada K, Ozawa K, Mano H. Molecular    cloning of a docking protein, BRDG1, that acts downstream of the Tec    tyrosine kinase. Proc Natl Acad Sci USA. 1999; 96:11976-11981.-   19. Brunner C, Avots A, Kreth H W, Serfling E, Schuster V. Bruton's    tyrosine kinase is activated upon CD40 stimulation in human B    lymphocytes. Immunobiology. 2002; 206:432-440.-   20. Qian Y, Qin J, Cui G, Naramura M, Snow E C, Ware C F, Fairchild    R L, Omori S A, Rickert R C, Scott M, Kotzin B L, Li X. Act1, a    Negative Regulator in CD40- and BAFF-Mediated B Cell Survival.    Immunity. 2004; 21:575-587.-   21. Xavier R, Rabizadeh S, Ishiguro K, Andre N, Ortiz J B, Wachtel    H, Morris D G, Lopez-Ilasaca M, Shaw A C, Swat W, Seed B. Discs    large (Dlg1) complexes in lymphocyte activation. J Cell Biol. 2004;    166:173-178.-   22. Pleiman C M, Clark M R, Gauen L K, Winitz S, Coggeshall K M,    Johnson G L, Shaw A S, Cambier J C. Mapping of sites on the Src    family protein tyrosine kinases p55blk, p59fyn, and p56lyn which    interact with the effector molecules phospholipase C-gamma 2,    microtubule-associated protein kinase, GTPase-activating protein,    and phosphatidylinositol 3-kinase. Mol Cell Biol. 1993;    13:5877-5887.-   23. Smit L, van der Horst G, Borst J. Sos, Vav, and C3G participate    in B cell receptor-induced signaling pathways and differentially    associate with Shc-Grb2, Crk, and Crk-L adaptors. J Biol Chem. 1996;    271:8564-8569.-   24. Ren H, Schmalstieg A, Yuan D, Gaynor R B. I-kappa B kinase beta    is critical for B cell proliferation and antibody response. J    Immunol. 2002; 168:577-587.-   25. Dal Porto J M, Burke K, Cambier J C. Regulation of BCR signal    transduction in B-1 cells requires the expression of the Src family    kinase Lck. Immunity. 2004; 21:443-453.-   26. van Kooten C, Banchereau J. CD40-CD40 ligand. J Leukoc Biol.    2000; 67:2-17.-   27. Gulbins E, Brenner B, Schlottmann K, Koppenhoefer U, Linderkamp    O, Coggeshall K M, Lang F. Activation of the Ras signaling pathway    by the CD40 receptor. J Immunol. 1996; 157:2844-2850.-   28. Ramakrishnan P, Wang W, Wallach D. Receptor-Specific Signaling    for Both the Alternative and the Canonical NF-kappaB Activation    Pathways by NF-kappaB-Inducing Kinase. Immunity. 2004; 21:477-489.-   29. Fu C, Turck C W, Kurosaki T, Chan A C. BLNK: a central linker    protein in B cell activation. Immunity. 1998; 9:93-103.-   30. Berberich I, Shu G L, Clark E A. Cross-linking CD40 on B cells    rapidly activates nuclear factor-kappa B. J Immunol. 1994;    153:4357-4366.-   31. Beinke S, Ley S C. Functions of NF-kappaB1 and NF-kappaB2 in    immune cell biology. Biochem J. 2004; Pt.-   32. Sakata N, Kawasome H, Terada N, Gerwins P, Johnson G L, Gelfand    E W. Differential activation and regulation of mitogen-activated    protein kinases through the antigen receptor and CD40 in human B    cells. Eur J Immunol. 1999; 29:2999-3008.-   33. Cheng G, Baltimore D. TANK, a co-inducer with TRAF2 of TNF- and    CD 40L-mediated NF-kappaB activation. Genes Dev. 1996; 10:963-973.

Example 3 Signaling in the LCK-VAV-MAPK Pathway Differs inCD40-Sensitive and CD40-Resistant Cell Lines

In lymphoma cells, CD40 signaling is mediated by three interactingpathways. Current evidence suggests that the NFκB pathway is the mostimportant of these pathways for controlling cell survival. Microarraystudies showed that CD40 sensitivity was not associated with differencesin expression of transcripts encoding members of this pathway, butrather with changes in the expression level of LCK and VAV1, whichactivate the RAS-RAF-ERK pathway. To further characterize theassociation between the MAPK pathway and CD40 sensitivity, weinvestigated activation of LCK (which activates VAV1) and MAP kinases(which are activated by VAV1). LCK is a member of the src protein familyof kinases, which can be phosphorylated at two sites, one of whichactivates the kinase, whereas the other is inhibitory. Western blotsshowed that activated LCK was present in all four cell lines in theabsence of CD40 stimulation (FIG. 7A). This is consistent with previousresults that have identified constitutively active LCK in the majorityof B-cell malignancies (27). In contrast, only CD40-sensitive OCI-Ly7and Su-DHL4 (but not CD40-resistant OCI-Ly1 or OCI-Ly8) containedconstitutively phosphorylated ERK p42/p44 (FIG. 7B). As p38 and jnk havealso been shown to be activated by CD40 (28), and are known to bedownstream targets of VAV (29, 30), we investigated the phosphorylationstate of these MAPK family proteins. p38 was constitutivelyphosphorylated in all cell lines and JNK was present but notphosphorylated in any of the cell lines.

LCK transgenic mice have been shown to develop thymic lymphomascontaining constitutively activated VAV and ERK, and cell lines derivedfrom such tumors were dependent on tyrosine phosphorylation andraf-dependent ERK activation for survival (31). CD40-sensitive but notCD40-resistant cell lines express VAV, a central part of the LCK-ERKsignal transduction pathway; therefore, we would expect growth ofCD40-sensitive but not CD40-resistant cells would be expected to beinhibited by blocking LCK or ERK activity. Cells were exposed to a rangeof concentrations of the src family kinase inhibitor PP1 (32). Aspredicted, growth of CD40-sensitive OCI-Ly7 and Su-DHL4 cells wasinhibited by PP1 more efficiently than growth of CD40-resistant OCI-Ly1and OCI-Ly8 cells (FIG. 8A). In contrast, similar experiments with theMEK 1/2 inhibitor U0126, which prevents phosphorylation of ERK (33), didnot show differential effects on growth of CD40-sensitive andCD40-resistant DLCBL lines (FIG. 8B). These observations suggest thatLCK but not ERK is involved in maintaining growth of CD40-sensitiveDLCBL cell lines.

Example 4 Phosphorylated ERK is Required for CD40-Mediated Cell Death

CD40 stimulation has been shown to activate both ERK and p38; however,inhibition of ERK, but not p38 phosphorylation, has been reported toenhance CD40-mediated apoptosis in a carcinoma cell line (34). Wetherefore determined the effect of CD40 stimulation on ERK activation byWestern blotting for phosphorylated and total ERK. ERK wasconstitutively phosphorylated in OCI-Ly7 and Su-DHL4 cells, and notphosphorylated before or after CD40 ligation in OCI-1 and OCI-Ly8 cells(FIG. 9). This suggests that unlike carcinoma cell lines, DLCBL celllines do not upregulate ERK activity upon CD40 signaling; however,constitutively active ERK may influence the outcome of CD40 signaling.For example, if ERK protects DLCBL against CD40-mediated apoptosis,inhibition of ERK prior to CD40 stimulation should enhance cell death inOCI-Ly7 and Su-DHL4 cells by reducing constitutive ERK activity, whereasOCI-Ly1 and OCI-Ly8 cells which lack active ERK should be unaffected byan ERK inhibitor. This hypothesis was tested using pharmacologicinhibitors of MEK. Su-DHL4 cells were incubated in the presence of 10 μMU0126 for 48 hours, permeabilized and stained with an anti-phospho-ERKantibody. Phosphorylation of ERK was reduced after addition of the MEKinhibitor U0126 as shown by flow cytometry. See Materials and Methodssection of Examples. To determine if ERK is involved in CD40-mediatedcell death, cells were treated with the MEK1/2 inhibitors U0126 orPD98058 prior to CD40 stimulation. The p38 inhibitor SB230580, which hasbeen shown previously to have no effect on activation-induced cell death(11) was used as a negative control. Viable cell counts were measured 96hours after CD40 ligation. The MEK1/2 inhibitors U0126 and PD98058, butnot the p38 inhibitor SB230580, reduced CD40-mediated cell death inOCI-Ly7 and Su-DHL4 cells (FIG. 10), suggesting that ERK promotes ratherthan opposes activation-induced cell death in DLCBL cell lines.

Example 5 Expression of p-SRC, VAV, and p-ERK in DLCBL Tumor Samples

To determine if variations in ERK signaling exist in human tumors,immunohistochemical staining for phosphorylated SRC family kinases(p-SRC), VAV, and p-ERK was performed. An initial set of 25 blocks waspre-screened for expression of the B-cell markers CD20 and CD79a. Twentysamples were found to be positive and stained with antibodies to p-SRC,VAV, and p-ERK. Staining intensity was scored using the H-score system,which combines the percentage of positive cells with an intensity gradeto yield a final range of 0 (negative staining) to 300 (all cellsstrongly positive).

TABLE 11 Intensity p-SRC VAV p-ERK 0 10 0 6  1-99 7 5 5 100-199 1 3 3200-300 2 12 6

The following correlations were observed. All six samples lackingphosphorylated ERK were also p-SRC negative. The four p-ERK positivesamples lacking p-SRC had very high levels of VAV expression, suggestingthat constitutive activation of VAV may abrogate the need for active SRCfamily kinases. Where VAV expression was moderate, staining intensity ofp-ERK correlated with intensity of p-SRC.

The tumor samples were from biopsies performed at the Montreal Generaland Royal Victoria Hospitals in Montreal between 1991 and 1993. Allsamples had been classified as diffuse large B-cell lymphoma atdiagnosis. This was confirmed by staining for expression of CD20 with anantibody from DAKO. CD20 is the standard marker for B-cells. Dr. ReneMichel of McGill University is kindly thanked for his assistance inthese immunohistochemical studies on tumor samples.

Antibodies for staining of VAV, phospho-ERK, and phospho-SRC family werefrom Cell Signaling Technology, Danvers, Mass., USA(www.cellsignal.com). The VAV antibody was #2502. The presence of VAVhas been associated with increased NFκB activity. The phospho-ERKantibody #4376 detects specifically the active form of ERK, the formthat is required for CD40-mediated cell death. The phospho-SRC family#2101 detects SRC as well as the related kinases Lyn, Fyn, Lck, Yes andHck in the active form. These kinases are part of a signaling pathwaythat can activate ERK.

While this invention has been particularly shown and described withreferences to preferred embodiments thereof, it will be understood bythose skilled in the art that various changes in form and details may bemade therein without departing from the scope of the inventionencompassed by the appended claims.

1. A method of determining whether first cells respond to CD40stimulation by undergoing apoptosis, said method comprising testing saidfirst cells for their profile of gene expression, and comparing saidprofile with a second profile of gene expression of second cells knownto respond to CD40 stimulation by undergoing apoptosis; wherein, if saidprofile of gene expression shows expression levels of genescharacteristic of the second profile, said cells respond to CD40stimulation by undergoing apoptosis.
 2. The method of claim 1 whereintesting is by analysis of RNA from said first cells and said secondcells on one or more arrays.
 3. A method of determining whether firstcells respond to CD40 stimulation by undergoing apoptosis, said methodcomprising testing said first cells for levels of expression of one ormore genes, and comparing a first set of levels of expression of saidone or more genes to a second set of levels of expression of said one ormore genes in second cells known to respond to CD40 stimulation byundergoing apoptosis; wherein, if the first set of levels of expressionof said one or more genes in said first cells is characteristic of saidsecond set of levels of the second cells, said first cells respond toCD40 stimulation by undergoing apoptosis.
 4. The method of claim 3wherein testing is by analysis of RNA from said first cells and saidsecond cells on one or more arrays.
 5. A method for determining whethera population of cells is CD40-sensitive, said method comprisingquantitating expression of one or more genes in a sample of cells fromthe population, wherein said one or more genes in diffuse large-cellB-lymphoma (DLCBL) cell lines are differentially regulated betweenCD40-sensitive DLCBL cell lines and CD40-resistant DLCBL cell lines, andcomparing quantities of expression of said one or more genes in saidsample to quantities of expression of said one or more genes inCD40-resistant DLCBL cell lines, wherein if said one or more genes aredifferentially regulated between the cells in the sample and theCD40-resistant DLCBL cell lines, then the population of cells isCD40-sensitive.
 6. The method of claim 5 wherein the one or more genesare selected from B-cell maturation specific genes.
 7. The method ofclaim 5 wherein the one or more genes are selected from members of theCD40 signaling pathway.
 8. The method of claim 5 wherein the one or moregenes are selected from the group consisting of: RAG1, RAG2, IGLL1, CD9,VPREB1, CD22, CD38, Bruton's tyrosine kinase, VAV1, LYN, LCK andMEK1/MAP2K1.
 9. The method of claim 5 wherein the gene is RAG1.
 10. Themethod of claim 5 wherein the gene is VAV1.
 11. The method of claim 5wherein quantitating expression is by reverse transcription polymerasechain reaction (RT-PCR).
 12. The method of claim 5 wherein quantitatingexpression and comparing quantities is by analysis on arrays.
 13. Themethod of claim 5 wherein quantitating expression and comparingquantities is by immunohistochemistry.
 14. A method for determiningwhether a population of cells is CD40-sensitive or CD40-resistant, saidmethod comprising testing a sample of cells from said population for thepresence or absence of phosphorylated ERK, whereby, if phosphorylatedERK is present, the population of cells is CD40-sensitive, and ifphosphorylated ERK is absent, the population of cells is CD40-resistant.15. The method of claim 14 wherein the sample of cells is tested byimmunoblot of non-denatured lysates from the sample of cells usinganti-phospho-ERK antibodies.
 16. The method of claim 14 wherein thesample of cells is tested by immunostaining.
 17. The method of claim 14wherein the immunostaining is by immunofluorescent labeledanti-phospho-ERK antibodies
 18. The method of claim 14 wherein theimmunostaining is by immunohistochemistry using anti-phospho-ERKantibodies conjugated to a reactive label.
 19. The method of claim 14wherein the sample of cells is a tissue biopsy or a fluid sample from ahuman or animal.
 20. The method of claim 14 wherein the population ofcells is a primary culture of cells from a human or animal.
 21. Themethod of claim 14 wherein the population of cells is a cell line. 22.The method of claim 14 wherein the population of cells comprises B-celllymphoma cells.
 23. The method of claim 14 wherein the population ofcells comprises diffuse large-cell B-lymphoma cells.
 24. The method ofclaim 14 wherein the population of cells comprises cancer cells.
 25. Themethod of claim 14 wherein the cancer cells are derived from endothelialcells.
 26. The method of claim 14 wherein the cancer cells are derivedfrom epithelial cells.
 27. The method of claim 14 wherein the cancercells are derived from fibroblasts.
 28. The method of claim 14 whereinthe cancer cells are breast cancer cells.
 29. The method of claim 14wherein the cancer cells are prostate cancer cells.
 30. The method ofclaim 14 wherein the cancer cells are lung cancer cells.
 31. The methodof claim 14 wherein the cancer cells are colon cancer cells.
 32. Amethod for determining whether a population of cells is CD40-sensitiveor CD40-resistant, said method comprising testing a sample of cells fromsaid population for the presence or absence of p-SRC, whereby, if p-SRCis absent, the population of cells is CD40-resistant.
 33. A kit fordetermining whether a population of cells is CD40-sensitive orCD40-resistant, comprising anti-phospho-ERK antibody, anti-VAV antibody,and anti-RAG1 antibody.